2. Gene
  3. Alk - anaplastic lymphoma kinase Gene

Alk - anaplastic lymphoma kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tcrz; CD246

Gene ID: 11682 | Gene type: protein coding

About Alk

Chromosome 17: 72,175,967-72,911,622 reverse strand.GRCm39:CM001010.3

This gene has 3 transcripts (splice variants), 195 orthologues, 53 paralogues and is associated with 38 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable identical protein binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in energy homeostasis; negative regulation of lipid catabolic process; and positive regulation of dendrite development. Acts upstream of or within several processes, including hippocampus development; response to environmental enrichment; and swimming behavior. Predicted to be located in axon; cell body; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Alk Products(1)

mRNA Protein Name
NM_007439.2 NP_031465.2 ALK tyrosine kinase receptor precursor

Alk Protein Structure

MAM

MAM: cd06263 (269 - 427)

LDLa

LDLa: smart00192 (444 - 470)

MAM

MAM: cl27660 (483 - 638)

PTKc_ALK_LTK

PTKc_ALK_LTK: cd05036 (1112 - 1388)

PHA03247

PHA03247: cl33720 (1373 - 1579)

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  • 1621 a.a.
Protein Preferred Names Protein Names

ALK tyrosine kinase receptor

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50878 Crizotinib 99.97% Yes
HY-15656 Ceritinib Inhibitor 99.98% Yes
HY-12215 Lorlatinib 99.92% Yes
HY-12678 Entrectinib 99.87% Yes
HY-13011 Alectinib Inhibitor 99.59% Yes
HY-12857 Brigatinib Inhibitor 99.98% Yes
HY-13011A Alectinib Hydrochloride Inhibitor 99.93% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.57% Yes
HY-50878A Crizotinib hydrochloride 99.86% Yes
HY-103714A Ensartinib dihydrochloride Inhibitor 99.53% Unkown
HY-100375 Diroximel fumarate 99.90% Yes
HY-123689 Samidorphan / Unkown
HY-103714 Ensartinib Inhibitor / Unkown
HY-50878B Crizotinib acetate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-145574 Iruplinalkib Inhibitor 99.29% Phase 3
HY-16590 X-376 Inhibitor 98.37% Phase 3
HY-19928 Vactosertib Inhibitor 99.58% Phase 2
HY-103022 Repotrectinib Inhibitor 99.90% Phase 2
HY-139279 Zotizalkib Inhibitor 95.73% Phase 2
HY-103021 LY3200882 Inhibitor 99.86% Phase 2
HY-19928A Vactosertib Hydrochloride Inhibitor 99.09% Phase 2
HY-109084 Conteltinib Inhibitor 99.54% Phase 2
HY-136788 ALK4290 Inhibitor 99.21% Phase 2
HY-109179 Itacnosertib Inhibitor 99.77% Phase 2
HY-17603 Belizatinib Inhibitor 99.64% Phase 2
HY-15841 CEP-37440 Inhibitor 99.58% Phase 1
HY-13326 ASP3026 99.73% Phase 1
HY-142287 Con B-1 Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2
HY-P99752 Nemvaleukin alfa 99.50% Phase 2
Pre-clinical Phase
Bioactive Molecules (150)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10431 SB-431542 Inhibitor 99.89% Unkown
HY-13418A Dorsomorphin Inhibitor 99.91% Unkown
HY-10432 A 83-01 Inhibitor 99.41% Unkown
HY-13418 Dorsomorphin dihydrochloride Inhibitor 99.91% Unkown
HY-12071 LDN193189 Inhibitor 99.48% Unkown
HY-13012 RepSox Inhibitor 99.93% Unkown
HY-12273 DMH-1 Inhibitor 99.95% Unkown
HY-12043 SB 525334 Inhibitor 99.97% Unkown
HY-12071A LDN193189 Tetrahydrochloride Inhibitor 99.86% Unkown
HY-10432A A 83-01 sodium Inhibitor ≥98.0% Unkown
HY-13521 SB-505124 Inhibitor 99.99% Unkown
HY-10192 NVP-TAE 684 99.27% Unkown
HY-W040304 Alkynyl Palmitic Acid ≥97.0% Unkown
HY-13020 GSK1838705A Inhibitor 99.14% Unkown
HY-10326 GW788388 Inhibitor 99.92% Unkown
HY-112155 MS4078 Inhibitor 99.63% Unkown
HY-15609 AZD-3463 99.58% Unkown
HY-15897 LDN-212854 Inhibitor 99.70% Unkown
HY-13227 SD-208 Inhibitor 99.87% Unkown
HY-12274 ML347 Inhibitor 99.89% Unkown
HY-12953 R-268712 Inhibitor 99.78% Unkown
HY-16712 LDN-214117 Inhibitor 99.92% Unkown
HY-12071B LDN-193189 dihydrochloride Inhibitor 99.75% Unkown
HY-12278 K02288 Inhibitor 99.73% Unkown
HY-18758 IN-1130 99.79% Unkown
HY-111482 SM 16 Inhibitor 99.88% Unkown
HY-19628 OD36 Inhibitor 98.70% Unkown
HY-13464 ALK-IN-1 Inhibitor 99.94% Unkown
HY-15358 ALK inhibitor 2 Inhibitor 99.57% Unkown
HY-12331 KRCA-0008 98.88% Unkown
HY-122856 AZ12601011 Inhibitor 99.88% Unkown
HY-123919 TL13-112 Inhibitor 98.15% Unkown
HY-18766 EW-7195 Inhibitor 99.20% Unkown
HY-78349 A 77-01 Inhibitor 99.68% Unkown
HY-112156 MS4077 Inhibitor 99.49% Unkown
HY-153386 CPD-1224 Inhibitor 99.24% Unkown
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% Unkown
HY-144043 ALK5-IN-8 Inhibitor 98.06% Unkown
HY-136773 KER047 Inhibitor 99.35% Unkown
HY-19990 ALK kinase inhibitor-1 Inhibitor 99.85% Unkown
HY-135366 HPN-01 Inhibitor 98.40% Unkown
HY-13012G RepSox (GMP) Inhibitor / Unkown
HY-145608 Zilurgisertib Inhibitor 99.77% Unkown
HY-112815 ALK2-IN-2 Inhibitor 99.56% Unkown
HY-136773A KER047 succinate Inhibitor 98.93% Unkown
HY-15357 ALK inhibitor 1 Inhibitor 99.62% Unkown
HY-15801 HG-14-10-04 Inhibitor 99.09% Unkown
HY-50878S Crizotinib-d5 ≥99.0% Unkown
HY-148234 M4K2234 Inhibitor 98.71% Unkown
HY-155163 APG-2449 Inhibitor 98.86% Unkown
HY-18030A CEP-28122 mesylate salt Inhibitor 99.08% Unkown
HY-112801 F-1 Inhibitor 98.65% Unkown
HY-122582 TL13-12 Inhibitor 98.06% Unkown
HY-152845 Ficonalkib Inhibitor 98.55% Unkown
HY-151289 ALK5-IN-34 Inhibitor 98.21% Unkown
HY-N4126 6-Demethoxytangeretin Inhibitor 99.37% Unkown
HY-156467A ALK-IN-27 TFA Inhibitor / Unkown
HY-145566 Envonalkib Inhibitor 99.73% Unkown
HY-147219A SIAIS164018 hydrochloride 99.84% Unkown
HY-10327 GW-6604 Inhibitor ≥98.0% Unkown
HY-12678S Entrectinib-d4 Inhibitor / Unkown
HY-13783 BIBF0775 Inhibitor 99.53% Unkown
HY-160520 ALK-IN-28 Inhibitor 98.49% Unkown
HY-13521A SB-505124 hydrochloride Inhibitor 99.34% Unkown
HY-125851 TP-008 Inhibitor / Unkown
HY-10432G A 83-01 (GMP) Inhibitor / Unkown
HY-111752 EML4-ALK kinase inhibitor 1 Inhibitor 98.49% Unkown
HY-112140 JH-VIII-157-02 Inhibitor 99.67% Unkown
HY-117887 Fidrisertib Inhibitor 96.72% Unkown
HY-147219 SIAIS164018 / Unkown
HY-147413 Unecritinib Inhibitor 98.83% Unkown
HY-109179A Itacnosertib (hydrocholide) Inhibitor 98.98% Unkown
HY-135887 ZX-29 99.52% Unkown
HY-156467 ALK-IN-27 Inhibitor 98.01% Unkown
HY-15656S Ceritinib-d7 Inhibitor 98.00% Unkown
HY-160506 PRO-6E / Unkown
HY-18030 CEP-28122 Inhibitor / Unkown
HY-111416 WY-135 Inhibitor / Unkown
HY-128569 ALK-IN-5 Inhibitor / Unkown
HY-128596 ALK-IN-6 Inhibitor / Unkown
HY-129171 TGFBR1-IN-1 Inhibitor / Unkown
HY-132229 LPM4870108 Inhibitor / Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-145566A Envonalkib citrate Inhibitor / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-110347 Mps1-IN-1 dihydrochloride Inhibitor / Unkown
HY-112877 ALK-5-IN-1 Inhibitor / Unkown
HY-12678S1 Entrectinib-d8 / Unkown
HY-12857S Brigatinib-13C6 Inhibitor / Unkown
HY-12973 ALK-IN-13 Inhibitor / Unkown
HY-13011S Alectinib-d8 Inhibitor / Unkown
HY-13011S1 Alectinib-d6 Inhibitor / Unkown
HY-130794 ALK/ROS1-IN-1 Inhibitor / Unkown
HY-131244 ALK-IN-9 Inhibitor / Unkown
HY-136194 TL13-22 Inhibitor / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-136788A ALK4290 dihydrochloride Inhibitor / Unkown
HY-142949 ALK5-IN-7 Inhibitor / Unkown
HY-142950 ALK5-IN-6 Inhibitor / Unkown
HY-143557 Trk-IN-7 Inhibitor / Unkown
HY-144423 Trk-IN-10 Inhibitor / Unkown
HY-144437 ALK5-IN-9 Inhibitor / Unkown
HY-144732 TRK/ALK-IN-1 Inhibitor / Unkown
HY-145855 J-1063 Inhibitor / Unkown
HY-146022 SIAIS117 Inhibitor / Unkown
HY-146408 ALK-IN-21 Inhibitor / Unkown
HY-146694 RIPK2-IN-1 Inhibitor / Unkown
HY-146780 TGFβRI-IN-4 Inhibitor / Unkown
HY-147206 Biotin-PEG-Alk (MW 600) / Unkown
HY-147206A Biotin-PEG-Alk (MW 1000) / Unkown
HY-147206B Biotin-PEG-Alk (MW 2000) / Unkown
HY-147206C Biotin-PEG-Alk (MW 3400) / Unkown
HY-147206D Biotin-PEG-Alk (MW 5000) / Unkown
HY-147206E Biotin-PEG-Alk (MW 10000) / Unkown
HY-147206F Biotin-PEG-Alk (MW 20000) / Unkown
HY-147833 ALK-IN-22 / Unkown
HY-148246 MU1700 Inhibitor / Unkown
HY-149403 J-1048 Inhibitor / Unkown
HY-150169 THRX-144644 Inhibitor / Unkown
HY-151155 ALK-IN-23 Inhibitor / Unkown
HY-151233 ALK5-IN-10 Inhibitor / Unkown
HY-151270 ALK5-IN-25 Inhibitor / Unkown
HY-151272 ALK5-IN-26 Inhibitor / Unkown
HY-151273 ALK5-IN-27 Inhibitor / Unkown
HY-151275 ALK5-IN-28 Inhibitor / Unkown
HY-151277 ALK5-IN-29 Inhibitor / Unkown
HY-151279 ALK5-IN-30 Inhibitor / Unkown
HY-151281 ALK5-IN-31 Inhibitor / Unkown
HY-151282 ALK5-IN-32 Inhibitor / Unkown
HY-151283 ALK5-IN-33 Inhibitor / Unkown
HY-153246 ALK2-IN-5 Inhibitor / Unkown
HY-155227 ALK/EGFR-IN-1 / Unkown
HY-155227A ALK/EGFR-IN-2 Inhibitor / Unkown
HY-155227B ALK/EGFR-IN-3 Inhibitor / Unkown
HY-155939 M4K2163 dihydrochloride Inhibitor / Unkown
HY-156432 ALK-IN-26 / Unkown
HY-156470 Multi-kinase-IN-6 / Unkown
HY-157391 ALK/ROS1-IN-3 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-161376 M4K2281 Inhibitor / Unkown
HY-161377 M4K2306 Inhibitor / Unkown
HY-163429 J-1149 Inhibitor / Unkown
HY-19628A OD36 hydrochloride Inhibitor / Unkown
HY-RS00598 ALK Human Pre-designed siRNA Set A / Unkown
HY-RS00599 Alk Mouse Pre-designed siRNA Set A / Unkown
HY-RS00600 ALK Rat Pre-designed siRNA Set A / Unkown
HY-118528 TP0427736 Inhibitor / Unkown
HY-160172 ALK/ROS1-IN-4 Inhibitor / Unkown
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / Unkown
HY-18030B CEP-28122 mesylate hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alk NCBI NCBI:238
Canis familiaris Alk NCBI NCBI:483021
Macaca fascicularis Alk NCBI NCBI:102128455
Rattus norvegicus Alk NCBI NCBI:266802
Macaca mulatta Alk NCBI NCBI:704823