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(+)-Magnoflorine iodide

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(+)-Magnoflorine iodide
(+)-Magnoflorine iodide
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2 Cited Publications
Cat. No.: HY-N0334A
CAS No.: 4277-43-4
Synonyms: Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide
Category:  

Alkaloids Magnoliaceae Metabolic Disease Phenols Polyphenols Magnolia Liliflora Desr. Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine iodide promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine iodide inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine iodide also has significant antifungal activity .
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