Cdk4 - cyclin-dependent kinase 4 Gene

Also Known as Crk3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12567

About Cdk4

Chromosome 10: 126,899,403-126,903,789 forward strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 229 orthologues, 25 paralogues and is associated with 63 phenotypes. Broad expression in CNS E11.5 (RPKM 315.3), limb E14.5 (RPKM 224.3) and 25 other tissues.

Summary

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to interleukin-4; cellular response to lipid; and regulation of lipid metabolic process. Located in bicellular tight junction; cytoplasm; and nucleus. Part of cyclin D2-CDK4 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Cdk4 Products (2)

mRNA Protein Name
NM_009870.4 NP_034000.1 cyclin-dependent kinase 4 isoform 1
NM_001355005.1 NP_001341934.1 cyclin-dependent kinase 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
23109711 MGI
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12970171 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
12124778 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8033213 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
12130539 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within cellular response to ionomycin IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within cellular response to phorbol 13-acetate 12-myristate IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12124778 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
12588994 MGI
acts upstream of or within regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
12917627 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12130539 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
21411630 MGI
part of cyclin D1-CDK4 complex IPI
IPI: Inferred from physical interaction
17948060 MGI
part of cyclin D2-CDK4 complex IDA
IDA: Inferred from direct assay
7739547 MGI
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
12970760 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8988060 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
10082561 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk4 Protein Structure

STKc_CDK4

STKc_CDK4: cd07863 (4 - 294)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 4

  • PSK-J3

  • cell division protein kinase 4

  • p34/cdk4

  • serine/threonine kinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (14)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-15777 Ribociclib Inhibitor 99.94% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.96% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-A0065 Palbociclib isethionate Inhibitor 99.98% Unkown
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-114338 Dalpiciclib Inhibitor 99.70% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.94% Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (24)
Cat. No. 상품명 효과
Purity Phase
HY-125101A Rafutrombopag diolamine Agonist / Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-175538 USP10-IN-4 Inhibitor / Phase 3
HY-10005 Flavopiridol Inhibitor 99.72% Phase 2
HY-101563 GSK3326595 99.83% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-114177 Ebvaciclib Inhibitor 99.98% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-13914 Roniciclib Inhibitor 98.00% Phase 2
HY-10424 Milciclib Inhibitor 99.89% Phase 2
HY-12624 Narazaciclib Inhibitor 98.66% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-45661 Inixaciclib Inhibitor 99.93% Phase 2
HY-201330 GDC-4198 Inhibitor 99.9% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-111361 FN-1501 Inhibitor 98.72% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1
HY-153336 PRT3645 Inhibitor / Phase 1
HY-172234 PF-06842874 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (182)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Unkown
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Yes
HY-116035 Nimbolide Inhibitor 99.79% Unkown
HY-122609 XO44 99.73% Unkown
HY-138946 XY028-140 Inhibitor 98.52% Unkown
HY-18299A Purvalanol A Inhibitor 98.61% Unkown
HY-15275 BMS-265246 Inhibitor 99.59% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-N0404 Sinigrin Inhibitor 99.97% Unkown
HY-114338A Dalpiciclib hydrochloride Inhibitor 99.41% Unkown
HY-136252 BSJ-04-132 Inhibitor 99.07% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-18629 SU9516 Inhibitor 99.85% Unkown
HY-122620 Rafutrombopag (tautomerism) Agonist 98.33% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-N0805 Alisol B 23-acetate Inhibitor 99.65% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-12422 Voruciclib Inhibitor 99.76% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.75% Unkown
HY-103712 Samuraciclib Inhibitor 99.55% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.18% Unkown
HY-168664 CPD-39 Degrader 98.06% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-112272 Lerociclib Inhibitor 96.42% Unkown
HY-N1431 Tabersonine Inhibitor 98.13% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 95.92% Unkown
HY-147007 β-catenin-IN-3 Inhibitor 95.64% Unkown
HY-129180 XY028-133 Inhibitor 99.07% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-100624 Ryuvidine Inhibitor 99.23% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor 98.01% Unkown
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-144995 BSJ-02-162 Degrader 98.07% Unkown
HY-163640 CDK4 degrader 1 Degrader 99.83% Unkown
HY-150280 Ironomycin Inhibitor 99.85% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-168660 CPD-10 Degrader 98.59% Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor 98.20% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-153894 SRX3177 Inhibitor 99.33% Unkown
HY-164129 CDK4-IN-3 Inhibitor 98.07% Unkown
HY-N7045 Isosilybin B Inhibitor 99.32% Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor 98.18% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-107419 NU6140 Inhibitor 99.53% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.67% Unkown
HY-16942 Damulin B Inhibitor 96.62% Unkown
HY-123045 PNU-292137 Inhibitor 99.95% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 99.26% Unkown
HY-103380 NSC 625987 Inhibitor 98.01% Unkown
HY-112822 ON-013100 Inhibitor 99.66% Unkown
HY-119715 AG-012986 Inhibitor 99.78% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-50940A AT7519 TFA Inhibitor 99.75% Unkown
HY-168996 LA-CB1 Degrader 98.20% Unkown
HY-115992 CDK4/6-IN-9 Inhibitor 99.46% Unkown
HY-112328 Fascaplysin Inhibitor 95.64% Unkown
HY-142696A CDK6/PIM1-IN-1 hydrochloride Inhibitor 99.38% Unkown
HY-108420 INK4C-IN-2 Activator 98.35% Unkown
HY-146213 CDK4/6-IN-12 Inhibitor 99.76% Unkown
HY-179688 PROTAC CDK2/4 Degrader-1 Degrader 98.10% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-145589 Rafutrombopag Agonist 95.29% Unkown
HY-168440 Aurora-A ligand 1 Ligand 98.75% Unkown
HY-115909 ZDLD20 Inhibitor 99.84% Unkown
HY-148366 NecroIr2 Inhibitor 98.02% Unkown
HY-148365 NecroIr1 Inhibitor 98.53% Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader 97.22% Unkown
HY-123535 P18IN003 Activator 99.49% Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.65% Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader 98.00% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-164906 TMX-2138 Degrader 98.99% Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-112418 CDK4/6-IN-18 Inhibitor 98.9% Unkown
HY-147125 DDO-6600 Inhibitor 99.2% Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-N2423 Sinigrin hydrate Inhibitor 99.92% Unkown
HY-112450 Olomoucine II Inhibitor 98.0% Unkown
HY-111207 CA224 Inhibitor 99.94% Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-160941 CDK2-IN-29 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-159155 CDK2/4-IN-1 Inhibitor / Unkown
HY-171656 G721-0282 Inhibitor 99.96% Unkown
HY-164376 CDK4/6-IN-21 Inhibitor / Unkown
HY-114338B Dalpiciclib isethionate Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-162530 CDK4/6-IN-20 Inhibitor / Unkown
HY-171740 CDK4-IN-4 Inhibitor / Unkown
HY-134303 CST651 Degrader / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-183571 JD128 Inhibitor / Unkown
HY-171826 PROTAC CDK2/4/6 Degrader-1 Inhibitor / Unkown
HY-176718 VEGFR-2-IN-69 Inhibitor / Unkown
HY-183297 CDK4-IN-5 Inhibitor / Unkown
HY-185487 CDK4/6-IN-27 Inhibitor / Unkown
HY-184418 CDK4-IN-6 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-155602 CDK2-IN-18 Inhibitor / Unkown
HY-143327 PROTAC BRD4 Degrader-16 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-178516 PROTAC CDK4/6/9 degrader 2 Degrader / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-115904 FLT3/CDK4-IN-1 Inhibitor / Unkown
HY-168444 CDK4/6-IN-23 Inhibitor / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-171481 Thio-acridone Inhibitor / Unkown
HY-150609 SHP2/CDK4-IN-1 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-162529 CDK4/6-IN-19 Inhibitor / Unkown
HY-128491 UNC10112785 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-161709 FLT3/CDKs ligand-1 Degrader / Unkown
HY-170992 Autophagy agonist-1 Inhibitor / Unkown
HY-182752 CDK1-IN-9 Inhibitor / Unkown
HY-W1047040 CDK2/4 ligand 1 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-182734 BMS-357075 Inhibitor / Unkown
HY-170651 CDK4/6/HDAC-IN-1 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-176365 Palbociclib-C4-Boc Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-182447 Contragestazol Inhibitor / Unkown
HY-178452 PROTAC CDK4/6/9 degrader 1 Degrader / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-164376A CDK4/6-IN-21 maleate Inhibitor / Unkown
HY-172127 NUAK1-IN-1 Inhibitor / Unkown
HY-183854 AG-12286 Inhibitor / Unkown
HY-181501 CDK2/4/6-IN-3 Inhibitor / Unkown
HY-162875 PROTAC BRD4 Degrader-27 Inhibitor / Unkown
HY-123859 SR-2890 Inhibitor / Unkown
HY-184707 CDK4/6-IN-29 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-182044 MRTX849-amide-C4-(o)-carborane Inhibitor / Unkown
HY-183771 CDK4/6-IN-28 Inhibitor / Unkown
HY-179151 CDK4/6-IN-26 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-163787 YY173 Inhibitor / Unkown
HY-115908 ZDLD13 Inhibitor / Unkown
HY-170815 CDK4/9-IN-1 Inhibitor / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-172198 GSK3-IN-10 Inhibitor / Unkown
HY-184444 CDK4-IN-7 Inhibitor / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-173237 CDK4/6/BRD4-IN-1 Inhibitor / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-184877 CDK4-IN-8 Inhibitor / Unkown
HY-183529 Antitrypanosomal agent 31 Inhibitor / Unkown
HY-11001A PHA-793887 hydrochloride Inhibitor / Unkown
HY-173172 MG-002 Inhibitor / Unkown
HY-102088 P18IN011 Inhibitor / Unkown
HY-118447 RO0505124 / Unkown
HY-N11852 Momilactone B Inhibitor 99.47% Unkown
HY-N1431A Tabersonine hydrochloride Inhibitor 98.55% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk4 NCBI NCBI:1019