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in vitro

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2346

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50

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80

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163

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0108
    Daptomycin
    20+ Cited Publications

    LY146032

    		 Bacterial Antibiotic Infection Cancer
    Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
    Daptomycin
  • HY-A0096
    Iloprost
    5 Publications Verification

    Ciloprost; ZK 36374

    		 Prostaglandin Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology Cancer
    Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .
    Iloprost
  • HY-D1451
    PKH 26
    Maximum Cited Publications
    36 Publications Verification

    		 Fluorescent Dye Others
    PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies .
    PKH 26
  • HY-N0077
    Ginkgolic acid
    15+ Cited Publications

    Ginkgolic acid I

    		 E1/E2/E3 Enzyme Cancer
    Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC50 of 3.0 μM in in vitro assay.
    Ginkgolic acid
  • HY-19735
    KJ Pyr 9
    5+ Cited Publications

    		 c-Myc Autophagy Cancer
    KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay.
    KJ Pyr 9
  • HY-129047E
    Trypsin, porcine pancreas (Cell culture grade)
    15+ Cited Publications

    		 Ser/Thr Protease Others
    Trypsin, porcine pancreas (Cell culture grade) is a serine protease that hydrolyzes proteins at the carboxyl side of lysine or arginine residues. Trypsin, porcine pancreas (Cell culture grade) exhibits excellent protein digestibility for α-lactalbumin and β-casein. Trypsin, porcine pancreas (Cell culture grade) removes cellular components while preserving extracellular matrix structures to achieve uniform decellularization of porcine pancreas .
    Trypsin, porcine pancreas (Cell culture grade)
  • HY-P99590A
    Sotatercept (mIgG2a)
    1 Publications Verification

    RAP-011

    		 TGF-β Receptor TGF-beta/Smad Cardiovascular Disease Metabolic Disease
    Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .
    Sotatercept (mIgG2a)
  • HY-100236
    Madrasin
    5+ Cited Publications

    DDD00107587

    		 DNA/RNA Synthesis Cancer
    Madrasin (DDD00107587) is a splicing inhibitor that prevents formation of both splicing intermediates and products in vitro and interferes with one or more early steps in the pathway of spliceosome assembly. Madrasin also can inhibit pre-mRNA splicing in vitro and modify splicing of endogenous pre-mRNA in cells .
    Madrasin
  • HY-137522
    Zidovudine O-β-D-glucuronide sodium

    3'-Azido-3'-deoxythymidine β-D-glucuronide sodium

    		 Drug Metabolite Others
    Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
    Zidovudine O-β-D-glucuronide sodium
  • HY-15878
    LDC000067
    10+ Cited Publications

    LDC067

    		 CDK Apoptosis Cancer
    LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro.
    LDC000067
  • HY-121388
    Ledol

    (+)-Ledol

    		 Fungal Infection
    Ledol ((+)-Ledol) is an antifungal agent isolated from the volatile oil components of Rhododendron tomentosum. Ledol also acts as an expectorant and antitussive, while it can cause adverse reactions such as dizziness, nausea and vomiting .
    Ledol
  • HY-DY1011
    PKH 26 (solution)

    		Fluorescent Dye Others
    PKH 26 (solution) is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm) , which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies .
    Solvent and concentration: DMSO: 5 mM
    PKH 26 (solution)
  • HY-N6635
    trans-Nerolidol

    		Fungal Infection Cancer
    trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (DOX) (HY-15142A) against intestinal cancer and breast cancer cells in vitro. trans-Nerolidol increases accumulation of DOX inside cells in vitro. trans-Nerolidol activates apoptosis in vivo .
    trans-Nerolidol
  • HY-136302
    Karrikinolide

    		Phytohormone Others
    Karrikinolide is a plant-active compound. Karrikinolide can be extracted from smoke water (SW). Karrikinolide promotes total Cytokinin production. Plants treated with Karrikinolide exhibit superior growth in terms of rooting, leaf and bulb size, and fresh weight .
    Karrikinolide
  • HY-N2938
    Biorobin

    Kaempferol 3-O-robinobioside

    		 Others Cancer
    Biorobin (Kaempferol 3-O-robinobioside), a flavonoid, significantly inhibits the human lymphocyte proliferation in vitro .
    Biorobin
  • HY-B1004
    Dinitolmide
    1 Publications Verification

    Zoalene

    		 Environmental Pollutants Parasite Infection
    Dinitolmide (Zoalene) is an orally active anticoccidial agent used as a fodder additive. Dinitolmide has a wide anticoccidial spectrum with no effect on host immunity. Dinitolmide mainly acts on the first generation merozoite stage of coccidia and also has an inhibitory effect on the sporulation process of oocysts. Dinitolmide has anti-Toxoplasma gondii effect in vitro with an EC50 of 3.625 μg/mL. Dinitolmide can be used to inhibits infections caused by Eimeria tenella .
    Dinitolmide
  • HY-N0500
    Mogroside III

    		Glycosidase Autophagy Metabolic Disease Endocrinology
    Mogroside III is a triterpenoid glycoside. Mogroside III exhibits maltase inhibitory effect with an IC50 value of 1.6 mM. Mogroside III enhances oocyte developmental potential by promoting autophagy in cumulus cells. Mogroside III, as the active ingredient of the low-polarity glycoside component (L-SGgly), L-SGgly can increase serum GLP-1 levels, improve insulin resistance, and reduce IL-6 levels, and has hypoglycemic, lipid-regulating and anti-inflammatory effects. Mogroside III can be used for the studies of type 2 diabetes mellitus (T2DM) and assisted reproductive technology .
    Mogroside III
  • HY-45609
    L-Cysteine S-sulfate sodium hydrate

    		Drug Derivative Metabolic Disease
    L-Cysteine S-sulfate sodium hydrate is an S-sulfated derivative of L-cysteine (HY-Y0337). L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry and chromatography analyses .
    L-Cysteine S-sulfate sodium hydrate
  • HY-E70090
    T7 RNA polymerase

    		DNA/RNA Synthesis Infection
    T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg 2+, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .
    T7 RNA polymerase
  • HY-156261
    Beef extract

    		Biochemical Assay Reagents Others
    Beef extract is a common ingredient in the preparation of biological culture media .
    Beef extract
  • HY-P5232
    Tetrapeptide-21

    		Collagen Metabolic Disease
    Tetrapeptide-21 is a bioactive peptide composed of four amino acids. Tetrapeptide-21 effectively enhances the vitality of human dermal fibroblasts. Tetrapeptide-21 upregulates the expression of key extracellular matrix (ECM) genes and promotes the synthesis of ECM proteins (such as type I collagen, hyaluronic acid synthase 1, and fibronectin). Tetrapeptide-21 has the efficacy of anti-wrinkle and improving skin elasticity, and has been reported to be used as a cosmetic ingredient .
    Tetrapeptide-21
  • HY-142052
    Anhydrotetracycline
    2 Publications Verification

    5a(6)-Anhydrotetracycline

    		 Antibiotic Infection
    Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro .
    Anhydrotetracycline
  • HY-113242
    5-Nonadecylresorcinol

    		Glycosidase Others
    5-Nonadecylresorcinol is an alkylresorcinol and has inhibitory effects on the release of β-hexosaminidase in vitro .
    5-Nonadecylresorcinol
  • HY-N2626
    Epimedoside A

    		Others Infection
    Epimedoside A is a flavonoid isolated from the roots of Epimedium wushanense. Epimedoside A exhibits significant antioxidant activity in vitro .
    Epimedoside A
  • HY-P1139
    Cortistatin-8

    PCFWKTCK

    		 GHSR Metabolic Disease
    Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .
    Cortistatin-8
  • HY-W013715B
    Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade

    dTTP trisodium,100 mM Solution,PCR Grade

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite Others
    Deoxythymidine-5'-triphosphate (dTTP) trisodium, 100 mM Solution, PCR Grade is one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. Deoxythymidine-5'-triphosphate trisodium, 100 mM Solution, PCR Grade is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied as an aqueous solution.
    Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-W796158
    Z-DEVD-CMK

    		Cathepsin Inflammation/Immunology
    Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro .
    Z-DEVD-CMK
  • HY-N11707
    Piscidic acid

    		Others Others
    Piscidic acid is an ester compound derived from Cimicifuga racemosa. Piscidic acid has in vitro estrogen activity .
    Piscidic acid
  • HY-N2297
    Kaji-ichigoside F1

    		Antibiotic Infection
    Kaji-ichigoside F1 is isolated from S. cuneata with hemolytic and in vitro antiviral activity.
    Kaji-ichigoside F1
  • HY-135818
    XM462

    		Dihydroceramide Desaturase 1 (DES1) Cancer
    XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor .
    XM462
  • HY-P3915
    Esculentin 1A

    		Bacterial Infection
    Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .
    Esculentin 1A
  • HY-P3516
    Barusiban

    FE-200440

    		 Oxytocin Receptor Endocrinology
    Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research .
    Barusiban
  • HY-15197
    ABT-046

    		Acyltransferase Metabolic Disease
    ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of both 8 nM against human and mouse DGAT-1 .
    ABT-046
  • HY-A0096R
    Iloprost (Standard)

    Ciloprost (Standard); ZK 36374 (Standard)

    		 Reference Standards Prostaglandin Receptor Endogenous Metabolite Endocrinology Cancer
    Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .
    Iloprost (Standard)
  • HY-N10373
    Caffeoyl alcohol

    		Others Others
    Caffeoyl alcohol is a monomer constituting Catechyl lignin. Catechyl lignin is a linear homopolymer of caffeyl alcohol, a natural source of carbon fiber and high-value chemicals .
    Caffeoyl alcohol
  • HY-101631
    Levophacetoperane hydrochloride

    		Dopamine Transporter Neurological Disease
    Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.
    Levophacetoperane hydrochloride
  • HY-13741
    RH1
    1 Publications Verification

    NSC 697726

    		 Apoptosis Cancer
    RH1 (NSC 697726) is a potent bioreductive agent with profound anti-cancer activity in vitro and in vivo.
    RH1
  • HY-134375
    cAIMP

    Cyclic Adenosine-inosine Monophosphate

    		 NF-κB IFNAR Inflammation/Immunology
    cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC50 of 6.4 μmol/L .
    cAIMP
  • HY-100167
    TAK-778

    		Phosphatase MMP TGF-β Receptor IGF-1R Drug Derivative Cancer
    TAK-778 is a derivative of ipriflavone and has been shown to induce bone growth in in vitro and in vivo models.
    TAK-778
  • HY-155241
    α-Amylase/α-Glucosidase-IN-4

    		Glycosidase Amylases Metabolic Disease
    α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC50s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .
    α-Amylase/α-Glucosidase-IN-4
  • HY-W015627
    3,5-Dichloropyridine

    		Drug Intermediate Inflammation/Immunology Cancer
    3,5-dichloropyridine is a drug intermediate that can be used to synthesize metal-organic framework (MOF) materials and P2X7 receptor antagonists .
    3,5-Dichloropyridine
  • HY-148291
    BrP-LPA sodium

    		LPL Receptor Phosphodiesterase (PDE) Cancer
    BrP-LPA sodium is a pan-opposite agent for lysophosphatidic acid (LPA). It has antagonistic activity against LPA1 (IC50 = 4520 nM), LPA2 (IC50 = 468 nM), LPA3, and LPA4. BrP-LPA sodium also has partial agonistic activity for LPA5, with its EC50 being 1282 nM. BrP-LPA sodium has ATX inhibitory activity. BrP-LPA sodium effectively inhibits the migration and invasion of breast cancer cells. BrP-LPA sodium achieves tumor regression and anti-angiogenesis in mice breast cancer xenograft model. BrP-LPA sodium can be used for the study of breast cancer .
    BrP-LPA sodium
  • HY-176960
    3-Amino-2-hydroxypropyl dihydrogen phosphate

    		Biochemical Assay Reagents Others
    3-Amino-2-hydroxypropyl dihydrogen phosphate is a chemical modification complex of the DNA phosphate backbone, which can be used to study the interaction between HIV integrase (IN) and DNA .
    3-Amino-2-hydroxypropyl dihydrogen phosphate
  • HY-115550
    Chalcone 4 hydrate

    		Parasite Infection
    Chalcone 4 hydrate is an anti-parasitic agent. Chalcone 4 hydrate inhibits the growth and proliferation of Babesia and Theileria in vitro. Chalcone 4 hydrate reduces the viability of mammalian fibroblasts and kidney cells in vitro. Chalcone 4 hydrate can be used for the research of parasitic infections .
    Chalcone 4 hydrate
  • HY-157316
    TZ-NBD

    		Fluorescent Dye Others
    TZ-NBD is a dual-channel sensitive fluorescence probe that exhibits fast response, and excellent selectivity to detect biothiols in vitro and in vivo .
    TZ-NBD
  • HY-157390
    DPP-4-IN-9

    		Dipeptidyl Peptidase Metabolic Disease
    DPP-4-IN-9 (compound 6l) is a potent inhibitor of dipeptidyl peptidase DPP-4 (IC50: 8.22 nM). DPP-4-IN-9 has antihyperglycemic activity .
    DPP-4-IN-9
  • HY-162856
    TRPV1-IN-2

    		TRP Channel Neurological Disease
    TRPV1-IN-2 ((R)-32) is a TRPV1 inhibitor. TRPV1-IN-2 has protective effects on ED epilepsy models .
    TRPV1-IN-2
  • HY-E70400
    Thermostable T7 RNA Polymerase

    		DNA/RNA Synthesis Others
    Thermostable T7 RNA Polymerase is a thermostable version of T7 RNA Polymerase (HY-E70090). Compared with T7 RNA Polymerase, it has high temperature resistance and stable activity. T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg 2+, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .
    Thermostable T7 RNA Polymerase
  • HY-106122
    NK-611

    VP 19

    		 Topoisomerase DNA/RNA Synthesis Cancer
    NK-611 (VP 19) is an epipodophyllotoxin derivative. NK-611 induces DNA double-strand breaks by inhibiting topoisomerase II (IC50 = 56 μM). NK-611 does not inhibit microtubule polymerization, thus avoiding the side effects of the parent compound, Podofilox (HY-15552). NK-611 exhibits broad-spectrum antitumor activity and demonstrates potent efficacy in in vivo models of leukemia. NK-611 can be used in cancer research .
    NK-611
  • HY-W419570
    (Rac)-BX 048

    		P2Y Receptor Cardiovascular Disease
    (Rac)-BX 048 is a BX 048 racemate. BX 048 is a P2Y12 receptor antagonist. BX 048 inhibits ADP-induced platelet aggregation in human, dog and rat whole blood. BX 048 also inhibits Arachidonic acid (HY-109590) induced platelet aggregation (IC50 of 15 μM) .
    (Rac)-BX 048

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