2. Gene
  3. Bax - BCL2 associated X, apoptosis regulator Gene

Bax - BCL2 associated X, apoptosis regulator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24887 | Gene type: protein coding

About Bax

Primary_assembly 1: 95,938,808-95,945,368 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 204 orthologues, 13 paralogues and is associated with 97 phenotypes. Biased expression in Spleen (RPKM 111.1), Thymus (RPKM 15.) and 9 other tissues.

Summary

Enables BH domain binding activity; chaperone binding activity; and heat shock protein binding activity. Involved in several processes, including glial cell apoptotic process; mitochondrion organization; and response to corticosterone. Located in cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain disease (multiple); heart disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human Bax (BCL2 associated X, Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Bax Products(1)

mRNA Protein Name
NM_017059.2 NP_058755.2 apoptosis regulator BAX

Bax Protein Structure

bcl-2

bcl-2: TIGR00865 (12 - 191)

  • 0
  • 100
  • 192 a.a.
Protein Preferred Names Protein Names

apoptosis regulator BAX

Bcl2-associated X protein

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1192 Estradiol benzoate 99.89% Unkown
HY-B1357 Digitoxin 99.36% Yes
HY-B0402A Amantadine hydrochloride Modulator ≥98.0% Yes
HY-B0621 Triclabendazole 98.72% Yes
HY-B0402B Amantadine sulfate Modulator / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13755 Sulforaphane Inhibitor 99.75% Phase 4
Pre-clinical Phase
Bioactive Molecules (43)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107202 Polyinosinic-polycytidylic acid 99.40% Unkown
HY-13594 Chlorin e6 97.24% Unkown
HY-103269 BAI1 Inhibitor 99.73% Unkown
HY-N0674 Dehydrocorydaline Modulator 99.77% Unkown
HY-P0081 Bax inhibitor peptide V5 Inhibitor 98.28% Unkown
HY-123054 BTSA1 Activator 99.49% Unkown
HY-N0361 Dihydrocapsaicin Modulator 99.86% Unkown
HY-13755A (R)-Sulforaphane Inhibitor 99.37% Unkown
HY-120079 MSN-125 Inhibitor 99.00% Unkown
HY-N0831 Jaceosidin Activator 99.51% Unkown
HY-13108 Bz 423 Activator 99.72% Unkown
HY-N6626 Pyraclostrobin 99.91% Unkown
HY-P1928 Humanin Inhibitor ≥95.0% Unkown
HY-15341 BAM7 Activator 98.53% Unkown
HY-118948 MSN-50 Inhibitor 98.40% Unkown
HY-W082785A L6H21 Modulator 99.46% Unkown
HY-132173 GL0388 Activator 98.01% Unkown
HY-N9802 n-Butyl-β-D-fructofuranoside Activator ≥97.0% Unkown
HY-122760 Bax activator-1 Activator 98.45% Unkown
HY-108164 Aspidin BB Modulator 98.08% Unkown
HY-157176 BAX-IN-1 Inhibitor ≥98.0% Unkown
HY-N1157 Thevetiaflavone Modulator ≥98.0% Unkown
HY-147889 BBR-BODIPY Activator 98.15% Unkown
HY-148368 CYD-4-61 Activator / Unkown
HY-N0831R Jaceosidin (Standard) Activator / Unkown
HY-147929 Apoptotic agent-3 Activator / Unkown
HY-N10313 Dehydrobruceine B Modulator / Unkown
HY-162360 EGFR-IN-109 Inhibitor / Unkown
HY-146105 Anticancer agent 65 Modulator / Unkown
HY-101996 SMBA1 Agonist / Unkown
HY-P3148 Astin B Modulator / Unkown
HY-151428 Antitumor agent-78 Inhibitor / Unkown
HY-117652 Lobetyol Modulator / Unkown
HY-151429 Antitumor agent-77 Inhibitor / Unkown
HY-150540 Bcl-2-IN-10 Inhibitor / Unkown
HY-144791 Bcl-2-IN-6 Modulator / Unkown
HY-146548 Anticancer agent 43 Inducer 98.58% Unkown
HY-147514 Anticancer agent 64 Modulator / Unkown
HY-146253 CDK1/2/4-IN-1 Activator / Unkown
HY-147928 Apoptotic agent-2 Activator / Unkown
HY-144792 Bcl-2-IN-7 Modulator / Unkown
HY-143235 BRD4 Inhibitor-15 Modulator / Unkown
HY-N10481 Aviculin Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bax NCBI NCBI:581