IL2 - interleukin 2 Gene
Also Known as IL-2; TCGF; lymphokine
Species: Homo sapiens
About IL2
This gene has 2 transcripts (splice variants), 89 orthologues and is associated with 31 phenotypes. Low expression observed in reference dataset.
Summary
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]
IL2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000586.4 | NP_000577.2 | interleukin-2 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cytokine activity |
IDA
IDA: Inferred from direct assay
|
1830926 | GOA |
| enables interleukin-2 receptor binding |
IDA
IDA: Inferred from direct assay
|
8262055 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16477002 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
18273057 | GOA |
IL2 Protein Structure
IL2: Interleukin 2 (7 - 150)
- 0
- 100
- 153 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interleukin-2 |
|
|
IL2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IL2 | P60568 | IL2RB | Homo sapiens | P14784 | 22446627 | |
|
Intra
|
IL2 | P60568 | IL2RB | Homo sapiens | P14784 | 16477002 | |
|
Intra
|
IL2 | P60568 | IL2RB | Homo sapiens | P14784 | 16477002 | |
|
Intra
|
IL2 | P60568 | IL2RA | Homo sapiens | P01589 | 17032757 | |
|
Intra
|
IL2 | P60568 | IL2RA | Homo sapiens | P01589 | 16477002 | |
|
Intra
|
IL2 | P60568 | IL2RA | Homo sapiens | P01589 | 16477002 |
Recombinant IL2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7037 | IL-2 Protein, Human | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7037A | IL-2 Protein, Human (CHO) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70758 | IL-2 Protein, Human (HEK293, His) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70775 | IL-2 Protein, Human (C145S) | P60568 (P22-T153, C145S) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70758G | GMP IL-2 Protein, Human (HEK293, His) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72385 | IL-2 Protein, Human (Biotinylated, HEK293, His-Avi) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72564 | IL-2 Protein, Human (L100F, R101D, L105V, I106V, I112F, HEK293, His) | P60568 (A21-T153, L100F, R101D, L105V, I106V, I112F) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78551 | GMP IL-2 Protein, Human (solution) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78858 | IL-2 Protein, Human (Biotinylated, HEK293, Fc-Avi) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7037B | IL-2 Protein, Human (His) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7037AF | Animal-Free IL-2 Protein, Human (His) | P60568 (A21-T153) | ≥ 95%, as determined by reducing SDS-PAGE. |
IL2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81709 | IL-2 Antibody (YA1454) | FC, ELISA | Human |
| HY-P84418 | IL-2 Antibody (YA4115) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P84418A | IL-2 Antibody (YA4115)(PBS only) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P85223 | IL-2 Antibody (YA4915) | WB, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Measles |
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| Sclerosing Keratitis |
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| Major Depressive Disorder |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Rheumatic Fever |
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| Leishmaniasis |
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| Type 1 Diabetes Mellitus |
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| Cutaneous Leishmaniasis |
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| Carpal Tunnel Syndrome |
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| Sarcoidosis 1 |
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| Immune Deficiency Disease |
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| 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis |
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| Psoriatic Arthritis |
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| Boutonneuse Fever |
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| Pemphigoid |
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| Factor Vii Deficiency |
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| Lipoprotein Quantitative Trait Locus |
|
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| Candidiasis |
|
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| Anogenital Venereal Wart |
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| Celiac Disease 1 |
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| Maxillary Sinus Adenoid Cystic Carcinoma |
|
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| Splenic Tuberculosis |
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| Anemia, Autoimmune Hemolytic |
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| Splenic Disease |
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| Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked |
|
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| Trypanosomiasis |
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| Tetanus |
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| Psoriasis |
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| Deep Keratitis |
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| Alopecia |
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| Fasciitis |
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| Burning Mouth Syndrome |
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| Breast Cancer |
|
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| Bilirubin Metabolic Disorder |
|
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| Myasthenia Gravis |
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| Leprosy 3 |
|
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| T-Cell Adult Acute Lymphocytic Leukemia |
|
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| X-Linked Monogenic Disease |
|
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| Peripheral T-Cell Lymphoma |
|
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| Thymus Cancer |
|
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| Brain Edema |
|
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| Miliary Tuberculosis |
|
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| Melanoma, Uveal |
|
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| Chagas Disease |
|
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| Genital Herpes |
|
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| Primary Biliary Cholangitis |
|
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| Farmer'S Lung |
|
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| Multiple Sclerosis |
|
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| Capillary Leak Syndrome |
|
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| Alopecia Areata |
|
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| Mast Cell Neoplasm |
|
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| Gaucher Disease, Type Ii |
|
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| Immunodeficiency 41 With Lymphoproliferation And Autoimmunity |
|
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| Nervous System Disease |
|
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| Autoimmune Disease Of Skin And Connective Tissue |
|
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| Systemic Lupus Erythematosus |
|
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| Ulcerative Colitis |
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| Autoimmune Vasculitis |
|
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| Rubella |
|
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| Cholangitis |
|
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| Chronic Fatigue Syndrome |
|
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| Hypertension, Essential |
|
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| Autoimmune Disease Of Eyes, Ear, Nose And Throat |
|
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| Hypothyroidism |
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| Taeniasis |
|
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| Systemic Scleroderma |
|
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| Ovarian Cancer |
|
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| Berylliosis |
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| Herpangina |
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| Acute Leukemia |
|
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| Primary Bacterial Infectious Disease |
|
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| Danubian Endemic Familial Nephropathy |
|
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| Schistosomiasis |
|
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| Orchitis |
|
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| Lymphopenia |
|
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| Immune System Disease |
|
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| Lichen Planus |
|
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| Gallbladder Melanoma |
|
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| Allergic Contact Dermatitis |
|
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| Tropical Spastic Paraparesis |
|
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| Prostatitis |
|
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| Plague |
|
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| Neutropenia |
|
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| Lepromatous Leprosy |
|
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| Allergic Disease |
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| Autoimmune Disease Of Musculoskeletal System |
|
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| Respiratory Allergy |
|
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| Bronchial Disease |
|
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| Bladder Cancer |
|
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| Crohn'S Disease |
|
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| Leukemia, Acute Lymphoblastic |
|
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| Deficiency Anemia |
|
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| Mature T-Cell And Nk-Cell Lymphoma |
|
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| Subacute Lymphocytic Thyroiditis |
|
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| Hemophagocytic Lymphohistiocytosis |
|
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| Autoimmune Disease |
|
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| Adult T-Cell Leukemia/Lymphoma |
|
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| Periodontitis |
|
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| Nasal Cavity Disease |
|
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| Dermatitis |
|
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| Diabetes Mellitus |
|
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| Lymphoproliferative Syndrome |
|
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| Anus Disease |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Myelodysplastic Syndrome |
|
|
| Leptospirosis |
|
|
| Dilated Cardiomyopathy |
|
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| Type 2 Diabetes Mellitus |
|
|
| Alopecia Universalis Congenita |
|
|
| Breast Adenocarcinoma |
|
|
| Autoimmune Myocarditis |
|
|
| Onchocerciasis |
|
|
| Sphingolipidosis |
|
|
| Diphtheria |
|
|
| Parasitic Helminthiasis Infectious Disease |
|
|
| Eye Disease |
|
|
| Chondroblastoma |
|
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| Gingival Overgrowth |
|
|
| Pfeiffer Syndrome |
|
|
| T Cell Deficiency |
|
|
| Malignant Anus Melanoma |
|
|
| Peripheral Nervous System Disease |
|
|
| Paracoccidioidomycosis |
|
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| Poliomyelitis |
|
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| Autoimmune Disease Of Cardiovascular System |
|
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| Narcolepsy |
|
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| Conjunctivitis |
|
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| Pulmonary Tuberculosis |
|
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| Inflammatory Bowel Disease |
|
|
| Esophagus Carcinoma In Situ |
|
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| Mycosis Fungoides |
|
|
| Capillary Disease |
|
|
| Common Variable Immunodeficiency |
|
|
| Critical Covid-19 |
|
|
| Flying Phobia |
|
|
| Disease By Infectious Agent |
|
|
| Cataract |
|
|
| Asthma |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Contact Dermatitis |
|
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| Stomatitis |
|
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| Headache |
|
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| Blood Platelet Disease |
|
|
| Rheumatoid Arthritis |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
|
| Oligodendroglioma |
|
|
| Angioedema |
|
|
| Myocarditis |
|
|
| Tuberculoid Leprosy |
|
|
| Ebola Hemorrhagic Fever |
|
|
| Chronic Mucocutaneous Candidiasis |
|
|
| Thymus Gland Disease |
|
|
| Colorectal Cancer |
|
|
| Erythema Multiforme |
|
|
| Combined Immunodeficiency |
|
|
| Temporal Arteritis |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Nk Cell Deficiency |
|
|
| Hairy Cell Leukemia |
|
|
| Connective Tissue Disease |
|
|
| Chronic Asthma |
|
|
| Coccidiosis |
|
|
| Thymoma |
|
|
| Smallpox |
|
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| Cystitis |
|
|
| Chromium Allergic Contact Dermatitis |
|
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| Pulmonary Sarcoidosis |
|
|
| X-Linked Recessive Disease |
|
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| Covid-19 |
|
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| Toxicodendron Dermatitis |
|
|
| Sezary'S Disease |
|
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| Commensal Bacterial Infectious Disease |
|
|
| Glioblastoma Neural Subtype |
|
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| Toxic Shock Syndrome |
|
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| Kidney Cancer |
|
|
| Leukocyte Disease |
|
|
| Extrinsic Cardiomyopathy |
|
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| Severe Acute Respiratory Syndrome |
|
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| Spondyloarthropathy |
|
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| B-Cell Lymphoma |
|
|
| Pelvic Inflammatory Disease |
|
|
| Severe Covid-19 |
|
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| Pars Planitis |
|
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| Diarrhea |
|
|
| Hair Disease |
|
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| Lichen Disease |
|
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| Myeloma, Multiple |
|
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| Demyelinating Disease |
|
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| Superficial Basal Cell Carcinoma |
|
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| Rectal Disease |
|
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| Plasmacytoma |
|
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| Bronchiolitis |
|
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| Lacrimal Apparatus Disease |
|
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| Common Cold |
|
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| Esophageal Cancer |
|
|
| Extrapulmonary Tuberculosis |
|
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| Gingivitis |
|
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| Listeriosis |
|
|
| Aseptic Meningitis |
|
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| Autoimmune Disease Of Gastrointestinal Tract |
|
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| Clonorchiasis |
|
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| B-Cell Expansion With Nfkb And T-Cell Anergy |
|
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| Skin Disease |
|
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| Autoimmune Uveitis |
|
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| Osteoporosis |
|
|
| Poems Syndrome |
|
|
| Progressive Multifocal Leukoencephalopathy |
|
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| Mcleod Syndrome |
|
|
| Uveitis |
|
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| Gaucher'S Disease |
|
|
| Leukemia |
|
|
| Autoimmune Disease Of Blood |
|
|
| Scalp Dermatosis |
|
|
| Appendicitis |
|
|
| Interstitial Lung Disease 2 |
|
|
| Posterior Uveitis |
|
|
| Erysipelas |
|
|
| Tonsillitis |
|
|
| Pleural Tuberculosis |
|
|
| Meningitis |
|
|
| Agammaglobulinemia |
|
|
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Nephrotic Syndrome |
|
|
| Chorioretinitis |
|
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| Hematologic Cancer |
|
|
| Exanthem |
|
|
| Intestinal Schistosomiasis |
|
|
| Cystic Fibrosis |
|
|
| Chickenpox |
|
|
| Pneumocystosis |
|
|
| Gliosarcoma |
|
|
| Cervicitis |
|
|
| Heart Disease |
|
|
| Mantle Cell Lymphoma |
|
|
| Dermatitis, Atopic |
|
|
| Fungal Meningitis |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Metal Allergy |
|
|
| Anus Cancer |
|
|
| Autoimmune Gastritis |
|
|
| Neuroblastoma |
|
|
| Subacute Sclerosing Panencephalitis |
|
|
| Opportunistic Mycosis |
|
|
| Blood Coagulation Disease |
|
|
| West Nile Encephalitis |
|
|
| Lymphoid Interstitial Pneumonia |
|
|
| Autoimmune Disease Of Exocrine System |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Herpes Zoster |
|
|
| Mucocutaneous Leishmaniasis |
|
|
| B Cell Deficiency |
|
|
| Aphthous Stomatitis |
|
|
| Thyroiditis |
|
|
| Filariasis |
|
|
| Fungal Infectious Disease |
|
|
| Salivary Gland Disease |
|
|
| Colitis |
|
|
| Visceral Leishmaniasis |
|
|
| Ocular Melanoma |
|
|
| Otitis Media |
|
|
| Severe Combined Immunodeficiency |
|
|
| Respiratory Failure |
|
|
| Nose Disease |
|
|
| Viral Infectious Disease |
|
|
| Hyper Ige Syndrome |
|
|
| Filarial Elephantiasis |
|
|
| Gingival Disease |
|
|
| Cryptococcal Meningitis |
|
|
| Severe Combined Immunodeficiency, X-Linked |
|
|
| Wilms Tumor 1 |
|
|
| Mucosal Melanoma |
|
|
| Hypereosinophilic Syndrome |
|
|
| Primary Systemic Mycosis |
|
|
| Integumentary System Disease |
|
|
| Melphalan Allergy |
|
|
| Conjunctival Disease |
|
|
| Thrombocytopenia |
|
|
| Brucellosis |
|
|
| Vaccinia |
|
|
| Churg-Strauss Syndrome |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Arthritis |
|
|
| Skin Sarcoidosis |
|
|
| Melanoma |
|
|
| Mumps |
|
|
| Lymphoma, Hodgkin, Classic |
|
|
| Malaria |
|
|
| Coronavirus Infectious Disease |
|
|
| Central Nervous System Vasculitis |
|
|
| Hemorrhagic Cystitis |
|
|
| Behcet Syndrome |
|
|
| Bone Inflammation Disease |
|
|
| Viral Pneumonia |
|
|
| Schizophrenia |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Periapical Granuloma |
|
|
| Uveal Disease |
|
|
| Vogt-Koyanagi-Harada Disease |
|
|
| T-Cell Large Granular Lymphocyte Leukemia |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Leukemia, Acute Myeloid |
|
|
| Lymph Node Disease |
|
|
| Ocular Cancer |
|
|
| Scleral Disease |
|
|
| Lymphoma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | IL2 | VGNC | VGNC:30137 |
| Macaca mulatta | IL2 | VGNC | VGNC:100237 |
| Rattus norvegicus | IL2 | RGD | RGD:620047 |
| Mus musculus | IL2 | MGD | MGI:96548 |
| Felis catus | IL2 | VGNC | VGNC:78516 |
| Canis familiaris | IL2 | VGNC | VGNC:41963 |
| Others | IL2 | NCBI |