Gmps - guanine monophosphate synthase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 295088

Summary

Enables GMP synthase activity and enzyme binding activity. Involved in GMP biosynthetic process; response to L-cysteine; and response to xenobiotic stimulus. Located in cytosol. Biomarker of hepatocellular carcinoma. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]

Gmps Products (1)

mRNA Protein Name
NM_001024754.1 NP_001019925.1 GMP synthase [glutamine-hydrolyzing]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GMP synthase (glutamine-hydrolyzing) activity IDA
IDA: Inferred from direct assay
3436958 RGD
enables GMP synthase activity IDA
IDA: Inferred from direct assay
3436958 RGD
enables enzyme binding IDA
IDA: Inferred from direct assay
3436958 RGD
Biological Process GO Annotation Evidence References Source
involved in GMP biosynthetic process IDA
IDA: Inferred from direct assay
3436958 RGD
involved in GMP salvage IDA
IDA: Inferred from direct assay
6180773 RGD
involved in response to L-cysteine IDA
IDA: Inferred from direct assay
2347042 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
3345200 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GMP synthase [glutamine-hydrolyzing]

  • GMP synthase

  • GMP synthetase

  • glutamine amidotransferase

  • guanine monophosphate synthetase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1730 Phensuximide 99.41% Unkown

Clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Phase
HY-101952G Prostaglandin E2 (GMP) / Phase 4
HY-15162G Monomethyl auristatin E (GMP) / Phase 4
HY-18085G Quercetin (GMP) / Phase 4
HY-B0166GL L-Ascorbic acid (GMP Like) 99.88% Phase 4
HY-50895G Gefitinib (GMP) / Phase 4
HY-14398GL Celecoxib (GMP Like) Inhibitor / Phase 4
HY-15233G Letermovir (GMP) Inhibitor / Phase 4
HY-13631AG Exatecan mesylate (GMP) Inhibitor / Phase 3
HY-14649G Retinoic acid (GMP) Agonist / Phase 3
HY-17500 Ataciguat Activator 99.70% Phase 3
HY-19980G Eprenetapopt (GMP) / Phase 3
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-B0166G L-Ascorbic acid (GMP) / Phase 2
HY-10254G Mirdametinib (GMP) Inhibitor / Phase 2
HY-111783G AZD-7648 (GMP) / Phase 2
HY-15150G Bemcentinib (GMP) Inhibitor / Phase 2
HY-163668 MK-2118 Agonist / Phase 1
HY-100164 SDZ-MKS 492 Inhibitor 99.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (293)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10182 Laduviglusib 99.76% Unkown
HY-114180 RU.521 Inhibitor 99.95% Unkown
HY-100564 2',3'-cGAMP Activator 99.95% Unkown
HY-100564A 2',3'-cGAMP sodium Activator 99.89% Unkown
HY-12512 cGAMP Activator 99.22% Unkown
HY-136769 Biotin-HPDP 99.73% Unkown
HY-133916 G140 Inhibitor 99.17% Unkown
HY-10583G Y-27632 dihydrochloride (GMP) Inhibitor / Unkown
HY-10182G Laduviglusib (GMP) / Unkown
HY-110382 Cyclic-di-GMP disodium Activator 98.78% Unkown
HY-128583 G150 Inhibitor 99.20% Unkown
HY-10431G SB-431542 (GMP) Inhibitor / Unkown
HY-110385 cGAMP disodium Activator 98.47% Unkown
HY-111673 8-CPT-Cyclic AMP sodium 99.92% Unkown
HY-113469 Cyclic GMP 99.77% Unkown
HY-15575G VcMMAE (GMP) / Unkown
HY-13012G RepSox (GMP) Inhibitor / Unkown
HY-114182 PF-06928215 Inhibitor 99.68% Unkown
HY-107413 SR11237 99.99% Unkown
HY-107780B Cyclic-di-GMP diammonium Activator 99.07% Unkown
HY-137662 5'-Phosphoguanylyl-(3',5')-guanosine Control 95.77% Unkown
HY-10182R Laduviglusib (Standard) 99.52% Unkown
HY-101835 Decoyinine Inhibitor 99.96% Unkown
HY-113469A Cyclic GMP sodium 99.89% Unkown
HY-12071G LDN193189 (GMP) Inhibitor / Unkown
HY-13027G DAPT (GMP) Inhibitor / Unkown
HY-12379 NS-2028 Inhibitor 99.58% Unkown
HY-107202GL Polyinosinic-polycytidylic acid (GMP Like) 90.5% Unkown
HY-10432G A 83-01 (GMP) Inhibitor / Unkown
HY-13257G Thiazovivin (GMP) Inhibitor / Unkown
HY-160546 cGAS-IN-2 Inhibitor 99.67% Unkown
HY-B0445GL NAD+ (GMP Like) 99.79% Unkown
HY-149526 cGAS-IN-1 Inhibitor 98.21% Unkown
HY-P0229 Ribonuclease T1, Aspergillus oryzae / Unkown
HY-15108G Purmorphamine (GMP) Agonist / Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.55% Unkown
HY-170362 cGAS-IN-4 Inhibitor 99.28% Unkown
HY-A0070AG Liothyronine (GMP) Agonist / Unkown
HY-W013111 2′-Deoxy-GDP trisodium Inhibitor 98.78% Unkown
HY-15001G Stemregenin 1 (GMP) Antagonist / Unkown
HY-N1938 D(+)-Raffinose pentahydrate ≥98.0% Unkown
HY-P5979 LRRKtide Substrate 99.94% Unkown
HY-W010759 Inosine-5′-monophosphate disodium salt octahydrate 98.0% Unkown
HY-124700 LYPLAL1-IN-1 99.9% Unkown
HY-400882 Tosylate-DPA-714 Ligand 98.78% Unkown
HY-10219G Rapamycin (GMP) / Unkown
HY-174802 XL-3158 Inhibitor 99.55% Unkown
HY-13912G IWP-2 (GMP) Inhibitor / Unkown
HY-14648G Dexamethasone (GMP) Agonist / Unkown
HY-50723 3-Methylxanthine 99.45% Unkown
HY-13418G Dorsomorphin dihydrochloride (GMP) Inhibitor / Unkown
HY-15147G XAV-939 (GMP) Inhibitor / Unkown
HY-110385A cGAMP diammonium Activator 96.63% Unkown
HY-112486G TA-316 (GMP) Agonist / Unkown
HY-13631EG Deruxtecan (GMP) / Unkown
HY-Y0320GL Dimethyl sulfoxide (GMP Like) Inhibitor 99.99% Unkown
HY-112754AGL DOTAP chloride (GMP Like) / Unkown
HY-15141G Staurosporine (GMP) Inhibitor / Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-50723R 3-Methylxanthine (Standard) 99.58% Unkown
HY-10219GL Rapamycin (GMP Like) 98.8% Unkown
HY-170362A (R)-cGAS-IN-4 Control 99.94% Unkown
HY-P1179A Guanylin(human) TFA Activator 98.54% Unkown
HY-148748G Butyzamide (GMP) Activator / Unkown
HY-107780 Cyclic-di-GMP Activator 98.18% Unkown
HY-12318G IBMX (GMP) Inhibitor / Unkown
HY-15659G Wnt-C59 (GMP) Inhibitor / Unkown
HY-100933 MY-5445 Inhibitor 99.79% Unkown
HY-108548 Rp-8-Br-PET-cGMPS sodium Inhibitor 99.42% Unkown
HY-123468 HA-1004 Inhibitor 99.04% Unkown
HY-P0229A Ribonuclease T1 (animal free) / Unkown
HY-P1179 Guanylin(human) Activator 99.77% Unkown
HY-100564BS 2',3'-cGAMP-d8 ammonium 99.90% Unkown
HY-134541GL SM-102 (GMP Like) / Unkown
HY-N0737AG Harmine (GMP) Inhibitor / Unkown
HY-N5134S2 5'-Guanylic acid-15N5 dilithium 99.33% Unkown
HY-113469B Cyclic GMP TBAOH / Unkown
HY-112764GL mPEG2000-DMG (GMP Like) 99.86% Unkown
HY-119808 Terrein 99.44% Unkown
HY-130530 AP-C5 99.30% Unkown
HY-17447AG Tranylcypromine hydrochloride (GMP) Inhibitor / Unkown
HY-W000423G DBCO-amine (GMP) / Unkown
HY-W654000 Cyclic GMP-13C,15N2 98.81% Unkown
HY-15764G A 419259 (GMP) / Unkown
HY-178589A Biotin-7-GMP lithium solution (100 mM ± 3 mM) 99.99% Unkown
HY-78932G Dap-NE hydrochloride (GMP) / Unkown
HY-10475G AM580 (GMP) Agonist / Unkown
HY-12323G ISX-9 (GMP) Activator / Unkown
HY-100224G SANT-1 (GMP) / Unkown
HY-100374G Val-Cit-PAB-MMAE (GMP) / Unkown
HY-10181G Dasatinib (GMP) / Unkown
HY-114548 Ebselen oxide Inhibitor 98.0% Unkown
HY-115745 Calmodulin antagonist-1 Antagonist 98.0% Unkown
HY-119611A Thioquinapiperifil dihydrochloride Inhibitor 99.22% Unkown
HY-119819 Psicofuranine Inhibitor 98.0% Unkown
HY-134541G SM-102 (GMP) / Unkown
HY-134919 CU-76 Inhibitor 97.6% Unkown
HY-13506G M344 (GMP) Inhibitor / Unkown
HY-135110 Rp-8-Br-cGMPS sodium 99.9% Unkown
HY-15682G TTNPB (GMP) Agonist / Unkown
HY-78738G MC-Val-Cit-PAB (GMP) / Unkown
HY-78921AG Fmoc-3VVD-OH (GMP) / Unkown
HY-B0185G Lidocaine (GMP) / Unkown
HY-W767865 Cyclic GMP sodium-13C5 99.03% Unkown
HY-Y0850AGL2 Polyvinyl alcohol, MW 64000 (GMP Like) / Unkown
HY-178589 Biotin-7-GMP / Unkown
HY-W507009 L-Arginyl-L-alanine 99.75% Unkown
HY-10182C Laduviglusib dihydrochloride / Unkown
HY-15371G Forskolin (GMP) / Unkown
HY-15582G Auristatin E (GMP) Inhibitor / Unkown
HY-78931G Boc-Dap-NE (GMP) / Unkown
HY-10407G SU 5402 (GMP) Inhibitor / Unkown
HY-12186G 3-Deazaneplanocin A hydrochloride (GMP) Inhibitor / Unkown
HY-13319G JNK-IN-8 (GMP) Inhibitor / Unkown
HY-13526G YO-01027 (GMP) Inhibitor / Unkown
HY-15578G McMMAF (GMP) / Unkown
HY-15579BG MMAF sodium (GMP) Inhibitor / Unkown
HY-15579G MMAF (GMP) Inhibitor / Unkown
HY-16700G PNU-159682 (GMP) Inhibitor / Unkown
HY-184095 Iptocigistat Inhibitor / Unkown
HY-50751G Linifanib (GMP) Inhibitor / Unkown
HY-U00449G AGN 193109 (GMP) Antagonist / Unkown
HY-100596G AS1842856 (GMP) Inducer / Unkown
HY-101445G Trolox (GMP) / Unkown
HY-101570G Nedisertib (GMP) Inhibitor / Unkown
HY-10181GL Dasatinib (GMP Like) / Unkown
HY-10221G Vorinostat (GMP) Inhibitor / Unkown
HY-10227G Bortezomib (GMP) / Unkown
HY-10320G Doramapimod (GMP) Inhibitor / Unkown
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-10585AG Valproic acid sodium (GMP) / Unkown
HY-106110 OP-2507 / Unkown
HY-106235 LB80317 Inhibitor / Unkown
HY-107413G SR11237 (GMP) / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-10966G SB-590885 (GMP) Inhibitor / Unkown
HY-110382S Cyclic-di-GMP-13C20,15N10 disodium Activator / Unkown
HY-112005G DOPE (GMP) Inhibitor / Unkown
HY-112005GL DOPE (GMP Like) / Unkown
HY-112251GL D-Lin-MC3-DMA (GMP Like) / Unkown
HY-112348 HA-1004 hydrochloride Inhibitor / Unkown
HY-116705G 2-Deoxy-2-fluoro-L-fucose (GMP) Inhibitor / Unkown
HY-119611 Thioquinapiperifil Inhibitor / Unkown
HY-12041G SP600125 (GMP) / Unkown
HY-12238G IWR-1 (GMP) Inhibitor / Unkown
HY-12278G K02288 (GMP) Inhibitor / Unkown
HY-12292G IM-12 (GMP) / Unkown
HY-12299G WH-4-023 (GMP) Inhibitor / Unkown
HY-12305G Q-VD-OPh (GMP) Inhibitor / Unkown
HY-12362G Val-cit-PAB-OH (GMP) / Unkown
HY-12519G Oltipraz (GMP) / Unkown
HY-126675G AS2863619 (GMP) / Unkown
HY-12879G IWP-4 (GMP) Inhibitor / Unkown
HY-128952G Tesirine (GMP) / Unkown
HY-129670 KMUP-1 / Unkown
HY-13067G Celastrol (GMP) / Unkown
HY-131817 5'-GMPS / Unkown
HY-131833G Fmoc-Gly-Gly-Phe-OH (GMP) / Unkown
HY-131990G MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) / Unkown
HY-13227G SD-208 (GMP) Inhibitor / Unkown
HY-13259G MG-132 (GMP) / Unkown
HY-13271AG Tubastatin A (GMP) / Unkown
HY-134242 6-T-5'-GMP disodium / Unkown
HY-134242A 6-T-5'-GMP / Unkown
HY-13441G (-)-Blebbistatin (GMP) Inhibitor / Unkown
HY-135146G GSK-3484862 (GMP) / Unkown
HY-13642G RG108 (GMP) Inhibitor / Unkown
HY-13689G Go 6983 (GMP) / Unkown
HY-137662A 5'-Phosphoguanylyl-(3',5')-guanosine trisodium Control / Unkown
HY-138300GL ALC-0159 (GMP Like) / Unkown
HY-138794G XL177A (GMP) Inhibitor / Unkown
HY-13990G NVP-TNKS656 (GMP) / Unkown
HY-141520G ART558 (GMP) Inhibitor / Unkown
HY-14176G Compound E (GMP) Inhibitor / Unkown
HY-14397G Indomethacin (GMP) Inhibitor / Unkown
HY-14398G Celecoxib (GMP) Inhibitor / Unkown
HY-145973AGL 3'OMe-m7GpppAmpG ammonium solution (100 mM) (GMP Like) Inhibitor / Unkown
HY-145974AGL m7GpppAmpG ammonium solution (100 mM) (GMP like) / Unkown
HY-14823G Sobetirome (GMP) Agonist / Unkown
HY-15149G Romidepsin (GMP) / Unkown
HY-15244G Alpelisib (GMP) / Unkown
HY-153209G Adjuvant-4 (GMP) / Unkown
HY-155337 eIF4E-IN-6 Inhibitor / Unkown
HY-156087 Cholicamideβ Inducer / Unkown
HY-156087G Cholicamideβ (GMP) Inducer / Unkown
HY-15772G Osimertinib (GMP) / Unkown
HY-15772GL Osimertinib (GMP Like) / Unkown
HY-15794G Nemorubicin (GMP) / Unkown
HY-15825G IWP L6 (GMP) Inhibitor / Unkown
HY-15893G DMOG (GMP) / Unkown
HY-15947G Ravoxertinib (GMP) Inhibitor / Unkown
HY-159642G Dabogratinib (GMP) Inhibitor / Unkown
HY-162459 cGAS-IN-3 Inhibitor / Unkown
HY-16294G LY2090314 (GMP) Inhibitor / Unkown
HY-16561G Resveratrol (GMP) / Unkown
HY-16658BG Z-VAD-FMK (GMP) Inhibitor / Unkown
HY-16900G Rolipram (GMP) Inhibitor / Unkown
HY-16910G WIKI4 (GMP) / Unkown
HY-171561G DOTAM-Maleimide triTFA (GMP) / Unkown
HY-172533 3′,5′-DiOA-dC Agonist / Unkown
HY-17356G Fenofibrate (GMP) / Unkown
HY-179624 cGAS-IN-7 Inhibitor / Unkown
HY-180211 cGAS-IN-8 Inhibitor / Unkown
HY-18733G Lipoic acid (GMP) / Unkown
HY-18740 Trequinsin Inhibitor / Unkown
HY-18964G MG-101 (GMP) / Unkown
HY-18985G Phorbol 12,13-dibutyrate (GMP) Activator / Unkown
HY-19318G Fmoc-Val-Cit-PAB (GMP) / Unkown
HY-20336G Mc-Val-Cit-PABC-PNP (GMP) / Unkown
HY-20457G TL8-506 (GMP) / Unkown
HY-42360G SMCC (GMP) / Unkown
HY-42972G DBCO-acid (GMP) / Unkown
HY-44980G Fmoc-Gly-NH-CH2-acetyloxy (GMP) / Unkown
HY-45672G Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) / Unkown
HY-50698G BI 2536 (GMP) / Unkown
HY-70044G GSK-1070916 (GMP) / Unkown
HY-78736G Val-Cit-PAB-OSBT (GMP) / Unkown
HY-B0150G Nicotinamide (GMP) Inhibitor / Unkown
HY-B0350AG Sodium butyrate (GMP) / Unkown
HY-B0356G Ciprofloxacin (GMP) / Unkown
HY-B0377G Famotidine (GMP) / Unkown
HY-B0399G L-Carnitine (GMP) / Unkown
HY-B0400CGL D-Sorbitol, M150 (GMP Like) / Unkown
HY-B0400DGL D-Sorbitol, M200 (GMP Like) / Unkown
HY-B0400EGL D-Sorbitol, M400 (GMP Like) / Unkown
HY-B0434G Ribavirin (GMP) Inhibitor / Unkown
HY-B0450AG Ciclopirox olamine (GMP) Inhibitor / Unkown
HY-B0497G Niclosamide (GMP) Inhibitor / Unkown
HY-B0793G AZ-5104 (GMP) / Unkown
HY-B0793GL AZ-5104 (GMP Like) Inhibitor / Unkown
HY-B1402G Hydrocortisone hemisuccinate (GMP) Inhibitor / Unkown
HY-B1505G Acefylline (GMP) / Unkown
HY-B1511G Cyclic AMP (GMP) / Unkown
HY-B2242GL Calcium phosphate (GMP Like) / Unkown
HY-E70069GL Endo S2, Streptococcus pyogenes (GMP Like) / Unkown
HY-E70441 Guanosine kinase / Unkown
HY-E71644 3',5'-Cyclic-GMP phosphodiesterase / Unkown
HY-E71893 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] Di phosphatase / Unkown
HY-E72007 7-Methylguanosine nucleotidase / Unkown
HY-E72030 8-Oxo-dGDP phosphatase / Unkown
HY-N0083G Betulin (GMP) / Unkown
HY-N0322GL Cholesterol (GMP Like, synthetic) 99.89% Unkown
HY-N0378AGL D-Mannitol, M200 (GMP Like) / Unkown
HY-N0378BGL D-Mannitol, M100 (GMP Like) / Unkown
HY-N0390G L-Glutamine (GMP) Inhibitor / Unkown
HY-N0565AG Doxycycline (hydrochloride) (GMP) / Unkown
HY-N15159 Cladophorol A Inhibitor / Unkown
HY-N5134S1 5'-Guanylic acid-13C10 dilithium / Unkown
HY-N5134S3 5'-Guanylic acid-d12 dilithium / Unkown
HY-P2865 Guanylate kinase / Unkown
HY-P2865A Guanylate Kinase, Porcine / Unkown
HY-P5072 GRP (14-27) (human, porcine, canine) Agonist / Unkown
HY-RS05528 GMPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W013636AG 2-Ketoglutaric acid Sodium (GMP) Inhibitor / Unkown
HY-W087187G DOTAGA-anhydride (GMP) / Unkown
HY-Y1311G Malic acid (GMP) / Unkown
HY-101085G SKL2001 (GMP) Agonist / Unkown
HY-107632G GYY4137 (GMP) / Unkown
HY-107780A Cyclic-di-GMP sodium Activator / Unkown
HY-111582G BBIQ (GMP) Agonist / Unkown
HY-112582AGL N1-Methylpseudouridine-5′-triphosphate (GMP like) / Unkown
HY-12273G DMH-1 (GMP) Inhibitor / Unkown
HY-123468A HA-1004 dihydrochloride Inhibitor / Unkown
HY-12848G SAG (GMP) Agonist / Unkown
HY-131764 2'-O-MB-cGMP sodium Inhibitor / Unkown
HY-133540G Maleimide-DOTA (GMP) / Unkown
HY-135110A Rp-8-Br-cGMPS / Unkown
HY-138170GL ALC-0315 (GMP Like) 99.86% Unkown
HY-141432G NX-1607 (GMP) Inhibitor / Unkown
HY-171020 8-Nitro-2'3'cGMP / Unkown
HY-171520 2'-O-MOE-GMP / Unkown
HY-171523 LNA-GMP / Unkown
HY-172512 3'-O-Methylguanosine-5'-monophosphate / Unkown
HY-178557 Im-3'-OMe-GMP / Unkown
HY-178572 3'-OMe-m7GMP / Unkown
HY-181713 Antibiofilm agent-19 / Unkown
HY-183863 N-(4-(1H-Pyrazol-1-yl)butyl)-5-(furan-2-yl)isoxazole-3-carboxamide / Unkown
HY-50723S1 3-Methylxanthine-d3 / Unkown
HY-B0342GL Meglumine (GMP Like) / Unkown
HY-B0764G Bucladesine sodium (GMP) Activator / Unkown
HY-N0391G L-Citrulline (GMP) Inhibitor / Unkown
HY-N0614GL Sucralose (GMP Like) / Unkown
HY-N11522 5-Methyluridine 5′-triphosphate / Unkown
HY-N15369 3′-GMP / Unkown
HY-N5134A ara-GMP / Unkown
HY-N5134S4 5'-Guanylic acid-15N5,d12 dilithium / Unkown
HY-N5134S5 5'-Guanylic acid-13C10,15N5 dilithium / Unkown
HY-RS20744 Gmps Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27256 Gmps Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011053GL Neotame (GMP Like) Inducer / Unkown
HY-W040193GL DSPC (GMP Like) / Unkown
HY-W1048843AG 4-Arm PEG5000-NH2 (GMP) / Unkown
HY-W1048843AGL 4-Arm PEG5000-NH2 (GMP Like) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gmps NCBI NCBI:8833