NLRP3 - NLR family pyrin domain containing 3 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 490576

About NLRP3

Primary_assembly 8: 301,633-360,913 forward strand.ROS_Cfam_1.0:CM025107.1

This gene has 4 transcripts (splice variants), 87 orthologues and 19 paralogues.

NLRP3 Products (11)

mRNA Protein Name
XM_038673023.1 XP_038528951.1 NACHT, LRR and PYD domains-containing protein 3 isoform X1
XM_038673032.1 XP_038528960.1 NACHT, LRR and PYD domains-containing protein 3 isoform X7
XM_038673027.1 XP_038528955.1 NACHT, LRR and PYD domains-containing protein 3 isoform X3
XM_038673031.1 XP_038528959.1 NACHT, LRR and PYD domains-containing protein 3 isoform X6
XM_038673029.1 XP_038528957.1 NACHT, LRR and PYD domains-containing protein 3 isoform X5
XM_038673025.1 XP_038528953.1 NACHT, LRR and PYD domains-containing protein 3 isoform X1
XM_038673026.1 XP_038528954.1 NACHT, LRR and PYD domains-containing protein 3 isoform X2
XM_038673024.1 XP_038528952.1 NACHT, LRR and PYD domains-containing protein 3 isoform X1
XM_038673028.1 XP_038528956.1 NACHT, LRR and PYD domains-containing protein 3 isoform X4
XM_038673033.1 XP_038528961.1 NACHT, LRR and PYD domains-containing protein 3 isoform X8
XM_038673030.1 XP_038528958.1 NACHT, LRR and PYD domains-containing protein 3 isoform X6

NLRP3 Protein Structure

Pyrin_NALPs

Pyrin_NALPs: cd08320 (7 - 90)

FISNA

FISNA: pfam14484 (133 - 202)

NACHT

NACHT: pfam05729 (212 - 381)

NOD2_WH

NOD2_WH: pfam17779 (458 - 512)

LRR_RI

LRR_RI: cd00116 (568 - 951)

LRR_RI

LRR_RI: sd00033 (741 - 769)

LRR_RI

LRR_RI: sd00033 (770 - 797)

LRR_RI

LRR_RI: sd00033 (798 - 826)

LRR_RI

LRR_RI: sd00033 (827 - 854)

LRR_RI

LRR_RI: sd00033 (855 - 883)

LRR_RI

LRR_RI: sd00033 (884 - 911)

LRR_RI

LRR_RI: sd00033 (912 - 936)

LRR_RI

LRR_RI: sd00033 (941 - 968)

LRR_RI

LRR_RI: smart00368 (966 - 993)

  • 0
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  • 1000
  • 1065 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2176 ATP Activator 99.88% Unkown
HY-132591A Inclisiran sodium Inhibitor 99.08% Unkown
HY-132591 Inclisiran Inhibitor 99.48% Unkown
HY-B0116 Stavudine Inhibitor 99.89% Yes
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.97% Unkown
HY-16059 Arglabin Inhibitor 99.87% Unkown
HY-B1239 Drofenine hydrochloride 98.10% Unkown
HY-17355B Dexpramipexole Inhibitor 99.56% Yes
HY-B0516 Articaine hydrochloride Inhibitor 99.38% Unkown
HY-B1239A Drofenine / Unkown
HY-B0516A Articaine Inhibitor / Unkown
HY-B0516R Articaine hydrochloride (Standard) Inhibitor / Unkown
HY-B0116A Stavudine sodium Inhibitor 99.40% Yes

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-156034A JT001 sodium Inhibitor 98.39% Phase 3
HY-156034 JT001 Inhibitor / Phase 3
HY-P10227 Xelafaslatide Inhibitor 99.88% Phase 2
HY-139396 BMS-986299 Agonist 99.96% Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99555 Tomaralimab Inhibitor 99.42% Phase 2

Pre-clinical Phase

Bioactive Molecules (166)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12815 MCC950 Inhibitor 99.78% Unkown
HY-127019 Nigericin Activator 99.64% Unkown
HY-100381 Nigericin sodium salt Activator 99.60% Unkown
HY-12815A MCC950 sodium Inhibitor 99.75% Unkown
HY-100573 Necrosulfonamide Inhibitor 98.61% Unkown
HY-116084 Trimethylamine N-oxide Activator 98.0% Unkown
HY-103666 CY-09 Inhibitor 99.58% Unkown
HY-144226 NLRP3/AIM2-IN-3 Inhibitor 98.23% Unkown
HY-17629 Dapansutrile Inhibitor 99.92% Yes
HY-101092 QS-21-Api Activator 99.73% Unkown
HY-156798 ADS032 Inhibitor 99.89% Unkown
HY-113298 Citraconic acid Inhibitor 99.08% Unkown
HY-N0373 Licochalcone B Inhibitor 99.91% Unkown
HY-N3005 Britannin Inhibitor 99.93% Unkown
HY-108915 Trimethylamine N-oxide dihydrate Activator 99.86% Unkown
HY-N0633 Muscone Inhibitor 98.0% Unkown
HY-100581 CORM-3 Inhibitor 97.5% Unkown
HY-155876 NVP-DFV890 Antagonist 99.97% Unkown
HY-N0806 Sweroside Inhibitor 99.76% Unkown
HY-N0496 Ruscogenin Inhibitor 99.85% Unkown
HY-132831 Selnoflast Inhibitor 99.46% Unkown
HY-W019670 N4-Acetylcytidine Activator 99.65% Unkown
HY-N2414 Periplogenin Inhibitor ≥99.70% Unkown
HY-161834 RG100204 Inhibitor 99.50% Unkown
HY-N5042 Forsythoside I Inhibitor 99.94% Unkown
HY-159520 Ofirnoflastum Inhibitor 99.93% Unkown
HY-N5063 Plantainoside D Inhibitor 99.15% Unkown
HY-169996 NP3-253 Inhibitor 99.78% Unkown
HY-173154B NK7-902 diTFA Inhibitor 99.88% Unkown
HY-162333 BAL-0028 Inhibitor 99.86% Unkown
HY-130494 (±)11(12)-EET Inhibitor 98.30% Unkown
HY-N0257 Epimedin A Inhibitor 99.43% Unkown
HY-152670 JC2-11 Inhibitor 98.03% Unkown
HY-119684 Maresin 2 Inhibitor 97.20% Unkown
HY-78263 MNS 99.55% Unkown
HY-W082785A L6H21 Inhibitor 99.19% Unkown
HY-N1939 Icariside I Agonist 98.76% Unkown
HY-B2176I ATP disodium salt, 100 mM Solution, PCR Grade Activator / Unkown
HY-N0381 Maackiain Activator 99.83% Unkown
HY-N1431 Tabersonine Inhibitor 98.13% Unkown
HY-137888A Oxidized ATP trisodium salt Inhibitor 98.0% Unkown
HY-117878 ML345 Inhibitor 99.37% Unkown
HY-144223 NLRP3-IN-94 Inhibitor 99.93% Unkown
HY-164304 INF 195 Inhibitor 99.58% Unkown
HY-P2310 Defensin HNP-1 human Activator 98.12% Unkown
HY-N6893 Ergolide Inhibitor 99.48% Unkown
HY-150206 NLRP3-IN-13 Inhibitor 98.03% Unkown
HY-N3242 Moronic acid Inhibitor 98.6% Unkown
HY-101868 INF39 Inhibitor 99.84% Unkown
HY-153261 NLRP3-IN-17 Inhibitor 99.02% Unkown
HY-120007 JC124 Inhibitor 99.72% Unkown
HY-163358 SLC3037 Inhibitor 99.85% Unkown
HY-W158030 2-Guanidinobezimidazole Agonist 95.74% Unkown
HY-N0699 Daphnoretin Inhibitor 99.83% Unkown
HY-N2485 4'-Methoxyresveratrol Activator 99.48% Unkown
HY-176860 NEK7 degrader-1 Activator 99.94% Unkown
HY-163159 NP3-562 Inhibitor 98.16% Unkown
HY-130252 YQ128 Inhibitor 99.74% Unkown
HY-N2128 Nigakinone Inhibitor 99.95% Unkown
HY-137245 Emlenoflast Inhibitor 99.30% Unkown
HY-N2157 Pteryxin Inhibitor 99.55% Unkown
HY-N7695 Physalin B Inhibitor 97.20% Unkown
HY-155751 HMGB1-IN-1 Inhibitor 98.40% Unkown
HY-160757 NLRP3 modulator 7 Modulator / Unkown
HY-146765 AMS-17 Inhibitor 98.09% Unkown
HY-179494 M464 Inhibitor 99.58% Unkown
HY-N8599 Cichoriin Inhibitor 99.9% Unkown
HY-161727 P2Y14R antagonist 1 Inhibitor 98.76% Unkown
HY-172941 VEN-02XX Inhibitor 99.66% Unkown
HY-122920 Soyasaponin II Inhibitor 99.81% Unkown
HY-126941 Hecogenin acetate Inhibitor 98.57% Unkown
HY-164853 Kanglexin Inhibitor 99.65% Unkown
HY-175278 BAL-1516 Inhibitor / Unkown
HY-161627 Anemoside A3-methyl 6-aminohexanoate Inhibitor 98.62% Unkown
HY-174270 NLRP3-IN-79 Inhibitor 99.10% Unkown
HY-W011082 NLRP3-IN-2 Inhibitor 98.00% Unkown
HY-137245A Emlenoflast sodium Inhibitor 98.31% Unkown
HY-117432 JC-171 Inhibitor 98.06% Unkown
HY-W017087 1,2,4-Trimethoxybenzene Inhibitor / Unkown
HY-186072 NT-0527 Inhibitor 99.80% Unkown
HY-131040 NLRP3-IN-NBC6 Inhibitor 99.40% Unkown
HY-162588 MC-ND-18 Degrader / Unkown
HY-161297 NT-0249 Inhibitor / Unkown
HY-153554 NLRP3-IN-18 Inhibitor 98.06% Unkown
HY-121988 INF4E Inhibitor 99.38% Unkown
HY-148187 NLRP3-IN-11 Inhibitor 98.79% Unkown
HY-P6084 RP-220 Inhibitor / Unkown
HY-179421 PROTAC HDAC6 degrader 7 Inhibitor / Unkown
HY-145087A NP3-146 sodium Inhibitor 99.26% Unkown
HY-W010253 Benzylurea Modulator 99.94% Unkown
HY-N10173 (+)-Epiloliolide Inhibitor 95.0% Unkown
HY-N10359 Isoandrographolide Inhibitor 98.34% Unkown
HY-150965 NDT-30805 Inhibitor / Unkown
HY-178898 7-Oxogedunin Inhibitor / Unkown
HY-183283 CAII-IN-15 Inhibitor / Unkown
HY-149123 NLRP3-IN-16 Inhibitor / Unkown
HY-146594 NLRP3-IN-8 Inhibitor / Unkown
HY-179429 NLRP3-IN-85 Inhibitor / Unkown
HY-182779 JNUTS013 Inhibitor / Unkown
HY-179024 NP3-742 Inhibitor / Unkown
HY-180830 NLRP3-IN-86 Inhibitor / Unkown
HY-145087 NP3-146 Inhibitor / Unkown
HY-175814 NLRP3-IN-83 Inhibitor / Unkown
HY-183995 SH-26 Inhibitor / Unkown
HY-182803 NLRP3-IN-90 Inhibitor / Unkown
HY-175464 NLRP3-IN-82 Inhibitor / Unkown
HY-179387 CXCR2-IN-3 Inhibitor / Unkown
HY-159482 SBN-284 Inhibitor / Unkown
HY-168264 MC1 Inhibitor / Unkown
HY-P11581 MNP2 Inhibitor / Unkown
HY-180168 NQO2 activator-1 Inhibitor / Unkown
HY-182102 NLRP3-IN-88 Inhibitor / Unkown
HY-163744 NLRP3-IN-42 Inhibitor / Unkown
HY-168737 NEK7-IN-2 Inhibitor / Unkown
HY-179131 TN-783 Inhibitor / Unkown
HY-146802 NLRP3-IN-9 Inhibitor / Unkown
HY-180916 CAII-IN-11 Inhibitor / Unkown
HY-N19847 LYRM03 Inhibitor / Unkown
HY-168009 NLRP3-IN-45 Inhibitor / Unkown
HY-N10312 Yadanzigan Inhibitor / Unkown
HY-132831C Selnoflast monopotassium Inhibitor / Unkown
HY-181809 BLT1-IN-1 Inhibitor / Unkown
HY-177559 NEK7 degrader-2 Inhibitor / Unkown
HY-132892 NLRP3-IN-4 Inhibitor / Unkown
HY-N10650 Caulerpin Inhibitor / Unkown
HY-172134 NLRP3-IN-70 Inhibitor / Unkown
HY-178953 NLRP3-IN-84 Inhibitor / Unkown
HY-182778 Anti-inflammatory agent 114 Inhibitor / Unkown
HY-149122 NLRP3-IN-15 Inhibitor / Unkown
HY-172778 HNW005 Inhibitor / Unkown
HY-178950 Hck-IN-3 Inhibitor / Unkown
HY-171589 NLRP3-IN-77 Inhibitor / Unkown
HY-184357 NLRP3-IN-92 Inhibitor / Unkown
HY-149121 NLRP3-IN-14 Inhibitor / Unkown
HY-182380 ODZ10117 Inhibitor / Unkown
HY-181488 NLRP3-IN-87 Inhibitor / Unkown
HY-169227 NLRP3-IN-55 Inhibitor / Unkown
HY-177128 Sebrinoflast Inhibitor / Unkown
HY-163497 NLRP3-IN-38 Inhibitor / Unkown
HY-174312 NLRP3-IN-81 Inhibitor / Unkown
HY-183296 NLRP3-IN-91 Inhibitor / Unkown
HY-172102 NLRP3-IN-68 Inhibitor / Unkown
HY-175645 NLRP3/URAT1-IN-1 Inhibitor / Unkown
HY-163494 NLRP3-IN-36 Inhibitor / Unkown
HY-168594 α-Glucosidase/NLRP3-IN-1 Inhibitor / Unkown
HY-180890 PPARγ agonist-21 Inhibitor / Unkown
HY-185311 NEK7 degrader-3 Inhibitor / Unkown
HY-149087 MR2938 Inhibitor / Unkown
HY-159898 AChE/BChE-IN-23 Inhibitor / Unkown
HY-169188 NLRP3-IN-50 Inhibitor / Unkown
HY-179132 TN-101 Inhibitor / Unkown
HY-161329 NLRP3-IN-32 Inhibitor / Unkown
HY-183796 GFAP/NF-κB/APOE/NLRP3-IN-1 Inhibitor / Unkown
HY-145910 NLRP3-IN-6 Inhibitor / Unkown
HY-N6189 MBL-1 Inhibitor / Unkown
HY-163695 NLRP3-IN-41 Inhibitor / Unkown
HY-179682 HDAC3 degrader-1 Inhibitor / Unkown
HY-103715 NLRP3 modulator 1 Modulator / Unkown
HY-N17383 Ligusticum cycloprolactam Inhibitor / Unkown
HY-145911 NLRP3-IN-7 Inhibitor / Unkown
HY-182794 NLRP3-IN-89 Inhibitor / Unkown
HY-182287 PRDX1-IN-4 Inhibitor / Unkown
HY-159007 BD-AcAc2 Inhibitor / Unkown
HY-173294 NLRP3-IN-74 Inhibitor / Unkown
HY-N1431A Tabersonine hydrochloride Inhibitor 98.55% Unkown
HY-183889 p-Ethoxychrysoidin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NLRP3 NCBI NCBI:114548
Mus musculus NLRP3 NCBI NCBI:216799