2. Gene
  3. Hdac3 - histone deacetylase 3 Gene

Hdac3 - histone deacetylase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 84578 | Gene type: protein coding

About Hdac3

Primary_assembly 18: 29,770,636-29,793,856 reverse strand.mRatBN7.2:CM026991.1

This gene has 4 transcripts (splice variants), 59 orthologues, 12 paralogues and is associated with 25 phenotypes. Biased expression in Thymus (RPKM 182.1), Lung (RPKM 168.9) and 9 other tissues.

Summary

Enables GTPase binding activity; chromatin binding activity; and deacetylase activity. Contributes to histone deacetylase activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cytokine production; and positive regulation of apoptotic process. Located in chromatin; cytoplasm; and nucleus. Biomarker of acute kidney failure and impotence. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hdac3 Products(1)

mRNA Protein Name
NM_053448.2 NP_445900.2 histone deacetylase 3

Hdac3 Protein Structure

HDAC3

HDAC3: cd10005 (2 - 382)

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  • 428 a.a.
Protein Preferred Names Protein Names

histone deacetylase 3

HD3

protein deacetylase HDAC3

protein deacylase HDAC3

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.95% Yes
HY-109015 Tucidinostat Inhibitor 98.70% Unkown
HY-12164 Mocetinostat Inhibitor 99.43% Yes
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Phase
HY-12163 Entinostat Inhibitor 99.65% Phase 3
HY-50934 Tacedinaline Inhibitor 99.55% Phase 3
HY-10990 Abexinostat Inhibitor 98.61% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-14718 Resminostat Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
Pre-clinical Phase
Bioactive Molecules (89)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13909 RGFP966 Inhibitor 99.81% Unkown
HY-13428 Tubacin Inhibitor 95.50% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-16699 Nexturastat A Inhibitor 99.03% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-100719 BRD-6929 Inhibitor 99.04% Unkown
HY-16425 RG2833 Inhibitor 99.86% Unkown
HY-19618 BRD3308 Inhibitor 98.82% Unkown
HY-104008 ACY-957 Inhibitor 99.87% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.39% Unkown
HY-N0071 Crotonoside Inhibitor 99.64% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-153358 TNG260 Inhibitor 99.91% Unkown
HY-19328 ACY-775 Inhibitor 99.83% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-18976 UF010 99.84% Unkown
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor ≥98.0% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-13267 Droxinostat Inhibitor 98.91% Unkown
HY-18712 BG45 Inhibitor 99.96% Unkown
HY-116818 Crebinostat Inhibitor 99.79% Unkown
HY-100384 NKL 22 Inhibitor 97.27% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-119017 SB-429201 Inhibitor 98.99% Unkown
HY-114483 AES-135 Inhibitor 98.21% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-138831 AES-350 Inhibitor 98.02% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-124053 BRD2492 Inhibitor 99.18% Unkown
HY-146346 HD-TAC7 Inhibitor 98.45% Unkown
HY-102083 BRD4884 Inhibitor ≥99.0% Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-149669 PH14 Inhibitor 98.23% Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-161154 HDAC3-IN-3 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-152174 HDAC-IN-52 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-117374 HDAC3-IN-1 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-109015S Tucidinostat-d4 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac3 NCBI NCBI:8841