6 Results for "

(+)-Ajmaline

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "(+)-Ajmaline" in MCE Product Catalog:

製品番号: HY-B1167
CAS 番号: 4360-12-7
別名: Cardiorythmine; (+)-Ajmaline
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .
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製品番号: HY-B1167R
CAS 番号: 4360-12-7
別名: Cardiorythmine (Standard); (+)-Ajmaline (Standard)
Ajmaline (Standard) is the analytical standard of Ajmaline. This product is intended for research and analytical applications. Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .
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製品番号: HY-B1167A
CAS 番号: 4410-48-4
別名: Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.
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製品番号: HY-105929
CAS 番号: 47562-08-3
別名: 17-MonochloroacetylAjmaline
Target:  

Sodium Channel

研究分野:  

Cardiovascular Disease

Lorajmine (17-Monochloroacetylajmaline) is an Ajmaline (HY-B1167) (Sodium channel blocker) prodrug .
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製品番号: HY-E71141
研究分野:  

Others

1,2-Dihydrovomilenine reductase (EC 1.3.1.73) forms part of the ajmaline biosynthesis pathway.
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製品番号: HY-E72071
研究分野:  

Others

Acetylajmaline esterase (EC 3.1.1.80) is a hydrolase that can catalyze multiple reactions, including reaction 1: convert 17-O-acetylajmaline and H2O into ajmaline, acetate and H +; reaction 2: convert 17-O-acetylnorajmaline and H2O into norajmaline, acetate and H +.
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