Parp1 - poly (ADP-ribose) polymerase family, member 1 Gene

Also Known as PARP; PPOL; ARTD1; Adprp; Adprt1; msPARP; parp-1; sPARP-1; 5830444G22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11545

About Parp1

Chromosome 1: 180,396,489-180,428,819 forward strand.GRCm39:CM000994.3

This gene has 8 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 48 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 6.8), CNS E14 (RPKM 38.) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; Bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022]

Parp1 Products (1)

mRNA Protein Name
NM_007415.3 NP_031441.2 poly [ADP-ribose] polymerase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
32822587 MGI
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
24550317 MGI
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
22736760 MGI
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
24449909 MGI
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
32822587 MGI
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
32822587 MGI
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
35460603 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24449909 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16979186 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within DNA metabolic process IMP
IMP: Inferred from mutant phenotype
11756244 MGI
involved in DNA repair IDA
IDA: Inferred from direct assay
22736760 MGI
acts upstream of or within base-excision repair IMP
IMP: Inferred from mutant phenotype
11948190 MGI
acts upstream of or within behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
24449909 MGI
acts upstream of or within cellular response to superoxide IDA
IDA: Inferred from direct assay
24191052 MGI
involved in decidualization IMP
IMP: Inferred from mutant phenotype
34580230 MGI
acts upstream of or within double-strand break repair IGI
IGI: Inferred from genetic interaction
21270334 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
25378300 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
32822587 MGI
involved in negative regulation of adipose tissue development IDA
IDA: Inferred from direct assay
32822587 MGI
involved in negative regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
35460603 MGI
acts upstream of or within negative regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
25470037 MGI
involved in negative regulation of telomere maintenance via telomere lengthening IMP
IMP: Inferred from mutant phenotype
26586427 MGI
involved in positive regulation of necroptotic process IDA
IDA: Inferred from direct assay
12114629 MGI
involved in positive regulation of single strand break repair IGI
IGI: Inferred from genetic interaction
28002403 MGI
acts upstream of or within protein poly-ADP-ribosylation IDA
IDA: Inferred from direct assay
24449909 MGI
involved in protein poly-ADP-ribosylation IDA
IDA: Inferred from direct assay
28991266 MGI
involved in regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
34798058 MGI
acts upstream of or within regulation of growth rate IMP
IMP: Inferred from mutant phenotype
12707040 MGI
acts upstream of or within regulation of single strand break repair IMP
IMP: Inferred from mutant phenotype
25378300 MGI
acts upstream of or within telomere maintenance IMP
IMP: Inferred from mutant phenotype
12707040 MGI
involved in voluntary musculoskeletal movement IGI
IGI: Inferred from genetic interaction
28002403 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in chromatin IDA
IDA: Inferred from direct assay
20647423 MGI
located in chromatin IDA
IDA: Inferred from direct assay
20647423 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19470756 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
15615785 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
15615785 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
28991266 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19470756 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19796622 MGI
is active in site of DNA damage IDA
IDA: Inferred from direct assay
22736760 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Parp1 Protein Structure

PLN03123

PLN03123: cl33639 (8 - 1009)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1014 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase 1

  • ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1

  • ADP-ribosyltransferase diphtheria toxin-like 1

  • ADPRT 1

  • DNA ADP-ribosyltransferase PARP1

  • NAD(+) ADP-ribosyltransferase 1

  • poly(ADP-ribose) polymerase

  • poly[ADP-ribose] synthase 1

  • poly[ADP-ribose] synthetase 1

  • protein poly-ADP-ribosyltransferase PARP1

Recombinant Parp1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P73337 PARP1 Protein, Mouse (sf9, His) Q921K2 (M1-W1014) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (17)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-10162 Olaparib Inhibitor 99.98% Yes
HY-16106 Talazoparib Inhibitor 99.89% Unkown
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-114778 Fluzoparib Inhibitor 99.96% Unkown
HY-10619A Niraparib hydrochloride Inhibitor 99.41% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-113041 Prostaglandin A2 Activator 99.9% Unkown
HY-B0960 Sulfabenzamide 99.68% Unkown
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-136489 KU-0058948 Inhibitor 99.79% Unkown
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (13)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-132167 Saruparib Inhibitor 99.76% Phase 3
HY-10129 Veliparib Inhibitor 99.77% Phase 3
HY-12032 AG14361 Inhibitor 99.42% Phase 3
HY-12015 Iniparib Inhibitor 99.74% Phase 3
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-137457 Venadaparib Inhibitor 98.52% Phase 2
HY-122661 Mefuparib hydrochloride Inhibitor 98.62% Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1
HY-13536 AZD-2461 Inhibitor 99.79% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-115552 Simmiparib Inhibitor 99.01% Phase 1
HY-170432 PARP1-IN-34 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (167)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-13688A PJ34 Inhibitor 99.66% Unkown
HY-171006 IRF1-IN-1 Inhibitor 99.72% Unkown
HY-145471 KSQ-4279 Inhibitor 99.96% Unkown
HY-139156 SK-575 Inhibitor 99.86% Unkown
HY-N0213 Peiminine 99.89% Unkown
HY-171007 IRF1-IN-2 Inhibitor 99.83% Unkown
HY-N3584 Paris saponin VII Inhibitor 99.84% Unkown
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-14478 UPF 1069 Inhibitor 99.02% Unkown
HY-13688 PJ34 hydrochloride Inhibitor 99.81% Unkown
HY-114869 DPQ Inhibitor 99.68% Unkown
HY-N6866 Gomisin N Activator 99.94% Unkown
HY-130644 iRucaparib-AP6 Degrader 99.03% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-75706 N-Descyclopropanecarbaldehyde Olaparib Inhibitor 99.46% Unkown
HY-100225 ME0328 Inhibitor 99.64% Unkown
HY-10130 Veliparib dihydrochloride Inhibitor 99.98% Yes
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-113352 7-Methylguanine Inhibitor 99.97% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-16106A (8R,9S)-Talazoparib Inhibitor 98.28% Unkown
HY-170620 PARP1 PROTAC 180055 Inhibitor 98.90% Unkown
HY-117889 PARP14 inhibitor H10 Inhibitor 99.46% Unkown
HY-158045 PROTAC PARP1 degrader-1 Degrader 99.86% Unkown
HY-108632 BYK204165 Inhibitor 99.89% Unkown
HY-18954 NMS-P118 Inhibitor 99.54% Unkown
HY-10619D Niraparib (R-enantiomer) Inhibitor 99.29% Unkown
HY-114324 PROTAC PARP1 degrader Degrader 99.74% Unkown
HY-156419 PARP7-IN-16 Inhibitor 99.91% Unkown
HY-156419A PARP7-IN-16 free base Inhibitor 99.40% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.56% Unkown
HY-10615 A-620223 Inhibitor 98.84% Unkown
HY-10614 A-966492 Inhibitor 99.00% Unkown
HY-149800 PARP-1-IN-3 Inhibitor 99.80% Unkown
HY-145749 PARPYnD Inhibitor 98.86% Unkown
HY-147027 PARP-1-IN-2 Inhibitor 99.48% Unkown
HY-114324A rel-PROTAC PARP1 degrader Degrader 98.32% Unkown
HY-164926 PARP1-IN-33 Inhibitor 99.02% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-145471A KSQ-4279 gentisate Inhibitor 99.75% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-15046 EB-47 Inhibitor 99.89% Unkown
HY-128599 NMS-P515 Inhibitor 98.18% Unkown
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.40% Unkown
HY-164475 PARP1-IN-29 Inhibitor / Unkown
HY-105692 DR2313 Inhibitor 99.66% Unkown
HY-182499 PARP1-IN-56 Inhibitor 99.03% Unkown
HY-168979 Itareparib Inhibitor 99.24% Unkown
HY-176713 KWZY-11 Inhibitor / Unkown
HY-160937 AZD-9574-acid Ligand 99.44% Unkown
HY-175885 PROTAC FTO degrader 1 Inducer / Unkown
HY-146548 Anticancer agent 43 Inducer 98.58% Unkown
HY-178496 DDO3602 Degrader / Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor 98.66% Unkown
HY-130646 iVeliparib-AP6 Degrader / Unkown
HY-123232 KU-0058684 Inhibitor 98.54% Unkown
HY-137457A Venadaparib hydrochloride Inhibitor / Unkown
HY-132297 PARP1-IN-5 Inhibitor / Unkown
HY-184737 TPP-C8-CO-DSG bromide Activator / Unkown
HY-183143 Lss-11 Activator / Unkown
HY-169170 PARP1/BRD4-IN-3 Inhibitor / Unkown
HY-149001 PARP1-IN-9 Inhibitor / Unkown
HY-178972 PARP1-IN-48 Inhibitor / Unkown
HY-172224 PARP1/CDK12-IN-1 Inhibitor / Unkown
HY-162114 PARP1-IN-18 Inhibitor / Unkown
HY-149003 PARP1-IN-10 Inhibitor / Unkown
HY-178032 PARP1-IN-44 Inhibitor / Unkown
HY-150765 PARP1-IN-12 Inhibitor / Unkown
HY-184967 XZ8078 Degrader / Unkown
HY-173441 PARP1 ligand-1 Ligand / Unkown
HY-W424851 DPQ hydrochloride Inhibitor 98.97% Unkown
HY-105253 PARP-2/1-IN-2 Inhibitor / Unkown
HY-W973851 2H-Indazole-7-carboxamide Degrader / Unkown
HY-168722 PROTAC PARP1 degrader-3 Degrader / Unkown
HY-130647 Vrucaparib-TP4 Degrader / Unkown
HY-136489A KU-0058948 hydrochloride Inhibitor / Unkown
HY-158681 PARP1-IN-22 Inhibitor / Unkown
HY-181158 PARP1-IN-52 Inhibitor / Unkown
HY-181460 PARP1 degrader-2 Degrader / Unkown
HY-157137 PARP1-IN-17 / Unkown
HY-144338 PARP1/BRD4-IN-1 Inhibitor / Unkown
HY-184597 PARP1-IN-57 Inhibitor / Unkown
HY-169299 TOPOI/PARP-1-IN-2 Inhibitor / Unkown
HY-181068 2'-Nitroflavone Inhibitor / Unkown
HY-176128 BWA-6047 / Unkown
HY-N17653 13'-Carboxy-δ-tocopherol / Unkown
HY-179386 PARP1/EZH2-IN-1 Inhibitor / Unkown
HY-182269 Cathepsin-IN-5 / Unkown
HY-184277 Tubulin/PARP1-IN-1 Inhibitor / Unkown
HY-181664 YCH3971 Inhibitor / Unkown
HY-181265 PARP1-IN-53 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-181842 PARP1/ERK IN-1 Inhibitor / Unkown
HY-148710 ARTD10/PARP10-IN-2 Inhibitor / Unkown
HY-179685 PARP1-IN-51 Inhibitor / Unkown
HY-168094 PARP1-IN-30 Inhibitor / Unkown
HY-179349 PARP-1/2-IN-5 Inhibitor / Unkown
HY-N20707 Castalagin Inhibitor / Unkown
HY-168851 PARP1-IN-35 Inhibitor / Unkown
HY-184895 CM002 Activator / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-175471 PARP1-IN-42 Inhibitor / Unkown
HY-184557 DZ-1-DHA Activator / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-147030 PARP1-IN-8 Inhibitor 99.29% Unkown
HY-129599 L-2286 Inhibitor / Unkown
HY-183317 IDO1-IN-34 Activator / Unkown
HY-180809 YCH3292 Inhibitor / Unkown
HY-158680 PARP1-IN-21 Inhibitor / Unkown
HY-147101 SK-575-NEG Inhibitor / Unkown
HY-148709 ARTD10/PARP10-IN-1 Inhibitor / Unkown
HY-161769 HL435 Activator / Unkown
HY-181254 PARP1/NAMPT-IN-1 Inhibitor / Unkown
HY-181746 Bcl-2/Mcl-1-IN-5 Activator / Unkown
HY-178178 PARP1-IN-46 Inhibitor / Unkown
HY-181928 PARP1/c-Met-IN-3 Inhibitor / Unkown
HY-179614 PARP1-IN-50 Inhibitor / Unkown
HY-161083 PARP/EZH2-IN-2 Inhibitor / Unkown
HY-181999 PC8 Inhibitor / Unkown
HY-163658 PARP-1-IN-23 Inhibitor / Unkown
HY-179020 PARP/VEGFR3-IN-1 Inhibitor / Unkown
HY-161606 PARP-1/2/7-IN-1 Inhibitor / Unkown
HY-187176 CPP-13 Degrader / Unkown
HY-155766 PARP1-IN-14 Inhibitor / Unkown
HY-180276 PARP1 degrader 1 Degrader / Unkown
HY-130645 iRucaparib-TP3 Degrader / Unkown
HY-161517 PARP1-IN-20 Inhibitor / Unkown
HY-178348 PARP1/c-Met-IN-2 Inhibitor / Unkown
HY-161868 DLC-50 Inhibitor / Unkown
HY-181140 UNPD139734 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-178100 PARP1-IN-45 Inhibitor / Unkown
HY-163817 PARP1/2-IN-3 Inhibitor / Unkown
HY-170978 PROTAC CDK9 degrader-11 Activator / Unkown
HY-175482 PARP1-IN-43 Inhibitor / Unkown
HY-174836 ZINC000081009201 Inhibitor / Unkown
HY-181720 Antitumor agent-214 Degrader / Unkown
HY-171543 PARP1-IN-37 Inhibitor / Unkown
HY-174828 ATR/PARP1-IN-1 Inhibitor / Unkown
HY-182246 MC2050 Inhibitor / Unkown
HY-150613 PARP1/BRD4-IN-2 Inhibitor / Unkown
HY-183373 EGFR/PARP-1-IN-1 Inhibitor / Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-178468 PARP1-IN-47 Inhibitor / Unkown
HY-161372 PARP1/c-Met-IN-1 Inhibitor / Unkown
HY-183765 PARP1/PKM2-IN-1 Inhibitor / Unkown
HY-173597 ZINC43120769 Inhibitor / Unkown
HY-184273 TH-407a Inhibitor / Unkown
HY-181967 PROTAC PARP1 degrader-5 Degrader / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-179406 PARP1-IN-49 Inhibitor / Unkown
HY-175175 MAPK-IN-5 Inhibitor / Unkown
HY-170942 CDK9/PARP-IN-1 Inhibitor / Unkown
HY-14687 (rac)-Talazoparib Inhibitor / Unkown
HY-181459 PARP1-IN-55 Inhibitor / Unkown
HY-175466 BER-IN-1 Inhibitor / Unkown
HY-167762 TNKS-2-IN-4 Inhibitor / Unkown
HY-115862 Benzo[c][1,8]naphthyridin-6(5H)-one Inhibitor / Unkown
HY-117423 ST7710AA1 Inhibitor / Unkown
HY-14477 UPF-1035 Inhibitor / Unkown
HY-108238 BSI-401 Inhibitor / Unkown
HY-132157 8-Chloroquinazolin-4-ol Inhibitor 98.44% Unkown
HY-U00223 WD2000-012547 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp1 NCBI NCBI:142