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( )-Menthol

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) Calcium Channel (2) Drug Derivative (3) Drug Intermediate (1) Drug Metabolite (2) Endogenous Metabolite (3) Environmental Pollutants (3) Fungal (3) GABA Receptor (2) Isotope-Labeled Compounds (5) Reference Standards (5) TRP Channel (7)
By Research Areas:	Cancer (3) Infection (3) Inflammation/Immunology (1) Neurological Disease (8)
Oligonucleotides:	Flavoring Agents (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-75161

(-)-Menthol 4 Publications Verification	Environmental Pollutants Endogenous Metabolite TRP Channel	Cancer
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-108449

Acoltremon 2 Publications Verification WS-12; AR-15512; AVX-012	TRP Channel	Neurological Disease
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

HY-Y1683

DL-Menthol RaceMenthol	Environmental Pollutants GABA Receptor	Infection Neurological Disease
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-W017277

(+)-Menthol D-Menthol	Fungal	Neurological Disease
(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-N7132

(-)-Menthyl acetate L-Menthyl acetate	Biochemical Assay Reagents Drug Derivative	Others
(-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol and also a skin penetration enhancer for 5-aminolevulinic acid (ALA). (-)-Menthyl acetate exhibits strong ALA skin penetration-enhancing activity .

HY-75161R

*(-)-Menthol* (Standard)**	Reference Standards TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-W1008636

Isomenthol	Drug Derivative	Others
Isomenthol is a isomer of menthol with two stable gas-phase conformers. Isomenthol has gas-phase conformers proposed to be non-minty due to axial methyl or axial isopropyl groups .

HY-122317

Menthol glucuronide	Drug Metabolite	Others
Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .

HY-N1369S

Menthol-d4	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes .

HY-W683864

Menthyl isovalerate	Drug Intermediate	Others
Menthyl isovalerate is an ester formed by menthol and isovaleric acid. Menthyl isovalerate can be used as a food additive for flavor and fragrance .

HY-N7536

Voacangine	TRP Channel	Others
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-108449S

Acoltremon-d3 WS-12-d₃; AR-15512-d₃; AVX-012-d₃	Isotope-Labeled Compounds TRP Channel	Neurological Disease
Acoltremon-d₃ (WS-12-d₃) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

HY-N1369S1

Menthol-d2	Calcium Channel Isotope-Labeled Compounds	Neurological Disease
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-W087943

Methyl octanoate	Environmental Pollutants Fungal	Infection
Methyl octanoate is an ester volatile compound with an odor activity value greater than 1. Methyl octanoate helps impart brandy-like and fruity characteristics to persimmon wine. Methyl octanoate has a strong odor of citrus holly, camphor and menthol. Methyl octanoate can serve as an early marker for grape infection by Coniella vitis. Methyl octanoate can be used in studies related to grape white rot .

HY-W017277R

*(+)-Menthol* (Standard)** D-Menthol (Standard)	Fungal Reference Standards	Infection Neurological Disease
(+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-Y1683R

*DL-Menthol* (Standard)** RaceMenthol (Standard)	Reference Standards GABA Receptor	Others
DL-Menthol (Standard) is the analytical standard of DL-Menthol. This product is intended for research and analytical applications. DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol relates to the activation of GABAA receptor .

HY-W711474

*(-)-Menthol-d4*	Isotope-Labeled Compounds TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol-d₄ is the deuterium labeled (-)-Menthol (HY-75161). (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-W087207

*Loxoprofen L-menthol* ester**	Drug Derivative	Inflammation/Immunology
Loxoprofen L-menthol ester is a degradation product Loxoprofen sodium (HY-B0578A). Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties .

HY-N9484S

Menthofuran-13C2	Drug Metabolite Isotope-Labeled Compounds	Others
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-135186

L-Monomenthyl glutarate	Biochemical Assay Reagents	Others
L-Monomenthyl glutarate is a menthol coolant. L-Monomenthyl glutarate has a strong volatility and permeability, high concentration of menthol vapor has a strong irritation and erosion effect on human skin and mucosa. L-Monomenthyl glutarate can be used in food, tobacco and other daily chemical products .

HY-N7132R

(-)-Menthyl acetate (Standard) L-Menthyl acetate (Standard)	Reference Standards Others	Others
(-)-Menthyl acetate (Standard) is the analytical standard of Menthyl acetate. This product is intended for research and analytical applications. (-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. (-)-Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

HY-108449R

Acoltremon (Standard) WS-12 (Standard); AR-15512 (Standard); AVX-012 (Standard)	Reference Standards TRP Channel	Neurological Disease
Acoltremon (Standard) is the analytical standard of Acoltremon (HY-108449). This product is intended for research and analytical applications. Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-75161

(-)-Menthol 4 Publications Verification	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Labiatae Erythrina poeppigiana Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite TRP Channel
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-Y1683

DL-Menthol RaceMenthol	Structural Classification Natural Products Classification of Application Fields Leguminosae Labiatae Other Diseases Erythrina poeppigiana Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Environmental Pollutants GABA Receptor
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-W017277

(+)-Menthol D-Menthol	Natural Products Labiatae Erythrina poeppigiana Plants Source Classification	Fungal
(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-N7132

(-)-Menthyl acetate L-Menthyl acetate	Structural Classification Natural Products Classification of Application Fields Acacia farnesiana (Linn.) Willd. Labiatae Other Diseases Plants Disease Research Fields Source Classification	Biochemical Assay Reagents Drug Derivative
(-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol and also a skin penetration enhancer for 5-aminolevulinic acid (ALA). (-)-Menthyl acetate exhibits strong ALA skin penetration-enhancing activity .

HY-75161R

*(-)-Menthol* (Standard)**	Structural Classification Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Labiatae Erythrina poeppigiana Plants Endogenous metabolite Source Classification	Reference Standards TRP Channel Endogenous Metabolite
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-W1008636

Isomenthol	Structural Classification Natural Products Labiatae Ainsliaea fragrans Champ. Plants Source Classification	Drug Derivative
Isomenthol is a isomer of menthol with two stable gas-phase conformers. Isomenthol has gas-phase conformers proposed to be non-minty due to axial methyl or axial isopropyl groups .

HY-N7536

Voacangine	Alkaloids other families Classification of Application Fields Other Diseases Plants Disease Research Fields Indole Alkaloids Source Classification	TRP Channel
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-W087943

Methyl octanoate	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants Fungal
Methyl octanoate is an ester volatile compound with an odor activity value greater than 1. Methyl octanoate helps impart brandy-like and fruity characteristics to persimmon wine. Methyl octanoate has a strong odor of citrus holly, camphor and menthol. Methyl octanoate can serve as an early marker for grape infection by Coniella vitis. Methyl octanoate can be used in studies related to grape white rot .

HY-W017277R

*(+)-Menthol* (Standard)** D-Menthol (Standard)	Natural Products Labiatae Erythrina poeppigiana Plants Source Classification	Fungal Reference Standards
(+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-Y1683R

*DL-Menthol* (Standard)** RaceMenthol (Standard)	Structural Classification Natural Products Leguminosae Labiatae Erythrina poeppigiana Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards GABA Receptor
DL-Menthol (Standard) is the analytical standard of DL-Menthol. This product is intended for research and analytical applications. DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol relates to the activation of GABAA receptor .

HY-N7132R

(-)-Menthyl acetate (Standard) L-Menthyl acetate (Standard)	Structural Classification Natural Products Acacia farnesiana (Linn.) Willd. Labiatae Plants Source Classification	Reference Standards Others
(-)-Menthyl acetate (Standard) is the analytical standard of Menthyl acetate. This product is intended for research and analytical applications. (-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. (-)-Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

Cat. No.	Product Name	Chemical Structure

HY-N1369S

Menthol-d4
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes .

HY-108449S

Acoltremon-d3
Acoltremon-d₃ (WS-12-d₃) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

HY-N1369S1

Menthol-d2
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-W711474

*(-)-Menthol-d4*
(-)-Menthol-d₄ is the deuterium labeled (-)-Menthol (HY-75161). (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-N9484S

Menthofuran-13C2
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Cat. No.	Product Name		Classification

HY-75161

(-)-Menthol 4 Publications Verification		Flavoring Agents
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

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( )-Menthol

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products