435 Results for "

β -oxidation

" in MedChemExpress (MCE) Product Catalog:

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149

Etomoxir

149 Publications Verification

Art. -Nr.: HY-50202

CAS. Nr.: 124083-20-1

Synonyms: (R)-(+)-Etomoxir

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Forschungsgebiete:

Metabolic Disease Cancer

Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

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149

Etomoxir sodium salt

149 Publications Verification

Art. -Nr.: HY-50202A

CAS. Nr.: 828934-41-4

Synonyms: (R)-(+)-Etomoxir sodium salt

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Forschungsgebiete:

Metabolic Disease Cancer

Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .

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130

Elesclomol

130 Cited Publications

Art. -Nr.: HY-12040

CAS. Nr.: 488832-69-5

Reinheit: 99.80%

Synonyms: STA-4783

Target:

Reactive Oxygen Species (ROS) Apoptosis Cuproptosis

Forschungsgebiete:

Cancer

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

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Vincristine

77 Cited Publications

Art. -Nr.: HY-N0488A

CAS. Nr.: 57-22-7

Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine

Category:

Apocynaceae Alkaloids Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

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Vincristine sulfate

77 Cited Publications

Art. -Nr.: HY-N0488

CAS. Nr.: 2068-78-2

Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate

Category:

Apocynaceae Alkaloids Anti-aging Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

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Ciprofloxacin hydrochloride monohydrate

57 Cited Publications

Art. -Nr.: HY-B0356B

CAS. Nr.: 86393-32-0

Synonyms: Bay-09867 hydrochloride monohydrate

Target:

Antibiotic Apoptosis Bacterial Reactive Oxygen Species (ROS) Topoisomerase Mitochondrial Metabolism Akt β-catenin

Forschungsgebiete:

Infection Cancer

Ciprofloxacin (Bay-09867) hydrochloride monohydrate is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin hydrochloride monohydrate exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin hydrochloride monohydrate inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin hydrochloride monohydrate induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin hydrochloride monohydrate can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity .

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Ciprofloxacin monohydrochloride

57 Cited Publications

Art. -Nr.: HY-B0356A

CAS. Nr.: 93107-08-5

Synonyms: Bay-09867 monohydrochloride

Target:

Antibiotic Apoptosis Bacterial Reactive Oxygen Species (ROS) Topoisomerase Mitochondrial Metabolism Akt β-catenin

Forschungsgebiete:

Infection Cancer

Ciprofloxacin (Bay-09867) monohydrochloride is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin monohydrochloride exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin monohydrochloride inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin monohydrochloride induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin monohydrochloride can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity .

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Midostaurin

39 Cited Publications

Art. -Nr.: HY-10230

CAS. Nr.: 120685-11-2

Reinheit: 99.91%

Synonyms: PKC412; CGP 41251

Target:

PKC VEGFR c-Kit NO Synthase Apoptosis

Forschungsgebiete:

Cancer

Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

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Rutin hydrate

34 Cited Publications

Art. -Nr.: HY-N0148A

CAS. Nr.: 207671-50-9

Synonyms: Rutoside hydrate; Quercetin 3-O-rutinoside hydrate

Category:

Flavonols other families Flavonoids Phenols Polyphenols Plants

Target:

Amyloid-β Autophagy Apoptosis Endogenous Metabolite

Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

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Rutin

34 Cited Publications

Art. -Nr.: HY-N0148

CAS. Nr.: 153-18-4

Synonyms: Rutoside; Quercetin 3-O-rutinoside

Category:

Flavonols Plants other families Flavonoids Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:

Amyloid-β Autophagy Apoptosis Endogenous Metabolite

Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

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β-Amyloid (1-42), human TFA

27 Cited Publications

Art. -Nr.: HY-P1363

Synonyms: Amyloid β-peptide (1-42) (human) TFA

Target:

Amyloid-β

Forschungsgebiete:

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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β-Amyloid (1-42), human

27 Cited Publications

Art. -Nr.: HY-P1363A

CAS. Nr.: 107761-42-2

Synonyms: Amyloid β-peptide (1-42) (human)

Target:

Amyloid-β

Forschungsgebiete:

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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β-Amyloid (1-42), human, HFIP-treated

27 Cited Publications

Art. -Nr.: HY-P1363B

CAS. Nr.: 107761-42-2

Target:

Amyloid-β

Forschungsgebiete:

Neurological Disease

β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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L-Carnitine

22 Cited Publications

Art. -Nr.: HY-B0399

CAS. Nr.: 541-15-1

Synonyms: (R)-Carnitine; Levocarnitine

Category:

Natural Products Neurological Disease Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Nervous System Disorder Disease Research Fields Cancer

Target:

Endogenous Metabolite

L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .

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L-Carnitine hydrochloride

22 Cited Publications

Art. -Nr.: HY-B2246

CAS. Nr.: 6645-46-1

Synonyms: (R)-Carnitine hydrochloride; Levocarnitine hydrochloride

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .

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L-Carnitine tartrate

22 Cited Publications

Art. -Nr.: HY-W105518

CAS. Nr.: 36687-82-8

L-Carnitine tartrate is a highly polar, small zwitterion. L-Carnitine tartrate is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine tartrate functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine tartrate is an antioxidant. L-Carnitine tartrate can ameliorate metabolic imbalances in many inborn errors of metabolism ^{[3] ^.}

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Trimetazidine dihydrochloride

19 Cited Publications

Art. -Nr.: HY-B0968

CAS. Nr.: 13171-25-0

Target:

Autophagy

Forschungsgebiete:

Cardiovascular Disease

Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC₅₀ of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .

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Trimetazidine

19 Cited Publications

Art. -Nr.: HY-B0968A

CAS. Nr.: 5011-34-7

Target:

Autophagy

Forschungsgebiete:

Cardiovascular Disease

Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC₅₀ of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .

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4-Hydroxynonenal

18 Cited Publications

Art. -Nr.: HY-113466

CAS. Nr.: 75899-68-2

Reinheit: 99.35%

Synonyms: 4-HNE

Category:

Neurological Disease Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer

Target:

Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite

4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

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Trimethylamine N-oxide

12 Cited Publications

Art. -Nr.: HY-116084

CAS. Nr.: 1184-78-7

Reinheit: ≥98.0%

Category:

Cardiovascular Disease Natural Products Microorganisms Other disease Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:

Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite

Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

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