JAK2 - Janus kinase 2 Gene

Also Known as JTK10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3717

About JAK2

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:4,984,390-5,129,948 (from NCBI)

This gene has 4 transcripts (splice variants), 265 orthologues, 32 paralogues and is associated with 132 phenotypes. Ubiquitous expression in appendix (RPKM 11.3), heart (RPKM 11.1) and 24 other tissues.

Summary

This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]

JAK2 Products (9)

mRNA	Protein	Name
NM_001322195.2	NP_001309124.1	tyrosine-protein kinase JAK2 isoform a
NM_001322199.2	NP_001309128.1	tyrosine-protein kinase JAK2 isoform c
NM_001322198.2	NP_001309127.1	tyrosine-protein kinase JAK2 isoform c
NM_004972.4	NP_004963.1	tyrosine-protein kinase JAK2 isoform a
NR_169763.1
NM_001322204.2	NP_001309133.1	tyrosine-protein kinase JAK2 isoform b
NM_001322194.2	NP_001309123.1	tyrosine-protein kinase JAK2 isoform a
NR_169764.1
NM_001322196.2	NP_001309125.1	tyrosine-protein kinase JAK2 isoform a

JAK2 Protein Structure

SH2

Pkinase_Tyr

0
200
400
600
800
1000
1132 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase JAK2	JAK-2 Janus kinase 2 (a protein tyrosine kinase)

JAK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	JAK2	O60674	CSF2RB	Homo sapiens	P32927	Anti Bait CoIP	18692472
Intra	JAK2	O60674	Slc40a1	Mus musculus	Q9JHI9	Anti Tag CoIP	19234114
Intra	JAK2	O60674	Slc40a1	Mus musculus	Q9JHI9	Anti Bait CoIP	19234114
Intra	JAK2	O60674	ROCK2	Homo sapiens	O75116	Anti Bait CoIP	30413785
Intra	JAK2	O60674	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	JAK2	O60674	UBP1	Homo sapiens	Q9NZI7	Anti Tag CoIP	25852190
Intra	JAK2	O60674	UBP1	Homo sapiens	Q9NZI7	Anti Tag CoIP	33961781
Intra	JAK2	O60674	PTPN1	Homo sapiens	P18031	Phosphatase Assay	21806020

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant JAK2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7989	Janus kinase 2/JAK2 Protein, Human (His)	O60674-1 (S833-G1132)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701102	Janus kinase 2/JAK2 Protein, Human (381a.a, His)	O60674-1 (H752-G1132)	≥ 90%, as determined by reducing SDS-PAGE.

JAK2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80421	JAK2 Antibody (YA721)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P80467	Phospho-JAK2 (Tyr1007+Tyr1008) Antibody (YA181)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
HY-P80727	JAK2 Antibody (YA330)	WB	Human, Mouse
HY-P80727A	JAK2 Antibody (YA330)(PBS only)	WB	Human, Mouse
HY-P83853	JAK2 Antibody (YA3550)	WB, ELISA	Human
HY-P83853A	JAK2 Antibody (YA3550)(PBS only)	WB, ELISA	Human
HY-P86385	JAK2 Antibody (YA6077)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Sm-Ahnmd	Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Haematological Non-Mast Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Hematological Non-Mast-Cell Lineage Disease
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Amegakaryocytic Thrombocytopenia, Congenital	Congenital Amegakaryocytic Thrombocytopenia CAMT Thrombocytopenia, Congenital Amegakaryocytic Congenital Amegakaryocytic Thrombocytopenic Purpura Thrombocytopenia Congenital Amegakaryocytic Thrombocytopenia, Amegakaryocytic, Congenital
Stress Polycythemia	Gaisbock'S Syndrome Polycythemia, Emotional Pseudopolycythaemia Gaisboeck'S Syndrome Pseudopolycythemia Gaisbock Syndrome Stress Erythrocytosis Pseudo-Polycythemia Relative Erythrocytosis
Immunodeficiency 35	Tyrosine Kinase 2 Deficiency IMD35 Tyk2 Deficiency Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis Susceptibility To Infection Due To Tyk2 Deficiency Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive Hies With Atypical Mycobacteriosis, Autosomal Recessive Autosomal Recessiv Hies With Atypical Mycobacteriosis Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency Autosomal Recessive Hies With Atypical Mycobacteriosis
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement	Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukaemia Atypical Chronic Myeloid Leukemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Erythroleukemia
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Papilledema	Choked Disk Edema Of The Optic Disc
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Primary Mediastinal B-Cell Lymphoma	Large Cell Lymphoma Of The Mediastinum Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Neutrophilia, Hereditary	Hereditary Neutrophilia NEUTROPHILIA Leukocytosis Disorders With Increased Neutrophil Counts
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Thrombocythemia 3	THCYT3 Thrombocytosis 3
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Acquired Von Willebrand Syndrome	Acquired Von Willebrand Disease Willebrand Disease, Acquired Avws
B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like	B Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like B-All Bcr-Abl1-Like
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Primary Polycythemia	Familial Erythrocytosis Familiar Polycythemia Benign Familial Polycythemia Congenital Erythrocytosis Familial Polycythemia Hereditary Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Familial Polycythemia Vera Primary Familial Polycythaemia Primary Inherited Polycythaemia
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic/Myeloproliferative Disease Myelodysplastic-Myeloproliferative Diseases Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Portal Hypertension	Hypertension, Portal Hypertension Portal Pht - [Portal Hypertension] Portal Htn
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Antithrombin Iii Deficiency	Hereditary Antithrombin Deficiency Hereditary Thrombophilia Due To Congenital Antithrombin Deficiency Congenital Antithrombin Iii Deficiency AT3D Thrombophilia Due To Antithrombin Iii Deficiency Thph7 Hereditary Thrombophilia Due To Congenital Antithrombin 3 Deficiency Thrombophilia 7 Due To Antithrombin Iii Deficiency At Iii Deficiency Congenital At-Iii Deficiency Inherited Antithrombin Deficiency Antithrombin 3 Deficiency Antithrombin Deficiency Antithrombin-Iii Deficiency At-Iii Deficiency Thrombophilia Due To Antithrombin-Iii Deficiency
Budd-Chiari Syndrome	Hepatic Vein Thrombosis BDCHS Membranous Obstruction Of The Inferior Vena Cava Chiari Syndrome Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Myelophthisic Anemia	Myelophthisis Anemia Leukoerythroblastic Anemia, Leukoerythroblastic Leukoerythroblastosis Anemia, Myelophthisic Leukoerythroblastic Anemia
Acquired Polycythemia	Secondary Polycythemia Polycythemia, Secondary Secondary Erythrocytosis Polycythemia Secondary
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Chronic Neutrophilic Leukemia	Cnl Leukemia Neutrophilic Chronic
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Thrombophilia	Hypercoagulability State
Erythrocytosis, Familial, 2	Chuvash Polycythemia ECYT2 Familial Erythrocytosis 2 Autosomal Recessive Benign Erythrocytosis Polycythemia, Vhl-Dependent Chuvash Erythromatosis Chuvash Type Polycythemia Chuvash Erythrocytosis Von Hippel-Lindau-Dependent Polycythemia Polycythemia Chuvash Type Vhl-Dependent Polycythemia Erythrocytosis, Familial, Type 2
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Sagittal Sinus Thrombosis	Thrombosis Of Superior Longitudinal Sinus Thrombosis Of Superior Sagittal Sinus Thrombosis Superior Sagittal Sinus
Hepatic Vascular Disease	Vascular Disorder Of Liver
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Lymphoblastic Leukemia, Acute, With Lymphomatous Features	LALL Lymphomatous All Leukemia, Acute Lymphoblastic Acute Lymphoblastic Leukemia With Lymphomatous Features
Erythrocytosis, Familial, 6	ECYT6 Erythrocytosis 6 Familial Erythrocytosis 6 Erythrocytosis, Beta-Globin Type Polycythemia, Beta-Globin Type Beta-Globin Type Erythrocytosis Beta-Globin Type Polycythemia
Hemangioblastoma	Capillary Hemangioblastoma
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Splenic Infarction	Splenic Infarct Splenic Infarcts Infarct Of The Spleen
Vein Disease	Disorder Of Vein
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Hyperglycemia
Portal Vein Thrombosis	Phlebitis Of Portal Vein Deep Vein Thrombosis Of Portal Vein Portal Thrombosis Pvt - [Portal Vein Thrombosis] Portal Venous Thrombosis Portal Venous Embolism Portal Venous Obstruction Portal Venous Block Portal Vein Embolism Portal Vein Block Portal Obstruction Portal Embolism Portal Block Hepatic Portal Vein Obstruction Occlusion Of Hepatic Portal Vein Portal Vein Obstruction
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Erythromelalgia	Primary Erythromelalgia Erythermalgia Primary Erythermalgia Mitchell Disease Familial Erythromelalgia
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Thrombosis	Thrombosis Of Blood Vessel
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Wernicke Encephalopathy	Wernicke'S Encephalopathy Wernicke'S Disease Encephalopathy, Wernicke'S Wernicke-Korsakoff Syndrome Encephalopathy Due To Vitamin B1 Deficiency Wernicke Disease Wernicke Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction Leptin
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Erythrocytosis, Familial, 1	ECYT1 Pfcp Primary Familial And Congenital Polycythemia Familial Erythrocytosis 1 Familial Erythrocytosis Polycythemia, Primary Familial And Congenital Autosomal Dominant Benign Erythrocytosis Familial Erythrocytosis Type 1 Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation Congenital Polycythemia Due To Erythropoietin Receptor Mutation Primary Congenital Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Autosomal Dominant Benign Erythrocytosis, Somatic Autosomal Dominant Familial Erythrocytosis-1 Erythrocytosis Autosomal Dominant Benign Familial Primary Polycythemia Familial Erythrocytosis, 1 Erythrocytosis, Familial, Type 1
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Acute Salpingo-Oophoritis	Acute Salpingitis And Oophoritis
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Splenomegaly
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Thrombocytosis	Thrombocythaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (25)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-50856	Ruxolitinib	Inhibitor	99.99%	Yes
HY-40354	Tofacitinib	Inhibitor	99.99%	Yes
HY-19569	Upadacitinib	Inhibitor	99.98%	Yes
HY-15315	Baricitinib	Inhibitor	99.97%	Yes
HY-10409	Fedratinib	Inhibitor	99.87%	Yes
HY-50858	Ruxolitinib phosphate	Inhibitor	99.97%	Yes
HY-40354A	Tofacitinib citrate	Inhibitor	99.94%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-107429	Abrocitinib	Inhibitor	99.26%	Unkown
HY-18300	Filgotinib	Inhibitor	99.77%	Yes
HY-19568	Peficitinib	Inhibitor	99.43%	Yes
HY-15315A	Baricitinib phosphate	Inhibitor	99.97%	Yes
HY-10409A	Fedratinib hydrochloride hydrate	Inhibitor	99.92%	Yes
HY-109053	Delgocitinib	Inhibitor	99.61%	Unkown
HY-13577	Oclacitinib	Inhibitor	99.03%	Unkown
HY-50867	Lestaurtinib	Inhibitor	99.66%	Unkown
HY-13577A	Oclacitinib monomaleate	Inhibitor	99.87%	Unkown
HY-15728	Radotinib	Inhibitor	99.19%	Yes
HY-50856S	Deuruxolitinib	Inhibitor	99.18%	Unkown
HY-18300A	Filgotinib maleate	Inhibitor	99.88%	Yes
HY-50859	Ruxolitinib sulfate	Inhibitor	/	Unkown
HY-19569A	Upadacitinib tartrate tetrahydrate	Inhibitor	/	Unkown
HY-19568A	Peficitinib hydrobromide	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-19568B	Peficitinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (33)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-155785	MTP	Inhibitor	/	Phase 4
HY-10961	Momelotinib	Inhibitor	98.93%	Phase 3
HY-112708	Brepocitinib	Inhibitor	99.97%	Phase 3
HY-50514	AT9283	Inhibitor	99.67%	Phase 3
HY-15999	Cerdulatinib	Inhibitor	99.06%	Phase 3
HY-12469	Decernotinib	Inhibitor	99.91%	Phase 3
HY-10962	Momelotinib sulfate	Inhibitor	98.63%	Phase 3
HY-112724	Ivarmacitinib	Inhibitor	99.62%	Phase 3
HY-13775	XL019	Inhibitor	99.65%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	98.96%	Phase 3
HY-109038	Mocravimod	Activator	98.39%	Phase 3
HY-10963	Momelotinib mesylate	Inhibitor	/	Phase 3
HY-15312	WP1066	Inhibitor	99.53%	Phase 2
HY-10193	AZD-1480	Inhibitor	99.74%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.86%	Phase 2
HY-130247	Flonoltinib	Inhibitor	99.48%	Phase 2
HY-15270	BMS-911543	Inhibitor	98.23%	Phase 2
HY-19631A	Ilginatinib	Inhibitor	99.81%	Phase 2
HY-156961	Cadefrecitinib	Inhibitor	99.81%	Phase 2
HY-112708A	Brepocitinib P-Tosylate	Inhibitor	99.99%	Phase 2
HY-15163	Zotiraciclib	Inhibitor	99.88%	Phase 2
HY-109179	Itacnosertib	Inhibitor	99.06%	Phase 2
HY-19631B	Ilginatinib hydrochloride	Inhibitor	98.92%	Phase 2
HY-19631	Ilginatinib maleate	Inhibitor	99.33%	Phase 2
HY-130247A	Flonoltinib TFA	Inhibitor	98.94%	Phase 2
HY-10058	AT9283 lactic acid	Inhibitor	/	Phase 2
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1
HY-101024	PF-06263276	Inhibitor	≥99.0%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Phase 1
HY-112809	GSK2646264	Inhibitor	99.74%	Phase 1
HY-124067	EC-70124	Inhibitor	/	Phase 1
HY-16449	SB1578	Inhibitor	/	Phase 1
HY-16021	AC-430	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (134)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-148748	Butyzamide	Activator	99.83%	Unkown
HY-18960	CHZ868	Inhibitor	98.69%	Unkown
HY-N1405	Cucurbitacin I	Inhibitor	99.60%	Unkown
HY-14435	Pyridone 6	Inhibitor	98.20%	Unkown
HY-15480	NSC 42834	Inhibitor	96.85%	Unkown
HY-15166	(E/Z)-Zotiraciclib	Inhibitor	99.96%	Unkown
HY-145696	SJ10542	Inhibitor	99.32%	Unkown
HY-15343	CEP-33779	Inhibitor	99.23%	Unkown
HY-145551	Atinvicitinib	Inhibitor	98.62%	Unkown
HY-151902	SJ988497	Degrader	99.03%	Unkown
HY-N0885	Telocinobufagin	Inhibitor	99.93%	Unkown
HY-N2963	Broussonin E	Activator	98.11%	Unkown
HY-113573	Protosappanin A		99.95%	Unkown
HY-10411	AZ960	Inhibitor	97.08%	Unkown
HY-14722	NVP-BSK805	Inhibitor	99.30%	Unkown
HY-10410	TG101209	Inhibitor	98.81%	Unkown
HY-100895	SAR-20347	Inhibitor	97.27%	Unkown
HY-108264	TCS 21311	Inhibitor	99.49%	Unkown
HY-137756	JAK2-IN-6	Inhibitor	97.07%	Unkown
HY-N1356	Reticuline	Inhibitor	98.89%	Unkown
HY-113787	(R)-9b	Inhibitor	99.51%	Unkown
HY-15166A	(E/Z)-Zotiraciclib hydrochloride	Inhibitor	99.90%	Unkown
HY-151262	JAK-IN-23	Inhibitor	98.88%	Unkown
HY-N0918	Desmethoxyyangonin	Inhibitor	99.00%	Unkown
HY-146186	JAK2 JH2 binder-1	Modulator	95.40%	Unkown
HY-153701S	Envudeucitinibum	Inhibitor	99.56%	Unkown
HY-115452	G5-7	Inhibitor	98.45%	Unkown
HY-14722A	NVP-BSK805 dihydrochloride	Inhibitor	99.36%	Unkown
HY-19544	JAK3-IN-1	Inhibitor	99.31%	Unkown
HY-15166B	(E/Z)-Zotiraciclib citrate	Inhibitor	99.83%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	98.31%	Unkown
HY-150720	TYK2-IN-12	Inhibitor	98.81%	Unkown
HY-124858	SC99	Inhibitor	98.90%	Unkown
HY-N3239	Mulberrofuran G	Inhibitor	97.86%	Unkown
HY-109179A	Itacnosertib hydrochloride	Inhibitor	99.43%	Unkown
HY-139423	JAK1-IN-8	Inhibitor	95.0%	Unkown
HY-143444	JAK-IN-20	Inhibitor	99.63%	Unkown
HY-120469	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	Inhibitor	99.80%	Unkown
HY-169326S	JAK2-IN-11	Inhibitor	98.03%	Unkown
HY-147330B	SJ1008030 formic	Inhibitor	98.91%	Unkown
HY-147330A	SJ1008030 TFA	Inhibitor	98.12%	Unkown
HY-179715	PROTAC JAK1/2 degrader-1	Degrader	99.47%	Unkown
HY-153440	Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate	Inhibitor	98.01%	Unkown
HY-162248	JAK1/2-IN-1	Inhibitor	98.36%	Unkown
HY-111750	JAK-IN-3	Inhibitor	98.92%	Unkown
HY-N0143A	Phlorizin dihydrate	Antagonist	99.51%	Unkown
HY-124727	ZT55	Inhibitor	99.51%	Unkown
HY-169853	M351-0056	Inhibitor	99.48%	Unkown
HY-167846	YLIU-4-105-1	Inhibitor	99.39%	Unkown
HY-126141	JAK/HDAC-IN-1	Inhibitor	98.63%	Unkown
HY-13961	GLPG0634 analog	Inhibitor	98.07%	Unkown
HY-164393	ON044580	Inhibitor	99.11%	Unkown
HY-161684	JAK2-IN-10	Inhibitor	97.97%	Unkown
HY-116505	JAK1-IN-4	Inhibitor	99.26%	Unkown
HY-152080	Blovacitinib	Inhibitor	99.71%	Unkown
HY-179716	JAK1/2 ligand 1	Ligand	99.91%	Unkown
HY-100849	JAK 3i	Inhibitor	99.81%	Unkown
HY-112391	SD-1029	Inhibitor	88.8%	Unkown
HY-120692	Cyclanoline chloride	Inhibitor	96.27%	Unkown
HY-159536	Frevecitinib	Inhibitor	99.42%	Unkown
HY-125542	DCZ3301	Inhibitor	99.73%	Unkown
HY-148060	JAK-IN-21	Inhibitor	99.72%	Unkown
HY-161618	MJ04	Inhibitor	98.08%	Unkown
HY-170772	Dual Cathepsin L/JAK-IN-1	Inhibitor	98.47%	Unkown
HY-143884	JAK2/TYK2-IN-1	Inhibitor	99.94%	Unkown
HY-107595	SD-1008	Inhibitor	99.10%	Unkown
HY-181929	RAI-20	Inhibitor	98.66%	Unkown
HY-14722C	NVP-BSK805 trihydrochloride	Inhibitor	/	Unkown
HY-184063	Vexicitinib	Inhibitor	/	Unkown
HY-151259	TK4b	Inhibitor	/	Unkown
HY-178282	JAK1-IN-19	Inhibitor	/	Unkown
HY-170723	JAK-IN-39	Inhibitor	/	Unkown
HY-149296	JAK1-IN-12	Inhibitor	/	Unkown
HY-115541	BRD4-IN-41		/	Unkown
HY-179428	JAK2-IN-17	Inhibitor	/	Unkown
HY-151256	JAK-2/3-IN-2	Inhibitor	/	Unkown
HY-177131	Soficitinib	Inhibitor	/	Unkown
HY-151258	TK4g	Inhibitor	/	Unkown
HY-156959	Ovalicin	Inhibitor	/	Unkown
HY-151285	JAK-2/3-IN-3	Inhibitor	/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-180766	JAK2-IN-19	Inhibitor	/	Unkown
HY-146727	JAK3-IN-11	Inhibitor	/	Unkown
HY-178936	JAK2-IN-15	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-W064657	Momelotinib dihydrochloride	Inhibitor	/	Unkown
HY-174999	JAK3-IN-18	Inhibitor	/	Unkown
HY-P10840	Tkip	Inhibitor	95.16%	Unkown
HY-183670	JAK2-IN-21	Inhibitor	/	Unkown
HY-161967	JAK2/FLT3-IN-3	Inhibitor	/	Unkown
HY-144440	JAK1-IN-9	Inhibitor	/	Unkown
HY-155746	JAK2-IN-9	Inhibitor	/	Unkown
HY-183370	JAK2/STAT3-IN-2	Inhibitor	/	Unkown
HY-174428	PROTAC JAK2 degrader-1	Degrader	/	Unkown
HY-N13352	Bufothionine	Inhibitor	/	Unkown
HY-179687	JAK2-IN-18	Inhibitor	/	Unkown
HY-161139	JAK1-IN-14	Inhibitor	/	Unkown
HY-178448	EGFR-IN-178	Inhibitor	/	Unkown
HY-175684	JAK2-IN-14	Inhibitor	/	Unkown
HY-108342	PF-00956980	Inhibitor	/	Unkown
HY-180274	JAK1/2-IN-3	Inhibitor	/	Unkown
HY-162885	YSY01A	Degrader	/	Unkown
HY-136734	JAK2-IN-5	Inhibitor	/	Unkown
HY-182430	NVP-BVB808	Inhibitor	/	Unkown
HY-10652	JAK-2/3-IN-1	Inhibitor	/	Unkown
HY-154994	JAK-IN-30	Inhibitor	/	Unkown
HY-183272	PI3K/Akt/mTOR-IN-7	Inhibitor	/	Unkown
HY-181691	JAK2-IN-20	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-117810	JAK2-IN-1	Inhibitor	/	Unkown
HY-177006	JAK1/2-IN-2	Inhibitor	/	Unkown
HY-174430	WWQ-131	Inhibitor	/	Unkown
HY-175610	PROTAC FLT3/JAK2/BRD4 Degrader-1	Degrader	/	Unkown
HY-N14094	Tubulosine	Inhibitor	/	Unkown
HY-18293	NSC 33994	Inhibitor	/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-129341	WP1193	Inhibitor	/	Unkown
HY-176793	JAK1-IN-18	Inhibitor	/	Unkown
HY-175611	FLT3/JAK2/BRD4 ligand-1	Ligand	/	Unkown
HY-174988	JAK2-IN-13	Inhibitor	/	Unkown
HY-147975	JAK3-IN-12	Inhibitor	/	Unkown
HY-160919	JAK2-IN-16	Inhibitor	/	Unkown
HY-168269	Tyk2-IN-20	Inhibitor	/	Unkown
HY-129679	NMS-P953	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-119009	TM-233	Inhibitor	/	Unkown
HY-183519	AH057	Inhibitor	/	Unkown
HY-157121	JAK-IN-34	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inhibitor	/	Unkown
HY-123187	AS2553627	Inhibitor	/	Unkown
HY-N8098	Pulchinenoside E2	Inhibitor	99.28%	Unkown
HY-130247B	Flonoltinib monomaleate	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inducer	/	Unkown
HY-124595	MPT0B098		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JAK2	VGNC	VGNC:73811
Bos taurus	JAK2	VGNC	VGNC:30365
Canis familiaris	JAK2	VGNC	VGNC:42176
Mus musculus	JAK2	MGD	MGI:96629
Felis catus	JAK2	VGNC	VGNC:67877
Rattus norvegicus	JAK2	RGD	RGD:2939
Others	JAK2	NCBI