CIT - citron rho-interacting serine/threonine kinase Gene

Homo sapiens

Also known as CITK; CRIK; STK21; MCPH17

Gene ID: 11113 | Gene type: protein coding

About CIT

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:119,685,791-119,877,320 (from NCBI)

This gene has 40 transcripts (splice variants), 272 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 9.1), testis (RPKM 3.2) and 18 other tissues.

Summary

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the Kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

CIT Products(2)

mRNA	Protein	Name
NM_001206999.2	NP_001193928.1	citron Rho-interacting kinase isoform 1
NM_007174.3	NP_009105.1	citron Rho-interacting kinase isoform 2

CIT Protein Structure

Pkinase

Pkinase_C

CNH

0
400
800
1200
1600
2027 a.a.

Protein Preferred Names

Protein Names

citron Rho-interacting kinase

citron (rho-interacting, serine/threonine kinase 21)

Related Diseases

Diseases

Alias

Microcephaly 17, Primary, Autosomal Recessive

MCPH17

Primary Autosomal Recessive Microcephaly 17

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Microcephaly 6, Primary, Autosomal Recessive

MCPH6	Primary Autosomal Recessive Microcephaly 6
Microcephaly, Primary Autosomal Recessive, 6	Microcephaly, Type 6, Primary, Autosomal Recessive

Cerebellar Hypoplasia

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Microcephaly 5, Primary, Autosomal Recessive

MCPH5	Primary Autosomal Recessive Microcephaly 5
Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern	Microcephaly, Primary Autosomal Recessive, 5

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-141601	Telisotuzumab vedotin	Inhibitor	99.81%	Phase 3
HY-160441	MC-Val-Cit-PAB-Ispinesib	Inhibitor	99.85%	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99612	Farletuzumab ecteribulin		97.87%	Phase 2

Pre-clinical Phase

Bioactive Molecules (136)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15575	VcMMAE	Inhibitor	99.97%	Unkown
HY-100374	Val-Cit-PAB-MMAE		99.83%	Unkown
HY-20336	Mc-Val-Cit-PABC-PNP		98.89%	Unkown
HY-78738	MC-Val-Cit-PAB		99.38%	Unkown
HY-112786	MC-Val-Cit-PAB-MMAF		98.16%	Unkown
HY-145929	MC-Val-Cit-PAB-Exatecan	Inhibitor	99.55%	Unkown
HY-12362	Val-cit-PAB-OH		99.62%	Unkown
HY-19318	Fmoc-Val-Cit-PAB		99.39%	Unkown
HY-131296	5-A-RU-PABC-Val-Cit-Fmoc		98.85%	Unkown
HY-41189	Fmoc-Val-Cit-PAB-PNP		98.99%	Unkown
HY-128904	MC-Val-Cit-PAB-duocarmycin chloride		98.16%	Unkown
HY-130990	DBCO-PEG4-Val-Cit-PAB-MMAF		99.99%	Unkown
HY-141156	Mal-PEG8-Val-Cit-PAB-MMAE		99.67%	Unkown
HY-100566	SuO-Val-Cit-PAB-MMAE		99.24%	Unkown
HY-100567	MAL-di-EG-Val-Cit-PAB-MMAE		98.04%	Unkown
HY-139642	Mal-(CH2)5-Val-Cit-PAB-Eribulin		99.82%	Unkown
HY-141154	Amino-PEG4-Val-Cit-PAB-MMAE		98.72%	Unkown
HY-141155	endo-BCN-PEG4-Val-Cit-PAB-MMAE		98.84%	Unkown
HY-100115	TA-02	Inhibitor	99.44%	Unkown
HY-W038702	Boc-Val-Cit-OH		≥98.0%	Unkown
HY-130989	SuO-Glu-Val-Cit-PAB-MMAE		99.20%	Unkown
HY-141142	Boc-Val-Cit-PAB-PNP		98.96%	Unkown
HY-128903	MC-Val-Cit-PAB-carfilzomib iodide		96.58%	Unkown
HY-136154	Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP		98.42%	Unkown
HY-44177	Val-Cit-PAB-MMAF sodium		98.43%	Unkown
HY-140150	Azido-PEG3-Val-Cit-PAB-PNP		99.09%	Unkown
HY-19813A	mDPR-Val-Cit-PAB-MMAE TFA		99.51%	Unkown
HY-19812	Acetylene-linker-Val-Cit-PABC-MMAE		95.08	Unkown
HY-128899	MC-Val-Cit-PAB-Auristatin E		96.97%	Unkown
HY-128902	MC-Val-Cit-PAB-vinblastine		92.87%	Unkown
HY-141833	Bi-Mc-VC-PAB-MMAE		99.78%	Unkown
HY-148875	Py-MAA-Val-Cit-PAB-MMAE		99.78%	Unkown
HY-15742	Vc-MMAD	Inhibitor	99.96%	Unkown
HY-140149	Azido-PEG4-Val-Cit-PAB-OH		≥98.0%	Unkown
HY-148245	OH-Glu-Val-Cit-PAB-MMAE		99.92%	Unkown
HY-153263	(Aminooxy)acetamide-Val-Cit-PAB-MMAE		97.01%	Unkown
HY-P4160	PDC31	Inhibitor	99.76%	Unkown
HY-15575G	VcMMAE (GMP)		/	Unkown
HY-130937	DBCO-Val-Cit-PABC-PNP		96.54%	Unkown
HY-130944	Mal-PEG1-Val-Cit-PABC-OH		95.01%	Unkown
HY-140145	Mal-PEG4-Val-Cit-PAB-PNP		98.05%	Unkown
HY-140147	Mal-amido-PEG2-Val-Cit-PAB-PNP		98.40%	Unkown
HY-141141	Boc-Val-Cit-PAB		99.99%	Unkown
HY-147286	Ac-Lys-Val-Cit-PABC-MMAE		99.99%	Unkown
HY-19811	Fmoc-Val-Cit-PAB-MMAE	Inhibitor	95.25%	Unkown
HY-112099	Mc-Val-Cit-PAB-Cl		≥95.0%	Unkown
HY-128711	MAL-di-EG-Val-Cit-PAB-MMAF		98.56%	Unkown
HY-145489	Mal-PEG2-Val-Cit-PABA		≥98.0%	Unkown
HY-148871	Mc-Val-Cit-PAB-Gefitinib chloride		98.69%	Unkown
HY-153031	Val-Cit-PAB-Exatecan	Inhibitor	99.21%	Unkown
HY-78736	Val-Cit-PAB-OSBT		99.51%	Unkown
HY-126532	Fmoc-Val-Cit-PAB-Duocarmycin TM		≥99.0%	Unkown
HY-128906	MC-Val-Cit-PAB-Retapamulin		99.00%	Unkown
HY-128909	MC-Val-Cit-PAB-rifabutin		95.33%	Unkown
HY-141860	PSMA-Val-Cit-PAB-MMAE	Inhibitor	/	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-126672	Mal-PEG4-Val-Cit-PAB		98.87%	Unkown
HY-128907	MC-Val-Cit-PAB-clindamycin		99.99%	Unkown
HY-128908	MC-Val-Cit-PAB-Indibulin		97.39%	Unkown
HY-140014	Val-Cit		99.38%	Unkown
HY-140143	Mal-PEG4-Val-Cit-PAB-OH		96.92%	Unkown
HY-147286A	Ac-Lys-Val-Cit-PABC-MMAE formic		99.96%	Unkown
HY-155052	PAD4-IN-2	Inhibitor	/	Unkown
HY-156758	Mal-PEG8-Val-Cit-PAB-MMAF		96.50%	Unkown
HY-19697	Aminocaproyl-Val-Cit-PABC-MMAE		/	Unkown
HY-W190943	Azido-PEG4-Val-Cit-PAB-MMAE		99.36%	Unkown
HY-126492	Vat-Cit-PAB-Monomethyl Dolastatin 10		/	Unkown
HY-128893	MC-Sq-Cit-PAB-Gefitinib		/	Unkown
HY-128905	MC-Val-Cit-PAB-dimethylDNA31		/	Unkown
HY-130936	DBCO-Val-Cit-PABC-OH		/	Unkown
HY-131156	Mal-PEG2-Val-Cit-PABA-PNP		96.82%	Unkown
HY-101909	Val-Cit-PAB-MMAF		/	Unkown
HY-100374G	Val-Cit-PAB-MMAE (GMP)		/	Unkown
HY-111121	cBu-Cit-OH		/	Unkown
HY-12362G	Val-cit-PAB-OH (GMP)		/	Unkown
HY-126533	PDP-C1-Ph-Val-Cit		/	Unkown
HY-126667	SC-Val-Cit-PAB		/	Unkown
HY-126670	mDPR(Boc)-Val-Cit-PAB		/	Unkown
HY-126671	Mal-Phe-C4-Val-Cit-PAB		/	Unkown
HY-126674	Mal-Phe-C4-Val-Cit-PAB-DMEA		/	Unkown
HY-126676	DBCO-(PEG2-Val-Cit-PAB)2		/	Unkown
HY-128894	MC-Sq-Cit-PAB-Dolastatin10		/	Unkown
HY-130222	Mal-PEG2-Val-Cit-PAB-OH		/	Unkown
HY-130922	BCN-PEG1-Val-Cit-OH		/	Unkown
HY-130923	BCN-PEG1-Val-Cit-PABC-OH		/	Unkown
HY-130930	Acid-propionylamino-Val-Cit-OH		/	Unkown
HY-130934	TCO-PEG1-Val-Cit-OH		/	Unkown
HY-130935	DBCO-Val-Cit-OH		/	Unkown
HY-130966	TCO-PEG1-Val-Cit-PABC-OH		/	Unkown
HY-132973	MC-Val-Cit-PAB-NH-C2-NH-Boc		≥95.0%	Unkown
HY-133459	Mal-PEG1-Val-Cit-OH		/	Unkown
HY-136034	Azido-PEG1-Val-Cit-OH		/	Unkown
HY-136098	DBCO-PEG4-acetic-Val-Cit-PAB		98.21%	Unkown
HY-136100	TCO-PEG1-Val-Cit-PABC-PNP		/	Unkown
HY-136103	DBCO-PEG4-Propionic-Val-Cit-PAB		/	Unkown
HY-136105	Azido-PEG1-Val-Cit-PABC-PNP		/	Unkown
HY-136106	Fmoc-Gly3-Val-Cit-PAB		≥98.0%	Unkown
HY-136108	Fmoc-Gly3-Val-Cit-PAB-PNP		/	Unkown
HY-136137	Azide-PEG1-Val-Cit-PABC-OH		/	Unkown
HY-140144	Mal-PEG1-Val-Cit-PAB-PNP		/	Unkown
HY-140146	Mal-amido-PEG2-Val-Cit-PAB-OH		/	Unkown
HY-140148	Azido-PEG3-Val-Cit-PAB-OH		/	Unkown
HY-141143	MC(C5)-Val-Cit		/	Unkown
HY-141144	OPSS-Val-Cit-PAB-OH		/	Unkown
HY-141145	OPSS-Val-Cit-PAB-PNP		/	Unkown
HY-147021	MC-Val-D-Cit-PAB-PNP		/	Unkown
HY-147021A	MC-D-Val-Cit-PAB-PNP		/	Unkown
HY-148326	Glu(OtBu)-Val-Cit-PAB-OH		/	Unkown
HY-151700	6-Azidohexanoyl-Val-Cit-PAB		/	Unkown
HY-153236	Py-MAA-Val-Cit-PAB-DX8951		/	Unkown
HY-153373	4A3-Cit		/	Unkown
HY-156727	Val-Cit-PABC-Ahx-May		/	Unkown
HY-156727A	Val-Cit-PABC-Ahx-May TFA		/	Unkown
HY-156896	Val-Cit-amide-Cbz-N(Me)-Maytansine		97.92%	Unkown
HY-156897	Val-Cit-amide-Ph-Maytansine		98.01%	Unkown
HY-158135	Val-Cit-PAB-DEA-COOH		/	Unkown
HY-158137	Val-Cit-PAB-DEA-Dxd		/	Unkown
HY-19318A	Fmoc-Val-D-Cit-PAB		/	Unkown
HY-19318B	Fmoc-D-Val-Cit-PAB		/	Unkown
HY-19318C	Fmoc-D-Val-D-Cit-PAB		98.97%	Unkown
HY-19318G	Fmoc-Val-Cit-PAB (GMP)		/	Unkown
HY-20336G	Mc-Val-Cit-PABC-PNP (GMP)		/	Unkown
HY-78736G	Val-Cit-PAB-OSBT (GMP)		/	Unkown
HY-78738G	MC-Val-Cit-PAB (GMP)		/	Unkown
HY-P4810	Polyphemusin II-Derived Peptide	Inhibitor	/	Unkown
HY-P5372	Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Agonist	/	Unkown
HY-P5836	Citrullinated LL-37 1cit	Inhibitor	/	Unkown
HY-P5837	Citrullinated LL-37 2cit	Inhibitor	/	Unkown
HY-P5842	Citrullinated LL-37 3cit	Inhibitor	/	Unkown
HY-P5843	Citrullinated LL-37 4cit	Inhibitor	/	Unkown
HY-RS02727	CIT Human Pre-designed siRNA Set A		/	Unkown
HY-151699	6-Azidohexanoyl-Val-Cit-PAB-PNP		/	Unkown
HY-151709	N3-L-Cit-OH		/	Unkown
HY-151709A	N3-L-Cit-OH (DCHA)		/	Unkown
HY-151726	Azido-PEG(4)-Val-Cit-PAB-PNP		/	Unkown
HY-15575S	VcMMAE-d8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIT	RGD	RGD:70878
Bos taurus	CIT	VGNC	VGNC:27375
Felis catus	CIT	VGNC	VGNC:80432
Mus musculus	CIT	MGD	MGI:105313
Macaca mulatta	CIT	VGNC	VGNC:71226
Canis familiaris	CIT	VGNC	VGNC:39282
Macaca fascicularis	CIT	NCBI
Others	CIT	NCBI

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