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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
(E/Z)-J147
" in MedChemExpress (MCE) Product Catalog:
Products (1)
Resources (0)
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1 Results for "(E/Z)-J147" in MCE Product Catalog:
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Most Publications
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Pathways
Recommended:
- GPCR/G Protein
- Stem Cell/Wnt
- Cytoskeleton
- Apoptosis
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- Epigenetics
- JAK/STAT Signaling
- TGF-beta/Smad
- Protein Tyrosine Kinase/RTK
- Antibody-Drug Conjugate/ADC Related
- PROTAC
- Vitamin D Related/Nuclear Receptor
- Anti-infection
- Immunology/Inflammation
- Cell Cycle/DNA Damage
- Autophagy
- Others
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- PI3K/Akt/mTOR
-
Isoforms
Recommended:
- iNOS
- CYP4
- PRMT7
- apoA4
- CXCR1
- PKD3
- GPX4
- PDE12
- CES1
- V1b Receptor
- LPAR6
- NEK1
- GFRα4
- FFAR4
- 3β-HSD III
- D2 Receptor
- Protein Polybromo-1
- MRCKα
- EHD3
- PTH3R
- HCAR1
- TRPV1
- DCAF11
- PRMT3
- TNFRSF3/CD18
- SHMT2
- SGLT1
- PGK1
- NOX2
- PRKY
- RUNX2
- EHMT1/GLP/KMT1D
- CA XII
- TRPM4
- JNK1
- JNK2
- JNK3
- PI3Kα
- PI3Kβ
- PI3Kδ
- CDK1
- CDK2
- CDK3
- CDK4
- CDK5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK11
- CDK12
- CDK13
- EGFR/ErbB1/HER1
- ErbB2/HER2
- ErbB3/HER3
- ErbB4/HER4
- VEGFR1/Flt-1
- VEGFR2/KDR/Flk-1
- VEGFR3/Flt-4
- HDAC1
- HDAC2
- HDAC3
- HDAC4
- HDAC5
- HDAC6
- HDAC7
- HDAC8
- HDAC9
- HDAC10
- HDAC11
- Akt2
- Akt3
- ROCK1
- ROCK2
- PDGFRβ
- B-Raf
- CDC
- CDK19
- JAK2
- GSK-3β
- Aurora A
- Aurora B
- GSK-3α
- TrkB
- TrkC
- ERK1
- ERK2
- CLK
- PDGFRα
- PI3Kγ
- Vps34
- ATM
- ATR
- BRD4
- MEK1
- N-type calcium channel
- PI3KC2β
- PI4KIIIβ
- PI4KIIIα
- PI3KC2α
- mTORC1
- mTORC2
- JAK3
- C-Raf
- TrkA
- HD1
- HD2
- SIRT1
- SIRT2
- SIRT3
- Chk1
- Chk2
- Aurora C
- MEK2
- JAK1
- IDO
- IDO1
- NUAK1
- NUAK2
- AMPK α1β1γ1
- AMPK α2β1γ1
- AMPK α1β2γ1
- AMPK α2β2γ1
- MMP-9
- PPARα
- PLK1
- PLK2
- PLK3
- PLK4
- PLK5
- RelB
- c-Rel
- IKK-β
- IKK-α
- IKKε
- TBK1
- MAP3K7/TAK1
- TNKS1/PARP5A
- TNKS2/PARP5B
- EP
- TXA2/TP
- ACAT1
- ACAT2
- MGAT2
- PDE2
- PDE10
- PDE11
- PDE4
- CBP/p300
- TIP60
- MAP4K4/HGK
- MAP4K5/KHS1
- MAP4K6/MINK1
- RGS4
- RGS19
- RGS16
- RGS8
- Abl
- PPARγ
- L-type calcium channel
- LIMK1
- LIMK2
- HIV-1
- HIV-2
- Topo I
- Topo II
- PARP1
- HSV-1
- HSV-2
- TXB2
-
Targets
Recommended:
- ROCK
- Phosphodiesterase (PDE)
- Asialoglycoprotein Receptor (ASGPR)
- EGFR
- Kallikrein
- Proton Pump
- Oxytocin Receptor
- IFNAR
- Endonuclease
- GPR109A
- Parasite
- Prolyl Endopeptidase (PREP)
- Amino Acid Derivatives
- BTB/POZ Family
- Oxysterol-binding Protein-related Protein (ORP)
- SOD
- YAP
- OAT
- Drug Metabolite
- Epigenetic Reader Domain
- FOXO
- Fluorescent Dye
- Gli
- Adiponectin Receptor
- PAI-1
- FKBP
- NEKs
- p62
- Ceramidase
- Drug Intermediate
- FABP
- Elastase
- MEK
- Amino Acid Decarboxylase
- VAP-1
- RIO Kinase
- GLP Receptor
- Pyk2
- Complement System
- Macrophage migration inhibitory factor (MIF)
- hnRNP
- Emopamil Binding Protein
- Ferrochelatase
- Dan family
- Dopamine Receptor
- LAG-3
- AP-1
- Carnitine Palmitoyltransferase (CPT)
- SLK
- Prion Protein
- SF3B1
- MAPKAPK2 (MK2)
- CXCR
- Amylases
- Ligands for E3 Ligase
- PERK
- JAK
- CD276/B7-H3
- ER-phagy
- Topoisomerase
- Adenylate Cyclase
- FLAP
- Akt
- HSV
- LDLR
- Insulin Receptor
- Antibody-Drug Conjugates (ADCs)
- Tryptophan Hydroxylase
- Nucleoside Antimetabolite/Analog
- CD22
- Telomerase
- MNK
- Fungal
- Calmodulin
- Factor VIIa
- Fc Receptor (FcR)
- FAP
- Sodium Chloride Cotransporter (NCC)
- RXFP Receptor
- PNPLA3
- TET Protein
- SHP2
- SDCBP
- Factor VIII
- PAK
- nAChR
- Neuropeptide S Receptor
- Factor XI
- Furin
- Enterovirus
- BMX Kinase
- Plant Growth Regulators
- Cathepsin
- RABV
- SnRK
- Melanopsin Receptor
- CMV
- Plasminogen/Plasmin
- Atg8/LC3
- Notch
- METTL3
- Cryptochrome
- Adrenergic Receptor
- Liposome
- Mitosis
- YB-1
- Dynamin
- STK33
- TrxR
- Ferroptosis
- Ketohexokinase
- HCV
- Stearoyl-CoA Desaturase (SCD)
- DNA Alkylator/Crosslinker
- TNF Receptor
- Microphthalmia Associated Transcription Factor (MITF)
- PARP
- Penicillin-binding protein (PBP)
- Glycosidase
- Disulfidptosis
- Chloride Channel
- Free Radical Scavengers
- Discoidin Domain Receptor
- Itk
- Acetolactate Synthase (ALS)
- FLT3
- Tissue Factor Pathway Inhibitor (TFPI)
- KLF
- Mitogen- and Stress-Activated Protein Kinase (MSK)
- Indoleamine 2,3-Dioxygenase (IDO)
- Others
- CFTR
- Pyroptosis
- Actin
- Thrombin
- Urease
- Photosystem II
- Opioid Receptor
- PI4P5K
- Myosin
- TMPRSS6
- 5-HT Receptor
- Tim3
- Glutamate Dehydrogenase (GLDH)
- Programmed Cell Death 4 (PDCD4)
- Apical Sodium-Dependent Bile Acid Transporter
- Integrin
- Xanthine Oxidase
- PKD
- Wnt
- Androgen Receptor
- Connective Peptide
- IKZF Family
- L-Selectin
- Autophagy
- Claudin
- Drug Isomer
- Bradykinin Receptor
- TSH Receptor
- OLIG2
- PDI
- Amylin Receptor
- Thyroid Hormone Receptor
- Photosensitizer
- Mineralocorticoid Receptor
- Angiotensin-converting Enzyme (ACE)
- URAT1
- Orthopoxvirus
- ABA Receptor
- SHP1
- Smo
- Arp2/3 Complex
- ALCAM/CD166
- Urea Transporter
- Raf
- Arenavirus
- PDK-1
- COMT
- Orphan GPCR
- Lysyl Oxidase
- PCSK9
- REV-ERB
- Glucocorticoid Receptor
- YTHDF
- Biochemical Assay Reagents
- HIV Integrase
- Keap1-Nrf2
- Kisspeptin Receptor
- Phosphorylase
- PEPCK
- CGRP Receptor
- RUNX
- DNA Stain
- PGE synthase
- MicroRNA
- Acetyl-CoA Carboxylase
- Lactate Dehydrogenase
- G-quadruplex
- Prokineticin Receptor
- ICMT
- Neuropeptide Y Receptor
- Interleukin Related
- mTOR
- SLC39 (Zinc Transporter)
- Cadherin
- Influenza Virus
- RAR/RXR
- BCL6
- Transferrin Receptor
- Protease Activated Receptor (PAR)
- Succinate Receptor 1
- Secretin Receptor
- ASCT
- Synaptic Vesicle Proteins
- NF-κB
- Reference Standards
- S-adenosylhomocysteine hydrolase (SAHH)
- GPR55
- Heme Oxygenase (HO)
- RIBOTAC
- Acetyl-CoA synthetase
- Drug Derivative
- Dengue Virus
- Bombesin Receptor
- RNA MTase
- ATTECs
- Fatty Acid Synthase (FASN)
- Oct3/4
- GPR88
- PI5P4K
- IRE1
- Nuclear Hormone Receptor 4A/NR4A
- p38 MAPK
- MCHR1 (GPR24)
- Dihydroceramide Desaturase 1 (DES1)
- Calcium Channel
- Transthyretin (TTR)
- GLUT
- N-myristoyltransferase
- Dihydroorotate Dehydrogenase
- Ligands for Target Protein for PROTAC
- GPR171
- ATGL
- DNA/RNA Synthesis
- Serine Racemase (SR)
- PI4K
- Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
- DNA-PK
- mAChR
- MARCKS
- C-type Lectin-like Receptors (CTLRs)
- Reactive Oxygen Species (ROS)
- ATF6
- Enolase
- HCN Channel
- CD3
- Monocarboxylate Transporter
- Measles Virus
- IGF-1R
- ATP Citrate Lyase
- Beta-secretase
- Dystrophin
- Carboxypeptidase
- VD/VDR
- LILRB
- Ferroportin
- Thymidylate Synthase
- Pim
- IPK Superfamily
- Survivin
- Amine N-methyltransferase
- Separase
- Eukaryotic Release Factor (eRF)
- IDE
- Factor Xa
- Pyruvate Kinase
- Dopamine Transporter
- NADPH Oxidase
- PROTAC-Linker Conjugates for PAC
- PROTAC Linkers
- P2Y Receptor
- Hormone-Sensitive Lipase (HSL)
- Galectin
- Angiotensin Receptor
- Isocitrate Dehydrogenase (IDH)
- β-glucuronidase
- CD1
- CDK
- HRASLS
- Microsomal Triglyceride Transfer Protein (MTP)
- Microtubule/Tubulin
- Deubiquitinase
- GPR35
- Glycine Receptor (GlyR)
- Transcription Factor ERG
- TREM receptor
- SRPK
- Ser/Thr Protease
- HDAC
- MELK
- PIKfyve
- STING
- GnRH Receptor
- GPR119
- Tyrosinase
- Scavenger Receptor Class B type I (SR-BI）
- NEDD8-activating Enzyme
- Hedgehog
- Casein Kinase
- Pyruvate Carboxylase (PC)
- Methylenetetrahydrofolate Dehydrogenase (MTHFD)
- Polo-like Kinase (PLK)
- Beclin1
- SphK
- Arginase
- α-synuclein
- Glucosylceramide Synthase (GCS)
- Nectin-4
- Arrestin
- ACSL Family
- Legumain
- HCV Protease
- FOXA
- CaSR
- TSPO
- TLK
- Flavivirus
- Thrombopoietin Receptor
- PANK
- AUTOTACs
- Acyltransferase
- Small Interfering RNA (siRNA)
- MAP3K
- CHIKV
- Somatostatin Receptor
- Ornithine decarboxylase (ODC)
- P-selectin
- G Protein-coupled Receptor Kinase (GRK)
- Orphan Receptor
- Phosphoramidites
- Steroid Sulfatase
- Glutathione S-transferase
- Adenosine Kinase
- HSP
- VEGFR
- CRAC Channel
- Dipeptidyl Peptidase
- TMV
- IMPDH
- Mixed Lineage Kinase
- ClpP
- 3β-HSD
- SHMT
- GSK-3
- MetAP
- GHR
- Radionuclide-Drug Conjugates (RDCs)
- Prostaglandin Receptor
- Urotensin Receptor
- ADAMTS
- Dihydropyrimidine Dehydrogenase (DPD)
- CD38
- PhosTACs
- Clathrin
- Natriuretic Peptide Receptor (NPR)
- PKC
- DNA Methyltransferase
- Neurokinin Receptor
- Hepatitis E Virus (HEV)
- ADC Payloads
- Melatonin Receptor
- Target Protein Ligand-Linker Conjugates
- Sigma Receptor
- Glucokinase
- Apelin Receptor (APJ)
- Hemoglobin
- DAPK
- Aminotransferases (Transaminases)
- Glycosyltransferase
- Orphan Nuclear Receptor
- VZV
- Exosomes
- Malate Dehydrogenase (MDH)
- Ser/Thr Kinase
- Monoamine Oxidase
- SGLT
- Calpain
- ByeTAC
- GDNF Receptor
- Hapten
- TRP Channel
- MOFs
- MAGL
- Cholecystokinin Receptor
- RSV
- GHSR
- GPR39
- Mesothelin
- STAT
- Glutaminase
- AUTACs
- Adhesion G Protein-coupled Receptors (AGPCRs)
- PPAR
- EHD Protein
- γ-secretase
- Kinesin
- Ninjurin
- Pregnane X Receptor (PXR)
- RAD51
- Neprilysin
- Histamine Receptor
- MHC
- KMO
- Nuclear Factor of activated T Cells (NFAT)
- c-Met/HGFR
- Aquaporin
- Sodium Channel
- Serpin
- MyD88
- FOXM1
- Potassium Channel
- Mps1
- Hexokinase
- Na+/K+ ATPase
- TNK1
- Progesterone Receptor
- Dopamine β-hydroxylase
- RGS Protein
- TGF-beta/Smad
- Amyloid-β
- Histone Methyltransferase
- TSSK
- Leukotriene Receptor
- Piezo Channel
- LYTACs
- MASTL
- Ack1
- Proteolytic Enzyme
- CaMK
- PKA
- PDHK
- Porcupine
- Serotonin Transporter
- Choline Kinase
- Bcr-Abl
- Gap Junction Protein
- Farnesyl Transferase
- S100 Protein
- Glycoprotein VI
- VISTA
- Guanylate Cyclase
- Cyclic GMP-AMP Synthase
- Metal Nanoparticles
- PD-1/PD-L1
- Mucin
- Sex Pheromone
- HIF/HIF Prolyl-Hydroxylase
- Zinc Finger Protein
- LXR
- GPR4
- EBI2/GPR183
- NAMPT
- Trk Receptor
- DNA Glycosylase
- Neuromedin U Receptor (NMUR)
- Filovirus
- 14-3-3 Protein
- CRFR
- AIM2
- Oxidative Phosphorylation
- Motilin Receptor
- Ferlin Family
- Adenosine Deaminase
- Endoplasmic Reticulum Oxidoreductase 1 (ERO1)
- PTEN
- Atg4
- Folate Receptor (FR)
- HIV
- MAP4K
- Galactokinase
- Olfactory Receptor
- CD6
- VSV
- Environmental Pollutants
- Transketolase
- Quinone Reductase
- ULK
- Hydroxycarboxylic Acid Receptor (HCAR)
- Sec61
- Mitophagy
- Haspin Kinase
- Ribosomal S6 Kinase (RSK)
- Antifolate
- Calcineurin
- Proteasome Cap Targeting Chimeras
- NOD-like Receptor (NLR)
- γ-Glutamyl Transferase (GGT)
- Carboxylesterase (CES)
- Phosphoglycerate Dehydrogenase (PHGDH)
- Amino Acid Oxidase
- Neuropeptide FF Receptor
- CDKL
- Na+/H+ Exchanger (NHE)
- Chemerin Receptor
- CD73
- Endothelin Receptor
- CX3CR1
- CD2
- Pantetheinase
- GPR139
- Huntingtin
- Epoxide Hydrolase
- Cholinesterase (ChE)
- Succinate Dehydrogenase
- DUBTACs
- Bacterial
- CD44
- SGK
- ASK1
- CD28
- DYRK
- Bcl-2 Family
- Squalene Monooxygenase
- G2A (GPR132)
- Organoid
- E-Selectin
- Nucleoside Transporters
- Neurotensin Receptor
- OGA
- SULT
- EBV
- CD19
- Branched Chain Amino Acid Transaminase (BCAT)
- LPL Receptor
- MALT1
- ROS Kinase
- Antibiotic
- FAK
- RET
- Erythropoietin Receptor (EpoR)
- ADC Linkers
- Phosphatase
- Amino acid Transporter
- Fructose-1,6-bisphosphate aldolase
- Carbonic Anhydrase
- Drug-Linker Conjugates for ADC
- Transglutaminase
- Tomato Spotted Wilt Virus (TSWV)
- DOCK
- Mas-related G-protein-coupled Receptor (MRGPR)
- Glutathione Peroxidase
- Src
- GGTase
- Hepcidin
- GABA Receptor
- Tyrosine Hydroxylase
- HPV
- NO Synthase
- PACAP Receptor
- CTLA-4
- HIV Protease
- CD20
- Peptide-Drug Conjugates (PDCs)
- Myotonin-Protein Kinase (DMPK)
- Aurora Kinase
- 15-PGDH
- mRNA
- Hsp-targeting Chimeras
- Estrogen Receptor/ERR
- MMP
- ELOVL
- Orexin Receptor (OX Receptor)
- VRK
- Aldehyde Dehydrogenase (ALDH)
- RPE65
- EAAT
- Osteopontin
- Proteasome
- RIG-I-like receptor (RLR)
- Imidazoline Receptor
- Na+/HCO3- Cotransporter
- P2X Receptor
- Protoporphyrinogen IX oxidase
- CD47
- Glutathione Reductase (GR)
- mGluR
- IKK
- ATM/ATR
- SPFH Protein Superfamily
- Sialyltransferase
- Melanocortin Receptor
- Methionine Adenosyltransferase (MAT)
- Phosphoglycerate Kinase (PGK)
- Glycolate Oxidase
- FOXP
- Lipocalin Family
- Apolipoprotein
- HMG-CoA Reductase (HMGCR)
- FATP
- PSMA
- DAGL
- Salt-inducible Kinase (SIK)
- BMI1
- c-Kit
- Paraptosis
- Adenosine Receptor
- IAP
- HBV
- FXR
- Anaplastic lymphoma kinase (ALK)
- HyT
- PIN1
- Btk
- Eukaryotic Initiation Factor (eIF)
- Connexin
- NADH Dehydrogenase
- Oligopeptide Cotransporter
- Microtubule‐associated serine/threonine kinase (MAST)
- 17β-HSD
- NKCC
- ADC Antibodies
- Toll-like Receptor (TLR)
- SNIPERs
- Carbamoyl Phosphate Synthetase (CPS)
- Tie
- CRM1
- GPR6
- Antibody-Oligonucleotide Conjugates (AOCs)
- Hippo (MST)
- Cyclin G-associated Kinase (GAK)
- Aminoacyl-tRNA Synthetase
- Cyclophilin
- PASK/STK37
- PROTACs
- P-glycoprotein
- ROR
- Necroptosis
- TOPK
- FASTK
- GPR65
- Repulsive guidance molecule
- MARK
- GPR84
- Enteropeptidase
- Collagen
- DGK
- Transmembrane Glycoprotein
- Phytohormone
- Sirtuin
- PROTECs
- OGT
- TROP2
- AAK1
- Lipoxygenase
- GSNOR
- Trace Amine-associated Receptor (TAAR)
- Monoamine Transporter
- 3α-HSD
- WDR5
- Renin
- Sodium Phosphate Cotransporter
- Fat Mass and Obesity-associated Protein (FTO)
- Dihydrofolate reductase (DHFR)
- HPPD
- IRAK
- GCGR
- Phosphomannose Isomerase (PMI)
- Peroxidase Enzyme
- β-catenin
- Malonyl-CoA Decarboxylase
- LOX-1
- Ephrin Receptor
- FGFR
- Free Fatty Acid Receptor
- CETP
- Large Tumor Suppressor (LATS)
- RIP kinase
- Wee1
- CCR
- FBPase
- c-Fms
- MDM-2/p53
- Endogenous Metabolite
- Tau Protein
- Caspase
- 5 alpha Reductase
- sFRP-1
- HMG Family
- Apoptosis
- Glyoxalase (GLO)
- E1/E2/E3 Enzyme
- TGF-β Receptor
- Phospholipase
- FAAH
- GPR52
- Taste Receptor
- PANoptosis
- BCRP
- VKOR
- Lipase
- Dimethylargininase (DDAH)
- ATP-binding cassette (ABC) transporters
- Slit Proteins
- LIM Kinase (LIMK)
- Constitutive Androstane Receptor
- PINK1/Parkin
- E3 Ligase Ligand-Linker Conjugates
- Syk
- Neuropeptide B/W Receptor
- Atg7
- WNK Kinase
- iGluR
- Aldose Reductase
- Aryl Hydrocarbon Receptor
- Cellulose Synthase
- Poly(ADP-ribose) Glycohydrolase (PARG)
- UGT
- G protein-coupled Bile Acid Receptor 1
- Carnosine-cleaving Enzyme
- BRK
- Insecticide
- HuR
- Formyl Peptide Receptor (FPR)
- Ras
- Creatine Kinase
- JNK
- ANGPTL
- Vasopressin Receptor
- Cdc42-binding kinase
- PGC-1α
- Virus Protease
- PDGFR
- GPR68
- FOXC
- 20α-HSD
- Isotope-Labeled Compounds
- Molecular Glues
- PTHR
- Platelet-activating Factor Receptor (PAFR)
- COX
- Aldehyde Oxidase (AO)
- ERK
- Checkpoint Kinase (Chk)
- Cuproptosis
- CD74
- p97
- Protein Arginine Deiminase
- Glucose-6-Phosphate Isomerase (GPI)
- Cytochrome P450
- SWI/SNF Complex
- RANKL/RANK
- TAM Receptor
- Herbicide
- Annexin A
- Early 2 Factor (E2F)
- GlyT
- PI3K
- Histone Demethylase
- VDAC
- Cannabinoid Receptor
- NTPDase
- Endothelin-Converting Enzyme (ECE)
- LRRK2
- Pirin
- Mitochondrial Metabolism
- c-Myc
- Procollagen C Proteinase
- Anion Exchangers
- Arf Family GTPase
- Protein Prenyltransferase
- Histone Acetyltransferase
- Carbonyl Reductase
- 11β-HSD
- PKG
- HOXA
- Beta-lactamase
- Na+/Ca2+ Exchanger
- Reverse Transcriptase
- ATP Synthase
- Aminopeptidase
- AMPK
- APC
- SOS1
- FOXJ
- SARS-CoV
Research Areas:
(E/Z)-J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z)-J147 can readily pass the blood brain barrier (BBB). (E/Z)-J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z)-J147 has potential for the study of Alzheimer’s disease (AD) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
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