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The Gut Microbiome And Ageing Trajectories: Mechanisms And Clinical Implications

Chronic Inflammation Metabolic Diseases Neurodegeneration Intercellular Communication & Diseases

The gut microbiome and ageing trajectories describe how intestinal microbial communities change across later life and influence resilience, frailty, inflammation, metabolism, immunity, and survival. Ageing microbiome research moved from cataloguing age-associated taxa to longitudinal and functional studies linking diet, residence, health status, microbiome uniqueness, and mortality. In older adults, faecal microbiota composition correlates with diet and health, and healthy ageing is associated with distinctive microbiome patterns that predict survival[1][2][3].

Mechanistically, ageing trajectories reflect both microbial composition and microbial function. Older people show greater inter-individual microbiome variation than younger adults, while microbiome differences associate with residence setting, diet diversity, inflammatory markers, and health decline. Aged microbiota can promote intestinal inflammation, leakage of inflammatory bacterial components into circulation, and systemic T-cell activation after transfer to germ-free mice. In mouse fecal microbiota transfer studies, aged donor microbiota accelerated inflammation in gut-brain and gut-retina axes, while young donor microbiota reversed several age-associated tissue effects[1][4][5][6].

Clinical implications now center on frailty prediction, nutrition, infection risk, immune ageing, and microbiome-directed interventions. Centenarians carry a distinct gut microbiome enriched for microorganisms capable of generating unique secondary bile acids, including isoallo-lithocholic acid, which showed antimicrobial activity against Gram-positive pathobionts. These findings support a model in which microbial metabolites, bile acids, short-chain fatty acids, epithelial barrier function, and immune tone shape healthier or more vulnerable ageing trajectories. Microbiome profiling could therefore support risk stratification, dietary intervention, probiotic or prebiotic development, and fecal microbiota transplantation research in ageing-related decline[2][3][5][7].

Major gaps remain in causality, personalization, safety, and translation. Human cohort studies reveal strong associations, but age, diet, medication, frailty, residence, disease burden, and geography confound microbiome signals. Animal transfer studies support causal effects, but human rejuvenation strategies require standardized donor selection, long-term safety data, strain-level resolution, functional metabolomics, and clinically meaningful endpoints. The strongest prospect is not a universal anti-ageing microbiome, but precision modulation of microbial functions that preserve barrier integrity, reduce inflammaging, maintain metabolic resilience, and support immune competence across individual ageing trajectories[2][3][5][6][7].

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Cat. No. Product Name Information Application Publication
HY-10219 Rapamycin
Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

Source: Streptomyces hygroscopicus

mTOR   FKBP   Molecular Glues   Fungal   Autophagy   Endogenous Metabolite   Antibiotic   Bacterial  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Bacterial Infection   Fungal Infection   Pain   Non-Small Cell Lung Cancer   Lung Adenocarcinoma   SARS-CoV-2 Infection   Obesity   Lung Fibrosis  
1475
HY-19312 3-Methyladenine
3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
PI3K   Autophagy   Mitophagy   Endogenous Metabolite  
Cancer  
1354
HY-B0215 Acetylcysteine
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine ​​is the most stable form of cysteine ​​during drug delivery and can be used in disulfidptosis studies.
Reactive Oxygen Species (ROS)   Endogenous Metabolite   Apoptosis   Ferroptosis   Influenza Virus   Disulfidptosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Breast Cancer   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection   Lung Fibrosis  
767
HY-90006 5-Fluorouracil
5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
Exosomes   Nucleoside Antimetabolite/Analog   HIV   Apoptosis   Endogenous Metabolite  
Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
356
HY-15371 Forskolin
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.
Organoid   Adenylate Cyclase   FXR   Autophagy   PKC  
Glucose Metabolism   Non-Small Cell Lung Cancer   Hypertension  
233
HY-K0208 Streptavidin Magnetic Beads

MCE Streptavidin Magnetic Beads provide a fast and convenient method for numerous applications, including purification of proteins and nucleic acids, protein interaction studies, immunoprecipitation, immunoassays, pull-down and cell isolation. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Purification Magnetic Beads

228
HY-B2176 ATP
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

Source: widespread

Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
178
HY-14649 Retinoic acid
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
Organoid   RAR/RXR   PPAR   Endogenous Metabolite   Autophagy  
Cancer   Digestive System Disease   Depression   Digestive System Inflammation   Obesity  
150
HY-N0830 Palmitic acid
Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.

Source: Widespread

Environmental Pollutants   HSP   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
124
HY-N0583 Hydrocortisone
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Environmental Pollutants   Glucocorticoid Receptor   Endogenous Metabolite  
Breast Cancer   Prostate Cancer   Pancreatic Cancer   Pain   Immunosuppression  
93
HY-12222 Obeticholic acid
Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.
FXR   Autophagy  
Digestive System Disease   Digestive System Inflammation   Glucose Metabolism  
88
HY-L078 Gut Microbial Metabolite Library
Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods. In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 475 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Metabolism Focused Libraries

85
HY-L123 Human Metabolite Library
Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development. MCE offers a unique collection of 6,767 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Metabolism Focused Libraries

85
HY-L182 Fatty Acids Compound Library
Fatty acids (FAs) are the main components of lipids. The synthesis of fatty acids mainly involves the Triglyceride (TG) cycle and De Novo Lipogenesis (DNL). Fatty acids which exist widely in organisms are components of cell membranes and play an indispensable role in cell signaling. In addition, FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and they are metabolized by β-oxidation and the citric acid cycle to release large amounts of energy in the form of ATP. Abnormal fatty acid metabolism is associated with the occurrence and development of cardiovascular diseases, diabetes, fatty liver, hyperthyroidism, and other diseases. MCE offers a unique collection of fatty acid compounds. Fatty Acids Compound Library is an important tool for the study of energy metabolism and drug development of metabolism-related diseases.

Structure Classified Libraries

84
HY-L0107V Life Chemicals Natural Product-like Compound Library
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.
83
HY-L198 Non-natural Amino Acid Compound Library
Unlike the 20 natural amino acids commonly found within living organisms, non-natural amino acids are synthesized through chemical or biosynthetic methods, thereby being endowed with unique chemical properties or biological activities. In drug development, these amino acids can be utilized to design novel pharmaceutical molecules that may exhibit superior pharmacological characteristics, such as increased selectivity, improved pharmacokinetic profiles, or reduced toxicity. In biomedical research, uon-natural amino acids can act as biological markers or probes for investigating biological processes like cell signaling, protein conformation, and protein-protein interactions. In addition, non-natural amino acids can also be used in the field of agriculture to develop new pesticides, plant growth regulators and so on.
83
HY-L208 Bile Acids Library
Bile acids are a class of amphiphilic molecules derived from the metabolic breakdown of cholesterol, primarily synthesized in the liver, and play a crucial role in the intestines. Based on their structural characteristics, bile acids are mainly divided into two categories: free bile acids (including Cholic acid, Deoxycholic acid, Chenodeoxycholic acid) and conjugated bile acids (including Glycocholic acid, Glycochenodeoxycholic acid, Taurocholic acid, etc.). Bile acids play a significant role in the pathophysiological research of liver and gastrointestinal diseases and are closely associated with the occurrence of metabolic diseases such as obesity, type II diabetes, non-alcoholic fatty liver disease, and atherosclerosis. Bile acids maintain metabolic balance within the body by regulating sugar metabolism, lipid metabolism, and amino acid metabolism, and they influence the activity of metabolism-related enzymes and transporters. In addition, Bile acids can also be used to construct a bile acid metabolism research platform, which helps to delve into the metabolic pathways and dynamic changes of bile acids in living organisms and aids in identifying new biomarkers for certain diseases. MCE included 62 bile acids, including Cholic acid, Deoxycholic acid, Glycocholic acid, etc., which are effective tools for the study of liver and gallbladder diseases.
83
HY-L227 Amino Acid Metabolite Compound Library
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 195 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Metabolism Focused Libraries

83
HY-L235 20 Amino Acids Library
Amino acids are indispensable building blocks for life activities and are widely involved in key biological processes such as cell signal transduction, energy metabolism, gene expression regulation, and neurotransmitter synthesis. As components of proteins, 20 kinds of amino acids make up over one million kinds of proteins in the human body. These amino acids can be classified into nine types of "essential amino acids" that the human body cannot synthesize on its own and must obtain from food, as well as eleven types of "non-essential amino acids" that the human body can synthesize on its own. MCE offers 18 kinds of amino acids provided which can be applied in research fields such as the study of amino acid metabolic processes, metabolite identification, food/cosmetic ingredient research, and the development of nutritional supplements.
83
HY-L263 Energy Metabolites Library
Energy metabolism is the most fundamental biochemical process in living organisms, encompassing glycolysis, the TCA cycle, oxidative phosphorylation, the pentose phosphate pathway, and fatty acid oxidation. These core pathways directly regulate cell survival, proliferation, differentiation, and apoptosis. Dysregulation of energy metabolism is closely linked to major diseases including cancer, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders, and ischemia‑reperfusion injury. Targeting these metabolic pathways has become a frontier in drug discovery and mechanistic research. The MCE Energy Metabolite Compound Library features 89 structurally defined small‑molecule compounds. It covers energy substrates, pathway intermediates, coenzymes and redox carriers, nucleotide derivatives, and microenvironmental modulators. This library is applicable to research areas including tumor metabolism, insulin resistance, mitochondrial dysfunction, oxidative stress, neuroprotection, and cardiometabolic diseases, providing a high‑quality tool for mechanistic studies, biomarker discovery, and high‑throughput drug screening.

Signaling Pathway Targeting Libraries

83
HY-L937 Unnatural Amino Acids Fragment library
Unnatural amino acids (UAAs), also referred to as non-canonical amino acids (ncAAs) or non-proteinogenic amino acids, are a class of amino acids that are distinct from the 20 standard natural amino acids. They can be obtained through chemical synthesis, biosynthesis, and other approaches, with structural diversity far exceeding that of natural amino acids. UAAs are mainly including naturally occurring non-canonical amino acids, chemically synthesized amino acids, and biosynthetic amino acids, which provide a molecular basis for protein function design. UAAs exhibit significant value in multiple fields. They can optimize the pharmacokinetic properties of peptide drugs and peptidomimetics, modify enzyme functions and endow them with new biological activities, thereby overcoming the limitations of traditional peptide drugs and expanding the chemical space . Meanwhile, UAAs can serve as molecular probes to analyze protein-protein interactions and investigate the regulatory mechanisms of protein functions. MCE has compiled a UAAs Fragment Library comprising nearly a thousand unnatural amino acid fragments with extensive coverage of chemical space and enhanced structural diversity. This compound library can be widely applied in peptide synthesis, drug design, and protein engineering.

Functional Fragment Libraries

83
HY-B2227 Lactic acid
Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid also has antimicrobial activity, which can be used as a food preservative.
Environmental Pollutants   Hydroxycarboxylic Acid Receptor (HCAR)   Bacterial   Endogenous Metabolite  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
67
HY-B2227B Lactic acid sodium (60% w/w in water)
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative.
This product has a content (w/w) of 60%, and 1 mL of the system contains 798 mg of Lactic acid sodium, i.e., a concentration of 798 mg/mL (i.e., 7.12 M).
Environmental Pollutants   Hydroxycarboxylic Acid Receptor (HCAR)   Bacterial   Endogenous Metabolite  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
66
HY-50108 GW 4064
GW 4064 is a potent FXR agonist with an EC50 of 65 nM.
FXR   Autophagy  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation  
57
HY-10626 T0901317
T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.
LXR   FXR   ROR   Apoptosis  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation   Cardiovascular Disease  
50
HY-K1014 PolyFast Transfection Reagent

MCE PolyFast Transfection Reagent consists of cationic polymers and can introduce nucleic acids (DNA or RNA) into eukaryotic cells efficiently, including some hard-to-transfect cells.

Cell Biology Cell Culture Cell Transfection

43
HY-13771 Ursodeoxycholic acid
Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active.
G protein-coupled Bile Acid Receptor 1   FXR   Angiotensin-converting Enzyme (ACE)   Endogenous Metabolite  
Cancer   SARS-CoV-2 Infection  
32
HY-76847 Chenodeoxycholic Acid
Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
FXR   Endogenous Metabolite   Autophagy  
Metabolic or Endocrine Disease   Colorectal Cancer   Digestive System Inflammation   SARS-CoV-2 Infection  
26
HY-107738 Guggulsterone
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.
Apoptosis   JNK   Akt   Caspase   FXR   Autophagy  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis  
22
HY-B0172 Lithocholic acid
Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist.
Autophagy   Endogenous Metabolite   Apoptosis   FXR  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Digestive System Inflammation   Obesity  
21
HY-109083 Cilofexor
Cilofexor (GS-9674) is a potent, selective and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. Cilofexor has anti-inflammatory and antifibrotic effects. Cilofexor has the potential for primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH) research.
FXR   Autophagy  
Digestive System Disease   Digestive System Inflammation  
11
HY-N0169A Hyodeoxycholic acid sodium
Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
G protein-coupled Bile Acid Receptor 1   Endogenous Metabolite  
Metabolic or Endocrine Disease  
7
HY-N0169 Hyodeoxycholic acid
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
G protein-coupled Bile Acid Receptor 1   Endogenous Metabolite  
Obesity  
7
HY-N9965 2'-Fucosyllactose
2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines.

Source: Human milk

TNF Receptor   Interleukin Related  
Infection   Digestive System Disease   Prostate Cancer   Depression   Pain   Digestive System Inflammation   Lung Fibrosis   Rheumatoid Arthritis  
5
HY-136064 4,4'-Dimethoxychalcone
4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties.
Autophagy  
Metabolic or Endocrine Disease  
4
HY-N1423 Glycocholic acid
Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).
P-glycoprotein   Endogenous Metabolite   FXR   LPL Receptor   G protein-coupled Bile Acid Receptor 1   Apoptosis   MDM-2/p53   Bcl-2 Family   Bacterial   Caspase  
Metabolic or Endocrine Disease   Lung Cancer   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
4
HY-K1007 Red Nucleic Acid Gel Stain (10,000×)

MCE Red Nucleic Acid Gel Stain (10,000×) is a nucleic acid stain that can be used as a safer alternative to the traditional ethidium bromide (EB) stain for detecting nucleic acids in agarose gels or polyacrylamide gels.

Molecular Biology Nucleic Acid Gel Electrophoresis Nucleic Acid Gel Stain

4
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.
Amyloid-β  
Neurological, Eye or Ear Disease  
3
HY-N0652 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions.
ERK   NF-κB  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Obesity  
3
HY-41324 7-keto-Deoxycholic acid
7-keto-Deoxycholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-Deoxycholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition.

Source: human

Drug Metabolite  
2
HY-P9929 Bezlotoxumab
Bezlotoxumab (BLA761046; MBL-CDB1; MDX-1388) is a fully humanized IgG1/kappa monoclonal antibody directed against Clostridium difficile toxin B. Bezlotoxumab mediates the early reconstitution of gut microbiota to reduce the risk of recurrent Clostridium difficile infection (CDI). Bezlotoxumab can be used for the study of recurrent Clostridium difficile infection prevention.

Species: Human

Bacterial  
Clostridium Difficile Infection  
1
HY-N0468 Rebaudioside D
Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research.
FXR   Acetyl-CoA Carboxylase  
Obesity  
1
HY-D1445 LysoSensor PDMPO
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes. (Abs=329 nm; Em=440/540 nm).
Fluorescent Dye  
Metabolic or Endocrine Disease  
1
HY-P99376 Narsoplimab
Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.

Species: Human

SARS-CoV  
Infection  
1
HY-K0221 Affinity Chromatography Column

MCE Affinity Chromatography (AC) Columns are designed for purification of recombinant proteins with different tags, enzymes, antibodies, antigens and nucleic acids.

Protein Biology Protein Purification Affinity Chromatography Column

1
HY-157350 Violet Red Bile Agar
Violet Red Bile Agar can be used for solid plate detection of coliforms (GB, SN standards). Violet Red Bile Agar ingredients include peptone, yeast powder, sodium chloride, lactose, bile salts, crystal violet, neutral red, agar.
Biochemical Assay Reagents  
/
HY-W032915S 5-Phenylvaleric acid-d13
5-Phenylvaleric acid-d13 (5-Phenylpentanoic acid-d13) is the deuterium labeled 5-Phenylvaleric acid (HY-W032915). 5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-P990083A Tegoprubart (powder)
Tegoprubart (powder) (AT-1501 (powder)) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart (powder) suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart (powder) preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart (powder) is applicable to research related to kidney transplantation and kidney transplant rejection.
TNF Receptor  
Autoimmune Disease  
/
HY-W777496 Saccharin-13C6
Saccharin-13C6 is the 13C-labeled Saccharin (HY-Y0272). Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties.
Isotope-Labeled Compounds   Bacterial  
Inflammation or Immune System Disease  
/
HY-118534 Cyclobutyrol
Cyclobutyrol is a potent choleretic agent. Cyclobutyrol also inhibits biliary lipid secretion. Cyclobutyrol induces choleretic is unrelated to bile acids. Cyclobutyrol and bile acids do not compete for the hepatobiliar transport mechanisms[1]
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-159669 Stercobilin hydrochloride (mixture of isomers)
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections.
HIV Protease  
Infection   Inflammation or Immune System Disease  
/
HY-185792S Bile acid standards Mix 2-conjugated
Bile acid standards Mix 2-unconjugated is a deuterium-labeled unconjugated bile acid used as an internal standard for quantitative analysis.
Isotope-Labeled Compounds  
/
HY-P992508 SPX-101
SPX-101 (SX001) is a humanized monoclonal antibody targeting CLDN18.2. CLDN18.2 is only transiently expressed in the differentiated epithelial cells of the gastric mucosa and is hardly found in healthy tissues, thus having an extremely wide therapeutic window. SPX-101 can be used for the study of solid tumors.

Species: Human

Claudin  
Cancer  
/
HY-P991153 Potravitug
Potravitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the major capsid protein VP1 of BK polyomavirus (BKV). Potravitug is promising for research of BKV-infection-related diseases, such as BKV-induced nephropathy after organ transplantation.

Species: Virus

Virus Protease  
Infection  
/
HY-D0035 MPAC-Br
MPAC-Br is a highly sensitive fluorescent derivatization reagent for carboxylic acids in HPLC.
Fluorescent Dye  
/
HY-P10352 Pediocin PA 1
Pediocin PA 1 is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA 1 shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA 1 can be used not only as a food biopreservative but also for research on listeriosis.
Bacterial  
Bacterial Infection  
/
HY-124265S1 4β-Hydroxycholesterol-d5
4β-Hydroxycholesterol-d5 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-157356 Violet Red Bile Glucose Agar
Violet Red Bile Glucose Agar can be used for counting intestinal bacteria and identification of enterobacteriaceae. The composition of 1 liter of Violet Red Bile Glucose Agar contains: 7.0 g gelatin pancreatic enzyme hydrolysate, 3.0 g yeast extract powder, 1.5 g sodium deoxycholate, 10.0 g glucose, 5.0 g sodium chloride, 0.03 g neutral red, 0.002 g crystal violet, and 15.0 g agar in per liter.
Bacterial  
/
HY-185791S Bile acid standards Mix 1-unconjugated
Bile acid standards Mix 1-unconjugated is a deuterium-labeled unconjugated bile acid used as an internal standard for quantitative analysis.
Isotope-Labeled Compounds  
/
HY-N0169S Hyodeoxycholic acid-d5
Hyodeoxycholic acid-d5 is the deuterium labeled Hyodeoxycholic acid. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
Isotope-Labeled Compounds   Endogenous Metabolite   G protein-coupled Bile Acid Receptor 1  
Metabolic or Endocrine Disease  
/
HY-157349 Brilliant Green Lactose Bile Broth
Brilliant Green Lactose Bile Broth can be used for confirmatory testing of coliform bacteria. The ingredients of Blood Enrichment Medium include tryptone, lactose, ox bile powder, and brilliant green.
Biochemical Assay Reagents  
/
HY-D0198 Acid yellow 61
Acid yellow 61 is an acidic yellow dye that can be adsorbed and removed by bentone clay.
Fluorescent Dye  
/
HY-D0366 Acid Violet 17
Acid Violet 17 is an acidic dye that can be adsorbed from aqueous solution by orange peel.
Fluorescent Dye  
/
HY-D0650 Acid violet 54
Acid violet 54 is an acidic dye that is adsorbed by Musa extract.
Fluorescent Dye  
/
HY-105047 Cholyl-Lys-fluorescein
Cholyl-Lys-fluorescein is a fluorescent-labelled bile salt and a marker of hepatic biliary transporter function. Cholyl-Lys-fluorescein can be used for metabolic research.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-D0410 C.I. Acid yellow 200
C.I. Acid yellow 200 is an acidic yellow dye that can be adsorbed and removed by bentone.
Fluorescent Dye  
/
HY-167255 JC-10
JC-10 is a lipophilic mitochondrial membrane potential indicator and is a fluorescent dye. JC-10 accumulates and aggregates in healthy mitochondria to emit red fluorescence; exists as a monomer emitting green fluorescence in the cytosol or apoptotic cells with collapsed mitochondrial membrane potential, enabling measurement of mitochondrial depolarization via the green/red fluorescence ratio.
Fluorescent Dye  
/
HY-P4285 β-Aspartylalanine
β-Aspartylalanine is a substrate for β-aspartyl peptidase and used to measure β-aspartyl peptidase activity in fecal supernatants.
Others  
/
HY-P11213 Ac-RYQK(Ac)-AMC
Ac-RYQK(Ac)-AMC (Compound S5) is a fluorescent substrate for SITR6, that is based on the H3 sequence. Ac-RYQK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with superior signal-to-background ratio. Ac-RYQK(Ac)-AMC can be used for ageing and cancers research.
Fluorescent Dye  
Cancer   Metabolic or Endocrine Disease  
/
HY-W718179 Hydroxypropyl starch
Hydroxypropyl starch (2-Hydroxypropyl starch) is a type of modified starch used as a food additive. Hydroxypropyl starch is not absorbed intact by the gut, but is significantly hydrolyzed by intestinal enzymes and then fermented by intestinal microbiota.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-P990127 Anti-Mouse CD80/B7-1 Antibody (RM80)
Anti-Mouse CD80/B7-1 Antibody (RM80) is an anti-mouse CD80/B7-1 IgG2a monoclonal antibody. Anti-Mouse CD80/B7-1 Antibody (RM80) can inhibit the number of tissue-resident memory (TRM) cells. Anti-Mouse CD80/B7-1 Antibody (RM80) can prolong the survival time of transplants combined with CD86 mAb. Anti-Mouse CD80/B7-1 Antibody (RM80) can be used for researches on inflammation conditions and immunology such as viral myocarditis and corneal transplant.

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-P11212 Ac-RHKK(Ac)-AMC
Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research.
Fluorescent Dye  
Cancer   Metabolic or Endocrine Disease  
/
HY-P3121 Caprooyl-tetrapeptide-3 triacetate
Caprooyl-tetrapeptide-3 acetate is used for fine lines and wrinkle reduction. Caprooyl-tetrapeptide-3 acetate stimulates the expression of collagen VII and laminin-5 in a model of corticoid-induced skin ageing.
Others  
Metabolic or Endocrine Disease  
/
HY-Y0272S Saccharin-d4
Saccharin-d4 is the deuterium labeled Saccharin. Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties.
Isotope-Labeled Compounds   Bacterial  
Inflammation or Immune System Disease  
/
HY-124265S 4β-Hydroxycholesterol-d7
4β-Hydroxycholesterol-d7 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-113270AS Actinine-d9 chloride
Actinine-d9 chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.
Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P10352A Pediocin PA 1 TFA
Pediocin PA-1 TFA is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA-1 TFA shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA-1 TFA can be used not only as a food biopreservative but also for research on listeriosis.
Bacterial  
Infection  
/
HY-W747583 Apocholic acid
Apocholic acid is a bile acid belonging to steroidal organic acids. Apocholic acid is an endogenous metabolite.

Source: human urine

Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P2959 Menhaden oil, crude source of omega-3 fatty acids
Menhaden oil, crude source of omega-3 fatty acids is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-157347A Yeast Nitrogen Base Medium without Amino Acids
Yeast Nitrogen Base Medium without Amino Acids (YNB Medium without Amino Acids) is a growth medium that lacks amino acids. Yeast Nitrogen Base Medium without Amino Acids can be used for the cultivation of yeast.
Biochemical Assay Reagents  
/
HY-N0324F Cholic acid-Biotin
Cholic acid-Biotin is a biotin-labeled Cholic acid (HY-N0324). Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid has orally activity.
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-124265S2 4β-Hydroxycholesterol-d4
4β-Hydroxycholesterol-d4 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265) . 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W423191 Maltobionic acid
Maltobionic acid (4-O-α-D-Glucopyranosyl-D-gluconic acid) is an orally active oligosaccharide and iron chelator with antibacterial activity. Maltobionic acid inhibits the expression of NFATc1, suppresses osteoclast differentiation, inhibits bone resorption, and increases serum calcitonin levels. Maltobionic acid protects mammalian cells from hydrogen peroxide (H2O2)-induced oxidative damage; resists fermentation by the gut microbiota; and exhibits anti-digestive and anti-fermentative properties. Maltobionic acid can be used in research related to osteoporosis, bacterial infections, and constipation.
Nuclear Factor of activated T Cells (NFAT)   Bacterial  
Bacterial Infection   Osteoporosis  
/
HY-P99257 Bleselumab
Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd: 0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection.

Species: Human

TNF Receptor  
Inflammation or Immune System Disease  
/
HY-N3383 Ligustroside
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages.
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease  
/
HY-124265 4β-Hydroxycholesterol
4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P0102 Dipeptide diaminobutyroyl benzylamide diacetate
Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a nAChR antagonist. Dipeptide diaminobutyroyl benzylamide diacetate mimics Waglerin-1 to block neuromuscular junction nicotinic acetylcholine receptors, partially inhibits neuronal signal transduction, and relaxes muscles. Dipeptide diaminobutyroyl benzylamide diacetate reduces appearance of facial wrinkles linked to repeated muscle movement.Dipeptide diaminobutyroyl benzylamide diacetate can be used for the research of mild-to-moderate fine and coarse periocular and perioral wrinkles and periorbital ageing.
nAChR  
Metabolic or Endocrine Disease   Parkinson's Disease  
/
HY-P990083 Tegoprubart
Tegoprubart (AT-1501) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart is applicable to research related to kidney transplantation and kidney transplant rejection.

Species: Human

TNF Receptor  
Autoimmune Disease  
/
HY-N8332 Bile extract
Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens.
Bacterial   DNA/RNA Synthesis  
Infection  
/
HY-P0045 Palmitoyl pentapeptide 4
Palmitoyl pentapeptide 4 (Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide) is a bioactive peptide with anti-ageing effect and has been reported used as a cosmetic ingredient[1]
Collagen  
/
HY-113270A Actinine chloride
Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Cardiovascular Disease  
/
HY-P99152 Muromonab
Muromonab (Muromonab-CD3; OKT3) is a mouse monoclonal antibody targeting the CD3 antigen. Muromonab specifically binds to the CD3 antigen on the surface of human and higher primate T cells. Muromonab blocks the function of T cell receptors to recognize foreign antigens and inhibits T cell-mediated immune responses, including cell-mediated lymphocyte lysis and T cell proliferation responses. Muromonab can be used to study acute kidney, liver, heart and combined kidney-pancreas transplant rejection, and can also be used to study graft-versus-host disease in bone marrow transplant patients.

Species: Human

CD3   IFNAR   Interleukin Related  
Inflammation or Immune System Disease   Leukemia/Lymphoma/Myeloma  
/
HY-108852 Basiliximab
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation.

Species: Human

Interleukin Related  
Acute Myeloid Leukemia   Acute Lymphoblastic Leukemia   Non-Hodgkin Lymphoma   Glioblastoma   Astrocytoma   SARS-CoV-2 Infection   Amyotrophic Lateral Sclerosis   Chronic Obstructive Pulmonary Disease   Ulcerative Colitis  
/
HY-D0908 Ninhydrin
Ninhydrin can be used as a chromogenic analytical probe for the quantification of amino acids and proteins.
Fluorescent Dye  
/
HY-P75705 DERP1 Protein, Dermatophagoides pteronyssinus (HEK293, His)
DERP1 Protein, a thiol protease, selectively cleaves target proteins with distinct structural features, favoring substrates with a large hydrophobic side chain in the P2 position or basic residues. This specificity underscores DERP1's functional significance in cellular processes. DERP1 Protein, Dermatophagoides pteronyssinus (HEK293, His) is the recombinant DERP1 protein, expressed by HEK293 , with C-10*His, C-His labeled tag.

Species: Others; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

/
HY-P75520 AKR1C2 Protein, Human (His)
AKR1C2 protein: Cytoplasmic aldehyde-keto reductase, which uses NADH and NADPH to reduce ketosteroids to hydroxysteroids. AKR1C2 Protein, Human (His) is the recombinant human-derived AKR1C2 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P71343 SULT2A1 Protein, Human (His)
The SULT2A1 protein utilizes PAPS for critical sulfonation of steroids and bile acids in the liver and adrenal glands. Its multifunctional activity extends to a variety of compounds, enhancing its water solubility to facilitate renal excretion. SULT2A1 Protein, Human (His) is the recombinant human-derived SULT2A1 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

/
HY-P75706 DERP1 Protein, Dermatophagoides pteronyssinus (C132A, N150E, HEK293, His)
DERP1 Protein, a thiol protease, selectively cleaves target proteins with distinct structural features, favoring substrates with a large hydrophobic side chain in the P2 position or basic residues. This specificity underscores DERP1's functional significance in cellular processes. DERP1 Protein, Dermatophagoides pteronyssinus (C132A, N150E, HEK293, His) is the recombinant DERP1 protein, expressed by HEK293 , with C-His labeled tag and C132A, N150E mutation.

Species: Others; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

/
HY-P7469 AKR1C2 Protein, Human
AKR1C2 Protein, Human is a recombinant human AKR1C2. AKR1C2 is a member of the aldo/keto reductase superfamily and has critical roles in the tumorigenesis and progression of malignant tumours.

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P704194 GPBAR1 Protein, Human (Cell-Free, His)
GPBAR1 Protein, Human (Cell-Free, His) is the recombinant human-derived GPBAR1 protein, expressed by E. coli cell-free system, with N-10*His tag.

Species: Human; Source: E. coli Cell-free

/
HY-P71390 TSTA3 Protein, Human (His)
The TSTA3 protein plays a key role in catalyzing the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose. The process involves successive epimerase and reductase reactions, ultimately leading to the biosynthesis of GDP-fucose. TSTA3 Protein, Human (His) is the recombinant human-derived TSTA3 protein, expressed by E. coli , with C-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Isomerases (EC 5)

/
HY-P74352 Carboxyl Ester Lipase/CEL Protein, Mouse (sf9, His)
Carboxyester lipase/CEL protein plays a crucial role in cellular processes as it catalyzes the hydrolysis of a variety of substrates, including cholesterol esters, phospholipids, lysophospholipids, diacylglycerols and triacylglycerols, and lipids of hydroxy fatty acids acid ester. FAHF). Carboxyl Ester Lipase/CEL Protein, Mouse (sf9, His) is the recombinant mouse-derived Carboxyl Ester Lipase/CEL protein, expressed by Sf9 insect cells , with C-His labeled tag.

Species: Mouse; Source: Sf9 insect cells

Enzymes & Regulators Hydrolases (EC 3)

/
HY-P704865 ITGB7 Protein, Human (His)

Species: Human; Source: E. coli

/
HY-P705614 SLC10A2 Protein-VLP, Human (HEK293, His)
SLC10A2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

Species: Human; Source: HEK293

/
HY-P80201 KLF4 Antibody (YA321)
KLF4 Antibody (YA321) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P80735 KLF4 Antibody (YA716)
KLF4 Antibody (YA716) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KLF4.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P81448 SLC7A5/LAT1 Antibody (YA1193)
SLC7A5/LAT1 Antibody (YA1193) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC7A5/LAT1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P86625 KLF4 Antibody (YA6317)
KLF4 Antibody (YA6317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P810996 ELOVL6/ FACE Antibody
ELOVL6/ FACE Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ELOVL6.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

/
HY-P81448A SLC7A5/LAT1 Antibody (YA1193)(PBS only)
SLC7A5/LAT1 Antibody (YA1193) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC7A5/LAT1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P86666 KLF4 Antibody (YA6358)
KLF4 Antibody (YA6358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P86666A KLF4 Antibody (YA6358)(PBS only)
KLF4 Antibody (YA6358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLF4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P80735A KLF4 Antibody (YA716)(PBS only)
KLF4 Antibody (YA716) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KLF4.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P811318 NTCP Antibody
NTCP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to NTCP.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

/
HY-K0223 Hydroxyl Magnetic Beads (200 nm, 10 mg/mL)

MCE Hydroxyl Magnetic beads (200 nm, 10 mg/mL) can rapidly isolate nucleic acids from biological samples, which is conducive to the automation and high throughput extraction of nucleic acids.

Protein Biology Protein Purification Magnetic Beads

/
HY-K0602 Alcian Blue Staining Solution (pH 2.5)

MCE Alcian Blue Staining Solution (pH 2.5) is commonly used for the detection of acidic mucopolysaccharides and mucins in histological studies. It is suitable for cartilage staining, visualization of mucin distribution, evaluation of intestinal metaplasia in gastrointestinal tissues, and the auxiliary identification of mucin-producing epithelial tumors.

Cell Biology Cell Analysis Staining Kit

/
HY-K0605 AB—PAS Staining Kit

MCE AB—PAS Staining Kit for Glycogen and Mucopolysaccharides combines Alcian Blue staining and PAS staining, allowing the simultaneous detection and differentiation of different types of mucins within the same tissue section. In this method, acidic mucins are typically stained blue, neutral mucins appear red or magenta, and mucins containing both acidic and neutral components may appear purple or bluish-purple. This technique is widely used in histological and pathological studies for the identification and distribution analysis of mucin types within tissues.

Cell Biology Cell Analysis Staining Kit

/
HY-K1046 L-Glutamine (100×), Sterile

L-glutamine is an important amino acid supplement commonly added to mammalian cell culture media. L-glutamine serves as an auxiliary energy source, especially when cells are rapidly dividing. L-glutamine is also important in the production of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate, other amino acids, and plays a role in protein synthesis and glucose production.

Cell Biology Cell Culture Cell Culture Supplements

/
HY-K3038 Sodium Bicarbonate Solution (7.5%)

MCE Sodium Bicarbonate Solution (7.5%) is designed to adjust the bicarbonate buffering system of cell culture media. Under appropriate CO2 culture conditions, sodium bicarbonate helps maintain physiological pH, neutralizes acidic metabolites produced by cellular metabolism, and provides a stable environment for cell growth. It also supplies bicarbonate ions required for certain cellular metabolic processes.

Cell Biology Cell Culture Cell Culture Supplements

/
HY-K3045 Advanced MEM Reduced-Serum Medium, no L-Glutamine, no HEPES

MCE Advanced MEM Reduced-Serum Medium (with Phenol Red, Sodium Pyruvate, and Non-Essential Amino Acids; without L-Glutamine or HEPES) is a reduced-serum medium optimized from classic Minimum Essential Medium (MEM) for the routine culture and proliferation of various mammalian cells.

Cell Biology Cell Culture Basal Cell Culture Media

/

Keywords

gut microbiome, ageing trajectories, healthy ageing, frailty, inflammaging, centenarians, bile acids, fecal microbiota transplantation, microbiome metabolites