Hdac3 - histone deacetylase 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15183

About Hdac3

Chromosome 18: 38,068,897-38,088,069 reverse strand.GRCm39:CM001011.3

This gene has 6 transcripts (splice variants), 155 orthologues, 10 paralogues and is associated with 7 phenotypes. Ubiquitous expression in CNS E14 (RPKM 54.1), limb E14.5 (RPKM 54.1) and 28 other tissues.

Summary

Enables chromatin DNA binding activity and protein deacetylase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including histone H4-K12 deacetylation; negative regulation of cardiac muscle cell differentiation; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hdac3 Products (1)

mRNA Protein Name
NM_010411.2 NP_034541.2 histone deacetylase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14980219 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
18458156 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15832170 MGI
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
17464331 MGI
enables histone deacetylase activity IMP
IMP: Inferred from mutant phenotype
15832170 MGI
enables histone decrotonylase activity IDA
IDA: Inferred from direct assay
30279482 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11641275 MGI
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
17158926 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
17158926 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within circadian regulation of gene expression IGI
IGI: Inferred from genetic interaction
19037247 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26776516 MGI
involved in cornified envelope assembly IMP
IMP: Inferred from mutant phenotype
32467224 MGI
involved in epidermis development IMP
IMP: Inferred from mutant phenotype
32467224 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
32467224 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
32467224 MGI
involved in in utero embryonic development IMP
IMP: Inferred from mutant phenotype
32467224 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
24565863 MGI
acts upstream of or within negative regulation of cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
24565863 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17158926 MGI
acts upstream of or within neural precursor cell proliferation IDA
IDA: Inferred from direct assay
25556659 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28614293 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
26776516 MGI
involved in random inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
25915022 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
26776516 MGI
acts upstream of or within regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
10542131 MGI
acts upstream of or within regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
19037247 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19463978 MGI
Cellular Component GO Annotation Evidence References Source
is active in chromatin IDA
IDA: Inferred from direct assay
25556659 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17158926 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17158926 MGI
is active in nucleus IPI
IPI: Inferred from physical interaction
32467224 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac3 Protein Structure

HDAC3

HDAC3: cd10005 (2 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

histone deacetylase 3

  • HD3

  • HDAC3 splicing HDAC3alpha

  • HDAC3 splicing HDAC3beta

  • HDAC3 splicing HDAC3delta

  • HDAC3 splicing HDAC3gamma

  • protein deacetylase HDAC3

  • protein deacylase HDAC3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-B0494 Bufexamac Inhibitor 98.47% Unkown
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-14718 Resminostat Inhibitor 99.44% Phase 4
HY-12163 Entinostat Inhibitor 99.98% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-101780 Tinostamustine Inhibitor 99.64% Phase 3
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-153358 TNG260 Inhibitor 99.33% Phase 2
HY-100748 Zabadinostat Inhibitor 99.83% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-16425 RG2833 Inhibitor 99.31% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1

Pre-clinical Phase

Bioactive Molecules (172)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13909 RGFP966 Inhibitor 99.81% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-125771 1-Stearoyl-sn-glycero-3-phosphocholine Inhibitor 99.53% Unkown
HY-19618 BRD3308 Inhibitor 98.34% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-100719 BRD-6929 Inhibitor 99.01% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-103596 Thalidomide-4-OH Degrader 99.62% Unkown
HY-N0071 Crotonoside Inhibitor 99.78% Unkown
HY-19328 ACY-775 Inhibitor 99.71% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-104008 ACY-957 Inhibitor 99.63% Unkown
HY-13267 Droxinostat Inhibitor 99.08% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-102083 BRD4884 Inhibitor 99.14% Unkown
HY-164233 YX968 Degrader 98.06% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-18976 UF010 99.83% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-149669 PH14 Inhibitor 99.29% Unkown
HY-145815A JPS014 TFA 98.12% Unkown
HY-18712 BG45 Inhibitor 99.95% Unkown
HY-14718A Resminostat hydrochloride Inhibitor 99.67% Yes
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor 95.0% Unkown
HY-116818 Crebinostat Inhibitor 98.83% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-146346 HD-TAC7 Degrader 98.53% Unkown
HY-124053 BRD2492 Inhibitor 99.22% Unkown
HY-114483 AES-135 Inhibitor 98.68% Unkown
HY-119017 SB-429201 Inhibitor 98.15% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-145819 JPS036 99.31% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-125771S 1-Stearoyl-sn-glycero-3-phosphocholine-d35 Inhibitor 99% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-142690A HDAC-IN-27 dihydrochloride Inhibitor 99.08% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-138831 AES-350 Inhibitor 99.30% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-117374 HDAC3-IN-1 Inhibitor 99.28% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-168287 HDAC3/8 ligand-1 / Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-168863 FF2049 Degrader / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-181640 HDAC1/3-IN-1 Inhibitor 99.81% Unkown
HY-145816 JPS016 / Unkown
HY-182720 FT108 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-175805 EGFR/HDAC-IN-2 Inhibitor / Unkown
HY-176561 IOR-160 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-179654 ST13 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-P11678 HDAC-IN-100 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-162769 HDAC3-IN-5 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-172136 LSQ-28 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-183150 HDAC1-IN-13 Inhibitor / Unkown
HY-173520 EGFR/HDAC-IN-1 Inhibitor / Unkown
HY-145815 JPS014 / Unkown
HY-181767 PROTAC HDAC3 degrader-1 Degrader / Unkown
HY-178110 HDAC6-IN-65 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-179682 HDAC3 degrader-1 Degrader / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-184398 cGAS/HDAC-IN-1 Inhibitor / Unkown
HY-175671 LSD1/HDAC-IN-3 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-179271 CA/HDAC-IN-1 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-163894 HDAC6-IN-48 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-161154 HDAC3-IN-3 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-172359 PROTAC HDAC6 degrader 4 Degrader / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-172601 HDAC3-IN-7 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-176904 JPS004 Degrader / Unkown
HY-162487 HDAC-IN-72 Inhibitor / Unkown
HY-184415 Syk/HDAC6-IN-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-145818 JPS035 Degrader / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-142690 HDAC-IN-27 Inhibitor 98.12% Unkown
HY-119316 CM-414 Inhibitor / Unkown
HY-178333 HDAC6-IN-66 Inhibitor / Unkown
HY-172891 CDK9/HDAC1/HDAC3-IN-1 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-153514 HDAC-IN-54 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-181768 HDAC3-IN-8 Inhibitor / Unkown
HY-119316A CM-545 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-13432A Nanatinostat TFA Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-172133 HDAC3-IN-6 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-172889 PI3K/HDAC-IN-4 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-N16881 Andrographidine E Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-168175 PROTAC HDAC8 Degrader-2 Degrader / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-184525 HDAC6-IN-85 Inhibitor 97.58% Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-172167 PD-L1/HDAC-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac3 NCBI NCBI:8841