2. Gene
  3. Il2 - interleukin 2 Gene

Il2 - interleukin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Il-2

Gene ID: 16183 | Gene type: protein coding

About Il2

Chromosome 3: 37,174,672-37,180,108 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 89 orthologues and is associated with 95 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Apr 2022]

Il2 Products(1)

mRNA Protein Name
NM_008366.3 NP_032392.1 interleukin-2 precursor

Il2 Protein Structure

IL2

IL2: smart00189 (0 - 167)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

interleukin-2

T-cell growth factor

TCGF

Recombinant Il2 Proteins

Cat. No. Product Name Accession Purity
HY-P7077 IL-2 Protein, Mouse P04351 (A21-Q169) ≥95%
HY-P70646 IL-2 Protein, Mouse (149a.a) P04351 (A21-Q169) ≥95%
HY-P78151 IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) P04351-1 (A21-Q169) ≥95%
HY-P78312 IL-2 Protein, Mouse (HEK293, His-Avi) P04351 (A21-Q169) ≥95%
HY-P70646AF Animal-Free IL-2 Protein, Mouse (His) P04351 (A21-Q169) ≥95%

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13756 Tacrolimus 99.93% Unkown
HY-A0003 Lenalidomide Inducer 99.91% Yes
HY-B1046 Clofazimine 99.20% Unkown
HY-13756A Tacrolimus monohydrate 99.67% Yes
HY-A0003B Lenalidomide hemihydrate Inducer 99.67% Yes
HY-A0003A Lenalidomide hydrochloride / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108738 Daclizumab Inhibitor 95.00% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0594 Deacetylasperulosidic Acid Inhibitor 99.86% Phase 4
HY-132304 CC-90005 Inhibitor 99.98% Phase 1
Inhibitory Antibodies (9)
Cat. No. Product Name Effect
Purity Phase
HY-P99664 Inolimomab Inhibitor 98.78% Phase 3
HY-P99499 Cetrelimab 100.00% Phase 3
HY-P99410 Ordesekimab Inhibitor 95.00% Phase 2
HY-P99752 Nemvaleukin alfa 99.50% Phase 2
HY-P99328 Tucotuzumab ≥95.0% Phase 2
HY-P99902 Simlukafusp alfa Inhibitor 99.90% Phase 2
HY-P99728 Melredableukin alfa / Phase 2
HY-P99498 Cergutuzumab amunaleukin Inhibitor 98.40% Phase 1
HY-P990029 Eciskafusp alfa Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (57)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153220 NX-2127 Inhibitor 99.72% Unkown
HY-138568 HPK1-IN-3 Inhibitor 99.32% Unkown
HY-N6607 Tryptanthrin 99.89% Unkown
HY-131140 BD750 Inhibitor 99.10% Unkown
HY-133987 AP-1/NF-κB activation inhibitor 1 Inhibitor 99.03% Unkown
HY-134820 MLT-943 Inhibitor 99.77% Unkown
HY-18303 AMG-47a Inhibitor 99.34% Unkown
HY-110117 BIRT 377 Inhibitor 98.07% Unkown
HY-110177 SP-100030 Inhibitor 99.86% Unkown
HY-113618B RO2959 monohydrochloride Inhibitor 98.21% Unkown
HY-N0600 Ginsenoside F3 Modulator 99.84% Unkown
HY-126328 PKC-theta inhibitor 1 Inhibitor 99.73% Unkown
HY-13756S Tacrolimus-13C,d2 98.36% Unkown
HY-21293 SU5201 98.50% Unkown
HY-119424 SP4206 Inhibitor 98.55% Unkown
HY-P3143A BMSpep-57 hydrochloride Inhibitor 99.69% Unkown
HY-P1453A CMD178 TFA Inhibitor 99.83% Unkown
HY-113618A RO2959 hydrochloride Inhibitor / Unkown
HY-112778 NFAT Transcription Factor Regulator-1 Inhibitor 99.37% Unkown
HY-150051 IL-2-IN-1 Inhibitor 99.95% Unkown
HY-A0003S Lenalidomide-d5 Inducer 99.32% Unkown
HY-P1453 CMD178 Inhibitor / Unkown
HY-100849 JAK 3i Inhibitor / Unkown
HY-106755 Tucaresol Inhibitor / Unkown
HY-110113 CTA056 Inhibitor / Unkown
HY-112335 Lck Inhibitor III Inhibitor / Unkown
HY-115756 4-Maleimidosalicylic acid / Unkown
HY-117843 Ppc-1 / Unkown
HY-121743 Ro26-4550 Antagonist / Unkown
HY-141864 ITK/TRKA-IN-1 Inhibitor / Unkown
HY-142648A (R)-MLT-985 Inhibitor / Unkown
HY-147504 Anticancer agent 63 / Unkown
HY-149206 HPK1-IN-33 Inhibitor / Unkown
HY-149232 HPK1-IN-35 Inhibitor / Unkown
HY-149916 A2AR-antagonist-1 Antagonist / Unkown
HY-149917 ITK degrader 1 Degrader / Unkown
HY-153952 Immuno modulator-1 Inhibitor / Unkown
HY-156149 CYP51/PD-L1-IN-1 Inhibitor / Unkown
HY-156150 CYP51/PD-L1-IN-2 Inhibitor / Unkown
HY-156151 CYP51/PD-L1-IN-3 Inhibitor / Unkown
HY-157569 PD1-PDL1-IN 2 / Unkown
HY-157838 HMC-B17 Inhibitor / Unkown
HY-163194 Cbl-b-IN-16 Inhibitor / Unkown
HY-P1997 Ferrichrome Iron-free / Unkown
HY-P3083 N-Myristoyl-Lys-Arg-Thr-Leu-Arg Inhibitor / Unkown
HY-P3143 BMSpep-57 Inhibitor / Unkown
HY-P3736 Myelopeptide-2 Inducer / Unkown
HY-P5870 KTX-Sp2 Inhibitor / Unkown
HY-RS06728 IL2 Human Pre-designed siRNA Set A / Unkown
HY-RS06729 Il2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06730 Il2 Rat Pre-designed siRNA Set A / Unkown
HY-RS06748 IL2RA Human Pre-designed siRNA Set A / Unkown
HY-RS06749 IL2RB Human Pre-designed siRNA Set A / Unkown
HY-RS06750 IL2RG Human Pre-designed siRNA Set A / Unkown
HY-101687 Nosantine racemate / Unkown
HY-161335 HPK1-IN-43 / Unkown
HY-N1726 cis-Burchellin / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99680 Keliximab Inhibitor 98.23% Unkown
HY-P990086 Vopikitug Inhibitor / Unkown
HY-P99817 Pegaldesleukin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il2 NCBI NCBI:3558
Canis familiaris Il2 NCBI NCBI:403989
Macaca fascicularis Il2 NCBI NCBI:102129830
Susscrofa domestica Il2 NCBI
Leporidae Il2 NCBI
Rattus norvegicus Il2 NCBI NCBI:116562
Macaca mulatta Il2 NCBI NCBI:708017