Cit - citron Gene
Also Known as CRIK; Cit-k; CRIK-SK; C030025P15Rik
Species: Mus musculus
Summary
Enables protein serine/threonine kinase activity. Involved in generation of neurons and mitotic cell cycle. Acts upstream of or within several processes, including generation of neurons; metaphase/anaphase transition of mitotic cell cycle; and mitotic sister chromatid segregation. Located in actin cytoskeleton; ruffle; and vacuole. Is expressed in several structures, including central nervous system; hemolymphoid system gland; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Cit Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_007708.3 | NP_031734.3 | citron Rho-interacting kinase |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
8543060 | MGI |
| enables protein serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
9792683 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within cytokinesis |
IMP
IMP: Inferred from mutant phenotype
|
11086988 | MGI |
| acts upstream of or within dendrite development |
IMP
IMP: Inferred from mutant phenotype
|
12781320 | MGI |
| involved in generation of neurons |
IDA
IDA: Inferred from direct assay
|
11086988 | MGI |
| acts upstream of or within metaphase/anaphase transition of mitotic cell cycle |
IMP
IMP: Inferred from mutant phenotype
|
12764032 | MGI |
| involved in mitotic cell cycle |
IDA
IDA: Inferred from direct assay
|
11086988 | MGI |
| acts upstream of or within mitotic sister chromatid segregation |
IMP
IMP: Inferred from mutant phenotype
|
12764032 | MGI |
| acts upstream of or within negative regulation of dendrite morphogenesis |
IDA
IDA: Inferred from direct assay
|
12781320 | MGI |
| acts upstream of or within spermatogenesis |
IMP
IMP: Inferred from mutant phenotype
|
12432070 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in actin cytoskeleton |
IDA
IDA: Inferred from direct assay
|
9792683 | MGI |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
12781320 | MGI |
| located in ruffle |
IDA
IDA: Inferred from direct assay
|
12781320 | MGI |
| located in vacuole |
IDA
IDA: Inferred from direct assay
|
17488780 | MGI |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
citron Rho-interacting kinase |
|
|