Cit - citron rho-interacting serine/threonine kinase Gene
Also Known as CRIK
Species: Rattus norvegicus
Summary
Predicted to enable several functions, including PDZ domain binding activity; scaffold protein binding activity; and transcription coactivator binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; liver development; and regulation of actin polymerization or depolymerization. Located in several cellular components, including Golgi cisterna; cleavage furrow; and midbody. Used to study epilepsy; microcephaly; and visual epilepsy. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Cit Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001029911.1 | NP_001025082.1 | citron rho-interacting kinase |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables scaffold protein binding |
IPI
IPI: Inferred from physical interaction
|
9870942 | RGD |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in G2/M transition of mitotic cell cycle |
IMP
IMP: Inferred from mutant phenotype
|
12411428 | RGD |
| involved in Golgi organization |
IMP
IMP: Inferred from mutant phenotype
|
14595335 | RGD |
| involved in gamma-aminobutyric acid signaling pathway |
IDA
IDA: Inferred from direct assay
|
9870942 | RGD |
| involved in liver development |
IEP
IEP: Inferred from expression pattern
|
12411428 | RGD |
| involved in postsynaptic cytoskeleton organization |
IDA
IDA: Inferred from direct assay
|
9870942 | RGD |
| involved in postsynaptic density protein 95 clustering |
IDA
IDA: Inferred from direct assay
|
9870942 | RGD |
| involved in regulation of actin polymerization or depolymerization |
IDA
IDA: Inferred from direct assay
|
14595335 | RGD |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in GABA-ergic synapse |
IDA
IDA: Inferred from direct assay
|
9870942 | RGD |
| located in Golgi cisterna |
IDA
IDA: Inferred from direct assay
|
14595335 | RGD |
| located in cleavage furrow |
IDA
IDA: Inferred from direct assay
|
11932363 | RGD |
| located in glutamatergic postsynaptic density |
IDA
IDA: Inferred from direct assay
|
9870942 | RGD |
| located in midbody |
IDA
IDA: Inferred from direct assay
|
17534152 | RGD |
| located in neuronal cell body |
IDA
IDA: Inferred from direct assay
|
14595335 | RGD |
| located in postsynaptic density, intracellular component |
IDA
IDA: Inferred from direct assay
|
9870942 | RGD |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
citron rho-interacting kinase |
|
|