Bax - BCL2 associated X, apoptosis regulator Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24887

About Bax

Primary_assembly 1: 95,938,808-95,945,368 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 204 orthologues, 13 paralogues and is associated with 97 phenotypes. Biased expression in Spleen (RPKM 111.1), Thymus (RPKM 15.) and 9 other tissues.

Summary

Enables BH domain binding activity; chaperone binding activity; and heat shock protein binding activity. Involved in several processes, including glial cell apoptotic process; mitochondrion organization; and response to corticosterone. Located in cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain disease (multiple); heart disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human Bax (BCL2 associated X, Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Bax Products (1)

mRNA Protein Name
NM_017059.2 NP_058755.2 apoptosis regulator BAX

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
12070120 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15004018 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
12070120 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular respiration IDA
IDA: Inferred from direct assay
12460673 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
25726415 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9813151 RGD
involved in glial cell apoptotic process IEP
IEP: Inferred from expression pattern
18931364 RGD
involved in inner mitochondrial membrane organization IDA
IDA: Inferred from direct assay
12460673 RGD
involved in outer mitochondrial membrane organization IDA
IDA: Inferred from direct assay
12460673 RGD
involved in ovarian follicle development IEP
IEP: Inferred from expression pattern
17570453 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9804769 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20385067 RGD
involved in release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
10724126 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
17084983 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
18289470 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
17562391 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
24089674 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
31583047 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17784886 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
10724126 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
15044178 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11299004 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bax Protein Structure

bcl-2

bcl-2: TIGR00865 (12 - 191)

  • 0
  • 100
  • 192 a.a.
Protein Preferred Names Protein Names

apoptosis regulator BAX

  • Bcl2-associated X protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1192 Estradiol benzoate 99.90% Unkown
HY-B1357 Digitoxin 99.22% Yes
HY-B0402 Amantadine Modulator 99.90% Unkown
HY-B0402A Amantadine hydrochloride Modulator 98.0% Yes
HY-B0621 Triclabendazole 99.36% Yes
HY-B0402B Amantadine sulfate Modulator / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-13755 Sulforaphane Inhibitor 99.75% Phase 4
HY-13560 AVN-944 Modulator 99.92% Phase 2
HY-18006 NKP608 Inhibitor 99.88% Phase 2
HY-168739 Topoisomerase I inhibitor 17 Activator / Phase 2
HY-141876 PRT543 Activator / Phase 1
HY-165550 Sphingosine Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991883 Metuzumab Modulator / Phase 4

Pre-clinical Phase

Bioactive Molecules (172)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107202 Polyinosinic-polycytidylic acid 99.40% Unkown
HY-N0171A Beta-Sitosterol (purity>98%) 99.74% Unkown
HY-103269 BAI1 Inhibitor 99.68% Unkown
HY-107202A Poly (I:C):Kanamycin (1:1) 48.6% Unkown
HY-W250111 Carboxymethyl chitosan Activator 90% Unkown
HY-P0081 Bax inhibitor peptide V5 Inhibitor 99.90% Unkown
HY-N0361 Dihydrocapsaicin Modulator 99.93% Unkown
HY-N0674 Dehydrocorydaline Modulator 99.77% Unkown
HY-B1971 Deltamethrin 99.96% Unkown
HY-120079 MSN-125 Inhibitor 99.67% Unkown
HY-13755A (R)-Sulforaphane Inhibitor 99.95% Unkown
HY-P1928 Humanin Inhibitor 99.73% Unkown
HY-N0060B (E)-Ferulic acid Activator 99.82% Unkown
HY-123054 BTSA1 Activator 99.77% Unkown
HY-157334 DEG-77 Activator 99.03% Unkown
HY-N6626 Pyraclostrobin 99.91% Unkown
HY-118948 MSN-50 Inhibitor 98.09% Unkown
HY-N0831 Jaceosidin Activator 99.51% Unkown
HY-W017982 CMIT/MIT (14.5% in water) Modulator 97.0% Unkown
HY-126437 Poly-L-lysine hydrobromide (MW 30000-70000) Inhibitor / Unkown
HY-W082785A L6H21 Modulator 99.19% Unkown
HY-13108 Bz 423 Activator 99.72% Unkown
HY-P2970 Stem bromelain Modulator / Unkown
HY-N2067 Vanillyl alcohol 99.68% Unkown
HY-N6005 Methyl caffeate Modulator 99.89% Unkown
HY-N6801 Nivalenol Activator 99.9% Unkown
HY-P1380A Difopein TFA Inhibitor 95.35% Unkown
HY-N0475 Triptophenolide Activator 99.98% Unkown
HY-N0699 Daphnoretin Inhibitor 99.83% Unkown
HY-N0566 23-Hydroxybetulinic acid 99.44% Unkown
HY-101310 SYM 2081 Activator 98.0% Unkown
HY-126421 Kansuinine A Modulator 99.81% Unkown
HY-N0905 Ginsenoside Rh4 Activator 99.28% Unkown
HY-157176 BAX-IN-1 Inhibitor 98.05% Unkown
HY-N1983 Caudatin 99.95% Unkown
HY-N0307 Ciwujianoside B Inhibitor 99.68% Unkown
HY-15341 BAM7 Activator 99.20% Unkown
HY-N2135 Puerarin 6''-O-Xyloside 99.81% Unkown
HY-N5008 Macranthoside B Modulator 99.95% Unkown
HY-132173 GL0388 Activator 99.22% Unkown
HY-W674241 4-Ethylphenyl sulfate / Unkown
HY-147929 Apoptotic agent-3 Activator 98.19% Unkown
HY-N1423B Glycocholic acid hydrate Modulator 99.85% Unkown
HY-101996 SMBA1 Agonist 99.5800% Unkown
HY-N0320 Salvianolic acid D Modulator 95.15% Unkown
HY-P2040 Nodularin Activator 99.85% Unkown
HY-147785 Pim-1 kinase inhibitor 2 Modulator 99.91% Unkown
HY-N1157 Thevetiaflavone Modulator 99.83% Unkown
HY-172262 WEHI-3773 Inhibitor 99.89% Unkown
HY-N7905 Myricetin 3'-glucoside Inhibitor 99.98% Unkown
HY-148368 CYD-4-61 Activator 99.92% Unkown
HY-N0882 Desacetylcinobufotalin Modulator 99.41% Unkown
HY-W072962 WX2-43 Activator 99.49% Unkown
HY-119979 Cardanol monoene 99.51% Unkown
HY-147889 BBR-BODIPY Activator 98.15% Unkown
HY-N10144 Shinpterocarpin / Unkown
HY-161659 Apoptosis inducer 19 Modulator 98.31% Unkown
HY-108164 Aspidin BB Modulator 98.02% Unkown
HY-122760 Bax activator-1 Activator 98.45% Unkown
HY-146548 Anticancer agent 43 Inducer 98.58% Unkown
HY-N9802 n-Butyl-β-D-fructofuranoside Activator 97.0% Unkown
HY-W017982A CMIT/MIT (2.0-2.5% in water) Modulator / Unkown
HY-175021 HDAC-IN-91 Inhibitor / Unkown
HY-182349 Bax activator-2 Activator / Unkown
HY-179022 CAIX/CDK-2-IN-1 Inhibitor / Unkown
HY-117652 Lobetyol Modulator / Unkown
HY-175332 Apoptosis inducer 43 Inhibitor / Unkown
HY-174855 PI3K/mTOR-IN-17 Inhibitor / Unkown
HY-144792 Bcl-2-IN-7 Modulator / Unkown
HY-186248 BCS12 Inhibitor / Unkown
HY-162360 EGFR-IN-109 Inhibitor / Unkown
HY-180274 JAK1/2-IN-3 / Unkown
HY-181769 Anticancer agent 306 Modulator / Unkown
HY-180324 Candidone Inhibitor / Unkown
HY-N8617 Trijuganone C Activator / Unkown
HY-175037 DNH28 Inhibitor / Unkown
HY-P11374 Bid BH3-Gly-r8 Ligand / Unkown
HY-181477 ERK5-IN-7 Modulator / Unkown
HY-177208 BW-AQ-113 / Unkown
HY-182360 Cytisine-platinum(IV) prodrug-1 / Unkown
HY-175588 EGFR-IN-170 / Unkown
HY-179052 Apoptosis inducer 50 Activator / Unkown
HY-167237 Calactin Modulator / Unkown
HY-181659 EGFR-IN-201 Inhibitor / Unkown
HY-175020 QNX-10 / Unkown
HY-147928 Apoptotic agent-2 Activator / Unkown
HY-174419 TFSeB Activator / Unkown
HY-184386 Aurora kinase-IN-15 Modulator / Unkown
HY-183330 Topo I/II-IN-3 Inhibitor / Unkown
HY-179614 PARP1-IN-50 / Unkown
HY-150540 Bcl-2-IN-10 Inhibitor / Unkown
HY-107272 Chuanbeinone / Unkown
HY-181015 α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu Modulator / Unkown
HY-184448 CIB-Q22 Modulator / Unkown
HY-179155 PI3K/mTOR-IN-19 Inhibitor / Unkown
HY-178142 Multi-kinase-IN-7 Inhibitor / Unkown
HY-184250 FGFR-IN-28 Modulator / Unkown
HY-184446 CDC25A/NF-κB-IN-1 Modulator / Unkown
HY-136893 SP-6-27 Activator / Unkown
HY-176279 Hsp90-IN-42 Modulator / Unkown
HY-183327 PI3K/mTOR-IN-22 / Unkown
HY-N0831R Jaceosidin (Standard) Activator / Unkown
HY-180150 PROTAC BRD4 Degrader-42 Activator / Unkown
HY-180823 Topoisomerase II/EGFR-IN-2 Inhibitor / Unkown
HY-146105 Anticancer agent 65 Modulator / Unkown
HY-P3148 Astin B Modulator 95.0% Unkown
HY-181837 IKKβ-IN-7 Modulator / Unkown
HY-108919 CG-1521 Inhibitor 95.71% Unkown
HY-P1380 Difopein Inhibitor / Unkown
HY-180154 EGFR/BRAFV600E-IN-6 / Unkown
HY-170912 Topo I/II-IN-2 / Unkown
HY-119408 MB725 Activator / Unkown
HY-144791 Bcl-2-IN-6 Modulator / Unkown
HY-116267 MHY219 / Unkown
HY-184145 AKT1-IN-13 Inhibitor / Unkown
HY-179520 XSJ151 Modulator / Unkown
HY-181248 BChE-IN-49 Inhibitor / Unkown
HY-175815 Apoptosis inducer 44 Inhibitor / Unkown
HY-N17816 Tambulin Inhibitor / Unkown
HY-174469 PROTAC PI3K/110β degrader-2 Inhibitor / Unkown
HY-179157 MA203 Modulator / Unkown
HY-168877 FMP / Unkown
HY-183772 TBC1D2-IN-1 Modulator / Unkown
HY-146253 CDK1/2/4-IN-1 Activator / Unkown
HY-181060 Apoptosis inducer 56 Modulator / Unkown
HY-181019 iMPZ-8 / Unkown
HY-15668 ST09 Activator / Unkown
HY-172886 PI3K-IN-58 Modulator / Unkown
HY-N17440 2-Methoxyjuglone Modulator / Unkown
HY-149517 EGFR/BRAFV600E-IN-2 Activator / Unkown
HY-181061 COX/5-LO-IN-2 Modulator / Unkown
HY-178104 HDAC-IN-93 Inhibitor / Unkown
HY-N12999 Stigmast-5-en-3-ol / Unkown
HY-183069 FKL-137 Modulator / Unkown
HY-P10993 CT20p / Unkown
HY-168623 EGFR-IN-134 Inhibitor / Unkown
HY-180242 EGFR/CDK2-IN-5 Modulator / Unkown
HY-181174 Antioxidant agent-22 / Unkown
HY-151429 Antitumor agent-77 Inhibitor / Unkown
HY-178942 EGFR/VEGFR2-IN-9 Inhibitor / Unkown
HY-151428 Antitumor agent-78 Inhibitor / Unkown
HY-181675 CHNQD-01522 Activator / Unkown
HY-170929 EMT inhibitor-3 / Unkown
HY-147514 Anticancer agent 64 Modulator / Unkown
HY-172394 ZSNI-21 Modulator / Unkown
HY-183791A Ferroptosis/apoptosis inducer-5 Modulator / Unkown
HY-184301 EGFR/HER2-IN-20 Activator / Unkown
HY-184116 A2AR/EGFR-IN-1 Modulator / Unkown
HY-180190 Tubulin polymerization-IN-85 / Unkown
HY-183312 Antitumor agent-217 Inhibitor / Unkown
HY-183369 VEGFR/PD-L1-IN-1 Activator / Unkown
HY-183355 KRAS G12D-IN-37 / Unkown
HY-181717 TKL002 Inhibitor 98.08% Unkown
HY-143235 BRD4 Inhibitor-15 Modulator / Unkown
HY-180196 EGFR-IN-187 / Unkown
HY-N6799 Neosolaniol Activator 99.72% Unkown
HY-178099 Apoptosis inducer 45 Inhibitor / Unkown
HY-N1326 Santamarine 98.85% Unkown
HY-P10992 YVPGP Modulator / Unkown
HY-184737 TPP-C8-CO-DSG bromide Modulator / Unkown
HY-N10313 Dehydrobruceine B Modulator / Unkown
HY-175019 VEGFR-2-IN-70 Agonist / Unkown
HY-182937 FLC-8 Modulator / Unkown
HY-181599 XAN-5 / Unkown
HY-175227 STAT3/NF-κB-IN-1 Inhibitor / Unkown
HY-181673 ICD inducer-2 / Unkown
HY-126311 4-Hydroxyresveratrol Inducer / Unkown
HY-N15466 Longan cerebroside II / Unkown
HY-119682 Bax agonist 1 / Unkown
HY-184835 Uranyl acetate Modulator / Unkown
HY-122481 Thaspine acetate / Unkown
HY-N8508 Myrothecine A Inducer / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bax NCBI NCBI:581