HDAC8 - histone deacetylase 8 Gene

Also Known as HD8; RGD1562895

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363481

About HDAC8

Primary_assembly X: 67,385,289-67,592,923 reverse strand.mRatBN7.2:CM026994.1

This gene has 4 transcripts (splice variants), 202 orthologues, 12 paralogues and is associated with 19 phenotypes. Biased expression in Thymus (RPKM 26.7), Brain (RPKM 23.8) and 9 other tissues.

Summary

Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of macromolecule metabolic process; and negative regulation of osteoblast differentiation. Located in nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]

HDAC8 Products (1)

mRNA Protein Name
NM_001126373.2 NP_001119845.2 histone deacetylase 8

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
28559304 RGD
enables deacetylase activity IDA
IDA: Inferred from direct assay
23868068 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to forskolin IDA
IDA: Inferred from direct assay
28559304 RGD
involved in cellular response to trichostatin A IDA
IDA: Inferred from direct assay
26391271 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28559304 RGD
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
25019367 RGD
involved in negative regulation of protein modification process IMP
IMP: Inferred from mutant phenotype
25019367 RGD
involved in response to 11-deoxycorticosterone IDA
IDA: Inferred from direct assay
23868068 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC8 Protein Structure

HDAC8

HDAC8: cd10000 (15 - 334)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

histone deacetylase 8

  • protein deacetylase HDAC8

  • protein decrotonylase HDAC8

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-B0494 Bufexamac Inhibitor 98.47% Unkown
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Phase
HY-14718 Resminostat Inhibitor 99.44% Phase 4
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-101780 Tinostamustine Inhibitor 99.64% Phase 3
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-138799 KA2507 Inhibitor 99.17% Phase 2
HY-124295 Imofinostat Inhibitor 99.40% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1
HY-10226 JNJ-16241199 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (164)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13271A Tubastatin A Inhibitor 99.07% Unkown
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 99.31% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-N6735 Apicidin Inhibitor 99.87% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-103596 Thalidomide-4-OH Degrader 99.62% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-111342 HDAC8-IN-1 Inhibitor 99.77% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.87% Unkown
HY-13267 Droxinostat Inhibitor 99.08% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-164782 PT3 Inhibitor 99.94% Unkown
HY-164233 YX968 Degrader 98.06% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-18976 UF010 99.83% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-14718A Resminostat hydrochloride Inhibitor 99.67% Yes
HY-117348 NCC-149 Inhibitor 99.29% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-152147 SZUH280 Degrader 99.38% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-172157 HDAC11-IN-2 Inhibitor 99.52% Unkown
HY-114483 AES-135 Inhibitor 98.68% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-149721 HDAC4-IN-1 Inhibitor 98.11% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.59% Unkown
HY-178948A HDAC10-IN-3 formic Inhibitor 97.16% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-178948 HDAC10-IN-3 Inhibitor / Unkown
HY-124782 HDAC8-IN-8 Inhibitor 99.01% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-168287 HDAC3/8 ligand-1 / Unkown
HY-126829 Coumarin-SAHA 99.9% Unkown
HY-W274807 TM-2-51 Activator 99.95% Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-187005 HDAC8 ligand 2 Ligand / Unkown
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / Unkown
HY-157314 HDAC6-IN-27 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-163846 HDAC8-IN-10 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-184525 HDAC6-IN-85 Inhibitor 97.58% Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-168175 PROTAC HDAC8 Degrader-2 Degrader / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-158308 HDAC6-IN-41 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-182035 HDAC8-IN-16 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-183565 HYF031 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-163920 PROTAC HDAC8 Degrader-1 Degrader / Unkown
HY-182720 FT108 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-168477 HDAC1-IN-8 Inhibitor / Unkown
HY-181023 PROTAC HDAC8 Degrader-3 Degrader / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-181024 PROTAC HDAC8 Degrader-4 Degrader / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-181086 FLT3/HDAC-IN-3 Inhibitor / Unkown
HY-181979 HDAC8-IN-15 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-174401 PROTAC HDAC6 degrader 5 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-115442 NHNB Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-178104 HDAC-IN-93 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-168176 HDAC8 ligand 1 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-150694 HDAC6-IN-11 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-151366 HDAC8/BRPF1-IN-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-181577 HDAC6-IN-73 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-178380 HDAC8-IN-14 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-179271 CA/HDAC-IN-1 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-185554A (S)-HDAC-IN-102 Inhibitor / Unkown
HY-139815 ZYJ-34c Inhibitor / Unkown
HY-187346 HDAC1-IN-15 Inhibitor / Unkown
HY-119550 J1075 Inhibitor / Unkown
HY-139795 ZYJ-25e Inhibitor / Unkown
HY-183426 MMH409 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HDAC8 NCBI NCBI:55869