Maob - monoamine oxidase B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25750

About Maob

Primary_assembly X: 5,907,266-6,011,003 forward strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 333 orthologues, 10 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 548.4), Lung (RPKM 237.7) and 5 other tissues.

Summary

Enables flavin adenine dinucleotide binding activity; identical protein binding activity; and primary amine oxidase activity. Involved in several processes, including negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; and response to corticosterone. Located in mitochondrial outer membrane. Biomarker of Parkinson's disease and cholestasis. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (Monoamine Oxidase B). [provided by Alliance of Genome Resources, Apr 2022]

Maob Products (1)

mRNA Protein Name
NM_013198.1 NP_037330.1 amine oxidase [flavin-containing] B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
18424170 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
18198902 RGD
enables monoamine oxidase activity IDA
IDA: Inferred from direct assay
20493079 RGD
enables primary methylamine oxidase activity IDA
IDA: Inferred from direct assay
18424170 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of serotonin secretion IMP
IMP: Inferred from mutant phenotype
12175458 RGD
involved in phenylethylamine catabolic process IDA
IDA: Inferred from direct assay
18539264 RGD
involved in positive regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
12175458 RGD
involved in response to aluminum ion IEP
IEP: Inferred from expression pattern
19526156 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
15919584 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20022592 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19779138 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
18304392 RGD
involved in response to steroid hormone IDA
IDA: Inferred from direct assay
18539264 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
16904659 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18256746 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
12379239 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
12379239 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12379239 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Maob Protein Structure

YobN

YobN: COG1231 (4 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

amine oxidase [flavin-containing] B

  • MAO-B

  • monoamine oxidase type B

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14199 Selegiline hydrochloride Inhibitor 99.96% Unkown
HY-12723 Apomorphine 99.48% Unkown
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-N0159 Paeonol 99.98% Unkown
HY-B1018A Phenelzine sulfate Inhibitor 99.96% Unkown
HY-A0091A Pargyline Inhibitor 99.92% Unkown
HY-70057 Safinamide Inhibitor 99.86% Yes
HY-A0091 Pargyline hydrochloride Inhibitor 99.91% Unkown
HY-70057A Safinamide mesylate Inhibitor 99.07% Yes
HY-14855B Tedizolid phosphate Inhibitor 99.61% Yes
HY-N0159R Paeonol (Standard) 99.98% Unkown
HY-B1558A Bifemelane hydrochloride Inhibitor 99.86% Unkown
HY-14198 Selegiline Inhibitor / Unkown
HY-14280R Entacapone (Standard) Inhibitor 99.24% Unkown
HY-12723R Apomorphine (Standard) / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-103164A 8-(3-Chlorostyryl)caffeine / Phase 4
HY-N0529 Rosmarinic acid 99.73% Phase 3
HY-154977 ETAP Inhibitor / Phase 3
HY-129388B Pulrodemstat benzenesulfonate Inhibitor 99.64% Phase 2
HY-112623 Vafidemstat Inhibitor 98.03% Phase 2
HY-129388A Pulrodemstat Inhibitor 98.86% Phase 2
HY-10400 Ladostigil hemitartrate Inhibitor 98.90% Phase 2
HY-10399A Ladostigil hydrochloride Inhibitor 99.91% Phase 2
HY-10399 Ladostigil Inhibitor / Phase 2
HY-129388 Pulrodemstat Methylbenzenesulfonate Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (190)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008566 Norharmane Inhibitor 99.93% Unkown
HY-N7204 4-Hydroxyderricin 99.79% Unkown
HY-W015490 1,4-Naphthoquinone Inhibitor 99.97% Unkown
HY-N0381 Maackiain 99.83% Unkown
HY-110130 RN-1 dihydrochloride Inhibitor 99.21% Unkown
HY-E70074 Monoamine oxidase, plasma / Unkown
HY-103164 (E)-8-(3-Chlorostyryl)caffeine 99.4% Unkown
HY-127109 Tisolagiline Inhibitor 99.85% Unkown
HY-N0026 2'-Acetylacteoside Inhibitor 99.73% Unkown
HY-19333 OG-L002 Inhibitor 99.55% Unkown
HY-N0918 Desmethoxyyangonin 99.00% Unkown
HY-N9540 Methyl citrate Inhibitor 98.0% Unkown
HY-119532 Nordeprenyl 95.13% Unkown
HY-16677A Mofegiline hydrochloride Inhibitor 99.57% Unkown
HY-114520 TT01001 Inhibitor 99.93% Unkown
HY-127109A Tisolagiline monomethylsulfate Inhibitor 99.83% Unkown
HY-131036 MAO-IN-M30 dihydrochloride Inhibitor 98.48% Unkown
HY-14201 Lazabemide Inhibitor 99.95% Unkown
HY-14203 (R)-Safinamide Inhibitor 99.89% Unkown
HY-D0004 Azure B Inhibitor 99.87% Unkown
HY-100588 VU0364770 Agonist 99.94% Unkown
HY-149213 LSD1/TLK1-IN-1 99.20% Unkown
HY-117173 (Rac)-Rasagiline Inhibitor ≥97.0% Unkown
HY-W655727 (-)-2-Phenylpropylamine Inhibitor 98.44% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-127109B Tisolagiline methylsulfate Inhibitor 99.82% Unkown
HY-142026 Vitisin A 96% Unkown
HY-W001601 Budipine Antagonist 99.41% Unkown
HY-W015490S 1,4-Naphthoquinone-d6 Inhibitor 99.20% Unkown
HY-W049881 9-Methyl-β-carboline 99.86% Unkown
HY-101578 2614W94 Inhibitor 99.76% Unkown
HY-114620 MAO-B-IN-55 Inhibitor 98.10% Unkown
HY-120419 PF9601N Inhibitor 99.85% Unkown
HY-120826 A2AAR/hMAO-B-IN-1 Inhibitor 99.0% Unkown
HY-132907 MAO-B-IN-2 Inhibitor 99.05% Unkown
HY-14280S Entacapone-d10 Inhibitor 98.6% Unkown
HY-146958 MAO-B-IN-8 Inhibitor 98.03% Unkown
HY-156255 MAO-B-IN-25 Inhibitor 99.11% Unkown
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% Unkown
HY-B1018AS Phenelzine-d5 sulfate Inhibitor 99.97% Unkown
HY-W010130 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.96% Unkown
HY-W845607 Milacemide Inhibitor 98.04% Unkown
HY-172451 MC4762 Inhibitor / Unkown
HY-100679B (R)-Pirlindole mesylate Inhibitor / Unkown
HY-103477 MAO-B-IN-51 Inhibitor / Unkown
HY-106972 SL-251131 Inhibitor / Unkown
HY-114915 PSB-1434 Inhibitor 98.05% Unkown
HY-115986 MAO-B-IN-5 Inhibitor / Unkown
HY-115987 MAO-B-IN-6 Inhibitor / Unkown
HY-116097 PSB-1491 Inhibitor / Unkown
HY-116765 MAO-B-IN-35 / Unkown
HY-117502 SL-25.1188 Inhibitor / Unkown
HY-123665 PSB-1410 Inhibitor 99.22% Unkown
HY-129388C Pulrodemstat hydrochloride Inhibitor / Unkown
HY-129479 Almoxatone Inhibitor / Unkown
HY-130205 Milacemide hydrochloride Inhibitor / Unkown
HY-131660 MAO-B-IN-54 Inhibitor / Unkown
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / Unkown
HY-136878 LSD1-IN-10 Inhibitor / Unkown
HY-14198B (±)-Selegiline hydrochloride Inhibitor / Unkown
HY-14202 Lazabemide hydrochloride Inhibitor 95.0% Unkown
HY-143244 Monoamine Oxidase B inhibitor 1 Inhibitor / Unkown
HY-143245 Monoamine Oxidase B inhibitor 2 Inhibitor / Unkown
HY-143329 MAO-B-IN-3 Inhibitor / Unkown
HY-143330 MAO-B-IN-4 Inhibitor / Unkown
HY-143438 2-PAT Inhibitor / Unkown
HY-144673 LSD1-IN-12 Inhibitor / Unkown
HY-144756 LSD1-IN-15 Inhibitor / Unkown
HY-144757 LSD1-IN-16 Inhibitor / Unkown
HY-144758 LSD1-IN-17 Inhibitor / Unkown
HY-144824 Monoamine oxidase/Aromatase-IN-1 Inhibitor / Unkown
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / Unkown
HY-146149 MAO-B-IN-11 Inhibitor / Unkown
HY-146150 MAO-B-IN-12 Inhibitor / Unkown
HY-146312 AChE/BChE/MAO-B-IN-1 Inhibitor 99.57% Unkown
HY-146314 MAO-B-IN-9 Inhibitor 99.70% Unkown
HY-146347 MAO-B-IN-10 Inhibitor / Unkown
HY-146677 5-HT6R/MAO-B modulator 1 / Unkown
HY-146762 MAO-B-IN-7 Inhibitor / Unkown
HY-147362 MAO-B-IN-14 Inhibitor / Unkown
HY-147953 MAO-B-IN-13 Inhibitor / Unkown
HY-149242 MAO-B-IN-20 Inhibitor / Unkown
HY-149477 IHC3 Inhibitor / Unkown
HY-149527 MAO-B-IN-23 Inhibitor / Unkown
HY-149528 MAO-B-IN-24 Inhibitor / Unkown
HY-149820 MAO-B-IN-22 Inhibitor / Unkown
HY-149978 LSD1-IN-26 / Unkown
HY-149984 MAO-B-IN-21 Inhibitor / Unkown
HY-150563 Neuroinflammatory-IN-2 Inhibitor / Unkown
HY-151094 FTEAA Inhibitor / Unkown
HY-151208 MAO-B-IN-16 Inhibitor / Unkown
HY-151209 MAO-B-IN-15 Inhibitor / Unkown
HY-151210 MAO-B-IN-17 Inhibitor ≥99.0% Unkown
HY-151800 MAO-A/B-IN-2 Inhibitor / Unkown
HY-152109 AChE/MAO-IN-1 Inhibitor / Unkown
HY-152110 AChE/MAO-IN-2 Inhibitor / Unkown
HY-152111 AChE/MAO-B-IN-3 Inhibitor / Unkown
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / Unkown
HY-152114 AChE/BChE/MAO-B-IN-4 Inhibitor / Unkown
HY-155330 PZ-1922 / Unkown
HY-155330A PZ-1922 free base / Unkown
HY-156348 MAO-B-IN-26 Inhibitor / Unkown
HY-157087 AChE/MAO-B-IN-4 Inhibitor / Unkown
HY-157089 AChE/MAO-B-IN-5 Inhibitor / Unkown
HY-157517 MAO-B-IN-29 Inhibitor / Unkown
HY-157934 MAO-IN-4 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-158732 MAO-B-IN-33 Inhibitor / Unkown
HY-159106 MeSeI / Unkown
HY-160002 MAO-B-IN-27 Inhibitor / Unkown
HY-161240 MAO-B-IN-30 Inhibitor 98.53% Unkown
HY-162061 ChEs/MAOs-IN-1 Inhibitor / Unkown
HY-162303 C175-0062 Inhibitor / Unkown
HY-162606 MAO-A/B-IN-3 Inhibitor / Unkown
HY-162760 COMT-IN-1 Inhibitor / Unkown
HY-163322 MAO-A inhibitor 2 Inhibitor / Unkown
HY-163380 CA/MAO-B-IN-1 Inhibitor 98.34% Unkown
HY-163474 MAO-B-IN-32 Inhibitor / Unkown
HY-163879 hMAO-B-IN-9 Inhibitor / Unkown
HY-16731 Sembragiline Inhibitor / Unkown
HY-168138 MAO-B-IN-34 Inhibitor / Unkown
HY-168590 MAO-B-IN-36 Inhibitor / Unkown
HY-168728 MAO-B-IN-37 Inhibitor / Unkown
HY-169156 HDAC6-IN-49 Inhibitor / Unkown
HY-170487 MAO-B-IN-38 Inhibitor / Unkown
HY-170798 Monoamine Oxidase B inhibitor 6 Inhibitor / Unkown
HY-170887 MAO-B-IN-39 / Unkown
HY-172101 AChE/MAO-B-IN-7 Inhibitor / Unkown
HY-172460 AChE/BChE/MAO-B-IN-5 Inhibitor / Unkown
HY-172461 MAO-IN-6 Inhibitor / Unkown
HY-173138 FCOB02 Ligand / Unkown
HY-173288 MAO-B-IN-40 Inhibitor / Unkown
HY-173336 MAO-B-IN-42 Inhibitor / Unkown
HY-174419 TFSeB / Unkown
HY-174834 MAO-B-IN-44 Inhibitor / Unkown
HY-175523 MAO-B-IN-48 Inhibitor / Unkown
HY-175524 BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-176245 Illudinine Inhibitor / Unkown
HY-176254 LSD1-IN-43 Inhibitor / Unkown
HY-176271 MAO-B-IN-45 / Unkown
HY-178149 MAO-A/B-IN-5 Inhibitor / Unkown
HY-178352 MAO-B-IN-49 / Unkown
HY-178454 Multitarget AD-IN-3 Inhibitor / Unkown
HY-179126 BChE/MAO-A-IN-1 Inhibitor / Unkown
HY-179167 K2V-9 Inhibitor / Unkown
HY-180114 NSS-18 / Unkown
HY-180842 MAO-B-IN-50 Inhibitor / Unkown
HY-180843 Aβ/tau aggregation-IN-4 Inhibitor / Unkown
HY-181141 AChE/MAO-B-IN-8 Inhibitor / Unkown
HY-181146 MK-7762 Inhibitor / Unkown
HY-181861 AChE/MAO-B-IN-9 Inhibitor / Unkown
HY-181937 Multi-target kinase-IN-10 Inhibitor / Unkown
HY-182481 MD-230254 Inhibitor / Unkown
HY-182786 MAO-B-IN-56 Inhibitor / Unkown
HY-184026 MAO-B-IN-58 Inhibitor / Unkown
HY-D3221 MAO Probe 1 / Unkown
HY-N15470 MAO-B-IN-52 Inhibitor / Unkown
HY-N15657 Geiparvarin / Unkown
HY-N1636 1-Methyl-2-nonyl-4(1H)-quinolone Inhibitor / Unkown
HY-N1638 1-Methyl-2-undecyl-4(1H)-quinolone Inhibitor / Unkown
HY-RS08022 MAOB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08023 Maob Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08024 Maob Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008566S Norharmane-13C / Unkown
HY-W035384 MAO-B ligand-1 Inhibitor / Unkown
HY-W083026 (E)-CHBO4 Inhibitor 97.04% Unkown
HY-W205529 RO 16-6491 free base / Unkown
HY-W269511 NW-1689 99.54% Unkown
HY-W335927 MAO-B-IN-19 Inhibitor / Unkown
HY-W628136 MAO-B-IN-47 Inhibitor / Unkown
HY-10399B (S)-Ladostigil Inhibitor / Unkown
HY-10400R Ladostigil hemitartrate (Standard) Inhibitor / Unkown
HY-105041 Tedizolid phosphate sodium Inhibitor / Unkown
HY-123556 SZV-558 Inhibitor / Unkown
HY-124885 MD 220661 Inhibitor / Unkown
HY-129444 MD 780236 free base Inhibitor / Unkown
HY-14198S Selegiline-d5 Inhibitor / Unkown
HY-14199S Selegiline-d5 hydrochloride Inhibitor / Unkown
HY-164649 Atibeprone Inhibitor / Unkown
HY-183437 MAO-B-IN-57 Inhibitor / Unkown
HY-19333A OG-L002 hydrochloride Inhibitor / Unkown
HY-70057S4 Safinamide-d5 Inhibitor / Unkown
HY-N12134 Methyl piperate Inhibitor / Unkown
HY-N13041 Acacetin 7-O-(6-O-malonylglucoside) Inhibitor / Unkown
HY-W029600 6,7-Dimethylisatin Inhibitor / Unkown
HY-W700241 Norharman-d7 Inhibitor / Unkown
HY-W792513 WAY-620147 Inhibitor 98.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Maob NCBI NCBI:4129