ALK - ALK receptor tyrosine kinase Gene

Also Known as ALK1; CD246; NBLST3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 238

About ALK

Cytogenetic location: 2p23.2-p23.1 Genomic coordinates (GRCh38): 2:29,192,774-29,921,586 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues, 53 paralogues and is associated with 188 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a receptor tyrosine kinase, which belongs to the Insulin Receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung Cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

ALK Products (3)

mRNA	Protein	Name
XR_001738688.3
NM_004304.5	NP_004295.2	ALK tyrosine kinase receptor isoform 1 precursor
NM_001353765.2	NP_001340694.1	ALK tyrosine kinase receptor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables heparin binding	IDA IDA: Inferred from direct assay	25605972	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25517749	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17681947	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9174053	GOA
enables receptor signaling protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	30061385	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9174053	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	25605972	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	30061385	GOA
involved in phosphorylation	IDA IDA: Inferred from direct assay	9174053	GOA
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	9174053	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	9174053	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	34646012	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9174053	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALK Protein Structure

MAM

Gly_rich

Pkinase_Tyr

0
300
600
900
1200
1500
1620 a.a.

Protein Preferred Names	Protein Names
ALK tyrosine kinase receptor	CD246 antigen anaplastic lymphoma receptor tyrosine kinase mutant anaplastic lymphoma kinase

ALK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ALK	Q9UM73	ALKAL2	Homo sapiens	Q6UX46	Anti Tag CoIP	26418745
Intra	ALK	Q9UM73	ALKAL2	Homo sapiens	Q6UX46	Anti Bait CoIP	26418745
Intra	ALK	Q9UM73	ALKAL2	Homo sapiens	Q6UX46	IF	26418745
Intra	ALK	Q9UM73	PTPRZ1	Homo sapiens	P23471	Pull Down	17681947
Intra	ALK	Q9UM73	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	ALK	Q9UM73	SHC1	Homo sapiens	P29353	BioID	35384245
Intra	ALK	Q9UM73	SHC1	Homo sapiens	P29353	Affinity Chrom	35384245
Intra	ALK	Q9UM73	SHC1	Homo sapiens	P29353	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

ALK Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P84879	ALK/p80 Antibody (YA4576)	WB, FC, ELISA	Human
HY-P84879A	ALK/p80 Antibody (YA4576)(PBS only)	WB, FC, ELISA	Human
HY-P84880	ALK/p80 Antibody (YA4577)	WB, IHC-P, FC, ELISA	Human
HY-P84880A	ALK/p80 Antibody (YA4577)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P86369	ALK/p80 Antibody (YA6061)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Breast Lymphoma	Lymphoma Of Breast Lymphoma Of The Breast Malignant Lymphoma Of Breast
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Trachea Carcinoma	Pancoast Tumor Carcinoma Of The Trachea Pancoast'S Tumor Malignant Superior Sulcus Tumor Malignant Superior Sulcus Tumour Pancoast Tumour Pancoast'S Syndrome Pancoast'S Tumour Pulmonary Sulcus Tumor Pulmonary Sulcus Tumour Superior Pulmonary Sulcus Syndrome Pancoast Syndrome
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Peripheral Nervous System Benign Neoplasm
Carbapenem Allergy
Central Nervous System Rhabdomyosarcoma	Rhabdomyosarcoma Of The Cns
Urethra Transitional Cell Carcinoma	Urethral Transitional Cell Carcinoma Urethral Urothelial Carcinoma
Multicentric Castleman Disease	Mcd Multicentric Giant Lymph Node Hyperplasia Plasmablastic Multicentric Castleman Disease Pmcd Multi-Centric Castleman'S Disease Idiopathic Multicentric Castleman'S Disease Multicentric Plasma Cell Variant Of Castleman'S Disease Idiopathic Multicentric Castleman Disease Hhv-8-Negative Multicentric Castleman Disease Human Herpesvirus-8-Negative Multicentric Castleman Disease
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Polyp Of Corpus Uteri	Endometrial/Uterine Polyp Polyp Of Endometrium Polyp Of The Uterus Polyp, Uterus
T-Cell Prolymphocytic Leukemia	T Cell Prolymphocytic Leukemia Prolymphocytic Leukemia, T-Cell Type T-Pll T-Cell Chronic Lymphocytic Leukemia Lymphocytic Leukemia T-Cell Chronic Doid:0081042 Leukemia, T-Cell, Chronic Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission
Main Bronchus Cancer	Malignant Neoplasm Of Main Bronchus Ca Main Bronchus
Hepatosplenic T-Cell Lymphoma	Doid:0081049
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Autonomic Nervous System Neoplasm	Tumor Of Autonomic Nervous System
Pseudosarcomatous Fibromatosis	Nodular Fasciitis Pseudosarcomatous Fasciitis Fasciitis - Nodular Fasciitis Nodular
Pericardial Effusion	Noninflammatory Pericardial Effusion Pericardium Effusion
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Pulmonary Adenocarcinoma In Situ	Bronchioalveolar Carcinoma
Bone Lymphoma	Lymphoma Of Bone Lymphoma Of The Bone
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Malignant Giant Cell Tumor Of The Tendon Sheath	Giant Cell Tumour Of Tendon Sheath, Malignant Malignant Giant Cell Neoplasm Of The Tendon Sheath
Lung Sarcomatoid Carcinoma	Pulmonary Sarcomatoid Carcinoma Sarcomatoid Carcinoma Of The Lung
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Heart Leiomyosarcoma	Leiomyosarcoma Of Heart Cardiac Leiomyosarcoma
Mucinous Adenocarcinoma	Mucin-Producing Adenocarcinoma Mucin-Secreting Adenocarcinoma Mucin-Secreting Carcinoma Mucous Carcinoma Pseudomyxoma Peritonei With Unknown Primary Site Adenocarcinoma, Mucinous
Childhood Fibrosarcoma	Pediatric Fibrosarcoma
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Pleomorphic Carcinoma
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Mucinous Lung Adenocarcinoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Autonomic Nervous System Benign Neoplasm
Heart Lymphoma	Lymphoma Of Heart Cardiac Lymphoma
Rectum Lymphoma	Lymphoma Of Rectum
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp XLP1 Lyp X-Linked Lymphoproliferative Disease Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Peach Allergy	Prunus Persica Fruit Allergy
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Pericardium Disease
Alk-Positive Anaplastic Large Cell Lymphoma	Alk+ Alcl Alk+ Anaplastic Large Cell Lymphoma Anaplastic Large Cell Lymphoma, Alk-Positive Anaplastic Large Cell Lymphoma, Alk Negative
Epithelioid Inflammatory Myofibroblastic Sarcoma
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Congenital Mesoblastic Nephroma	Nephroma, Mesoblastic Mesoblastic Nephroma
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Inflammatory Liposarcoma
Pollen Allergy	Hay Fever
Latex Allergy
Congenital Fibrosarcoma	Infantile Fibrosarcoma
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Exanthem	Exanthema Rash Rashes
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Pleural Disease	Pleural Diseases Disorder Of Pleura Non-Neoplastic Pleural Disease Pleural Disorders Non-Neoplastic Pleural Disorder
Maxillary Sinus Inverted Papilloma	Inverted Papilloma Of The Maxillary Sinus
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Lung Carcinoma In Situ
Malignant Gastric Germ Cell Tumor	Germ Cell Tumor Of The Stomach Germ Cell Tumour Of The Stomach Malignant Gastric Germ Cell Tumour
Bile Duct Carcinoma In Situ
Collecting Duct Carcinoma	Kidney Medullary Carcinoma Renal Medullary Carcinoma Bdc Bellini Carcinoma Bellini Duct Carcinoma Cdc Collecting Duct Carcinoma Of The Kidney Renal Cell Adenocarcinoma Carcinoma Of Renal Collecting Duct Renal Carcinoma, Collecting Duct Type Renal Cell Carcinoma Bellini'S Duct Carcinoma Renal Collecting Duct Carcinoma Adenocarcinoma Of Kidney
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Peripheral Nervous System Neoplasm	Nerve Sheath Neoplasm Peripheral Nervous System Neoplasms Neoplasm Of Peripheral Nerve Tumor Of Pns Nerve Sheath Neoplasms Nerve Sheath Tumors
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Inflammatory Leiomyosarcoma
Thyroid Gland Hurthle Cell Carcinoma	Oncocytic Carcinoma Of The Thyroid Thyroid Cancer, Hurthle Cell
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Sarcomatoid Transitional Cell Carcinoma	Transitional Cell Carcinoma, Sarcomatoid Transitional Spindle Cell Carcinoma Transitional Cell Carcinoma, Spindle Cell
Large Cell Neuroendocrine Carcinoma
Vulvar Keratinizing Squamous Cell Carcinoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Alk-Positive Large B-Cell Lymphoma	Alk+ Lbcl Alk+ Large B-Cell Lymphoma Alk Positive Large B-Cell Lymphoma Diffuse Large B-Cell Lymphoma, Alk Positive
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Adult Lymphoma
Fibrous Histiocytoma	Histiocytoma, Benign Fibrous Benign Fibrous Histiocytoma Fibroxanthoma Histiocytoma Fibrous
Rhabdomyosarcoma
Liver Leiomyoma	Leiomyoma Of The Liver
Adenosquamous Carcinoma	Adenosquamous Cell Carcinoma Mixed Adenocarcinoma And Squamous Carcinoma Carcinoma Adenosquamous Carcinoma, Adenosquamous
Lung Non-Squamous Non-Small Cell Carcinoma	Non- Squamous Nsclc
Bronchus Cancer	Malignant Neoplasm Of Bronchus And Lung Bronchus Carcinoma Bronchogenic Carcinoma Malignant Neoplasm Of Bronchus Or Lung Bc - Bronchogenic Carcinoma Carcinoma, Bronchogenic Bronchial Neoplasms
Neuroblastoma 3	Neuroblastoma, Susceptibility To, 3 NBLST3 Neuroblastoma, Susceptibility To, Type 3
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Reticulosarcoma	Histiocytic Lymphoma Large-Cell Lymphomas Lymphoma, Large-Cell Lymphoma Large Cell Diffuse Large B-Cell Lymphoma Histiocytic Sarcoma
Maxillary Sinus Benign Neoplasm	Neoplasm Of Maxillary Sinus Tumor Of Maxillofacial Sinus Maxillary Sinus Neoplasms Maxillary Sinus Neoplasm
Lymphoepithelioma-Like Carcinoma	Lymphoepithelial Carcinoma Nasopharyngeal Type Undifferentiated Carcinoma
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Occipital Lobe Neoplasm	Neoplasm Of Occipital Lobe Malignant Neoplasm Of Occipital Lobe Tumor Of Occipital Lobe
Lung Sarcoma	Pulmonary Sarcoma
Idiopathic Peripheral Autonomic Neuropathy
Lung Combined Large Cell Neuroendocrine Carcinoma	Combined Large Cell Neuroendocrine Carcinoma Of Lung Pulmonary Combined Large Cell Neuroendocrine Carcinoma Combined Large Cell Lung Neuroendocrine Carcinoma
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Infantile Myofibromatosis	Lipofibromatosis Myofibromatosis
Spitzoid Melanoma	Atypical Spitz Nevus
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Pulmonary Plasma Cell Granuloma	Plasma Cell Granuloma, Pulmonary Granuloma, Plasma Cell, Pulmonary Lymphocytic Pseudotumor Of Lung Sclerosing Hemangiocytoma Of Lung
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Malignant Fibrous Histiocytoma, Fibrous, Malignant
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Adenosquamous Lung Carcinoma
Nodular Ganglioneuroblastoma	Ganglioneuroblastoma, Nodular
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Lymphangitis	Inflammation Of Lymphatics
Pneumothorax	Pneumothorax Nos Air Leak Nos Pleural Air Leak Nos
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Persistent Moderate Asthma
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Ganglioneuroblastoma
Lung Giant Cell Carcinoma	Carcinoma, Giant Cell Giant Cell Carcinoma Giant Cell Lung Carcinoma Carcinoma Giant Cell Giant Cell Carcinoma Of Lung
Signet Ring Lung Adenocarcinoma
Intravascular Fasciitis	Intravascular Pseudosarcomatous Fasciitis
Malignant Gastric Teratoma	Malignant Teratoma Of Stomach Immature Gastric Teratoma
Childhood Lymphoma	Pediatric Lymphoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Adenocarcinoma In Situ
Esophagus Lymphoma	Lymphoma Of Esophagus Lymphoma Of Oesophagus Oesophagus Lymphoma Esophageal Lymphoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Histiocytosis	Chronic Histiocytosis X Hand Schuller Christian Disease Hand-Schüller-Christian Disease Histiocytic Syndrome Histiocytosis, Langerhans-Cell
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (20)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-50878	Crizotinib	Inhibitor	99.97%	Yes
HY-12215	Lorlatinib		99.99%	Yes
HY-12678	Entrectinib		99.26%	Yes
HY-15656	Ceritinib	Inhibitor	99.95%	Yes
HY-13011	Alectinib	Inhibitor	99.78%	Yes
HY-12857	Brigatinib	Inhibitor	99.98%	Yes
HY-103022	Repotrectinib	Inhibitor	99.95%	Unkown
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.90%	Yes
HY-13011A	Alectinib Hydrochloride	Inhibitor	99.92%	Yes
HY-50878A	Crizotinib hydrochloride		99.86%	Yes
HY-103714	Ensartinib	Inhibitor	99.93%	Unkown
HY-103714A	Ensartinib dihydrochloride	Inhibitor	99.73%	Unkown
HY-145574	Iruplinalkib	Inhibitor	99.62%	Unkown
HY-100375	Diroximel fumarate	Activator	99.60%	Yes
HY-123689	Samidorphan		99.04%	Unkown
HY-12215R	Lorlatinib (Standard)		99.92%	Unkown
HY-13011AR	Alectinib Hydrochloride (Standard)	Inhibitor	99.80%	Unkown
HY-50878B	Crizotinib acetate	Inhibitor	/	Unkown
HY-15656AR	Ceritinib dihydrochloride (Standard)	Inhibitor	/	Unkown
HY-15656R	Ceritinib (Standard)	Inhibitor	99.72%	Unkown

Clinical Phase

Bioactive Molecules (19)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-16590	X-376	Inhibitor	98.10%	Phase 3
HY-19928	Vactosertib	Inhibitor	99.53%	Phase 2
HY-103021	LY3200882	Inhibitor	99.87%	Phase 2
HY-145608	Zilurgisertib	Inhibitor	98.25%	Phase 2
HY-109084	Conteltinib	Inhibitor	99.0%	Phase 2
HY-139279	Zotizalkib	Inhibitor	98.02%	Phase 2
HY-172412	Alixorexton	Agonist	99.96%	Phase 2
HY-17603	Belizatinib	Inhibitor	99.62%	Phase 2
HY-109179	Itacnosertib	Inhibitor	99.06%	Phase 2
HY-136788	ALK4290	Inhibitor	99.79%	Phase 2
HY-136773	KER047	Inhibitor	98.80%	Phase 2
HY-136773A	KER047 succinate	Inhibitor	98.93%	Phase 2
HY-136788A	ALK4290 dihydrochloride	Inhibitor	/	Phase 2
HY-15841	CEP-37440	Inhibitor	99.91%	Phase 1
HY-117887	Fidrisertib	Inhibitor	98.58%	Phase 1
HY-155163	APG-2449	Inhibitor	98.93%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-135366	HPN-01	Inhibitor	98.61%	Phase 1
HY-142287	Con B-1	Inhibitor	/	Phase 1

Inhibitory Antibodies (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P99353	Ascrinvacumab	Inhibitor	97.45%	Phase 2
HY-P99752	Nemvaleukin alfa		99.50%	Phase 2
HY-P990022	Prafnosbart	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (296)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-10431	SB-431542	Inhibitor	99.85%	Unkown
HY-10432	A 83-01	Inhibitor	99.41%	Unkown
HY-13418A	Dorsomorphin	Inhibitor	99.91%	Unkown
HY-12071	LDN193189	Inhibitor	99.72%	Unkown
HY-13418	Dorsomorphin dihydrochloride	Inhibitor	99.91%	Unkown
HY-13012	RepSox	Inhibitor	99.92%	Unkown
HY-12043	SB 525334	Inhibitor	99.97%	Unkown
HY-12071B	LDN193189 dihydrochloride	Inhibitor	99.50%	Unkown
HY-12071A	LDN193189 Tetrahydrochloride	Inhibitor	99.79%	Unkown
HY-10432A	A 83-01 sodium	Inhibitor	98.03%	Unkown
HY-131442	Alkyne-phenol		99.72%	Unkown
HY-13521	SB-505124	Inhibitor	99.73%	Unkown
HY-W040304	Alkynyl Palmitic Acid		99.90%	Unkown
HY-16712	LDN-214117	Inhibitor	99.54%	Unkown
HY-12278	K02288	Inhibitor	99.95%	Unkown
HY-13227	SD-208	Inhibitor	99.87%	Unkown
HY-10326	GW788388	Inhibitor	99.92%	Unkown
HY-156467	Neladalkib		99.90%	Unkown
HY-13012G	RepSox (GMP)	Inhibitor	/	Unkown
HY-10192	NVP-TAE 684		99.70%	Unkown
HY-15609	AZD-3463		99.31%	Unkown
HY-15897	LDN-212854	Inhibitor	99.62%	Unkown
HY-10431R	SB-431542 (Standard)	Inhibitor	99.51%	Unkown
HY-12274	ML347	Inhibitor	99.94%	Unkown
HY-112155	MS4078	Inhibitor	99.72%	Unkown
HY-12953	R-268712	Inhibitor	99.92%	Unkown
HY-19928A	Vactosertib Hydrochloride	Inhibitor	99.22%	Yes
HY-13020	GSK1838705A	Inhibitor	99.58%	Unkown
HY-150169	THRX-144644	Inhibitor	99.90%	Unkown
HY-12071G	LDN193189 (GMP)	Inhibitor	/	Unkown
HY-153386	CPD-1224	Inhibitor	99.83%	Unkown
HY-10432G	A 83-01 (GMP)	Inhibitor	/	Unkown
HY-111482	SM 16	Inhibitor	99.82%	Unkown
HY-183116	TRI-611	Degrader	99.07%	Unkown
HY-123919	TL13-112	Inhibitor	98.01%	Unkown
HY-148234	M4K2234	Inhibitor	98.31%	Unkown
HY-168990	Ontunisertib	Inhibitor	99.95%	Unkown
HY-123856	MY10		99.86%	Unkown
HY-78349	A 77-01	Inhibitor	99.92%	Unkown
HY-18758	IN-1130	Inhibitor	99.93%	Unkown
HY-160506	PRO-6E		99.10%	Unkown
HY-172240	Tosposertib	Inhibitor	99.89%	Unkown
HY-12071C	LDN193189 hydrochloride	Inhibitor	98.62%	Unkown
HY-144043	ALK5-IN-8	Inhibitor	98.21%	Unkown
HY-19628	OD36	Inhibitor	99.33%	Unkown
HY-10432R	A 83-01 (Standard)	Inhibitor	/	Unkown
HY-18766	EW-7195	Inhibitor	98.84%	Unkown
HY-122856	AZ12601011	Inhibitor	99.78%	Unkown
HY-13464	ALK-IN-1	Inhibitor	99.94%	Unkown
HY-18030A	CEP-28122 mesylate salt	Inhibitor	99.92%	Unkown
HY-112815	ALK2-IN-2	Inhibitor	99.93%	Unkown
HY-147219A	SIAIS164018 hydrochloride		98.06%	Unkown
HY-N4107	Phyllanthin	Inhibitor	99.97%	Unkown
HY-122582	TL13-12	Degrader	98.16%	Unkown
HY-N1510	Kaempferol 3-O-gentiobioside	Inhibitor	99.88%	Unkown
HY-13521A	SB-505124 hydrochloride	Inhibitor	98.52%	Unkown
HY-112156	MS4077	Inhibitor	99.66%	Unkown
HY-125851	TP-008	Inhibitor	99.42%	Unkown
HY-149591	M4K-2009	Inhibitor	99.35%	Unkown
HY-150910	Brigatinib C	Inhibitor	99.72%	Unkown
HY-160237	HYL001	Inhibitor	99.94%	Unkown
HY-159147	SIAIS039		99.68%	Unkown
HY-10327	GW-6604	Inhibitor	98.0%	Unkown
HY-118528A	TP0427736 hydrochloride	Inhibitor	99.91%	Unkown
HY-12678S1	Entrectinib-d8		99.82%	Unkown
HY-13783	BIBF0775	Inhibitor	99.42%	Unkown
HY-137918	TGF-βRI inhibitor 3	Inhibitor	99.16%	Unkown
HY-109179A	Itacnosertib hydrochloride	Inhibitor	99.43%	Unkown
HY-155939	M4K2163 dihydrochloride	Inhibitor	98.58%	Unkown
HY-50878S	Crizotinib-d5		99.60%	Unkown
HY-P11354A	THR-123 TFA		/	Unkown
HY-112140	JH-VIII-157-02	Inhibitor	98.98%	Unkown
HY-152845	Ficonalkib	Inhibitor	98.89%	Unkown
HY-109084A	Conteltinib tetrahydrochloride	Inhibitor	99.60%	Unkown
HY-12273R	DMH-1 (Standard)	Inhibitor	99.78%	Unkown
HY-12331	KRCA-0008		96.19%	Unkown
HY-15358	ALK inhibitor 2	Inhibitor	99.72%	Unkown
HY-160520	ALK-IN-28	Inhibitor	99.30%	Unkown
HY-164397	XMU-MP-5		99.00%	Unkown
HY-19990	ALK kinase inhibitor-1	Inhibitor	99.87%	Unkown
HY-13011S	Alectinib-d8	Inhibitor	95.84%	Unkown
HY-151289	ALK5-IN-34	Inhibitor	98.21%	Unkown
HY-15801	HG-14-10-04	Inhibitor	99.09%	Unkown
HY-172412A	Alixorexton enantiomer	Agonist	99.42%	Unkown
HY-173149	CDD-2789	Inhibitor	/	Unkown
HY-N4126	6-Demethoxytangeretin	Inhibitor	99.37%	Unkown
HY-112801	F-1	Inhibitor	98.03%	Unkown
HY-111752	EML4-ALK kinase inhibitor 1	Inhibitor	98.02%	Unkown
HY-12678S	Entrectinib-d4	Inhibitor	/	Unkown
HY-135887	ZX-29		98.59%	Unkown
HY-136194	TL13-22	Inhibitor	99.71%	Unkown
HY-147219	SIAIS164018		/	Unkown
HY-15357	ALK inhibitor 1	Inhibitor	99.16%	Unkown
HY-156432	ALK-IN-26		99.87%	Unkown
HY-156467A	Neladalkib TFA		99.70%	Unkown
HY-15656S	Ceritinib-d7	Inhibitor	98.00%	Unkown
HY-169481	AP-1	Degrader	97.8%	Unkown
HY-170928	DA-0157	Inhibitor	99.59%	Unkown
HY-19628A	OD36 hydrochloride	Inhibitor	/	Unkown
HY-123689S	Samidorphan-d4	Antagonist	/	Unkown
HY-123689S1	Samidorphan-d5	Antagonist	/	Unkown
HY-N12973	Peonidin 3-arabinoside		95.0%	Unkown
HY-RS00598	ALK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-18030	CEP-28122	Inhibitor	/	Unkown
HY-111416	WY-135	Inhibitor	/	Unkown
HY-12215S2	Deulorlatinib		99.84%	Unkown
HY-128569	ALK-IN-5	Inhibitor	/	Unkown
HY-128596	ALK-IN-6	Inhibitor	/	Unkown
HY-13011S1	Alectinib-d6	Inhibitor	98.05%	Unkown
HY-132229	LPM4870108	Inhibitor	/	Unkown
HY-135509	Lorlatinib acetate		/	Unkown
HY-111277	CEP-14513		/	Unkown
HY-131909	CJ-2360	Inhibitor	/	Unkown
HY-184540	ALK ligand-2	Ligand	/	Unkown
HY-184541	ALK protein ligand-1-PEG2-N3	Ligand	/	Unkown
HY-105369	KF-20444		/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-110347	Mps1-IN-1 dihydrochloride	Inhibitor	/	Unkown
HY-112877	ALK-5-IN-1	Inhibitor	/	Unkown
HY-116636	KRCA-0377	Inhibitor	/	Unkown
HY-117806	TSR-011-isomer		/	Unkown
HY-120387	SMU-B	Inhibitor	/	Unkown
HY-120663	KRCA-0713	Inhibitor	/	Unkown
HY-12278G	K02288 (GMP)	Inhibitor	/	Unkown
HY-12857S	Brigatinib-13C6	Inhibitor	/	Unkown
HY-12973	ALK-IN-13	Inhibitor	/	Unkown
HY-13012S	RepSox-d5		/	Unkown
HY-130794	ALK/ROS1-IN-1	Inhibitor	/	Unkown
HY-131244	ALK-IN-9	Inhibitor	/	Unkown
HY-13227G	SD-208 (GMP)	Inhibitor	/	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-142949	ALK5-IN-7	Inhibitor	/	Unkown
HY-142950	ALK5-IN-6	Inhibitor	/	Unkown
HY-143557	Trk-IN-7	Inhibitor	/	Unkown
HY-144423	Trk-IN-10	Inhibitor	/	Unkown
HY-144437	ALK5-IN-9	Inhibitor	/	Unkown
HY-144732	TRK/ALK-IN-1	Inhibitor	/	Unkown
HY-145855	J-1063	Inhibitor	/	Unkown
HY-146022	SIAIS117	Inhibitor	/	Unkown
HY-146408	ALK-IN-21	Inhibitor	/	Unkown
HY-146694	RIPK2-IN-1	Inhibitor	/	Unkown
HY-146780	TGFβRI-IN-4	Inhibitor	/	Unkown
HY-147206	Biotin-PEG600-Alk		/	Unkown
HY-147206A	Biotin-PEG1000-Alk		/	Unkown
HY-147206B	Biotin-PEG2000-Alk		/	Unkown
HY-147206C	Biotin-PEG3400-Alk		/	Unkown
HY-147206D	Biotin-PEG5000-Alk		/	Unkown
HY-147206E	Biotin-PEG10000-Alk		/	Unkown
HY-147206F	Biotin-PEG20000-Alk		/	Unkown
HY-147833	ALK-IN-22		/	Unkown
HY-148246	MU1700	Inhibitor	/	Unkown
HY-149403	J-1048	Inhibitor	/	Unkown
HY-151155	ALK-IN-23	Inhibitor	/	Unkown
HY-151233	ALK5-IN-10	Inhibitor	/	Unkown
HY-151270	ALK5-IN-25	Inhibitor	/	Unkown
HY-151272	ALK5-IN-26	Inhibitor	/	Unkown
HY-151273	ALK5-IN-27	Inhibitor	/	Unkown
HY-151275	ALK5-IN-28	Inhibitor	/	Unkown
HY-151277	ALK5-IN-29	Inhibitor	/	Unkown
HY-151279	ALK5-IN-30	Inhibitor	/	Unkown
HY-151281	ALK5-IN-31	Inhibitor	/	Unkown
HY-151282	ALK5-IN-32	Inhibitor	/	Unkown
HY-151283	ALK5-IN-33	Inhibitor	/	Unkown
HY-153246	ALK2-IN-5	Inhibitor	/	Unkown
HY-153503	ALK-IN-24	Inhibitor	/	Unkown
HY-155227	ALK/EGFR-IN-1		/	Unkown
HY-155227A	ALK/EGFR-IN-2	Inhibitor	/	Unkown
HY-155227B	ALK/EGFR-IN-3	Inhibitor	/	Unkown
HY-155227S	ALK/EGFR-IN-1-d5		/	Unkown
HY-156470	Multi-kinase-IN-6		/	Unkown
HY-15656B	Ceritinib mesylate	Inhibitor	/	Unkown
HY-157391	ALK/ROS1-IN-3	Inhibitor	/	Unkown
HY-159952	ALK5-IN-84	Inhibitor	/	Unkown
HY-161350	ALK/HDAC-IN-1	Inhibitor	/	Unkown
HY-161376	M4K2281	Inhibitor	/	Unkown
HY-161377	M4K2306	Inhibitor	/	Unkown
HY-161662	ALK5-IN-80	Inhibitor	/	Unkown
HY-161749	PROTAC ALK degrader-1	Degrader	/	Unkown
HY-161750	PROTAC ALK degrader-2	Degrader	/	Unkown
HY-161910	SH-E4A-66	Inhibitor	/	Unkown
HY-163429	J-1149	Inhibitor	/	Unkown
HY-163507	ALK5-IN-79	Inhibitor	/	Unkown
HY-165284	CM-118	Inhibitor	/	Unkown
HY-167388	PLLA5000-PEG5000-ALK		/	Unkown
HY-167389	PLLA5000-PEG3000-ALK		/	Unkown
HY-167390	PLLA5000-PEG2000-ALK		/	Unkown
HY-167391	PLLA5000-PEG1000-ALK		/	Unkown
HY-167392	PLLA4000-PEG5000-ALK		/	Unkown
HY-167393	PLLA4000-PEG3000-ALK		/	Unkown
HY-167394	PLLA4000-PEG2000-ALK		/	Unkown
HY-167395	PLLA4000-PEG1000-ALK		/	Unkown
HY-167396	PLLA3000-PEG5000-ALK		/	Unkown
HY-167397	PLLA3000-PEG3000-ALK		/	Unkown
HY-167398	PLLA3000-PEG2000-ALK		/	Unkown
HY-167399	PLLA3000-PEG1000-ALK		/	Unkown
HY-167400	PLLA2000-PEG5000-ALK		/	Unkown
HY-167401	PLLA2000-PEG3000-ALK		/	Unkown
HY-167402	PLLA2000-PEG2000-ALK		/	Unkown
HY-167403	PLLA2000-PEG1000-ALK		/	Unkown
HY-167404	PLLA1000-PEG5000-ALK		/	Unkown
HY-167405	PLLA1000-PEG3000-ALK		/	Unkown
HY-167406	PLLA1000-PEG2000-ALK		/	Unkown
HY-167407	PLLA1000-PEG1000-ALK		/	Unkown
HY-167408	PLLA10000-PEG5000-ALK		/	Unkown
HY-167409	PLLA10000-PEG3000-ALK		/	Unkown
HY-167410	PLLA10000-PEG2000-ALK		/	Unkown
HY-16769	Panulisib		/	Unkown
HY-167864	M4K2308	Inhibitor	/	Unkown
HY-168163	CDK12/13 ligand 1	Degrader	/	Unkown
HY-168513	ALK-IN-29	Inhibitor	/	Unkown
HY-168551	PROTAC ALK degrader-3	Degrader	/	Unkown
HY-168552	3-Hydroxyazetidine-Cyclohexanol		/	Unkown
HY-168553	3-Hydroxyazetidine-Cyclohexanol-5-Aminothalidomide		/	Unkown
HY-168607	ALK5-IN-83	Inhibitor	/	Unkown
HY-169482	ALK protein ligand-1	Inhibitor	/	Unkown
HY-170418	ALK/ROS1-IN-5		/	Unkown
HY-170592	dALK-3	Degrader	/	Unkown
HY-171825	SIAIS001	Degrader	/	Unkown
HY-172426	Dirozalkib	Inhibitor	/	Unkown
HY-172958	F6524-1593	Inhibitor	/	Unkown
HY-173007	ALK/PI3K/AKT-IN-1		/	Unkown
HY-173493	ALK-IN-31		/	Unkown
HY-174314	WZH-15-125	Inhibitor	/	Unkown
HY-174315	WZH-17-002		/	Unkown
HY-174368	PROTAC EML4-ALK Degrader-1		/	Unkown
HY-175271	JWJ-01-378		/	Unkown
HY-175527	ALK degrader 2		/	Unkown
HY-175528	ALK ligand-Linker Conjugate 1		/	Unkown
HY-175849	ALK degrader 1		/	Unkown
HY-17603A	(E)-Belizatinib	Inhibitor	/	Unkown
HY-17661	Depiperazine-DM3189	Inhibitor	/	Unkown
HY-176941	ALK2-IN-6	Inhibitor	/	Unkown
HY-177945	MS99-β-Gal	Degrader	/	Unkown
HY-178057	EGFR-IN-176		/	Unkown
HY-178231	ALK5-IN-85	Inhibitor	/	Unkown
HY-178391	SMU-037		/	Unkown
HY-179732	PROTAC ALK degrader-4		/	Unkown
HY-179733	CRBN ligand-191		/	Unkown
HY-179735	CRBN ligand-192		/	Unkown
HY-18030B	CEP-28122 mesylate hydrochloride	Inhibitor	/	Unkown
HY-180811	ALK/HDAC-IN-2		/	Unkown
HY-180818	ALK-IN-33		/	Unkown
HY-180956	PROTAC ALK degrader-5		/	Unkown
HY-180964	Lys-PEG3-BA	Degrader	/	Unkown
HY-180965	Pro-PEG3-BA		/	Unkown
HY-180966	Gly-PEG3-BA	Degrader	/	Unkown
HY-180970	TD-004	Degrader	/	Unkown
HY-180972	PROTAC EML4-ALK Degrader-2	Inhibitor	/	Unkown
HY-181113	ALK-IN-34	Inhibitor	/	Unkown
HY-181139	ALK5-IN-86	Inhibitor	/	Unkown
HY-182057	ALK degrader 4	Degrader	/	Unkown
HY-182087	ALK degrader 3	Degrader	/	Unkown
HY-182547	LY580276	Inhibitor	/	Unkown
HY-183358	ALK-IN-37		/	Unkown
HY-183440	Amine-C2-piperazine-C4-OH		/	Unkown
HY-183441	ALK5 ligand-1	Ligand	/	Unkown
HY-183442	ALK5 ligand-1-amine-C2-piperazine-C4-OH	Ligand	/	Unkown
HY-183717	M4K3233		/	Unkown
HY-183718	M4K3250	Degrader	/	Unkown
HY-183767	Aurora kinase/ALK-IN-1		/	Unkown
HY-183785	PROTAC ALK5 Degrader-1	Degrader	/	Unkown
HY-183950	ALK5-IN-87	Inhibitor	/	Unkown
HY-184652	LRRK2/JNK3-IN-1	Inhibitor	/	Unkown
HY-185430	HM-279	Inhibitor	/	Unkown
HY-50878AS	Crizotinib-d9 hydrochloride		/	Unkown
HY-E70642	ALK C1156Y Recombinant Human Active Protein Kinase		/	Unkown
HY-E70643	ALK F1174L Recombinant Human Active Protein Kinase		/	Unkown
HY-E70644	ALK F1174S Recombinant Human Active Protein Kinase		/	Unkown
HY-E70645	ALK G1202R Recombinant Human Active Protein Kinase		/	Unkown
HY-E70646	ALK L1196M Recombinant Human Active Protein Kinase		/	Unkown
HY-E70647	ALK R1275Q Recombinant Human Active Protein Kinase		/	Unkown
HY-E70713	EML4 ALK Recombinant Human Active Protein Kinase		/	Unkown
HY-E70714	EML4 ALK F1174L Recombinant Human Active Protein Kinase		/	Unkown
HY-E70760	NPM1 ALK Recombinant Human Active Protein Kinase		/	Unkown
HY-E70761	NPM1 ALK F1174L Recombinant Human Active Protein Kinase		/	Unkown
HY-N0679S	Retinyl acetate-d3		/	Unkown
HY-P11354	THR-123		/	Unkown
HY-RS00599	Alk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00600	ALK Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W1139353	Tetraasterane		/	Unkown
HY-W707119	RepSox hydrochloride	Inhibitor	/	Unkown
HY-W754809	ALK ligand-1	Ligand	/	Unkown
HY-107386	PF-03671148	Inhibitor	/	Unkown
HY-118528	TP0427736	Inhibitor	/	Unkown
HY-12071BR	LDN193189 dihydrochloride (Standard)	Inhibitor	/	Unkown
HY-12857S2	Brigatinib-d11	Inhibitor	/	Unkown
HY-14243	CEP-14083	Inhibitor	/	Unkown
HY-158905	MTDB-Alkyne	Degrader	/	Unkown
HY-160172	ALK/ROS1-IN-4	Inhibitor	/	Unkown
HY-160172A	ALK/ROS1-IN-4 hydrate	Inhibitor	/	Unkown
HY-162902	ALK5-IN-82	Inhibitor	/	Unkown
HY-179400	LDN-193688	Inhibitor	/	Unkown
HY-184317	M4K2149	Inhibitor	/	Unkown
HY-50878S1	Crizotinib-d8		/	Unkown
HY-50878S2	Crizotinib-d9		/	Unkown
HY-W814315	Alectinib analog		/	Unkown

Inhibitory Antibodies (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P992188	Anti-ALK7 Antibody		/	Unkown
HY-P991533	DLX-521	Inhibitor	/	Unkown
HY-P991855	RKER-216	Inhibitor	/	Unkown
HY-P991862	CDX-0125-TEI Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ALK	VGNC	VGNC:69793
Mus musculus	ALK	MGD	MGI:103305
Bos taurus	ALK	VGNC	VGNC:25832
Canis familiaris	ALK	VGNC	VGNC:37802
Felis catus	ALK	VGNC	VGNC:98505
Rattus norvegicus	ALK	RGD	RGD:628622
Others	ALK	NCBI