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Results for "

(-)-Epipodophyllotoxin

" in MedChemExpress (MCE) Product Catalog:

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阻害剤およびアゴニスト

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天然物

製品番号 製品名 Target 研究分野 構造式
  • HY-N7654
    (-)-Epipodophyllotoxin

    		Apoptosis Cancer
    (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro .
    (-)-Epipodophyllotoxin
  • HY-N2812
    Epipodophyllotoxin acetate

    4-O-Epipodophyllotoxinyl acetate

    		 HSV VSV Infection Cancer
    Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits HSV and VSV, with IC50s of 0.2 and 0.1 μg/mL, respectively .
    Epipodophyllotoxin acetate
  • HY-106122
    NK-611

    VP 19

    		 Topoisomerase DNA/RNA Synthesis Cancer
    NK-611 (VP 19) is an epipodophyllotoxin derivative. NK-611 induces DNA double-strand breaks by inhibiting topoisomerase II (IC50 = 56 μM). NK-611 does not inhibit microtubule polymerization, thus avoiding the side effects of the parent compound, Podofilox (HY-15552). NK-611 exhibits broad-spectrum antitumor activity and demonstrates potent efficacy in in vivo models of leukemia. NK-611 can be used in cancer research .
    NK-611

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