GMPS - guanine monophosphate synthase Gene

Also Known as GATD7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8833

About GMPS

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:155,869,430-155,944,020 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and is associated with 60 phenotypes. Broad expression in testis (RPKM 20.3), thyroid (RPKM 6.3) and 25 other tissues.

Summary

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 Enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

GMPS Products (1)

mRNA Protein Name
NM_003875.3 NP_003866.1 GMP synthase [glutamine-hydrolyzing]
Molecular Function GO Annotation Evidence References Source
enables GMP synthase (glutamine-hydrolyzing) activity EXP
EXP: Inferred from Experiment
7706277 GOA
enables GMP synthase (glutamine-hydrolyzing) activity IDA
IDA: Inferred from direct assay
8089153 GOA
enables GMP synthase activity IDA
IDA: Inferred from direct assay
8081953 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within GMP biosynthetic process IDA
IDA: Inferred from direct assay
8089153 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
8089153 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMPS Protein Structure

GATase

GATase: Glutamine amidotransferase class-I (29 - 208)

NAD_synthase

NAD_synthase: NAD synthase (224 - 302)

GMP_synt_C

GMP_synt_C: GMP synthase C terminal domain (493 - 692)

  • 0
  • 200
  • 400
  • 600
  • 693 a.a.
Protein Preferred Names Protein Names

GMP synthase [glutamine-hydrolyzing]

  • GMP synthase

GMPS Antibodies

Cat. No. Product Name Application Reactivity
HY-P89638 GMPS Antibody (YA8982) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Thiopurines, Poor Metabolism Of, 1
  • Thiopurine S-Methyltransferase Deficiency

  • Tpmt Deficiency

  • Thiopurine Methyltransferase Deficiency

  • Thiopurine S Methyltranferase Deficiency

  • THPM1

  • Tpmtd

  • Poor Metabolism Of Thiopurines-1

  • 6-Mercaptopurine Sensitivity

  • Thiopurines, Poor Metabolism Of

  • Poor Metabolism Of Thiopurines

Orotic Aciduria
  • Hereditary Orotic Aciduria

  • Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency

  • Uridine Monophosphate Synthase Deficiency

  • Umps Deficiency

  • Uridine Monophosphate Synthetase Deficiency

  • Orotic Aciduria I

  • Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency

  • Oprt And Odc Deficiency

  • Ump Synthase Deficiency

  • Orotic Aciduria Ii

  • Oroticaciduria 1

  • Orotic Aciduria Hereditary

  • Orotic Aciduria Type 1

  • Hereditary Orotic Aciduria Without Megaloblastic Anemia

  • Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency

  • Ump Synthtase Deficiency

  • Umps

  • Orotidylic Decarboxylase Deficiency

  • Orotic Aciduria 1

  • ORAC1

  • Aciduria, Orotic

  • Hereditary Orotic Aciduria, Type 1

  • Orotic Aciduria Nos

  • Orotaciduric Anaemia

  • Orotic Aciduria Anaemia

  • Orotic Aciduria Megaloblastic Anaemia

Pyrimidine Metabolic Disorder
  • Disorder Of Pyrimidine Metabolism

  • Pyrimidine Metabolism Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus GMPS VGNC VGNC:29443
Canis familiaris GMPS VGNC VGNC:41296
Macaca mulatta GMPS VGNC VGNC:73084
Mus musculus GMPS MGD MGI:2448526
Felis catus GMPS VGNC VGNC:62614
Rattus norvegicus GMPS RGD RGD:1310063
Others GMPS NCBI