2. Gene
  3. Hdac3 - histone deacetylase 3 Gene

Hdac3 - histone deacetylase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 15183 | Gene type: protein coding

About Hdac3

Chromosome 18: 38,068,897-38,088,069 reverse strand.GRCm39:CM001011.3

This gene has 6 transcripts (splice variants), 155 orthologues, 10 paralogues and is associated with 7 phenotypes. Ubiquitous expression in CNS E14 (RPKM 54.1), limb E14.5 (RPKM 54.1) and 28 other tissues.

Summary

Enables chromatin DNA binding activity and protein deacetylase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including histone H4-K12 deacetylation; negative regulation of cardiac muscle cell differentiation; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hdac3 Products(1)

mRNA Protein Name
NM_010411.2 NP_034541.2 histone deacetylase 3

Hdac3 Protein Structure

HDAC3

HDAC3: cd10005 (2 - 382)

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  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

histone deacetylase 3

HD3

HDAC3 splicing HDAC3alpha

HDAC3 splicing HDAC3beta

HDAC3 splicing HDAC3delta

HDAC3 splicing HDAC3gamma

protein deacetylase HDAC3

protein deacylase HDAC3

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.95% Yes
HY-109015 Tucidinostat Inhibitor 98.70% Unkown
HY-12164 Mocetinostat Inhibitor 99.43% Yes
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Phase
HY-12163 Entinostat Inhibitor 99.65% Phase 3
HY-50934 Tacedinaline Inhibitor 99.55% Phase 3
HY-10990 Abexinostat Inhibitor 98.61% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-14718 Resminostat Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
Pre-clinical Phase
Bioactive Molecules (89)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13909 RGFP966 Inhibitor 99.81% Unkown
HY-13428 Tubacin Inhibitor 95.50% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-16699 Nexturastat A Inhibitor 99.03% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-100719 BRD-6929 Inhibitor 99.04% Unkown
HY-16425 RG2833 Inhibitor 99.86% Unkown
HY-19618 BRD3308 Inhibitor 98.82% Unkown
HY-104008 ACY-957 Inhibitor 99.87% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.39% Unkown
HY-N0071 Crotonoside Inhibitor 99.64% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-153358 TNG260 Inhibitor 99.91% Unkown
HY-19328 ACY-775 Inhibitor 99.83% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-18976 UF010 99.84% Unkown
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor ≥98.0% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-18712 BG45 Inhibitor 99.96% Unkown
HY-13267 Droxinostat Inhibitor 98.91% Unkown
HY-116818 Crebinostat Inhibitor 99.79% Unkown
HY-100384 NKL 22 Inhibitor 97.27% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-119017 SB-429201 Inhibitor 98.99% Unkown
HY-114483 AES-135 Inhibitor 98.21% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-138831 AES-350 Inhibitor 98.02% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-124053 BRD2492 Inhibitor 99.18% Unkown
HY-146346 HD-TAC7 Inhibitor 98.45% Unkown
HY-102083 BRD4884 Inhibitor ≥99.0% Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-149669 PH14 Inhibitor 98.23% Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-161154 HDAC3-IN-3 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-152174 HDAC-IN-52 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-117374 HDAC3-IN-1 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-109015S Tucidinostat-d4 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac3 NCBI NCBI:8841