CIT - citron rho-interacting serine/threonine kinase Gene
Also Known as CITK; CRIK; STK21; MCPH17
Species: Homo sapiens
About CIT
This gene has 40 transcripts (splice variants), 272 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 9.1), testis (RPKM 3.2) and 18 other tissues.
Summary
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the Kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
CIT Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001206999.2 | NP_001193928.1 | citron Rho-interacting kinase isoform 1 |
| NM_007174.3 | NP_009105.1 | citron Rho-interacting kinase isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables PDZ domain binding |
IDA
IDA: Inferred from direct assay
|
17474715 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16431929 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
30865227 | GOA |
| enables protein serine/threonine kinase inhibitor activity |
IDA
IDA: Inferred from direct assay
|
30865227 | GOA |
| enables scaffold protein binding |
IDA
IDA: Inferred from direct assay
|
17474715 | GOA |
| enables transcription coactivator binding |
IPI
IPI: Inferred from physical interaction
|
30865227 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in mitotic cytokinesis |
IMP
IMP: Inferred from mutant phenotype
|
16236794 | GOA |
| involved in negative regulation of hippo signaling |
IMP
IMP: Inferred from mutant phenotype
|
30865227 | GOA |
| involved in neuron apoptotic process |
IMP
IMP: Inferred from mutant phenotype
|
27453578 | GOA |
| involved in positive regulation of cytokinesis |
IMP
IMP: Inferred from mutant phenotype
|
16431929 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
30865227 | GOA |
CIT Protein Structure
Pkinase: Protein kinase domain (98 - 360)
Pkinase_C: Protein kinase C terminal domain (379 - 422)
CNH: CNH domain (1601 - 1855)
- 0
- 400
- 800
- 1200
- 1600
- 2027 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
citron Rho-interacting kinase |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Microcephaly 17, Primary, Autosomal Recessive |
|
|
| Primary Autosomal Recessive Microcephaly |
|
|
| Microcephaly 6, Primary, Autosomal Recessive |
|
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| Cerebellar Hypoplasia |
|
|
| Microcephaly |
|
|
| Bipolar Disorder |
|
|
| Microcephaly 5, Primary, Autosomal Recessive |
|
|
| Schizophrenia |
|
|
| Lissencephaly |
|
|
| Primary Microcephaly |
|
|
| Congenital Nervous System Abnormality |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | CIT | RGD | RGD:70878 |
| Bos taurus | CIT | VGNC | VGNC:27375 |
| Felis catus | CIT | VGNC | VGNC:80432 |
| Mus musculus | CIT | MGD | MGI:105313 |
| Macaca mulatta | CIT | VGNC | VGNC:71226 |
| Canis familiaris | CIT | VGNC | VGNC:39282 |
| Others | CIT | NCBI |