CIT - citron rho-interacting serine/threonine kinase Gene

Also Known as CITK; CRIK; STK21; MCPH17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11113

About CIT

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:119,685,791-119,877,320 (from NCBI)

This gene has 40 transcripts (splice variants), 272 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 9.1), testis (RPKM 3.2) and 18 other tissues.

Summary

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the Kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

CIT Products (2)

mRNA Protein Name
NM_001206999.2 NP_001193928.1 citron Rho-interacting kinase isoform 1
NM_007174.3 NP_009105.1 citron Rho-interacting kinase isoform 2
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
17474715 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16431929 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
30865227 GOA
enables protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
30865227 GOA
enables scaffold protein binding IDA
IDA: Inferred from direct assay
17474715 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
30865227 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
16236794 GOA
involved in negative regulation of hippo signaling IMP
IMP: Inferred from mutant phenotype
30865227 GOA
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
27453578 GOA
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
16431929 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
30865227 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIT Protein Structure

Pkinase

Pkinase: Protein kinase domain (98 - 360)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (379 - 422)

CNH

CNH: CNH domain (1601 - 1855)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2027 a.a.
Protein Preferred Names Protein Names

citron Rho-interacting kinase

  • citron (rho-interacting, serine/threonine kinase 21)

Related Diseases

Diseases Alias
Microcephaly 17, Primary, Autosomal Recessive
  • MCPH17

  • Primary Autosomal Recessive Microcephaly 17

Primary Autosomal Recessive Microcephaly
  • Autosomal Recessive Primary Microcephaly

  • Mcph

  • True Microcephaly

  • Microcephalia Vera

  • Microcephaly Vera

  • Microcephaly Primary Hereditary

  • Microcephaly, Primary, Autosomal Recessive

  • Primary Microcephaly

Microcephaly 6, Primary, Autosomal Recessive
  • MCPH6

  • Primary Autosomal Recessive Microcephaly 6

  • Microcephaly, Primary Autosomal Recessive, 6

  • Microcephaly, Type 6, Primary, Autosomal Recessive

Cerebellar Hypoplasia
Microcephaly
  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly

Bipolar Disorder
  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2

Microcephaly 5, Primary, Autosomal Recessive
  • MCPH5

  • Primary Autosomal Recessive Microcephaly 5

  • Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern

  • Microcephaly, Primary Autosomal Recessive, 5

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Lissencephaly
  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria

Primary Microcephaly
  • True Microcephaly

  • Microcephaly, Primary

Congenital Nervous System Abnormality
  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CIT RGD RGD:70878
Bos taurus CIT VGNC VGNC:27375
Felis catus CIT VGNC VGNC:80432
Mus musculus CIT MGD MGI:105313
Macaca mulatta CIT VGNC VGNC:71226
Canis familiaris CIT VGNC VGNC:39282
Others CIT NCBI