BCHE - butyrylcholinesterase Gene

Also Known as E1; CHE1; CHE2; BCHED

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 590

About BCHE

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:165,772,904-165,837,423 (from NCBI)

This gene has 5 transcripts (splice variants), 130 orthologues, 13 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 60.4), brain (RPKM 16.9) and 12 other tissues.

Summary

This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/Lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]

BCHE Products (3)

mRNA	Protein	Name
NR_137636.2
NR_137635.2
NM_000055.4	NP_000046.1	cholinesterase precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables cholinesterase activity	IDA IDA: Inferred from direct assay	19452557	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17660298	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCHE Protein Structure

COesterase

AChE_tetra

0
100
200
300
400
500
602 a.a.

Protein Preferred Names	Protein Names
cholinesterase	acylcholine acylhydrolase butyrylcholine esterase choline esterase II cholinesterase (serum) 2 cholinesterase 1 pseudocholinesterase

BCHE Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCHE	P06276	SEC11A	Homo sapiens	P67812	Validated Y2H	32296183
Intra	BCHE	P06276	SEC11A	Homo sapiens	P67812	Y2H Array	32296183
Intra	BCHE	P06276	SEC11A	Homo sapiens	P67812	Y2H Prey Pooling	32296183
Intra	BCHE	P06276	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	BCHE	P06276	BCHE	Homo sapiens	P06276	GMS	21059932
Intra	BCHE	P06276	BCHE	Homo sapiens	P06276	GMS	17660298
Intra	BCHE	P06276	BCHE	Homo sapiens	P06276	X-Ray Diffraction	22726956
Intra	BCHE	P06276	BCHE	Homo sapiens	P06276	Solution Sedimentation	21059932
Intra	BCHE	P06276	BCHE	Homo sapiens	P06276	Comig Non-Denat Gel	17660298
Intra	BCHE	P06276	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Intra	BCHE	P06276	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053
Intra	BCHE	P06276	BCHE	Homo sapiens	P06276	Chromatography	20883446

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCHE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7690	Butyrylcholinesterase/BCHE Protein, Human (HEK293, His)	P06276 (E29-L602)	≥ 95%, as determined by reducing SDS-PAGE.

BCHE Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82715	Butyrylcholinesterase Antibody (YA2460)	WB	Human

Related Diseases

Diseases	Alias
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Psp Progressive Supranuclear Ophthalmoplegia PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Neuronopathy, Distal Hereditary Motor, Type Viia	HMN7A Hmn Viia Dhmn7a Neuropathy, Distal Hereditary Motor, Type Viia Dhmnvp Harper-Young Myopathy Distal Hereditary Motor Neuronopathy Type 7a Distal Hereditary Motor Neuropathy Type Viia Neuronopathy, Distal Hereditary Motor, Type 7a Spinal Muscular Atrophy, Distal, With Vocal Cord Paralysis Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7a Harper-Young Myopath Neuronopathy, Distal Hereditary Motor, 7a Distal Hereditary Motor Neuronopathy Type Viia Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Neuropathy, Motor, Distal, Hereditary, Type Viia
Mild Cognitive Impairment
Drug Psychosis	Drug-Induced Psychosis Drug-Induced Psychotic Disorder Psychoses, Substance-Induced Psychoses, Drug
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Vascular Dementia	Dementia, Vascular Multi Infarct Dementia Multifocal Dementia Dementia Vascular Vascular Dementia, Susceptibility To Dementia, Multi-Infarct Multi-Infarct Dementia
Alzheimer Disease 10	Ad10 Alzheimer Disease-10 Alzheimer'S Disease 10 Alzheimer Disease, Familial, 10 Alzheimer Disease Familial 10 Alzheimer'S Disease 10, Early Onset
Associative Agnosia
Myasthenic Syndrome, Congenital, 11, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 11 CMS11 Cms Ie Cms1e Myasthenic Syndrome, Congenital, Ie Myasthenic Syndrome, Congenital, Ie, Formerly Cms1e, Formerly Cms Ie, Formerly Congenital Myasthenic Syndrome 11 Associated With Acetylcholine Receptor Deficiency Congenital Myasthenic Syndrome 1e Myasthenic Syndrome, Congenital, Type 11, Associated With Acetylcholine Receptor Deficiency
Writing Disorder
Substance-Induced Psychosis
Ideomotor Apraxia	Apraxia, Ideomotor Classic Apraxia Ideomotor Dyspraxia Limb-Kinetic Apraxia Transcortical Apraxia
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Butyrylcholinesterase Deficiency	Pseudocholinesterase Deficiency Suxamethonium Sensitivity Acholinesterasemia Postanesthetic Apnea BCHED Apnea, Postanesthetic Succinylcholine Sensitivity Deficiency Of Butyrylcholinesterase Butyrylcholinesterase Deficiency, Fluoride-Resistant, Japanese Type Apnea, Postanesthetic, Susceptibility To, Due To Bche Deficiency Apnea, Postanesthetic Due To Bche Deficiency Cholinesterase 2 Deficiency Pseudocholinesterase E1 Cholinesterase Ii Deficiency Deficiency Of Butyrylcholine Esterase Pseudocholinesterase E1 Deficiency Fluoride-Resistant Butyrylcholinesterase Deficiency Japanese Type Fluoride-Resistant Hypocholinesterasemia Japanese Type
Persian Gulf Syndrome	Gulf War Syndrome
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Cortical Deafness
Epilepsy, Familial Temporal Lobe, 2	Familial Temporal Lobe Epilepsy 2 Temporal Epilepsy, Familial ETL2 Ftle Epilepsy, Familial Temporal Lobe Familial Temporal Lobe Epilepsy
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Congenital Megacolon Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against Hirschsprung'S Disease Congenital Intestinal Aganglionosis HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Disease Of Mental Health	Mental Health Mental Disorders
Functional Colonic Disease	Colonic Diseases, Functional
Spina Bifida Aperta	Open Spina Bifida Spina Bifida Without Hydrocephalus Spina Bifida Manifesta Spina Bifida Aperta With Tethered Spinal Cord
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Anaerobic Pneumonia	Pneumonia Due To Anaerobes
Cocaine Abuse	Cocaine-Related Disorders
Chronic Congestive Splenomegaly
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Drug-Induced Mental Disorder
Congenital Myasthenic Syndrome	Congenital Myasthenia Congenital Myasthenic Syndromes Cms Myasthenic Syndromes, Congenital Myasthenic Syndromes Congenital Myasthenic Syndrome, Congenital Congenital Myasthenic Syndrome Ib Congenital And Developmental Myasthenia Developmental Myasthenia
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Hellp Syndrome	Hemolysis, Elevated Liver Enzymes, Lowered Platelets Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet] Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome
Cocaine Intoxication	Bad Trip Due To Cocaine Acute Cocaine Intoxication
Colonic Pseudo-Obstruction	Primary Chronic Pseudo-Obstruction Of Colon
Movement Disease	Movement Disorders Movement Disorder
Capgras Syndrome	Capgras Delusion Theory
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Anosognosia
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Rem Sleep Behavior Disorder	Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behavior Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Myasthenic Syndrome, Congenital, 5	Endplate Acetylcholinesterase Deficiency Congenital Myasthenic Syndrome 5 CMS5 Ead Engel Congenital Myasthenic Syndrome Myasthenic Syndrome, Congenital, Engel Type Cms Ic Congenital Myasthenic Syndrome Type Ic Congenital Myasthenic Syndrome Type Ic, Formerly Cms1c, Formerly Cms Ic, Formerly Congenital Myasthenic Syndrome Engel Type End Plate Acetylcholinesterase Deficiency Synaptic Congenital Myasthenic Syndromes Cms1c Cmse Congenital Myasthenic Syndrome Type 1c End-Plate Acetylcholinesterase Deficiency Myasthenic Syndrome, Congenital, Type 5
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Hyperhomocysteinemia
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Malignant Hyperthermia	Anesthesia Related Hyperthermia Malignant Hyperpyrexia Due To Anesthesia Hyperpyrexia, Malignant Hyperthermia, Malignant Malignant Hyperpyrexia Mhs Malignant Fever
Communicating Hydrocephalus	Acquired Communicating Hydrocephalus
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Subjective Cognitive Decline
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Neuromuscular Junction Disease	Neuromuscular Junction Diseases
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Diabetes Mellitus	Diabetes
Chorea, Benign Hereditary	Benign Hereditary Chorea BHC Chorea, Hereditary Benign Benign Familial Chorea Bch Hereditary Progressive Chorea Without Dementia Chorea Familial Benign Hereditary Chorea Without Dementia Chorea Benign Hereditary Bche Deficiency Chorea, Hereditary, Benign Chorea, Benign Familial
Atypical Autism	Pdd
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Outlet Dysfunction Constipation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17368	Rivastigmine	Inhibitor	99.95%	Yes
HY-B1488	Tacrine hydrochloride	Inhibitor	99.90%	Unkown
HY-107922	Ethopropazine hydrochloride	Inhibitor	99.32%	Unkown
HY-B1239	Drofenine hydrochloride	Inhibitor	98.10%	Unkown
HY-100919	Ambenonium chloride	Inhibitor	96.18%	Yes
HY-B2244	Tacrine hydrochloride hydrate	Inhibitor	99.98%	Unkown
HY-B1542A	Benactyzine hydrochloride	Inhibitor	99.02%	Unkown
HY-16183	Echothiopate iodide	Inhibitor	/	Unkown
HY-B1239A	Drofenine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114422	p38α-IN-13	Inhibitor	/	Phase 3
HY-105157A	Icopezil maleate	Inhibitor	/	Phase 2
HY-108048	Desoxypeganine	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (211)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0285	Imperatorin	Inhibitor	98.59%	Unkown
HY-107569	Garcinol	Inhibitor	98.85%	Unkown
HY-N0226A	Epiberberine chloride	Inhibitor	98.68%	Unkown
HY-N0631	Cornuside	Inhibitor	99.99%	Unkown
HY-N4225	Aaptamine	Inhibitor	99.71%	Unkown
HY-W130025	p-Xylene bispyridinium bromide	Inhibitor	99.60%	Unkown
HY-122140	ACG548B	Inhibitor	99.72%	Unkown
HY-34408	6-Methoxy-1-tetralone		99.89%	Unkown
HY-N2157	Pteryxin	Inhibitor	99.55%	Unkown
HY-121382	Gypsogenin	Inhibitor	99.51%	Unkown
HY-N2129	N-Nornuciferine	Inhibitor	99.94%	Unkown
HY-W130236	Methylene Violet 3RAX	Inhibitor	95.54%	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.78%	Unkown
HY-155140	BChE-IN-17	Inhibitor	99.07%	Unkown
HY-107275	Ebeiedinone	Inhibitor	99.90%	Unkown
HY-119577	Ubretid		99.0%	Yes
HY-121072	ASS234	Inhibitor	99.6%	Unkown
HY-N7263	Galanthamine N-Oxide	Inhibitor	99.90%	Unkown
HY-149212	SD-6	Inhibitor	≥98.0%	Unkown
HY-N12581	Kuwanon U	Inhibitor	97.30%	Unkown
HY-151368	AChE/BChE-IN-10	Inhibitor	99.67%	Unkown
HY-103373	PE154	Inhibitor	99.01%	Unkown
HY-P11392	Ac-IEAR-pNA	Substrate	99.82%	Unkown
HY-N0226	Epiberberine	Inhibitor	98.46%	Unkown
HY-N2960	Broussonin A	Inhibitor	97%	Unkown
HY-N10488	BChE-IN-11	Inhibitor	98.78%	Unkown
HY-N7346	Lucidadiol	Inhibitor	98.0%	Unkown
HY-W185336	Dibutyl phenyl phosphate	Inhibitor	98.06%	Unkown
HY-162340	Z32439948	Inhibitor	/	Unkown
HY-151436	ZLMT-12	Inhibitor	/	Unkown
HY-168052	hAChE-IN-9	Inhibitor	/	Unkown
HY-172782	BuChE-IN-20	Inhibitor	/	Unkown
HY-151405	Z164597606	Inhibitor	/	Unkown
HY-173152	AChE/BChE-IN-26	Inhibitor	/	Unkown
HY-161508	AChE/BChE-IN-19	Inhibitor	/	Unkown
HY-180783	AChE/BChE/MAO-A-IN-1	Inhibitor	/	Unkown
HY-184664	BChE-IN-51	Inhibitor	/	Unkown
HY-157382	AChE-IN-51	Inhibitor	/	Unkown
HY-163883	BChE-IN-34	Inhibitor	/	Unkown
HY-146251	BuChE-IN-6	Inhibitor	/	Unkown
HY-157437	AChE/BChE-IN-16	Inhibitor	/	Unkown
HY-149087	MR2938	Inhibitor	/	Unkown
HY-149300	SB-1436	Inhibitor	/	Unkown
HY-161507	CAI/II-IN-8	Inhibitor	/	Unkown
HY-170417	hAChE/hBuChE/GSK-3β-IN-1	Inhibitor	/	Unkown
HY-150545	AChE-IN-21	Inhibitor	/	Unkown
HY-162693	AChE-IN-68	Inhibitor	/	Unkown
HY-175973	AChE/BChE-IN-30	Inhibitor	/	Unkown
HY-146315	AChE/BChE-IN-6	Inhibitor	/	Unkown
HY-183750	BChE reactivator-1		/	Unkown
HY-179363	BChE-IN-46	Inhibitor	/	Unkown
HY-108048A	Desoxypeganine hydrochloride	Inhibitor	/	Unkown
HY-161643	S21-1011	Inhibitor	/	Unkown
HY-163909	AChE-IN-72	Inhibitor	/	Unkown
HY-144762	K027	Inhibitor	/	Unkown
HY-149993	hBChE-IN-2	Inhibitor	99.76%	Unkown
HY-153432	TRV-7019		98.00%	Unkown
HY-158696	BChE/MAO-B-IN-1	Inhibitor	/	Unkown
HY-N10489	BChE-IN-12	Inhibitor	/	Unkown
HY-155085	hAChE-IN-3	Inhibitor	/	Unkown
HY-162812	H3R antagonist 4	Inhibitor	/	Unkown
HY-N21822	(+)-(R)-Ribalinine	Inhibitor	/	Unkown
HY-162338	BChE-IN-29	Inhibitor	/	Unkown
HY-186298	Brassicasteryl linoleate	Inhibitor	/	Unkown
HY-149243	BChE-IN-16	Inhibitor	/	Unkown
HY-179126	BChE/MAO-A-IN-1	Inhibitor	/	Unkown
HY-180243	AChE-IN-102	Inhibitor	/	Unkown
HY-N2129A	N-Nornuciferine hydrochloride	Inhibitor	/	Unkown
HY-162671	BuChE-IN-12	Inhibitor	/	Unkown
HY-175658	AChE/BChE-IN-29	Inhibitor	/	Unkown
HY-162681	eeAChE-IN-3	Inhibitor	/	Unkown
HY-181445	NSC 620023 TFA	Inhibitor	/	Unkown
HY-180146	BChE-IN-48	Inhibitor	/	Unkown
HY-183352	BuChE-IN-23	Inhibitor	/	Unkown
HY-181597	LINS05414	Inhibitor	/	Unkown
HY-150585	BuChE-IN-5	Inhibitor	/	Unkown
HY-174399	AChE/BChE-IN-27	Inhibitor	/	Unkown
HY-181865	BuChE-IN-22	Inhibitor	/	Unkown
HY-170976	BuChE-IN-16		/	Unkown
HY-146687	BuChE-IN-4	Inhibitor	/	Unkown
HY-161453	BChE-IN-32	Inhibitor	/	Unkown
HY-163514	hAChE-IN-8	Inhibitor	/	Unkown
HY-157982	BChE-IN-28	Inhibitor	/	Unkown
HY-169234	BChE-IN-35	Inhibitor	/	Unkown
HY-168731	AChE/BChE-IN-25	Inhibitor	/	Unkown
HY-N9846	Luteolin 5,3'-dimethyl ether		/	Unkown
HY-172460	AChE/BChE/MAO-B-IN-5	Inhibitor	/	Unkown
HY-149090	AChE/BuChE/MAO-B-IN-2		/	Unkown
HY-159482	SBN-284	Inhibitor	/	Unkown
HY-147870	COX-2-IN-22	Inhibitor	/	Unkown
HY-152632	BuChE-IN-7	Inhibitor	/	Unkown
HY-N10486	BChE-IN-10	Inhibitor	/	Unkown
HY-W800535	Cryptolepine	Inhibitor	/	Unkown
HY-182786	MAO-B-IN-56	Inhibitor	/	Unkown
HY-147939	AChE/BuChE-IN-3	Inhibitor	/	Unkown
HY-179726	BChE-IN-47	Inhibitor	/	Unkown
HY-184791	AChE-IN-120	Inhibitor	/	Unkown
HY-159081	AChE/BChE-IN-20	Inhibitor	/	Unkown
HY-183760	AChE/BChE-IN-37	Inhibitor	/	Unkown
HY-N19871	Monogynol A	Inhibitor	/	Unkown
HY-149273	hBChE-IN-1	Inhibitor	/	Unkown
HY-175211	BChE-IN-42	Inhibitor	/	Unkown
HY-184583	S27-1047	Inhibitor	/	Unkown
HY-184159	AChE/BChE/MAO-A-IN-2	Inhibitor	/	Unkown
HY-174328	BChE/AChE-IN-1	Inhibitor	/	Unkown
HY-DY1110	PE154 (solution)	Inhibitor	/	Unkown
HY-179496	ChE/GSK-3β-IN-1	Inhibitor	/	Unkown
HY-170389	BChE-IN-39	Inhibitor	/	Unkown
HY-180892	Multi-kinase-IN-10	Inhibitor	/	Unkown
HY-170561	AChE/BuChE-IN-6	Inhibitor	/	Unkown
HY-N10781	Isograndifoliol	Inhibitor	/	Unkown
HY-180797	S1R agonist/BChE-IN-1	Inhibitor	/	Unkown
HY-127087	Isogarcinol	Inhibitor	/	Unkown
HY-181248	BChE-IN-49	Inhibitor	/	Unkown
HY-N21823	Methyl isoplatydesmine	Inhibitor	/	Unkown
HY-149287	hAChE/hBACE-1-IN-1	Inhibitor	/	Unkown
HY-183303	AChE-IN-116	Inhibitor	/	Unkown
HY-105157	Icopezil	Inhibitor	/	Unkown
HY-179122	BChE-IN-45	Inhibitor	/	Unkown
HY-178017	BChE/hCA II-IN-1	Inhibitor	/	Unkown
HY-161331	S16–1029	Inhibitor	/	Unkown
HY-152112	AChE/BChE/MAO-B-IN-2	Inhibitor	/	Unkown
HY-175655	BChE/p38-α MAPK-IN-1	Inhibitor	/	Unkown
HY-161842	AChE-IN-67	Inhibitor	/	Unkown
HY-182615	Cymserine	Inhibitor	/	Unkown
HY-161512	hAChE/hBACE-1-IN-4	Inhibitor	/	Unkown
HY-158092	ChEs/MAOs-IN-2	Inhibitor	/	Unkown
HY-158261	AChE-IN-63	Inhibitor	/	Unkown
HY-158978	Multitarget AD inhibitor-2	Inhibitor	/	Unkown
HY-175524	BChE/MAO-B-IN-2	Inhibitor	/	Unkown
HY-146663A	AChE/BChE-IN-3 hydrochloride	Inhibitor	/	Unkown
HY-181503	AChE/BuChE-IN-8	Inhibitor	/	Unkown
HY-155366	hAChE-IN-6	Inhibitor	/	Unkown
HY-159898	AChE/BChE-IN-23	Inhibitor	/	Unkown
HY-107272	Chuanbeinone	Inhibitor	/	Unkown
HY-178356	BChE-IN-44	Inhibitor	/	Unkown
HY-W746884	2-Methyl-2-butenyl (E)-Caffeate	Inhibitor	/	Unkown
HY-170938	AChE-IN-82	Inhibitor	/	Unkown
HY-169962	hCA I-IN-4	Inhibitor	/	Unkown
HY-144689	BChE-IN-3	Inhibitor	/	Unkown
HY-149272	tau/Aβ40 aggregation-IN-1	Inhibitor	/	Unkown
HY-162036	α-Amylase/α-Glucosidase-IN-7	Inhibitor	/	Unkown
HY-157978	AChE-IN-59	Inhibitor	/	Unkown
HY-182290	AChE/BChE-IN-36	Inhibitor	/	Unkown
HY-185347	AChE-IN-114	Inhibitor	/	Unkown
HY-152113	AChE/BChE/MAO-B-IN-3	Inhibitor	/	Unkown
HY-162639	α-Glucosidase-IN-68	Inhibitor	/	Unkown
HY-182254	AChE/BChE-IN-35	Inhibitor	/	Unkown
HY-121191	Bisnorcymserine	Inhibitor	/	Unkown
HY-178433	BChE/p38-α MAPK-IN-2	Inhibitor	/	Unkown
HY-N18289	8-Hydroxydihydrochelerythrine	Inhibitor	/	Unkown
HY-N10490	Blestrin D	Inhibitor	/	Unkown
HY-N21824	(+)-(3S)-ψ-Ribalinine	Inhibitor	/	Unkown
HY-149288	hAChE/hBACE-1-IN-2	Inhibitor	/	Unkown
HY-161156	BChE-IN-26	Inhibitor	/	Unkown
HY-179711	AChE/BChE-IN-32	Inhibitor	/	Unkown
HY-149211	AChE/BChE-IN-12	Inhibitor	/	Unkown
HY-157981	AChE-IN-60	Inhibitor	/	Unkown
HY-143465	BChE-IN-5	Inhibitor	/	Unkown
HY-169162	hBChE-IN-3	Inhibitor	/	Unkown
HY-184704	BChE-IN-52	Inhibitor	/	Unkown
HY-182001	Multi-kinase-IN-13	Inhibitor	/	Unkown
HY-175523	MAO-B-IN-48	Inhibitor	/	Unkown
HY-180819	AChE/BChE-IN-33	Inhibitor	/	Unkown
HY-180891	Multitarget AD-IN-4	Inhibitor	/	Unkown
HY-N17425	Lakoochin C	Inhibitor	/	Unkown
HY-174464	AChE/BChE-IN-28	Inhibitor	/	Unkown
HY-181041	Multitarget AD-IN-5	Inhibitor	/	Unkown
HY-172461	MAO-IN-6	Inhibitor	/	Unkown
HY-152232	BChE-IN-15	Inhibitor	/	Unkown
HY-169961	BChE-IN-38	Inhibitor	/	Unkown
HY-131971	AChE/BChE-IN-1	Inhibitor	/	Unkown
HY-159143	BChE-IN-33	Inhibitor	/	Unkown
HY-144446	BuChE-IN-1	Inhibitor	/	Unkown
HY-163537	AChE/BuChE-IN-5	Inhibitor	/	Unkown
HY-159880	AChE/BChE-IN-24	Inhibitor	/	Unkown
HY-180552	AChE-IN-104	Inhibitor	/	Unkown
HY-146669	BChE-IN-6	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-N15710	Magnotriol B	Inhibitor	/	Unkown
HY-181851	AChE-IN-109	Inhibitor	/	Unkown
HY-D3171	AD-BChE/HClO		/	Unkown
HY-181167	AChE/BChE-IN-34	Inhibitor	/	Unkown
HY-172219	CUR-IPA	Inhibitor	/	Unkown
HY-178943	Neuroprotective agent 15	Inhibitor	/	Unkown
HY-168301	CL-13	Inhibitor	/	Unkown
HY-163746	BuChE-IN-11	Inhibitor	/	Unkown
HY-155284	K1833	Inhibitor	/	Unkown
HY-156031	BChE-IN-19	Inhibitor	/	Unkown
HY-119292	AP2238	Inhibitor	/	Unkown
HY-161150	AChE/BChE-IN-17	Inhibitor	/	Unkown
HY-184292	COX-2-IN-67	Inhibitor	/	Unkown
HY-163441	BChE-IN-31	Inhibitor	/	Unkown
HY-184658	BChE-IN-50	Inhibitor	/	Unkown
HY-118729	Difeterol	Inhibitor	/	Unkown
HY-169163	BChE-IN-36	Inhibitor	/	Unkown
HY-151562	AChE/BuChE/MAO-B-IN-1	Inhibitor	/	Unkown
HY-157384	BChE-IN-22	Inhibitor	/	Unkown
HY-183798	BChE/MAO-B-IN-6	Inhibitor	/	Unkown
HY-N10701	AChE/BChE-IN-11	Inhibitor	/	Unkown
HY-W332450	Demeton-S	Inhibitor	/	Unkown
HY-113905	ZINC12613047	Inhibitor	/	Unkown
HY-113737	Trichlorfon ethyl	Inhibitor	/	Unkown
HY-159977	1,2-Didehydrotanshinone IIA	Inhibitor	/	Unkown
HY-W1058380	BChE-IN-53	Inhibitor	/	Unkown
HY-B1542	Benactyzine	Inhibitor	/	Unkown
HY-N1151	Thunberginol C	Inhibitor	/	Unkown
HY-183403	Ganstigmine	Inhibitor	/	Unkown
HY-N19401	Vescalagin	Inhibitor	/	Unkown
HY-W049312	7-Methoxytacrine	Inhibitor	/	Unkown
HY-116041	Anabasamine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BCHE	RGD	RGD:619996
Mus musculus	BCHE	MGD	MGI:894278
Bos taurus	BCHE	VGNC	VGNC:26443
Felis catus	BCHE	VGNC	VGNC:69221
Macaca mulatta	BCHE	VGNC	VGNC:70238
Canis familiaris	BCHE	VGNC	VGNC:38405
Others	BCHE	NCBI