Hdac3 - histone deacetylase 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84578

About Hdac3

Primary_assembly 18: 29,770,636-29,793,856 reverse strand.mRatBN7.2:CM026991.1

This gene has 4 transcripts (splice variants), 59 orthologues, 12 paralogues and is associated with 25 phenotypes. Biased expression in Thymus (RPKM 182.1), Lung (RPKM 168.9) and 9 other tissues.

Summary

Enables GTPase binding activity; chromatin binding activity; and deacetylase activity. Contributes to histone deacetylase activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cytokine production; and positive regulation of apoptotic process. Located in chromatin; cytoplasm; and nucleus. Biomarker of acute kidney failure and impotence. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hdac3 Products (1)

mRNA Protein Name
NM_053448.2 NP_445900.2 histone deacetylase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
22679019 RGD
enables chromatin binding IMP
IMP: Inferred from mutant phenotype
22679019 RGD
enables deacetylase activity IDA
IDA: Inferred from direct assay
23868068 RGD
contributes to histone deacetylase activity IDA
IDA: Inferred from direct assay
17079677 RGD
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
17079677 RGD
enables ubiquitin-specific protease binding IPI
IPI: Inferred from physical interaction
17079677 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19261284 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
20097749 RGD
involved in negative regulation of interleukin-1 production IMP
IMP: Inferred from mutant phenotype
22772764 RGD
involved in negative regulation of protein export from nucleus IMP
IMP: Inferred from mutant phenotype
21695276 RGD
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22772764 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21289184 RGD
involved in positive regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22772764 RGD
involved in protein modification process IDA
IDA: Inferred from direct assay
17079677 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
20538901 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
21763752 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18550052 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
17456789 RGD
located in nucleus IDA
IDA: Inferred from direct assay
17079677 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac3 Protein Structure

HDAC3

HDAC3: cd10005 (2 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

histone deacetylase 3

  • HD3

  • protein deacetylase HDAC3

  • protein deacylase HDAC3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-B0494 Bufexamac Inhibitor 98.47% Unkown
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-14718 Resminostat Inhibitor 99.44% Phase 4
HY-12163 Entinostat Inhibitor 99.98% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-101780 Tinostamustine Inhibitor 99.64% Phase 3
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-153358 TNG260 Inhibitor 99.33% Phase 2
HY-100748 Zabadinostat Inhibitor 99.83% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-16425 RG2833 Inhibitor 99.31% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1

Pre-clinical Phase

Bioactive Molecules (172)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13909 RGFP966 Inhibitor 99.81% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-125771 1-Stearoyl-sn-glycero-3-phosphocholine Inhibitor 99.53% Unkown
HY-19618 BRD3308 Inhibitor 98.34% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-100719 BRD-6929 Inhibitor 99.01% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-103596 Thalidomide-4-OH Degrader 99.62% Unkown
HY-N0071 Crotonoside Inhibitor 99.78% Unkown
HY-19328 ACY-775 Inhibitor 99.71% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-104008 ACY-957 Inhibitor 99.63% Unkown
HY-13267 Droxinostat Inhibitor 99.08% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-102083 BRD4884 Inhibitor 99.14% Unkown
HY-164233 YX968 Degrader 98.06% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-18976 UF010 99.83% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-149669 PH14 Inhibitor 99.29% Unkown
HY-145815A JPS014 TFA 98.12% Unkown
HY-18712 BG45 Inhibitor 99.95% Unkown
HY-14718A Resminostat hydrochloride Inhibitor 99.67% Yes
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor 95.0% Unkown
HY-116818 Crebinostat Inhibitor 98.83% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-146346 HD-TAC7 Degrader 98.53% Unkown
HY-124053 BRD2492 Inhibitor 99.22% Unkown
HY-114483 AES-135 Inhibitor 98.68% Unkown
HY-119017 SB-429201 Inhibitor 98.15% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-145819 JPS036 99.31% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-125771S 1-Stearoyl-sn-glycero-3-phosphocholine-d35 Inhibitor 99% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-142690A HDAC-IN-27 dihydrochloride Inhibitor 99.08% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-138831 AES-350 Inhibitor 99.30% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-117374 HDAC3-IN-1 Inhibitor 99.28% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-168287 HDAC3/8 ligand-1 / Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-168863 FF2049 Degrader / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-145816 JPS016 / Unkown
HY-181640 HDAC1/3-IN-1 Inhibitor 99.81% Unkown
HY-182720 FT108 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-176561 IOR-160 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-175805 EGFR/HDAC-IN-2 Inhibitor / Unkown
HY-179654 ST13 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-162769 HDAC3-IN-5 Inhibitor / Unkown
HY-P11678 HDAC-IN-100 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-172136 LSQ-28 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-183150 HDAC1-IN-13 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-173520 EGFR/HDAC-IN-1 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-178110 HDAC6-IN-65 Inhibitor / Unkown
HY-145815 JPS014 / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-181767 PROTAC HDAC3 degrader-1 Degrader / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-179682 HDAC3 degrader-1 Degrader / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-184398 cGAS/HDAC-IN-1 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-175671 LSD1/HDAC-IN-3 Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-179271 CA/HDAC-IN-1 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-163894 HDAC6-IN-48 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-161154 HDAC3-IN-3 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-172359 PROTAC HDAC6 degrader 4 Degrader / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-172601 HDAC3-IN-7 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-162487 HDAC-IN-72 Inhibitor / Unkown
HY-184415 Syk/HDAC6-IN-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-176904 JPS004 Degrader / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-145818 JPS035 Degrader / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-178333 HDAC6-IN-66 Inhibitor / Unkown
HY-142690 HDAC-IN-27 Inhibitor 98.12% Unkown
HY-172891 CDK9/HDAC1/HDAC3-IN-1 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-153514 HDAC-IN-54 Inhibitor / Unkown
HY-119316 CM-414 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-181768 HDAC3-IN-8 Inhibitor / Unkown
HY-119316A CM-545 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-13432A Nanatinostat TFA Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-172133 HDAC3-IN-6 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-172889 PI3K/HDAC-IN-4 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-N16881 Andrographidine E Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-168175 PROTAC HDAC8 Degrader-2 Degrader / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-184525 HDAC6-IN-85 Inhibitor 97.58% Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-172167 PD-L1/HDAC-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac3 NCBI NCBI:8841