Search Result

Results for "

A/WS/33 (H1N1) virus

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (2) 5 alpha Reductase (2) 5-HT Receptor (8) AAK1 (2) Acetyl-CoA Carboxylase (2) Acyltransferase (6) Adrenergic Receptor (8) Akt (16) Aldehyde Oxidase (AO) (1) Aldose Reductase (2) Amino Acid Derivatives (2) Aminotransferases (Transaminases) (1) AMPK (3) Amyloid-β (9) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (90) Antifolate (6) Apelin Receptor (APJ) (3) Apoptosis (134) Arenavirus (26) Arrestin (1) Aurora Kinase (4) Autophagy (60) Bacterial (152) Bcl-2 Family (23) Bcr-Abl (2) BCRP (4) Biochemical Assay Reagents (30) BMI1 (1) Branched Chain Amino Acid Transaminase (BCAT) (1) Btk (2) c-Myc (1) C-type Lectin-like Receptors (CTLRs) (1) Calcium Channel (8) CaMK (5) Carbonic Anhydrase (2) Carboxylesterase (CES) (1) Carboxypeptidase (1) Caspase (21) Cathepsin (6) CCR (6) CD1 (1) CD3 (2) CDK (18) Ceramidase (2) CHIKV (32) Cholinesterase (ChE) (5) Claudin (1) CMV (45) Collagen (1) Complement System (4) COX (9) CRM1 (1) CTLA-4 (1) Cuproptosis (1) CXCR (11) Cyclic GMP-AMP Synthase (3) Cyclin G-associated Kinase (GAK) (3) Cyclophilin (2) Cytochrome P450 (11) Dengue Virus (108) Deubiquitinase (3) DGK (1) Dihydroorotate Dehydrogenase (10) Disulfidptosis (4) DNA Alkylator/Crosslinker (5) DNA Methyltransferase (3) DNA Stain (1) DNA/RNA Synthesis (164) Dopamine Receptor (6) Drug Derivative (23) Drug Intermediate (23) Drug Isomer (6) Drug Metabolite (20) DYRK (1) E1/E2/E3 Enzyme (4) E3 Ligase Ligand-Linker Conjugates (1) EAAT (1) EBI2/GPR183 (3) EBV (55) EGFR (15) Endogenous Metabolite (68) Endonuclease (4) Enterovirus (36) Environmental Pollutants (20) Ephrin Receptor (1) Epigenetic Reader Domain (3) ERK (10) Estrogen Receptor/ERR (7) Exosomes (2) FAAH (2) Factor Xa (1) Farnesyl Transferase (4) FASTK (1) Fc Receptor (FcR) (1) Ferroptosis (12) Filovirus (43) FLAP (1) Flavivirus (142) Fluorescent Dye (26) FOXO (1) Fungal (49) Furin (1) FXR (4) G-quadruplex (3) GABA Receptor (1) Gap Junction Protein (4) Glucocorticoid Receptor (3) Glucokinase (1) GLUT (2) Glutaminase (2) Glutathione Peroxidase (3) Glutathione S-transferase (2) Glycosidase (17) GSK-3 (4) HBV (160) HCV (195) HCV Protease (36) HDAC (7) Heme Oxygenase (HO) (2) Hepatitis E Virus (HEV) (2) HIF/HIF Prolyl-Hydroxylase (5) Histamine Receptor (20) Histone Demethylase (6) Histone Methyltransferase (4) HIV (250) HIV Integrase (14) HIV Protease (30) hnRNP (1) HPV (12) HSP (9) HSV (141) IFNAR (29) IGF-1R (3) iGluR (4) IKK (5) Indoleamine 2,3-Dioxygenase (IDO) (7) Influenza Virus (459) Insecticide (6) Insulin Receptor (1) Integrin (10) Interleukin Related (40) IRE1 (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (88) JAK (3) JNK (12) Keap1-Nrf2 (8) Lactate Dehydrogenase (4) Liposome (8) Lipoxygenase (1) mAChR (4) Macrophage migration inhibitory factor (MIF) (1) MDM-2/p53 (6) Measles Virus (2) MEK (3) Melanocortin Receptor (1) MHC (8) MicroRNA (2) Microtubule/Tubulin (5) Mitochondrial Metabolism (1) Mitophagy (3) Mixed Lineage Kinase (1) MMP (6) MNK (1) MOFs (1) mRNA (6) mTOR (3) Myosin (2) Na+/K+ ATPase (2) nAChR (7) NADPH Oxidase (2) Necroptosis (5) Neurotensin Receptor (1) NF-κB (34) NO Synthase (12) NOD-like Receptor (NLR) (7) Notch (1) Nucleoside Antimetabolite/Analog (45) OAT (3) Opioid Receptor (1) Orthopoxvirus (68) P-glycoprotein (8) P2X Receptor (1) p38 MAPK (14) p97 (1) PAI-1 (1) PAK (1) Parasite (43) PARP (1) PD-1/PD-L1 (4) PDGFR (2) Phosphatase (5) Phosphodiesterase (PDE) (1) Phospholipase (2) Phosphoramidites (1) Photosensitizer (2) Photosystem II (3) Phytohormone (2) PI3K (14) PI4K (6) Pim (1) PKA (2) PKC (11) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (5) PPAR (7) PROTAC Linkers (3) PROTACs (10) Protease Activated Receptor (PAR) (2) Proteasome (3) Protein Arginine Deiminase (2) Proton Pump (4) Pyroptosis (3) RABV (13) RAR/RXR (3) Ras (7) Reactive Oxygen Species (ROS) (44) Reference Standards (203) REV-ERB (1) Reverse Transcriptase (42) RIBOTAC (4) RIG-I-like receptor (RLR) (3) RIP kinase (2) ROR (3) RSV (95) S100 Protein (2) SARS-CoV (199) Sec61 (3) Ser/Thr Kinase (1) Ser/Thr Protease (12) SGK (2) Sialyltransferase (1) Sirtuin (5) Small Interfering RNA (siRNA) (4) SOD (5) Sodium Channel (2) SphK (3) Src (5) STAT (16) Stearoyl-CoA Desaturase (SCD) (1) STING (10) Survivin (1) TAM Receptor (1) Taste Receptor (1) Tau Protein (5) TGF-beta/Smad (8) TGF-β Receptor (5) Thrombin (3) Thymidylate Synthase (1) Thyroid Hormone Receptor (2) Tim3 (1) TMV (31) TNF Receptor (18) Toll-like Receptor (TLR) (28) Tomato Spotted Wilt Virus (TSWV) (1) Topoisomerase (5) Transferrin Receptor (1) Transmembrane Glycoprotein (9) Transthyretin (TTR) (2) TRP Channel (4) Tyrosinase (2) VEGFR (9) Virus Protease (96) VSV (18) VZV (14) YB-1 (1) β-glucuronidase (1)
By Research Areas:	Cancer (428) Cardiovascular Disease (46) Endocrinology (35) Infection (1926) Inflammation/Immunology (348) Metabolic Disease (71) Neurological Disease (123)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (9) Alkynes (6)
Oligonucleotides:	Antigens (1) Adenosine (2) Guanosine (2) Chemokine & Receptors (1) Nucleotide Analogs (6) Liposome (1) Thymidine (1) mRNA (5) Phospholipids (3) siRNA drugs (11) Cap Analogs (1) Antisense Oligonucleotides (10) Adenine Nucleotide (1) Cytidine (3) siRNAs (11) Pegylated Lipids (3) Aptamers (2) Nucleoside Analogs (13) CpG ODNs (4) Uridine (4) Cationic Lipids (1) Adjuvant (1) Cytosine (1) Phosphoramidites (1)

2205

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

203

Peptides

MCE Kits

102

Inhibitory Antibodies

381

Natural
Products

348

Recombinant Proteins

109

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10964

Vadimezan 70+ Cited Publications DMXAA; ASA-404	STING IFNAR Influenza Virus	Infection Cancer
Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus *H1N1-PR8* activities.

HY-13317

Oseltamivir 45+ Cited Publications GS 4104	Influenza Virus	Infection Cancer
Oseltamivir (GS 4104) is an orally active *influenza virus* neuraminidase** inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-N0736

Coptisine chloride 10+ Cited Publications	Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus	Infection Metabolic Disease Cancer
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K_i value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6?μg/mL and can be used for influenza A (H1N1) infection.

HY-107201

β-Cyclodextrin Maximum Cited Publications 9 Publications Verification Betadex	Environmental Pollutants Influenza Virus	Infection
β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus *H1N1* activities.

HY-N0243

Theaflavin 5+ Cited Publications	Influenza Virus Endogenous Metabolite	Infection
Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N0638

Dendrobine 5+ Cited Publications	Influenza Virus JNK p38 MAPK Apoptosis CDK Keap1-Nrf2 SOD Reactive Oxygen Species (ROS)	Infection Neurological Disease Inflammation/Immunology Cancer
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC₅₀s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties .

HY-P990825

*Anti-Chikungunya virus* E2 Antibody (CHK-265)**	Flavivirus CHIKV	Infection
Anti-Chikungunya virus E2 Antibody (CHK-265) is mouse-derived IgG2c κ type antibody inhibitor, targeting to *Chikungunya virus* E2*. Anti-Chikungunya virus* E2 Antibody (CHK-265) reacts with a conserved epitope on the B domain of the E2 glycoprotein of chikungunya virus. Anti-Chikungunya virus E2 Antibody (CHK-265) can block viral entry and egress. Anti-Chikungunya virus E2 Antibody (CHK-265) can be used for the research of infection, such as Chikungunya virus (CHIKV), Mayaro (MAYV) and O’nyong’nyong virus (ONNV) .

HY-P99620

Firivumab CT-P22; CT120	Influenza Virus	Infection
Firivumab (CT-P22; CT120) is a human IgG1 monoclonal *influenza A virus* hemagglutinin (Anti-IAV HA)** antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .

HY-126136

ML303	Influenza Virus	Infection
ML303 is a pyrazolopyridine *influenza virus* nonstructural protein 1 (NS1) antagonist (IC₉₀ = 155 nM), with an EC₅₀** of 0.7 μM for Influenza A virus H1N1 .

HY-P991059

VIS-410	Influenza Virus	Infection
VIS-410 is an antibody inhibitor targeting the stem region of hemagglutinin (HA). VIS-410 inhibits influenza virus replication by blocking HA-mediated membrane fusion. VIS-410 exhibits broad-spectrum neutralization against influenza A viruses with group 1 and group 2 hemagglutinins, including subtypes such as *H1N1, H3N2, H5N1, and H7N9* (H5N1 IC₅₀ = 1.5 μg/mL). VIS-410 is applicable to research related to influenza A virus infection .

HY-13317S

Oseltamivir-d3	Influenza Virus	Infection
Oseltamivir-d₃ is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-B1404

Nylidrin hydrochloride Buphenine hydrochloride	iGluR Influenza Virus	Infection Cardiovascular Disease Inflammation/Immunology
Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1_A/2B NMDA receptors (IC₅₀ = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple *H1N1* subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects .

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Influenza Virus	Infection Inflammation/Immunology
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-A0235

Antrafenine Stakane	Drug Derivative Influenza Virus	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Antrafenine (Stakane) is a derivative of 2-(quinolin-4-ylamino) benzoate, and is an orally active anti-inflammatory and analgesic agent. Antrafenine protects mammalian epithelial cells from cell death upon exposure to influenza A virus A/WSN/33 (H1N1). Antrafenine inhibits carrageenan-induced paw swelling in rats, and reduces exudate volume and total leukocyte infiltration in carrageenan- and calcium pyrophosphate dihydrate crystal-induced pleurisy in rats. Antrafenine can be used in studies related to influenza and pseudogout .

HY-P1837

Influenza HA (518-526)	Influenza Virus HSV	Infection
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various H5N1, some H9N2, and *H1N1* strains. Influenza HA (518-526) binds to the mouse MHC class I allele K ^d to form a complex, which is then recognized by specific CD8 ⁺ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8 ⁺ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), influenza virus, and H5N1 influenza .

HY-N0440R

Germacrone (Standard)	Reference Standards Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis	Infection Neurological Disease Inflammation/Immunology Endocrinology Cancer
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 inﬂuenza A viruses and the inﬂuenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .

HY-131233

*Anti-virus* agent 1** Remdesivir isopropyl ester analog	Antibiotic	Infection
Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV) .

HY-137334

Neuraminidase-IN-1	Influenza Virus	Infection
Neuraminidase-IN-1 is a neuraminidase inhibitor, with an IC₅₀ of 0.21 μM. Neuraminidase-IN-1 has excellent activity against **H1N1 influenza virus** .

HY-13317R

Oseltamivir (Standard) GS 4104 (Standard)	Reference Standards Influenza Virus	Infection
Oseltamivir (Standard) is the analytical standard of Oseltamivir. This product is intended for research and analytical applications. Oseltamivir (GS 4104) is an orally active *influenza virus* neuraminidase** inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-143494

RSV/IAV-IN-3	RSV Influenza Virus	Infection
RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of *respiratory syncytial virus* (RSV) and influenza A virus (IAV) with EC₅₀** values of 2.92 µM and 1.90 µM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC₅₀ values of 3.25 µM and 1.50 µM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC₅₀ of 3.89 µM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage .

HY-10964R

Vadimezan (Standard) DMXAA (Standard); ASA-404 (Standard)	STING IFNAR Influenza Virus Reference Standards	Infection Cancer
Vadimezan (Standard) (DMXAA (Standard)) is the analytical standard of Vadimezan (HY-10964). This product is intended for research and analytical applications. Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.

HY-131069A

MBX2329	Influenza Virus	Infection
MBX2329, a potent influenza virus inhibitor, specifically inhibits hemagglutinin (HA)-mediated viral entry with HIV/HA(H5) displaying IC₉₀ of 8.6 μM. MBX2329 inhibits a wide spectrum of influenza A viruses, which includes the 2009 pandemic influenza virus A/H1N1/2009, highly pathogenic avian influenza (HPAI) virus A/H5N1, and oseltamivir-resistant A/H1N1 strains .

HY-N0224A

Goitrin (S)-Goitrin; L-5-Vinyl-2-thiooxazolidone	Influenza Virus	Metabolic Disease
Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity .

HY-P4030

*Herpes virus* inhibitor 2**	HIV Protease	Infection
Herpes virus inhibitor 2 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure. Herpes virus inhibitor 2 inhibits viral replication .

HY-P990817

*Anti-West Nile/dengue virus* E protein Antibody (E60)**	Dengue Virus Flavivirus	Infection
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to *West Nile/dengue virus* E protein*. Anti-West Nile/dengue virus* E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .

HY-156786

TLD-1433	Reactive Oxygen Species (ROS) Influenza Virus SARS-CoV HSV	Infection
TLD-1433 is the fourth-generation ruthenium (II) based photodynamic compound (PDC). TLD-1433 is activated by green light (525 ± 25 nm) and efficiently generates ROS to achieve pathogen inactivation. After photoinactivation, TLD-1433 significantly induces lipid peroxidation of the cell membrane, which can directly damage the integrity of the viral envelope. TLD-1433 has ID₅₀ for enveloped viruses (such as *H1N1* influenza virus, coronavirus OC43, HSV-1, Zika virus) is as low as nanomolar level; for non-enveloped viruses (such as adenovirus Ad5, mammalian rotavirus MRV), a concentration of micro-molar level is required for inactivation. TLD-1433 has antigen retention property and can be used for the preparation of inactivated vaccines .

HY-N0243R

Theaflavin (Standard)	Reference Standards Influenza Virus Endogenous Metabolite	Infection
Theaflavin (Standard) is the analytical standard of Theaflavin. This product is intended for research and analytical applications. Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N10843

4-O-Methylepisappanol	Influenza Virus	Infection
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

HY-129150

Ganoderic acid TR	Influenza Virus	Infection
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC₅₀ values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .

HY-P10975

P9R	SARS-CoV Influenza Virus Enterovirus	Infection
P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), *A(H1N1)pdm09, A(H7N9) virus, and rhinovirus. P9R directly binds to viruses* and inhibits virus-host endosomal acidification. P9R significantly protects mice from A(H1N1)pdm09 infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research .

HY-131059

CBS1117	Influenza Virus	Infection
CBS1117 is a virus entry inhibitor with an IC₅₀ of 70 nM for *influenza A virus, A/Puerto Rico/8/34* (H1N1). CBS1117 interferes with the hemagglutinin (HA)-mediated fusion process .

HY-147974

HSP90-IN-14	HSP Influenza Virus	Infection
HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a K_d of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC₅₀ values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively .

HY-N7915

Nepasaikosaponin K	Influenza Virus	Infection
Nepasaikosaponin K is an anti-influenza agent. Nepasaikosaponin K shows an EC₅₀ of 17.91 μM against influenza virus A/WSN/33 (H1N1) in 239T-Gluc cells .

HY-161902

MI-1904	Ser/Thr Protease Influenza Virus SARS-CoV	Infection
MI-1904 is the inhibitor for matriptase/TMPRSS2, that exhibits antiviral activity against influenza virus H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus .

HY-N16441

Pulvic acid	Endogenous Metabolite Influenza Virus	Infection
Pulvic acid (Compound 3), a butenolide, is a microbial secondary metabolite. Pulvic acid can be isolated from the marine-derived fungus Aspergillus terreus Gwq-48. Pulvic acid has significant antiviral activity with an IC₅₀ of 29.1 μg/mL for influenza A H1N1 virus. Pulvic acid can be used for influenza virus infections research .

HY-177791

vRNPs degrader-1	PROTACs Influenza Virus	Infection
vRNPs degrader-1 is a potent PROTAC viral ribonucleoproteins (vRNPs) degrader. vRNPs degrader-1 shows broad-spectrum anti-influenza A viruses (IAV) activity by targeting the conserved 5′ end of viral RNA, thereby inducing proteasomal degradation of viral proteins. vRNPs degrader-1 inhibits H1N1, H9N2, and H3N2 infection in mice. vRNPs degrader-1 can be used for influenza research .

HY-N17236

Forsyshiyanine A	β-glucuronidase Influenza Virus RSV	Infection
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of β-glucuronidase from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-N0736R

Coptisine chloride (Standard)	Indoleamine 2,3-Dioxygenase (IDO) Reference Standards Bacterial Influenza Virus	Infection Metabolic Disease Cancer
Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride). This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6 μg/mL and can be used for influenza A (H1N1) infection.

HY-N15215

Antiviral agent 64	Enterovirus Influenza Virus RSV HSV	Infection Cancer
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC₅₀ of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-131179

*Influenza A virus-IN-1*	Influenza Virus	Infection
Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of *influenza A virus* (IAV) with IC₅₀** values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA .

HY-155476

*Influenza virus-IN-8*	Influenza Virus	Infection
Influenza virus-IN-8 (compound A4) is an inhibitor of influenza virus (Influenza Virus) that induces viral nucleoprotein (NP) aggregation and prevents its nuclear accumulation. Influenza virus-IN-8 has broad-spectrum anti-influenza activity and can inhibit the replication and transcription of influenza A virus. Influenza virus-IN-8 also inhibits Oseltamivir (HY-13317)-resistant H1N1/pdm09 strains .

HY-100858

PP7	Influenza Virus	Infection
PP7 is a potent PB1-PB2 interaction inhibitor with an IC₅₀ of 8.6 μM, and their inhibition against viral polymerase activity (IC₅₀=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC₅₀=1.4 μM), A(H7N9) and A(H9N2) subtypes .

HY-N2264

Wulignan A1	Influenza Virus	Infection
Wulignan A1 is isolated from the stems of Schisandra henryi. Wulignan A1 exhibits anti-influenza virus *H1N1* and *H1N1-TR* (a Tamiflu agent resistant virus strain) activities .

HY-162242

Cap-dependent endonuclease-IN-27	Influenza Virus	Infection
Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase (EC₅₀ = 12.26 nM) .

HY-116182

RO5487624	Influenza Virus	Infection
RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus .

HY-175808

VF-57a	Influenza Virus	Infection
VF-57a (Compound 23) is an *Influenza A virus* (IAV) fusion** inhibitor. VF-57 has potent antiviral activities against authentic A/H1N1 virus with EC₅₀s of 0.92 and 0.31 μM for the A/H1N1 PR8 and A/H1N1 Virg09 strains, respectively. VF-57 significantly inhibits HA-mediated cell entry of A/H1N1- and A/H5N1-pseudoviruses, prevents the HA refolding at pH 5.2. VF-57a can be used for IAV infections research .

HY-162492

*Influenza A virus-IN-14*	Influenza Virus	Infection
Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC₅₀ of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC₅₀ of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse .

HY-N16425

Mitorubrin (-)-Mitorubrin	Influenza Virus	Infection
Mitorubrin ((-)-Mitorubrin) is a compound that can be isolated from Penicillium purpurogenum JS03-21. Mitorubrin shows no significant inhibitory activity against the H1N1 influenza virus (IC₅₀ > 200 μM) .

HY-163659

Anti-Influenza agent 6	Influenza Virus	Infection
Anti-Influenza agent 6 (compound 19b) shows inhibitory activity against A/WSN/33/H1N1 (EC₅₀ = 0.015 μM) and influenza B virus Yamagata/16/88 (EC₅₀ = 0.073 μM) and Victotis/2/87 (EC₅₀ = 0.067 μM) .

HY-157249

Antiviral agent 43	Influenza Virus	Infection
Antiviral agent 43 (compound 16) is a potent and orally active influenza A viruses entry inhibitor. Antiviral agent 43 inhibits replications of influenza A strains VH04-H5N1 and PR8-H1N1 with EC₅₀s of 240 nM and 72 nM, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0736

Coptisine chloride 10+ Cited Publications	Infection Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K_i value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6?μg/mL and can be used for influenza A (H1N1) infection.

HY-B0421

Mycophenolic acid 10+ Cited Publications Mycophenolate	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Dengue Virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-N0035

Arctigenin 10+ Cited Publications (-)-Arctigenin	Neurological Disease Classification of Application Fields Anti-aging Lignans Metabolic Disease Plants Compositae Caesalpinia magnifoliolata Metc. Endogenous metabolite Infection Human Gut Microbiota Metabolites Phenylpropanoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	MMP Influenza Virus Autophagy Apoptosis
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-N0243

Theaflavin 5+ Cited Publications	Infection Flavonoids other families Classification of Application Fields Flavanols Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification	Influenza Virus Endogenous Metabolite
Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N0638

Dendrobine 5+ Cited Publications	Infection Alkaloids Pyrrole Alkaloids Classification of Application Fields Orchidaceae Plants Disease Research Fields Dendrobium nobile Lindl. Source Classification	Influenza Virus JNK p38 MAPK Apoptosis CDK Keap1-Nrf2 SOD Reactive Oxygen Species (ROS)
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC₅₀s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties .

HY-Y0073

4-Hydroxyacetophenone 1 Publications Verification P-hydroxyacetophenone	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Plants Compositae Inflammation/Immunology Disease Research Fields Artemisia capillaris Thunb. Source Classification	HBV Myosin
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Crassulaceae Sedum sarmentosum Bunge Plants Disease Research Fields Source Classification	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against *A/H1N1* strains** (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-N0168A

(Rac)-Hesperetin	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	TGF-beta/Smad NF-κB
(Rac)-Hesperetin is the racemate of Hesperetin (HY-N0168), an orally active multi-target inhibitor. (Rac)-Hesperetin exhibits significant anti-tumor and anti-inflammatory activities by blocking the TGF-β1-mediated Fyn/RhoA signaling axis and the TLR4-MyD88-NF-κB inflammatory pathway. (Rac)-Hesperetin inhibits the formation of actin stress fibers and the migration and invasion of cancer cells, and is suitable for triple-negative breast cancer research. In inflammation models, (Rac)-Hesperetin effectively alleviates lung injury by reducing the release of pro-inflammatory mediators and regulating the activity of oxidative stress enzymes, and is suitable for acute lung injury research. (Rac)-Hesperetin also interferes with the entry and early replication processes of channel catfish virus, inhibits viral gene expression and progeny virus production, thereby protecting cells from virus-induced cytopathic effects .

HY-N0249

Saikosaponin C 2 Publications Verification	Triterpenes Structural Classification Terpenoids Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	MMP
Saikosaponin C is an orally active MMP-2 inducer. Saikosaponin C induces the survival, growth, migration and capillary tube formation of endothelial cells. Saikosaponin C inhibits the early stage of hepatitis C virus infection. Saikosaponin C can be used in research related to ischemic tissue diseases, chronic kidney diseases and hepatitis C virus infection .

HY-N0440

Germacrone 2 Publications Verification	Infection Classification of Application Fields Terpenoids Sesquiterpenes Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae	Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the *H1N1* and H3N2 inﬂuenza A virus and the inﬂuenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .

HY-N0392

Polygalasaponin F	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polygalaceae Polygala japonica Houtt. Plants Inflammation/Immunology Disease Research Fields Source Classification	Toll-like Receptor (TLR) PI3K Akt NF-κB MDM-2/p53 Caspase MEK Bcl-2 Family p38 MAPK Mitophagy Reactive Oxygen Species (ROS) Apoptosis Calcium Channel
Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax, p53, caspase-3, NF-κB p65 and MEK1; restores and upregulates the expression of Bcl-2; activates the PI3K/Akt signaling pathway; inhibits the phosphorylation of p38 MAPK, nuclear translocation of NF-κB, TLR4-mediated signaling pathway, mitophagy (Mitophagy) and ROS production; enhances cell viability and suppresses apoptosis (Apoptosis). Polygalasaponin F maintains mitochondrial function, alleviates Ca ²⁺ overload, upregulates pCREB and BDNF, preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A *H1N1* and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinson's disease, cerebral ischemia, pneumonia induced by influenza A *H1N1*, stroke and Alzheimer's disease .

HY-128744

Phosphonoacetic acid 2 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Orthopoxvirus HSV DNA/RNA Synthesis
Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit HSV DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins .

HY-N0093

Ancitabine hydrochloride 1 Publications Verification Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C	Classification of Application Fields Disease Research Fields Cancer	Autophagy CMV DNA/RNA Synthesis
Ancitabine hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer .

HY-N0891

Tubeimoside II Tubeimoside-B	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	EGFR TGF-β Receptor RIG-I-like receptor (RLR) SARS-CoV
Tubeimoside II is an orally active triterpenoid saponin and antiviral agent that binds to PACT/PRKRA with K_d values of 5.37 μM and 133.1 μM, respectively. Tubeimoside II inhibits oxidase-dependent EGFR activation and reduces TGF-β1-induced oxidative stress. Tubeimoside II activates the RIG-I signaling pathway and increases IFN-β secretion. Tubeimoside II suppresses TPA-induced ear edema, mouse sarcoma 180 growth, and TPA-induced skin tumor formation. Tubeimoside II exerts broad-spectrum antiviral activity against SARS-CoV-2, HCoV-OC43, and *IAV-H1N1/FM1*. Tubeimoside II can be used in research related to retinoblastoma, respiratory viral infections, skin tumors, and sarcoma 180 .

HY-N4294

Arjungenin	Triterpenes Classification of Application Fields Terpenoids Combretaceae Metabolic Disease Terminalia chebula Retz. Plants Disease Research Fields Source Classification	FXR Insecticide
Arjungenin, a pentacyclic triterpenoid compound, is a FXR agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV) .

HY-B0421A

Mycophenolic acid sodium 10+ Cited Publications Mycophenolate sodium	Infection Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Dengue Virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Source Classification	Influenza Virus
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-P0285

*Rabies Virus* Glycoprotein** 1 Publications Verification	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	RABV
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-133721

Chamaechromone	Flavonoids Classification of Application Fields Thymelaeaceae Phenols Polyphenols Plants Biflavones Disease Research Fields Inflammation/Immunology Source Classification Stellera chamaejasme L.	HBV
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses *anti-hepatitis B virus* (HBV)** effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities .

HY-130430

Neplanocin A (-)-Neplanocin A	Natural Products Microorganisms Source Classification	Antibiotic Orthopoxvirus
Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (K_i=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia *virus. Neplanocin A is obtained from Ampulariella regularis* .

HY-W013605A

4-Methoxycinnamaldehyde 2 Publications Verification p-Methoxycinnamaldehyde	Infection Structural Classification Classification of Application Fields Araceae Ketones, Aldehydes, Acids Acorus gramineus Soland. Plants Disease Research Fields Source Classification	Environmental Pollutants RSV
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC₅₀ of 0.055 μg/mL .

HY-135646

Eleutheroside B1	other families Classification of Application Fields Coumarins Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC₅₀ value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities .

HY-N7691

3,29-O-Dibenzoyloxykarounidiol Karounidiol dibenzoate	Infection Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Source Classification	EBV
3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a triterpene benzoate isolated from the fruit of Momordica grosvenori. 3,29-O-Dibenzoyloxykarounidiol has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) .

HY-N7677

Isookanin	Structural Classification Classification of Application Fields Plants Compositae Infection Flavonoids Deguelia rufescens (Benth.) R.A.Camargo & A.M.G.Azevedo Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	VZV HSV
Isookanin can be used for the research of various illnesses including cancers, skin rashes, snake and insects bites, diabetes mellitus, diarrhoea. Isookanin acts as an anti-viral agent against HSV and varicella-zoster virus (VZV). Antioxidant activity .

HY-N0440R

Germacrone (Standard)	Structural Classification Terpenoids Sesquiterpenes Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 inﬂuenza A viruses and the inﬂuenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .

HY-N11096

Sinococuline	Alkaloids Piperidine Alkaloids Plants Menispermaceae Stephania japonica (Thunb.) Miers Source Classification	Flavivirus Dengue Virus
Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor .

HY-B0421R

Mycophenolic acid (Standard) Mycophenolate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Dengue Virus Reference Standards Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-N3388

Licoisoflavone B	Structural Classification Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	Stearoyl-CoA Desaturase (SCD)
Licoisoflavone B is an orally active flavonoid found in licorice. Licoisoflavone B alleviates psoriasis via SCD1-targeted lipid metabolism reprogramming and suppression of Th17/IL-17-mediated inflammation. Licoisoflavone B inhiibits superoxide anion generation and superoxide anion-induced lipid peroxidation. Licoisoflavone B binds tightly to Lassa virus nucleoprotein and can be used as a nucleoprotein antagonist of Lassa virus. Licoisoflavone B exhibits anti-mutagenic activity against carcinogenic mutagen, by preventing DNA damage. Licoisoflavone B can be used for the research of psoriasis, Lassa fever, inflammation and cancer .

HY-N2432

Paederoside 1 Publications Verification	Infection Iridoids Classification of Application Fields Terpenoids Paederia scandens (Lour.) Merr. Rubiaceae Plants Disease Research Fields Source Classification	EBV HBV
Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa. Paederoside shows a high anti-tumor promoting activity against the Epstein-Barr virus activation .

HY-N3035

Tetrahydroepiberberine 1 Publications Verification	Infection Alkaloids Classification of Application Fields Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Fungal Influenza Virus
Tetrahydroepiberberine is a isoquinoline alkaloid isolated from Corydalis impatiens (Pall). Tetrahydroepiberberine has antifungal and selective inhibition against the PI-3 virus activities .

HY-113806

(±)-Trolline (±)-Oleracein E	Alkaloids Trollius chinensis Bunge Ranunculaceae Pyridine Alkaloids Plants Source Classification	Bacterial Influenza Virus Apoptosis
(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against *influenza virus* A and B. (±)-Trolline significantly induces HSC apoptosis**. (±)-Trolline can be used for the research of liver fibrosis .

HY-N12110

SMU-CX1	Apocynaceae Alkaloids Other Alkaloids Plants Source Classification	Toll-like Receptor (TLR) SARS-CoV
SMU-CX1 is a specific TLR3 inhibitor (IC₅₀: 0.11 μM) with IC₅₀ ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC₅₀ of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5 .

HY-N14107

Cinnabarin	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Endogenous Metabolite
Cinnabarin is a natural phenoxazinone red pigment derived from Pycnoporus sanguineus. Cinnabarin reduces rabies virus infection levels in neuroblastoma cells and causes cytopathic effects on neuroblastoma cell monolayers at high concentrations. Cinnabarin exhibits antibacterial activity against bacteria, with a preference for Gram-positive bacteria and human isolates. Cinnabarin can be used in studies related to rabies and drug-resistant Gram-positive bacteria .

HY-N0224A

Goitrin (S)-Goitrin; L-5-Vinyl-2-thiooxazolidone	Natural Products Cruciferous vegetables Classification of Application Fields Metabolic Disease Plants Brassicaceae Endogenous metabolite Disease Research Fields Source Classification	Influenza Virus
Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity .

HY-N0243R

Theaflavin (Standard)	Structural Classification Flavonoids other families Flavanols Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Influenza Virus Endogenous Metabolite
Theaflavin (Standard) is the analytical standard of Theaflavin. This product is intended for research and analytical applications. Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N10843

4-O-Methylepisappanol	Flavanonols Flavonoids Caesalpiniaceae Plants Source Classification	Influenza Virus
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

HY-N2076

Cephaeline hydrochloride (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride	Infection Alkaloids Monophenols other families Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Flavivirus Filovirus
Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections .

HY-N12201

Funiculosin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-129150

Ganoderic acid TR	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	Influenza Virus
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC₅₀ values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .

HY-N7346

Lucidadiol	Triterpenes Microorganisms Terpenoids Source Classification	HSV Cholinesterase (ChE)
Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC₅₀ values of 31 μM. Lucidadiol shows antiviral activity against *influenza virus* type A** and HSV type 1 .

HY-119458

Luotonin A	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Quinoline Alkaloids Plants Source Classification	Topoisomerase TMV Fungal
Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity .

HY-N10581

Flutimide	Microorganisms	Influenza Virus
Flutimide is a novel endonuclease inhibitor of influenza virus. Flutimide selectively inhibits endonuclease with an IC₅₀ value of 3 μM. Flutimide shows antiviral activity in cell culture. Flutimide can be used for the research of acute contagious respiratory disease, such as influenza .

HY-N7915

Nepasaikosaponin K	Triterpenes Lychnophora antillana Terpenoids Plants Umbelliferae Source Classification	Influenza Virus
Nepasaikosaponin K is an anti-influenza agent. Nepasaikosaponin K shows an EC₅₀ of 17.91 μM against influenza virus A/WSN/33 (H1N1) in 239T-Gluc cells .

HY-N16441

Pulvic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite Influenza Virus
Pulvic acid (Compound 3), a butenolide, is a microbial secondary metabolite. Pulvic acid can be isolated from the marine-derived fungus Aspergillus terreus Gwq-48. Pulvic acid has significant antiviral activity with an IC₅₀ of 29.1 μg/mL for influenza A H1N1 virus. Pulvic acid can be used for influenza virus infections research .

HY-N17236

Forsyshiyanine A	Structural Classification Alkaloids Oleaceae Pyridine Alkaloids Forsythia suspensa (Thunb.) Vahl Plants Source Classification	β-glucuronidase Influenza Virus RSV
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of β-glucuronidase from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-N0736R

Coptisine chloride (Standard)	Alkaloids Structural Classification Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Source Classification	Indoleamine 2,3-Dioxygenase (IDO) Reference Standards Bacterial Influenza Virus
Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride). This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6 μg/mL and can be used for influenza A (H1N1) infection.

HY-N15215

Antiviral agent 64	Structural Classification Monophenols Phenols Alpinia officinarum Hance Plants Source Classification Zingiberaceae	Enterovirus Influenza Virus RSV HSV
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC₅₀ of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-N2264

Wulignan A1	Infection Classification of Application Fields Lignans Phenols Polyphenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Source Classification	Influenza Virus
Wulignan A1 is isolated from the stems of Schisandra henryi. Wulignan A1 exhibits anti-influenza virus *H1N1* and *H1N1-TR* (a Tamiflu agent resistant virus strain) activities .

HY-N12612

CNP0296775	Structural Classification Natural Products Arecaceae Plants Source Classification	DNA Methyltransferase Dengue Virus
CNP0296775 is an inhibitor of dengue virus methyltransferase (DENV MTase) that has the potential to disrupt the viral replication process .

Cat. No.	Product Name	Chemical Structure

HY-145119AS

Mindeudesivir hydrobromide
Mindeudesivir (JT001; VV116; GS-621763-d₁) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 .

HY-B0421S

Mycophenolic acid-d3

Mycophenolic acid-d₃ (Mycophenolate-d₃) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-13318S

Oseltamivir acid-d3

Oseltamivir acid-d₃ is a deuterium labeled Oseltamivir acid (HY-13318). Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

HY-15005S1

Sofosbuvir-d6 1 Publications Verification
Sofosbuvir-d₆ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-Y0507S

DL-Serine-2,3,3-d3
DL-Serine-2,3,3-d₃ is the deuterium labeled DL-Serine. DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV) .

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-13317S

Oseltamivir-d3
Oseltamivir-d₃ is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-B0272S2

Rifampicin-d4
Rifampicin-d₄ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-B0272S1

Rifampicin-d8
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-N0100S

Naringenin-d4 1 Publications Verification
Naringenin-d₄ is the deuterated version of Naringenin (HY-N0100). Naringenin shows strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity .

HY-17043S1

Loratadine-d5
Loratadine-d₅ is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-B0402S1

Amantadine-d6

Amantadine-d₆ is the deuterium labeled Amantadine . Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

HY-20685S

Palmitoylethanolamide-d4
Palmitoylethanolamide-d₄ is the deuterium labeled Palmitoylethanolamide. Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.

HY-N0172S

Caffeic acid-13C3
Caffeic acid- ¹³C₃ is an ¹³C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses .

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-B0402S

Amantadine-d15
Amantadine-d₁₅ is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent .

HY-135853S

Molnupiravir-d7
Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .

HY-Y0136S1

3-Indoleacetonitrile-d4

3-Indoleacetonitrile-d₄ is deuterium labeled 3-Indoleacetonitrile (HY-Y0136). 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.

HY-20685S2

Palmitoylethanolamide-d5
Palmitoylethanolamide-d₅ (Palmidol-d₅, PEA-15,15,16,16,16-d₅) is deuterium labeled Palmitoylethanolamide. Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract .

HY-14532S

Brincidofovir-d6

Brincidofovir-d₆ (CMX001-d₆) is the deuterium labeled Brincidofovir (HY-14532). Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .

HY-14805S

Tecovirimat-d4

Tecovirimat-d₄ (ST-246-d₄) is a deuterium-labelled Tecovirimat (HY-14805). Tecovirimat is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC₅₀ values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat could be used in the study for orthopoxvirus-induced diseases .

HY-B1414S

Chloroxylenol-d6
Chloroxylenol-d₆ is the deuterium labeled Chloroxylenol. Chloroxylenol is a broad spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.

HY-78726S

Fosamprenavir-d4

Fosamprenavir-d₄ is the Deuterium-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-N0168AS1

(Rac)-Hesperetin-13C,d3

(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin (HY-N0168), an orally active multi-target inhibitor. (Rac)-Hesperetin exhibits significant anti-tumor and anti-inflammatory activities by blocking the TGF-β1-mediated Fyn/RhoA signaling axis and the TLR4-MyD88-NF-κB inflammatory pathway. (Rac)-Hesperetin inhibits the formation of actin stress fibers and the migration and invasion of cancer cells, and is suitable for triple-negative breast cancer research. In inflammation models, (Rac)-Hesperetin effectively alleviates lung injury by reducing the release of pro-inflammatory mediators and regulating the activity of oxidative stress enzymes, and is suitable for acute lung injury research. (Rac)-Hesperetin also interferes with the entry and early replication processes of channel catfish virus, inhibits viral gene expression and progeny virus production, thereby protecting cells from virus-induced cytopathic effects .

HY-15602AS

Ledipasvir-d6 hydrochloride
Ledipasvir-d₆ hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the *hepatitis C virus* NS5A, with EC₅₀** values of 34 pM against GT1a and 4 pM against GT1b replicon.

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-A0021S

Palonosetron-d3 hydrochloride

Palonosetron-d₃ hydrochloride is the deuterium labeled Palonosetron hydrochloride (HY-A0021). Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity .

HY-B0421S2

Mycophenolic acid-13C17

Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

HY-131606S

Cidofovir diphosphate-13C3

Cidofovir diphosphate- ¹³C₃ is the ¹³C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is the intracellular active metabolite of Cidofovir (HY-17438) and its oral prodrug Brincidofovir (HY-14532). By inhibiting viral DNA polymerase (Ki ≈ 76.3 μM), cidofovir diphosphate is widely used in studies on double-stranded DNA virus infections, including cytomegalovirus (CMV), adenovirus (AdV), and poxviruses (such as monkeypox and molluscum contagiosum virus, MCV) .

HY-B0272S

Rifampicin-d3
Rifampicin-d₃ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities .

HY-B0434S

Ribavirin-13C5
Ribavirin- ¹³C₅ is the ¹³C-labeled Ribavirin. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.

HY-12687S

Tizoxanide-d4
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities .

HY-15005S

Sofosbuvir-13C,d3
Sofosbuvir- ¹³C,d₃ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-N6715S

Tenuazonic acid-13C10

Tenuazonic acid- ¹³C₁₀ is ¹³C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-B0222S

1-Docosanol-d45
1-Docosanol-d₄₅ is the deuterium labeled 1-Docosanol. 1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement. 1-Docosanol is an inhibitor of lipid-enveloped viruses including herpes simplex.

HY-B0434S1

Ribavirin-15N, d2
Ribavirin- ¹⁵N, d2 is ¹⁵N and deuterated labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.

HY-B0272S3

Rifampicin-d11
Rifampicin-d₁₁ (Rifampin-d₁₁; Rifamycin AMP-d₁₁) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .

HY-15602S

Ledipasvir-d6
Ledipasvir-d₆ is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.62 μM .

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .

HY-10574S

Rilpivirine-d6
Rilpivirine-d₆ is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-B0510S3

Trimethoprim-13C3

Trimethoprim- ¹³C₃ is the deuterium labeled Trimethoprim (HY-B0510) . Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-12530S1

Velpatasvir-d3
Velpatasvir-d₃ (GS-5816-d₃) is deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 2.16 μM .

HY-10224S

Panobinostat-d4

Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10224S1

Panobinostat-d4 hydrochloride

Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-13317S3

Oseltamivir-d5
Oseltamivir-d₅ is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀ of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-13317S4

Oseltamivir-d3 hydrochloride
Oseltamivir-d₃ hydrochloride is the deuterium-labeled Oseltamivir (HY-13317) . Oseltamivir is an *influenza virus* neuraminidase** inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-13317S1

Oseltamivir-d3-1
Oseltamivir-d₃-1 is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-14904AS

Umifenovir-d6 hydrochloride

Umifenovir-d₆ (hydrochloride) is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells . Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15233G

Letermovir AIC246; MK-8228	CMV	Infection
Letermovir (GMP) is the GMP grade of Letermovir (HY-15233). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Letermovir (GMP) is an orally active CMV inhibitor. Letermovir (GMP) targets the CMV terminase complex rather than CMV DNA polymerase and exerts its antiviral activity. Letermovir (GMP) can be used in the study of CMV infection .

HY-B0434G

Ribavirin Ribasphere; ICN-1229	Antibiotic RSV HCV Orthopoxvirus	Infection
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks