18 Results for "

(+)-Cotinine

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "(+)-Cotinine" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-B1178
CAS No.: 486-56-6
Synonyms: (-)-Cotinine; (S)-Cotinine; NIH-10498
Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .
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Cat. No.: HY-113239
CAS No.: 34834-67-8
Purity:  99.00%
Hydroxycotinine is a nicotine metabolite commonly found in the urine of smokers. Hydroxycotinine is the primary biomarker of tobacco/nicotine vapor exposure, formed from the conversion of nicotine via cotinine. Hydroxycotinine serum levels in rodents are influenced by sex and co-exposure to nicotine vapor and ethanol. Hydroxycotinine elevation is associated with decreased eGFR and increased risk of chronic kidney disease. Hydroxycotinine can be used in research related to chronic kidney disease .
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Cat. No.: HY-B1178S
CAS No.: 110952-70-0
Synonyms: (±)-Cotinine-d3; (Rac)-NIH-10498-d3
(Rac)-Cotinine-d3 is the deuterium labeled (Rac)-Cotinine .
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Cat. No.: HY-W588194
CAS No.: 139427-57-9
Target:  

Drug Metabolite

Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .
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Cat. No.: HY-B1178S1
CAS No.: 350818-68-7
Synonyms: (±)-Cotinine-d4; (Rac)-NIH-10498-d4
(Rac)-Cotinine-d4 is the deuterium labeled (Rac)-Cotinine .
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Cat. No.: HY-B1178A
CAS No.: 32162-64-4
Synonyms: (+)-Cotinine; (R)-Cotinine; (R)-NIH-10498
Target:  

nAChR

Research Areas:  

Neurological Disease

R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs .
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Cat. No.: HY-B1178R
CAS No.: 486-56-6
Synonyms: (-)-Cotinine (Standard); (S)-Cotinine (Standard); NIH-10498 (Standard)
Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke
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Cat. No.: HY-155456
Target:  

Cytochrome P450

Research Areas:  

Metabolic Disease

CD-6 is a flavonoid CYP2A6 inhibitor (IC50: 1.566 μM). CYP2A6 inhibits the metabolism of nicotine to cotinine, resulting in an increase in the amount of nicotine available in the blood, leading to increased smoking behavior. CD-6 mediates CYP2A6 inhibition and can be used in research on smoking cessation or smoking-related diseases .
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Cat. No.: HY-B1178S2
CAS No.: 2241872-22-8
Synonyms: (±)-Cotinine-d7; (Rac)-NIH-10498-d7
(Rac)-Cotinine-d7 is deuterium labeled Cotinine.
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Cat. No.: HY-150159S
Cotinine-d3 N-β-D-Glucuronide is the deuterium labeled Cotinine N-β-D-Glucuronide (HY-W588194). Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .
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Cat. No.: HY-W588194S
(±)-Cotinine-N-β-Glucuronide-d3 is deuterated labeled (±)-Cotinine-N-β-Glucuronide.
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Cat. No.: HY-W739718
CAS No.: 1215561-37-7
(R,S)-Cotinine-d3 N-Oxide is the deuterium labeled (R,S)-Cotinine N-Oxide.
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Cat. No.: HY-W777620
CAS No.: 1215842-75-3
Synonyms: rac-Cotinine-13C,d3
1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone- 13C,d3 (rac-Cotinine- 13C,d3) is the deuterium and 13C-labeled 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (HY-W588192).
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Cat. No.: HY-W749366
CAS No.: 2714418-11-6
trans-3'-Hydroxy Cotinine-d3 Acetate is the deuterium labeled trans-3'-Hydroxy Cotinine Acetate (HY-W739934).
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Cat. No.: HY-113239S1
CAS No.: 159956-78-2
rel-Hydroxycotinine-d3 is the d3-labeled Hydroxycotinine (HY-113239). Hydroxycotinine is a nicotine metabolite commonly found in the urine of smokers. Hydroxycotinine is the primary biomarker of tobacco/nicotine vapor exposure, formed from the conversion of nicotine via cotinine. Hydroxycotinine serum levels in rodents are influenced by sex and co-exposure to nicotine vapor and ethanol. Hydroxycotinine elevation is associated with decreased eGFR and increased risk of chronic kidney disease. Hydroxycotinine can be used in research related to chronic kidney disease .
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Cat. No.: HY-113239S
CAS No.: 1311275-10-1
Hydroxycotinine-d3 is the d3-labeled Hydroxycotinine (HY-113239). Hydroxycotinine is a nicotine metabolite commonly found in the urine of smokers. Hydroxycotinine is the primary biomarker of tobacco/nicotine vapor exposure, formed from the conversion of nicotine via cotinine. Hydroxycotinine serum levels in rodents are influenced by sex and co-exposure to nicotine vapor and ethanol. Hydroxycotinine elevation is associated with decreased eGFR and increased risk of chronic kidney disease. Hydroxycotinine can be used in research related to chronic kidney disease .
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Cat. No.: HY-W765751
trans-3'-Hydroxy Cotinine-d3 N-b-D-Glucuronide is the deuterium labeled trans-3'-Hydroxy Cotinine N-b-D-Glucuronide.
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Cat. No.: HY-W795548
CAS No.: 713-05-3
Target:  

Endogenous Metabolite

Research Areas:  

Others

N-Methyl-4-oxo-4-(pyridin-3-yl) butanamide is a urinary metabolite of (±)-Cotinine in rats and an intermediate in the bacterial catabolism of Nicotine. N-Methyl-4-oxo-4-(pyridin-3-yl) butanamide serves as a tool molecule for studies on Nicotine metabolism.
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