Hdac2 - histone deacetylase 2 Gene

Also Known as YAF1; Yy1bp; mRPD3; D10Wsu179e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15182

About Hdac2

Chromosome 10: 36,850,540-36,877,885 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 43 phenotypes. Broad expression in CNS E11.5 (RPKM 72.6), CNS E14 (RPKM 53.5) and 19 other tissues.

Summary

Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including histone modification; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hdac2 Products (1)

mRNA Protein Name
NM_008229.2 NP_032255.2 histone deacetylase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
33795231 MGI
enables Krueppel-associated box domain binding IPI
IPI: Inferred from physical interaction
21177534 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24137001 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
18458156 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
17392792 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
20972425 MGI
enables histone H4K16 deacetylase activity IMP
IMP: Inferred from mutant phenotype
23516383 MGI
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
12975471 MGI
enables histone deacetylase activity IGI
IGI: Inferred from genetic interaction
12975471 MGI
enables histone decrotonylase activity IDA
IDA: Inferred from direct assay
30279482 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10888872 MGI
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
18754010 MGI
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
12007404 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of or within cellular response to trichostatin A IDA
IDA: Inferred from direct assay
24137001 MGI
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
15226430 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
18754010 MGI
involved in embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in epidermal cell differentiation IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in eyelid development in camera-type eye IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in fungiform papilla formation IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in hair follicle placode formation IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
19380719 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18754010 MGI
involved in negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19503085 MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in negative regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
24675724 MGI
involved in negative regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
24675724 MGI
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
18754010 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10431247 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
19380719 MGI
involved in odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
19503085 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20833366 MGI
involved in positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
19503085 MGI
involved in protein deacetylation IDA
IDA: Inferred from direct assay
18754010 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of or within regulation of protein deacetylation IGI
IGI: Inferred from genetic interaction
20833366 MGI
acts upstream of or within regulation of sarcomere organization IMP
IMP: Inferred from mutant phenotype
17322895 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription repressor complex IDA
IDA: Inferred from direct assay
12007404 MGI
located in chromatin IDA
IDA: Inferred from direct assay
12007404 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
14519686 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20720167 MGI
located in replication fork IDA
IDA: Inferred from direct assay
10888872 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
17182846 MGI
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
17182846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac2 Protein Structure

HDAC2

HDAC2: cd10011 (8 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

histone deacetylase 2

  • HD2

  • YY1 transcription factor-binding protein

  • protein deacylase HDAC2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-10585 Valproic acid Inhibitor 99.89% Unkown
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-10585A Valproic acid sodium Inhibitor 99.65% Unkown
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes
HY-10585B Valproic acid sodium (2:1) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-12163 Entinostat Inhibitor 99.98% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-100748 Zabadinostat Inhibitor 99.83% Phase 2
HY-16012A Domatinostat Inhibitor 99.34% Phase 2
HY-101780 Tinostamustine Inhibitor 99.64% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-13432A Nanatinostat TFA Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1
HY-164782 PT3 Inhibitor 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (172)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0931 Santacruzamate A Inhibitor 99.54% Unkown
HY-13428 Tubacin Inhibitor 97.11% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-19618 BRD3308 Inhibitor 98.34% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-100719 BRD-6929 Inhibitor 99.01% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-19328 ACY-775 Inhibitor 99.71% Unkown
HY-104008 ACY-957 Inhibitor 99.63% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-102083 BRD4884 Inhibitor 99.14% Unkown
HY-18976 UF010 99.83% Unkown
HY-10585R Valproic acid (Standard) Inhibitor 99.97% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-145815A JPS014 TFA Degrader 98.12% Unkown
HY-18712 BG45 Inhibitor 99.95% Unkown
HY-150109 Purinostat mesylate Inhibitor 99.45% Unkown
HY-117709 BRD6688 Inhibitor 98.06% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-116818 Crebinostat Inhibitor 98.83% Unkown
HY-172762 S234984 99.46% Unkown
HY-124295 Imofinostat Inhibitor 99.40% Unkown
HY-146346 HD-TAC7 Degrader 98.53% Unkown
HY-124053 BRD2492 Inhibitor 99.22% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-150109A Purinostat Inhibitor 98.04% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-145819 JPS036 99.31% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-142690A HDAC-IN-27 dihydrochloride Inhibitor 99.08% Unkown
HY-156422 KPZ560 Inhibitor 99.72% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-124337 BG48 Inhibitor 99.09% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-149721 HDAC4-IN-1 Inhibitor 98.11% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-117583 cis-BG47 Inhibitor 98.02% Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor 95.17% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-W103792 4-Phenylcinnamic acid Inhibitor ≥97.0% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-117374 HDAC3-IN-1 Inhibitor 99.28% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-180224 HDAC6-IN-70 Inhibitor / Unkown
HY-145816 JPS016 / Unkown
HY-179654 ST13 Inhibitor / Unkown
HY-153514 HDAC-IN-54 Inhibitor / Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-176904 JPS004 Degrader / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-172394 ZSNI-21 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-119316 CM-414 Inhibitor / Unkown
HY-13906 Largazole Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-183150 HDAC1-IN-13 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-173160 HDAC1-IN-10 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-181768 HDAC3-IN-8 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-185554B (R)-HDAC-IN-102 Inhibitor / Unkown
HY-178161 HDAC degrader-2 Degrader / Unkown
HY-175671 LSD1/HDAC-IN-3 Inhibitor / Unkown
HY-175021 HDAC-IN-91 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-177768 HDAC-IN-96 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-108919 CG-1521 Inhibitor 95.71% Unkown
HY-172889 PI3K/HDAC-IN-4 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-142690 HDAC-IN-27 Inhibitor 98.12% Unkown
HY-176561 IOR-160 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-162487 HDAC-IN-72 Inhibitor / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-P11678 HDAC-IN-100 Inhibitor / Unkown
HY-179655 ST17 / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-145818 JPS035 / Unkown
HY-162769 HDAC3-IN-5 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-124792 MRLB-223 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-119316A CM-545 Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-172159 FF2039 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-179374 Aurora kinase/HDAC-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-125645 M122 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-181843 HDAC-IN-99 Inhibitor / Unkown
HY-182321 HDAC2-IN-3 Inhibitor / Unkown
HY-179216 KTT-1 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-172359 PROTAC HDAC6 degrader 4 Degrader / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-161667 GSK-3β/HDAC-IN-1 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-145815 JPS014 / Unkown
HY-178336 AC-340 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-172167 PD-L1/HDAC-IN-1 Inhibitor / Unkown
HY-117583A BG47 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac2 NCBI NCBI:3066