HDAC2 - histone deacetylase 2 Gene

Also Known as HD2; RPD3; YAF1; KDAC2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3066

About HDAC2

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:113,933,028-113,971,148 (from NCBI)

This gene has 17 transcripts (splice variants), 205 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 14.8), endometrium (RPKM 10.6) and 25 other tissues.

Summary

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

HDAC2 Products (4)

mRNA	Protein	Name
NR_033441.2
NR_073443.2
NM_001527.4	NP_001518.3	histone deacetylase 2
XM_047418692.1	XP_047274648.1	histone deacetylase 2 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	17785205	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17827154	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11062478	GOA
enables histone binding	IDA IDA: Inferred from direct assay	19276356	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	16642021	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	28046085	GOA
enables histone decrotonylase activity	IDA IDA: Inferred from direct assay	28497810	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9150135	GOA
enables protein de-2-hydroxyisobutyrylase activity	IDA IDA: Inferred from direct assay	29192674	GOA
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	19041327	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA
involved in heterochromatin formation	IMP IMP: Inferred from mutant phenotype	19372552	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19041327	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19041327	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	19276356	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18347167	GOA
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	19041327	GOA
acts upstream of positive regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	18316616	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19041327	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	20075857	GOA
part of NuRD complex	IDA IDA: Inferred from direct assay	17827154	GOA
part of Sin3-type complex	IDA IDA: Inferred from direct assay	14966270	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	25150861	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24970816	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	9651585	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18347167	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28046085	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC2 Protein Structure

Hist_deacetyl

0
100
200
300
400
488 a.a.

Protein Preferred Names	Protein Names
histone deacetylase 2	YY1-associated factor 1 protein deacylase HDAC2 transcriptional regulator homolog RPD3

HDAC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Cross	HDAC2	Q92769	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Pull Down	33060197
Intra	HDAC2	Q92769	ZNF516	Homo sapiens	Q92618	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Crosslink	26949739
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	22416134
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	9150135
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Crosslink	26949739
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Pull Down	16254079
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	SUV39H1	Homo sapiens	O43463	Pull Down	12711603
Intra	HDAC2	Q92769	MYC	Homo sapiens	P01106	Display Tech	20195357
Intra	HDAC2	Q92769	BCL11B	Homo sapiens	Q9C0K0	Anti Tag CoIP	17245431
Intra	HDAC2	Q92769	BCL11B	Homo sapiens	Q9C0K0	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Crosslink	26949739
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Bait CoIP	20651739
Intra	HDAC2	Q92769	BRMS1	Homo sapiens	Q9HCU9	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	BRMS1	Homo sapiens	Q9HCU9	Anti Tag CoIP	16919237
Intra	HDAC2	Q92769	BRMS1	Homo sapiens	Q9HCU9	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	SRA1	Homo sapiens	Q9HD15	Anti Bait CoIP	20398657
Intra	HDAC2	Q92769	DAXX	Homo sapiens	Q9UER7	CoIP	12140263
Intra	HDAC2	Q92769	MBD1	Homo sapiens	Q9UIS9	Pull Down	12711603
Cross	HDAC2	Q92769	K8	Human herpesvirus 8	Q2HR82	Anti Bait CoIP	22416134
Intra	HDAC2	Q92769	RFX5	Homo sapiens	P48382	Anti Bait CoIP	16464847
Intra	HDAC2	Q92769	RFX5	Homo sapiens	P48382	Anti Tag CoIP	16464847

Cross: Cross-species interaction Intra: Intraspecies interaction

HDAC2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80151	HDAC2 Antibody (YA393)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
HY-P80699	HDAC2 Antibody (YA742)	WB, ICC/IF	Human, Mouse, Rat, Monkey
HY-P80699A	HDAC2 Antibody (YA742)(PBS only)	WB, ICC/IF	Human, Mouse, Rat, Monkey
HY-P86612	HDAC2 Antibody (YA6304)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation Rts
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Primary Hyperoxaluria	Hyperoxaluria, Primary Oxalosis Hyperoxaluria Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures	OPA10 Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures Optic Atrophy 10 Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson-Gilford Disease Hutchinson Gilford Progeria Syndrome Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Otopalatodigital Syndrome, Type I	Otopalatodigital Syndrome Type 1 Taybi Syndrome OPD1 Opd Syndrome 1 Oto-Palato-Digital Syndrome Type 1 Opd I Syndrome Oto-Palato-Digital Syndrome, Type I Otopalatodigital Syndrome Type I Opd Syndrome Cranioorodigital Syndrome Faciopalatoosseous Syndrome Fpo Opd Syndrome, Type 1 Otopalatodigital Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-10221	Vorinostat	Inhibitor	99.96%	Yes
HY-10585	Valproic acid	Inhibitor	99.90%	Unkown
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-10585A	Valproic acid sodium	Inhibitor	99.65%	Unkown
HY-109015	Tucidinostat	Inhibitor	98.74%	Unkown
HY-12164	Mocetinostat	Inhibitor	99.68%	Yes
HY-14842	Givinostat	Inhibitor	98.67%	Yes
HY-13322	Pracinostat	Inhibitor	99.80%	Yes
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	99.63%	Yes
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Yes
HY-10585B	Valproic acid sodium (2:1)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (17)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-12163	Entinostat	Inhibitor	99.98%	Phase 3
HY-50934	Tacedinaline	Inhibitor	99.32%	Phase 3
HY-10990	Abexinostat	Inhibitor	99.00%	Phase 3
HY-175513	ZWZH-21	Inhibitor	/	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	99.71%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-100748	Zabadinostat	Inhibitor	99.83%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.34%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.64%	Phase 2
HY-13432	Nanatinostat	Inhibitor	99.67%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-13432A	Nanatinostat TFA	Inhibitor	/	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.55%	Phase 1
HY-164782	PT3	Inhibitor	99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (174)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-N0931	Santacruzamate A	Inhibitor	99.54%	Unkown
HY-13428	Tubacin	Inhibitor	97.11%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-19618	BRD3308	Inhibitor	98.34%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.69%	Unkown
HY-100719	BRD-6929	Inhibitor	99.01%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-18613	CAY10603	Inhibitor	99.76%	Unkown
HY-111400	SR-4370	Inhibitor	98.38%	Unkown
HY-19328	ACY-775	Inhibitor	99.71%	Unkown
HY-104008	ACY-957	Inhibitor	99.63%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-102083	BRD4884	Inhibitor	99.14%	Unkown
HY-18976	UF010		99.83%	Unkown
HY-10585R	Valproic acid (Standard)	Inhibitor	99.97%	Unkown
HY-19348	Pimelic Diphenylamide 106	Inhibitor	98.54%	Unkown
HY-145815A	JPS014 TFA	Degrader	98.12%	Unkown
HY-18712	BG45	Inhibitor	99.95%	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-117709	BRD6688	Inhibitor	98.06%	Unkown
HY-172762	S234984		99.46%	Unkown
HY-135714	Bavarostat	Inhibitor	99.51%	Unkown
HY-124295	Imofinostat	Inhibitor	99.40%	Unkown
HY-116818	Crebinostat	Inhibitor	98.83%	Unkown
HY-100871	WT-161	Inhibitor	98.04%	Unkown
HY-124053	BRD2492	Inhibitor	99.22%	Unkown
HY-146346	HD-TAC7	Degrader	98.53%	Unkown
HY-150109A	Purinostat	Inhibitor	98.04%	Unkown
HY-19747	HPOB	Inhibitor	99.54%	Unkown
HY-100384	NKL 22	Inhibitor	97.26%	Unkown
HY-145819	JPS036		99.31%	Unkown
HY-18700	BRD73954	Inhibitor	99.13%	Unkown
HY-142690A	HDAC-IN-27 dihydrochloride	Inhibitor	99.08%	Unkown
HY-126141	JAK/HDAC-IN-1	Inhibitor	98.63%	Unkown
HY-156422	KPZ560	Inhibitor	99.72%	Unkown
HY-110280	MC1742	Inhibitor	98.95%	Unkown
HY-124337	BG48	Inhibitor	99.09%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-152174	HDAC-IN-52	Inhibitor	99.46%	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	98.11%	Unkown
HY-148624	CHDI-00484077	Inhibitor	98.38%	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.12%	Unkown
HY-P3364A	Ac-QPKK(Ac)-AMC acetate	Substrate	99.38%	Unkown
HY-157740	XSJ-10	Inhibitor	95.16%	Unkown
HY-109015S	Tucidinostat-d4	Inhibitor	98.63%	Unkown
HY-169938	LSD1/HDAC-IN-2	Inhibitor	/	Unkown
HY-117583	cis-BG47	Inhibitor	98.02%	Unkown
HY-W103792	4-Phenylcinnamic acid	Inhibitor	≥97.0%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-149208	HDAC-IN-53	Inhibitor	95.73%	Unkown
HY-117374	HDAC3-IN-1	Inhibitor	99.28%	Unkown
HY-157388	CARM1/HDAC2-IN-1	Inhibitor	95.17%	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-128582	PI3K/HDAC-IN-1	Inhibitor	/	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-143497	HDAC1/2 and CDK2-IN-1	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-145816	JPS016		/	Unkown
HY-144332	PHD2/HDACs-IN-1	Inhibitor	/	Unkown
HY-161524	HDAC6-IN-43	Inhibitor	/	Unkown
HY-176868	Rodin-C	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-184203	SM-06-09	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-184415	Syk/HDAC6-IN-1	Inhibitor	/	Unkown
HY-163282	NB512	Inhibitor	/	Unkown
HY-13906	Largazole	Inhibitor	/	Unkown
HY-P11678	HDAC-IN-100	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-144293	HDAC-IN-31	Inhibitor	/	Unkown
HY-181843	HDAC-IN-99	Inhibitor	/	Unkown
HY-183150	HDAC1-IN-13	Inhibitor	/	Unkown
HY-161783	HDAC6-IN-45	Inhibitor	/	Unkown
HY-119316A	CM-545	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-182747	HDAC6-IN-79	Inhibitor	/	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-175030	TNI-97	Inhibitor	/	Unkown
HY-172159	FF2039	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-157481	HDAC1-IN-6	Inhibitor	/	Unkown
HY-179272	Wee1/HDAC-IN-1	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-173064	DS-103	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-179019	HDAC-IN-94	Inhibitor	/	Unkown
HY-175671	LSD1/HDAC-IN-3	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-173330	HDAC-IN-89	Inhibitor	/	Unkown
HY-146392	HDAC-IN-39	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	98.71%	Unkown
HY-179216	KTT-1	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-115941	HDAC-IN-9	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-177768	HDAC-IN-96	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-161667	GSK-3β/HDAC-IN-1	Inhibitor	/	Unkown
HY-172889	PI3K/HDAC-IN-4	Inhibitor	/	Unkown
HY-152173	HDAC-IN-51	Inhibitor	/	Unkown
HY-178336	AC-340	Inhibitor	/	Unkown
HY-142690	HDAC-IN-27	Inhibitor	98.12%	Unkown
HY-154855	HDAC-IN-56	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-179654	ST13	Inhibitor	/	Unkown
HY-184574	HDAC-IN-104	Inhibitor	/	Unkown
HY-162487	HDAC-IN-72	Inhibitor	/	Unkown
HY-172394	ZSNI-21	Inhibitor	/	Unkown
HY-179655	ST17		/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-176904	JPS004	Degrader	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-119316	CM-414	Inhibitor	/	Unkown
HY-124792	MRLB-223	Inhibitor	/	Unkown
HY-174302	PIM-1/HDAC-IN-2	Inhibitor	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-162769	HDAC3-IN-5	Inhibitor	/	Unkown
HY-182321	HDAC2-IN-3	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-145818	JPS035		/	Unkown
HY-173160	HDAC1-IN-10	Inhibitor	/	Unkown
HY-181009	HDAC-IN-98	Inhibitor	98.36%	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-174398	GSK-3β/HDAC-IN-2	Inhibitor	/	Unkown
HY-181768	HDAC3-IN-8	Inhibitor	/	Unkown
HY-149946	HDAC-IN-57	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-162319	Tubulin/HDAC-IN-4	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-15433B	Quisinostat hydrochloride	Inhibitor	/	Unkown
HY-175021	HDAC-IN-91	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-185554B	(R)-HDAC-IN-102	Inhibitor	/	Unkown
HY-178161	HDAC degrader-2	Degrader	/	Unkown
HY-125645	M122	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-172359	PROTAC HDAC6 degrader 4	Degrader	/	Unkown
HY-179374	Aurora kinase/HDAC-IN-1	Inhibitor	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-181579	HDAC6-IN-74	Inhibitor	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-176733	HDAC6-IN-61	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-170379	HDAC-IN-84	Inhibitor	/	Unkown
HY-145815	JPS014		/	Unkown
HY-151248	HDAC2-IN-1	Inhibitor	/	Unkown
HY-108919	CG-1521	Inhibitor	95.71%	Unkown
HY-162910	HDAC-IN-79	Inhibitor	/	Unkown
HY-180224	HDAC6-IN-70	Inhibitor	/	Unkown
HY-183560	HDAC6-IN-82	Inhibitor	/	Unkown
HY-153514	HDAC-IN-54	Inhibitor	/	Unkown
HY-147840	HDAC-IN-41	Inhibitor	/	Unkown
HY-176561	IOR-160	Inhibitor	/	Unkown
HY-168962	HDAC-IN-88	Inhibitor	/	Unkown
HY-162955	LSD1/HDAC-IN-1	Inhibitor	/	Unkown
HY-117583A	BG47	Inhibitor	/	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown
HY-172167	PD-L1/HDAC-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HDAC2	RGD	RGD:619976
Canis familiaris	HDAC2	VGNC	VGNC:49101
Mus musculus	HDAC2	MGD	MGI:1097691
Bos taurus	HDAC2	VGNC	VGNC:50610
Felis catus	HDAC2	VGNC	VGNC:97454
Macaca mulatta	HDAC2	VGNC	VGNC:73358
Others	HDAC2	NCBI