Btk - Bruton agammaglobulinemia tyrosine kinase Gene

Also Known as xid

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12229

About Btk

Chromosome X: 133,443,085-133,484,319 reverse strand.GRCm39:CM001013.3

This gene has 5 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 48 phenotypes. Biased expression in liver E14 (RPKM 7.3), liver E14.5 (RPKM 5.9) and 11 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in negative regulation of cytokine production. Acts upstream of or within several processes, including B cell affinity maturation; I-kappaB kinase/NF-kappaB signaling; and negative regulation of B cell proliferation. Located in cytoplasmic vesicle and nucleus. Is expressed in liver left lobe; liver right lobe; spleen; and thymus primordium. Used to study X-linked agammaglobulinemia. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human Btk (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Btk Products (1)

mRNA Protein Name
NM_013482.2 NP_038510.2 tyrosine-protein kinase BTK

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11007757 MGI
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
7565679 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10872802 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell affinity maturation IMP
IMP: Inferred from mutant phenotype
7680896 MGI
acts upstream of or within cell maturation IMP
IMP: Inferred from mutant phenotype
14734712 MGI
acts upstream of or within cellular response to interleukin-7 IMP
IMP: Inferred from mutant phenotype
7680896 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
7680896 MGI
involved in negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
23544144 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
34554188 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12235209 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11007757 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
14657254 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
23478294 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11007757 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Btk Protein Structure

PH_Btk

PH_Btk: cd01238 (5 - 165)

SH3_BTK

SH3_BTK: cd11906 (216 - 270)

SH2_Tec_Btk

SH2_Tec_Btk: cd10397 (273 - 377)

PTKc_Btk_Bmx

PTKc_Btk_Bmx: cd05113 (396 - 651)

  • 0
  • 200
  • 400
  • 600
  • 659 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase BTK

  • ATK

  • B-cell progenitor kinase

  • BPK

  • Bruton's tyrosine kinase

  • Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB)

  • X-linked immune deficiency

  • agammaglobulinaemia tyrosine kinase

  • agammaglobulinemia tyrosine kinase

  • bruton tyrosine kinase

  • kinase EMB

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10997 Ibrutinib Inhibitor 99.97% Yes
HY-17600 Acalabrutinib Inhibitor 99.88% Yes
HY-131328 Pirtobrutinib Inhibitor 99.90% Unkown
HY-101474A Zanubrutinib Inhibitor 99.71% Yes
HY-128757 Remibrutinib Inhibitor 99.76% Yes
HY-109192 Tolebrutinib Inhibitor 99.12% Yes
HY-129390 Orelabrutinib Inhibitor 99.97% Yes
HY-132842 Sunvozertinib Inhibitor 99.62% Unkown
HY-15771 Tirabrutinib Inhibitor 99.71% Yes
HY-10997A Ibrutinib Racemate Inhibitor 95.39% Unkown
HY-15771A Tirabrutinib hydrochloride Inhibitor 99.66% Yes
HY-101474AR Zanubrutinib (Standard) Inhibitor 99.90% Unkown
HY-151232 (E/Z)-Rilzabrutinib Inhibitor / Unkown
HY-109192R Tolebrutinib (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Phase
HY-17600A Acalabrutinib maleate Inhibitor / Phase 4
HY-19834 Fenebrutinib Inhibitor 99.89% Phase 3
HY-153321 Bexobrutideg Degrader 99.33% Phase 3
HY-112166 Rilzabrutinib Inhibitor 98.97% Phase 3
HY-101215 Evobrutinib Inhibitor 99.60% Phase 3
HY-112215 Nemtabrutinib Inhibitor 99.32% Phase 3
HY-19816A Avitinib maleate Inhibitor 99.86% Phase 3
HY-160167 Birelentinib Inhibitor / Phase 3
HY-112161 Branebrutinib Inhibitor 99.78% Phase 2
HY-109078 Vecabrutinib Inhibitor 99.76% Phase 2
HY-139984 Corubrutinib Inhibitor 99.85% Phase 2
HY-109010 Poseltinib Inhibitor 98.11% Phase 2
HY-109143 Elsubrutinib Inhibitor 98.0% Phase 2
HY-101856 BMS-986142 Inhibitor 99.38% Phase 2
HY-139481 Flixebrutinib Inhibitor 99.86% Phase 2
HY-132808 Atuzabrutinib Inhibitor 98.00% Phase 2
HY-18012A Spebrutinib besylate Inhibitor / Phase 2
HY-153220 Zelebrudomide Inhibitor 99.72% Phase 1
HY-139535 Luxeptinib Inhibitor 98.95% Phase 1
HY-137438 Edralbrutinib Inhibitor 99.75% Phase 1
HY-153110 Larotinib Inhibitor 99.50% Phase 1
HY-132879 TAK-020 Inhibitor 99.93% Phase 1
HY-153245 JNJ-64264681 Inhibitor 98.14% Phase 1
HY-131342 BIIB068 Inhibitor 98.35% Phase 1
HY-163827 ABBV-992 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (217)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160141 Catadegbrutinib Degrader 99.18% Unkown
HY-19816 Avitinib Inhibitor 99.95% Unkown
HY-18012 Spebrutinib Inhibitor 99.22% Unkown
HY-100342 Ibrutinib-biotin Inhibitor 99.66% Unkown
HY-80002 BMX-IN-1 Inhibitor 99.04% Unkown
HY-11999 CGI-1746 Inhibitor 99.25% Unkown
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-13036A IBT6A Inhibitor 99.59% Unkown
HY-122562 MT-802 Degrader 98.35% Unkown
HY-147943 PROTAC BTK Degrader-1 99.92% Unkown
HY-100335 PCI-33380 Inhibitor 98.0% Unkown
HY-153803 GBD-9 Degrader 99.91% Unkown
HY-12679 PF-06658607 Inhibitor 99.69% Unkown
HY-15805 KIN-8194 Inhibitor 99.26% Unkown
HY-80003 QL47 Inhibitor 99.50% Unkown
HY-169396 TAE648 Ligand 99.50% Unkown
HY-107447 N-Deshydroxyethyl Dasatinib Ligand 97.19% Unkown
HY-133137 SJF620 Inhibitor 98.98% Unkown
HY-153357 NRX-0492 Degrader 98.30% Unkown
HY-144288 BLK-IN-2 Inhibitor 98.61% Unkown
HY-78727 Ibrutinib deacryloylpiperidine Inhibitor 99.96% Unkown
HY-163962 L18I Degrader 99.89% Unkown
HY-15427 GDC-0834 Inhibitor 98.05% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.80% Unkown
HY-49421 BTK ligand 12 Ligand 98.23% Unkown
HY-163295 BTK degrader-1 Degrader 99.40% Unkown
HY-100338 CNX-500 Inhibitor 99.86% Unkown
HY-122830 DD-03-171 Degrader 98.72% Unkown
HY-18951 ONO-4059 analog Inhibitor 99.81% Unkown
HY-13943 CNX-774 Inhibitor 99.54% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-163565 BIIB129 Inhibitor 99.54% Unkown
HY-124645 QL-X-138 Inhibitor 98.17% Unkown
HY-18018 RN486 Inhibitor 98.91% Unkown
HY-135334 ACP-5862 Inhibitor 98.32% Unkown
HY-101474 (±)-Zanubrutinib Inhibitor 99.70% Unkown
HY-43521 Ibrutinib-MPEA Inhibitor 99.71% Unkown
HY-18010 PCI 29732 Inhibitor 99.59% Unkown
HY-10644 Lck inhibitor 2 Inhibitor 99.73% Unkown
HY-122828 PROTAC BTK Degrader-2 Degrader 99.93% Unkown
HY-15809 (Rac)-Ibrutinib alkyne Inhibitor 99.35% Unkown
HY-101474B (R)-Zanubrutinib 98.97% Unkown
HY-153220A (R)-Zelebrudomide Degrader 98.93% Unkown
HY-101793 BMS-935177 Inhibitor 98.35% Unkown
HY-150023 BI-1622 Inhibitor 98.02% Unkown
HY-130983 N-piperidine Ibrutinib hydrochloride Inhibitor 98.06% Unkown
HY-149391 PROTAC BTK Degrader-6 Degrader 99.24% Unkown
HY-160142 UBX-382 Degrader 96.20% Unkown
HY-110002 LFM-A13 Inhibitor 99.65% Unkown
HY-101941 BTK IN-1 Inhibitor 98.09% Unkown
HY-101766 Btk inhibitor 2 Inhibitor 99.53% Unkown
HY-17600S Acalabrutinib-d4 Inhibitor 99.50% Unkown
HY-136531 XMU-MP-3 Inhibitor 95.78% Unkown
HY-153110A Larotinib mesylate hydrate Inhibitor 98.66% Unkown
HY-149051 BGB-8035 Inhibitor 99.00% Unkown
HY-100659 Dihydrodiol-Ibrutinib Inhibitor 99.91% Unkown
HY-10997S Ibrutinib-d5 Inhibitor 98.08% Unkown
HY-101522 CHMFL-EGFR-202 Inhibitor 99.75% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-160966 Omtebrutideg Degrader 99.24% Unkown
HY-157763 Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 Degrader / Unkown
HY-125997 BTK inhibitor 10 Inhibitor 99.66% Unkown
HY-15427B GDC-0834 (S-enantiomer) / Unkown
HY-131705 BTK inhibitor 17 Inhibitor 99.53% Unkown
HY-132842A (S)-Sunvozertinib Inhibitor 99.05% Unkown
HY-131328A (R)-Pirtobrutinib 99.88% Unkown
HY-133137A SJF620 hydrochloride Inhibitor 99.28% Unkown
HY-101474S Zanubrutinib-d5 Inhibitor 99.0% Unkown
HY-15427A GDC-0834 Racemate 98.04% Unkown
HY-160246 QL47B Inhibitor / Unkown
HY-136113 Ibrutinib dimer Inhibitor 98.47% Unkown
HY-109143B (R)-Elsubrutinib Inhibitor 98.0% Unkown
HY-110013 Terreic acid Inhibitor / Unkown
HY-154860 PTD10 Degrader 97.38% Unkown
HY-100659S Dihydrodiol-Ibrutinib-d5 Inhibitor 99.19% Unkown
HY-13036B IBT6A hydrochloride Inhibitor 99.35% Unkown
HY-13036 (Rac)-IBT6A Inhibitor 98.03% Unkown
HY-160245 QL47R 99.94% Unkown
HY-160246A QL47B TFA Inhibitor 96.03% Unkown
HY-115876 BTK-IN-5 Inhibitor / Unkown
HY-132196 BTK inhibitor 18 Inhibitor / Unkown
HY-111781 Civorebrutinib Inhibitor / Unkown
HY-156746 DBt-10 Degrader / Unkown
HY-130255 BTK inhibitor 13 Inhibitor / Unkown
HY-174129 TM471-1 Inhibitor / Unkown
HY-151808 JS25 Inhibitor 98.06% Unkown
HY-174850 CFON-026 Inhibitor / Unkown
HY-181050 DFCI-002-06 Degrader / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-102036 G-744 Inhibitor / Unkown
HY-156604 Cinsebrutinib Inhibitor / Unkown
HY-101521 CHMFL-BTK-01 Inhibitor / Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-159947 PROTAC BTK Degrader-11 Degrader / Unkown
HY-169228 WS-11 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-170758 BTK ligand 13 / Unkown
HY-176131 AMX5160 Inhibitor / Unkown
HY-152212 BTK-IN-19 Inhibitor / Unkown
HY-168302 BTK ligand 10 99.49% Unkown
HY-162257 BTK-IN-34 Inhibitor / Unkown
HY-181547 HBC-12551 Inhibitor / Unkown
HY-161876 GSTO1-IN-2 Inhibitor / Unkown
HY-184940 BTK-IN-50 Inhibitor / Unkown
HY-168965 BTK ligand 15 Ligand / Unkown
HY-164002 PF-303 Inhibitor / Unkown
HY-175541 TQ-3959 Degrader / Unkown
HY-175909 BTK ligand-18 Ligand / Unkown
HY-173143 BTK-IN-42 Inhibitor / Unkown
HY-179948 BTK-IN-45 Inhibitor / Unkown
HY-151211 BTK-IN-16 Inhibitor 98.93% Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-170413 PROTAC BTK Degrader-12 Degrader / Unkown
HY-147584 BTK-IN-14 Inhibitor / Unkown
HY-156745 PROTAC DDa-1 Degrader / Unkown
HY-162081 BTK-IN-32 Inhibitor / Unkown
HY-141689 BTK-IN-3 Inhibitor / Unkown
HY-158064 BTK-IN-36 Inhibitor / Unkown
HY-P10609 Btk substrate peptide / Unkown
HY-181996 BTK-IN-47 Inhibitor / Unkown
HY-143717 JAK3/BTK-IN-2 Inhibitor / Unkown
HY-175788 BTK ligand-17 Ligand / Unkown
HY-179076 BTK/IKZF1/3 ligand 1 Ligand / Unkown
HY-182910 PROTAC BTK Degrader-15 Degrader / Unkown
HY-173125 FDU73 Degrader / Unkown
HY-153951S BTK-IN-26 Inhibitor / Unkown
HY-151920 BTK-IN-17 Inhibitor / Unkown
HY-143719 JAK3/BTK-IN-4 Inhibitor / Unkown
HY-101474BS (R)-Zanubrutinib-d5 / Unkown
HY-E70808 BTK C481R Recombinant Human Active Protein Kinase / Unkown
HY-182943 BTK-IN-49 Inhibitor / Unkown
HY-177103 Midobrutinib Inhibitor / Unkown
HY-171893 CRBN ligand-185 Ligand / Unkown
HY-148584 BTK-IN-21 Inhibitor / Unkown
HY-182293 BTK-IN-48 Inhibitor / Unkown
HY-142932 BTK-IN-6 Inhibitor / Unkown
HY-172589 BTK-IN-43 Inhibitor / Unkown
HY-150885 BTK ligand 1 Degrader / Unkown
HY-128408 PROTAC BTK Degrader-4 Degrader / Unkown
HY-124605 IQS-019 Inhibitor / Unkown
HY-151961 RSH-7 Inhibitor 98.74% Unkown
HY-143718 JAK3/BTK-IN-3 Inhibitor / Unkown
HY-152201 BTK-IN-18 Inhibitor / Unkown
HY-147580 BTK-IN-10 Inhibitor / Unkown
HY-153536 PROTAC BTK Degrader-3 Degrader / Unkown
HY-147741 DPPY Inhibitor / Unkown
HY-120406 PLS-123 Inhibitor / Unkown
HY-148832 BTK-IN-20 Inhibitor / Unkown
HY-182933 BTK ligand-20 Ligand / Unkown
HY-143720 JAK3/BTK-IN-5 Inhibitor / Unkown
HY-147784 HZ-A-005 Inhibitor / Unkown
HY-153705 BTK-IN-25 Inhibitor / Unkown
HY-110113 CTA056 Inhibitor / Unkown
HY-159956 BTK-IN-39 Ligand / Unkown
HY-143900 BTK-IN-7 Inhibitor / Unkown
HY-145884 BTK-IN-8 Inhibitor / Unkown
HY-172822 TLT8 Degrader / Unkown
HY-123117 VA5 Inhibitor / Unkown
HY-160168 BTK-IN-31 Inhibitor / Unkown
HY-171131 BTK-IN-41 Inhibitor / Unkown
HY-170324 BTK-IN-40 Inhibitor / Unkown
HY-180884 BTK-IN-46 Inhibitor / Unkown
HY-143730 BTK inhibitor 20 Inhibitor / Unkown
HY-W062695 (R)-Acalabrutinib Inhibitor / Unkown
HY-150898 BTK ligand 3 Ligand / Unkown
HY-179077 PROTAC BTK/IKZF1/3 Degrader-1 Degrader / Unkown
HY-117499 RN941 Inhibitor / Unkown
HY-162280 PROTAC BTK Degrader-9 Degrader / Unkown
HY-144170 RET-IN-14 Inhibitor / Unkown
HY-181546 Ibt-DOX Inhibitor / Unkown
HY-183103 PDD-87 Inhibitor / Unkown
HY-144283 BLK-IN-1 Inhibitor / Unkown
HY-160219S GFH647 Inhibitor / Unkown
HY-124153 GNE-431 Inhibitor / Unkown
HY-173126 BTK ligand-14 Inhibitor / Unkown
HY-143901 EGFR-IN-40 Inhibitor / Unkown
HY-181624 BTK ligand-19 Ligand / Unkown
HY-175543 BTK ligand 16 Ligand / Unkown
HY-184792 CA/PRAK-IN-1 Inhibitor / Unkown
HY-147582 BTK-IN-12 Inhibitor / Unkown
HY-157159 BTK-IN-28 Inhibitor / Unkown
HY-182671 SRX3305 Inhibitor / Unkown
HY-147581 BTK-IN-11 Inhibitor / Unkown
HY-155072 PROTAC BTK Degrader-5 Degrader / Unkown
HY-163183 JAK3/BTK-IN-7 Inhibitor / Unkown
HY-148594 BTK-IN-23 Inhibitor / Unkown
HY-179562 BTK degrader-2 Degrader / Unkown
HY-168427 Avitinib maleate dihydrate Inhibitor / Unkown
HY-176172 BTK-IN-44 Inhibitor / Unkown
HY-E70809 BTK V416L Recombinant Human Active Protein Kinase / Unkown
HY-150752 BTK-IN-15 Inhibitor / Unkown
HY-139881 BTK inhibitor 19 Inhibitor / Unkown
HY-159589 BTK-IN-37 Inhibitor / Unkown
HY-153321A (R,R)-Bexobrutideg Degrader 98.83% Unkown
HY-117628 RN983 Inhibitor / Unkown
HY-156553 BTK-IN-27 Inhibitor / Unkown
HY-143716 JAK3/BTK-IN-1 Inhibitor / Unkown
HY-169307 BTK-IN-38 Inhibitor / Unkown
HY-148585 BTK-IN-22 Inhibitor / Unkown
HY-162407 I-As-1 Inhibitor / Unkown
HY-142621 BCPyr Degrader / Unkown
HY-168314 BTK ligand 11 Ligand / Unkown
HY-131328S Pirtobrutinib-13C,d3 Inhibitor / Unkown
HY-156969 Topoisomerase I inhibitor 11 / Unkown
HY-115944 BTK-IN-9 Inhibitor / Unkown
HY-168963 PROTAC BTK Degrader-13 Degrader / Unkown
HY-181623 PROTAC BTK degrader-14 Degrader / Unkown
HY-101474R (±)-Zanubrutinib (Standard) Inhibitor / Unkown
HY-18016 CGI 560 Inhibitor / Unkown
HY-13036C (Rac)-IBT6A hydrochloride Inhibitor / Unkown
HY-128403 BTK inhibitor 8 Inhibitor 99.96% Unkown
HY-160167A (R,R)-Birelentinib Inhibitor / Unkown
HY-135334S ACP-5862-d4 Inhibitor / Unkown
HY-168292 BTK ligand 9 / Unkown
HY-176526 BTK degrader-1 intermediate Degrader / Unkown
HY-183397 Avitinib dihydrochloride Inhibitor / Unkown
HY-101766R Btk inhibitor 2 (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Btk NCBI NCBI:695