2. Gene
  3. Hdac2 - histone deacetylase 2 Gene

Hdac2 - histone deacetylase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as YAF1; Yy1bp; mRPD3; D10Wsu179e

Gene ID: 15182 | Gene type: protein coding

About Hdac2

Chromosome 10: 36,850,540-36,877,885 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 43 phenotypes. Broad expression in CNS E11.5 (RPKM 72.6), CNS E14 (RPKM 53.5) and 19 other tissues.

Summary

Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including histone modification; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hdac2 Products(1)

mRNA Protein Name
NM_008229.2 NP_032255.2 histone deacetylase 2

Hdac2 Protein Structure

HDAC2

HDAC2: cd10011 (8 - 373)

  • 0
  • 100
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  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

histone deacetylase 2

HD2

YY1 transcription factor-binding protein

protein deacylase HDAC2

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.95% Yes
HY-10585 Valproic acid Inhibitor ≥98.0% Unkown
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-109015 Tucidinostat Inhibitor 98.70% Unkown
HY-10585A Valproic acid sodium Inhibitor 98.14% Unkown
HY-12164 Mocetinostat Inhibitor 99.43% Yes
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-10585B Valproic acid (sodium)(2:1) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-12163 Entinostat Inhibitor 99.65% Phase 3
HY-50934 Tacedinaline Inhibitor 99.55% Phase 3
HY-10990 Abexinostat Inhibitor 98.61% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
Pre-clinical Phase
Bioactive Molecules (88)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0931 Santacruzamate A Inhibitor 99.04% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-13428 Tubacin Inhibitor 95.50% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-16699 Nexturastat A Inhibitor 99.03% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-100719 BRD-6929 Inhibitor 99.04% Unkown
HY-104008 ACY-957 Inhibitor 99.87% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.39% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-19328 ACY-775 Inhibitor 99.83% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-18976 UF010 99.84% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-18712 BG45 Inhibitor 99.96% Unkown
HY-116818 Crebinostat Inhibitor 99.79% Unkown
HY-100384 NKL 22 Inhibitor 97.27% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-117583 cis-BG47 Inhibitor 98.02% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-117709 BRD6688 Inhibitor 98.90% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor / Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-124053 BRD2492 Inhibitor 99.18% Unkown
HY-156422 KPZ560 Inhibitor / Unkown
HY-146346 HD-TAC7 Inhibitor 98.45% Unkown
HY-102083 BRD4884 Inhibitor ≥99.0% Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-149721 HDAC4-IN-1 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-152174 HDAC-IN-52 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-117374 HDAC3-IN-1 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-109015S Tucidinostat-d4 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-162377 HDAC-IN-70 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac2 NCBI NCBI:3066