2. Gene
  3. Flt3 - FMS-like tyrosine kinase 3 Gene

Flt3 - FMS-like tyrosine kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04

Gene ID: 14255 | Gene type: protein coding

About Flt3

Chromosome 5: 147,267,551-147,337,299 reverse strand.GRCm39:CM000998.3

This gene has 2 transcripts (splice variants), 134 orthologues, 53 paralogues and is associated with 56 phenotypes. Biased expression in cerebellum adult (RPKM 4.3), spleen adult (RPKM 2.2) and 14 other tissues.

Summary

Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; hemopoiesis; and lymphocyte proliferation. Acts upstream of or within several processes, including dendritic cell homeostasis; hematopoietic or lymphoid organ development; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including brain; dorsal aorta; immune system; reproductive system; and spinal cord. Used to study acute myeloid leukemia and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; colorectal adenocarcinoma; hepatocellular carcinoma; and prostate Cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Flt3 Products(1)

mRNA Protein Name
NM_010229.2 NP_034359.2 receptor-type tyrosine-protein kinase FLT3 precursor

Flt3 Protein Structure

ig

ig: pfam00047 (255 - 345)

Ig

Ig: cd00096 (268 - 272)

Ig

Ig: cd00096 (282 - 286)

Ig

Ig: cd00096 (314 - 317)

Ig

Ig: cd00096 (327 - 332)

7tm_GPCRs

7tm_GPCRs: cl28897 (490 - 585)

PKc_like

PKc_like: cl21453 (572 - 949)

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Protein Preferred Names Protein Names

receptor-type tyrosine-protein kinase FLT3

FL cytokine receptor

fetal liver kinase 2

tyrosine-protein kinase FLT3

tyrosine-protein kinase receptor flk-2

Recombinant Flt3 Proteins

Cat. No. Product Name Accession Purity
HY-P74151 FLT3 Protein, Mouse (HEK293, His) NP_034359.2 (N28-S544) ≥95%
HY-P78731 FLT3 Protein, Mouse (517a.a, HEK293, His) NP_034359.2 (N28-S544) ≥95%

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib Inhibitor 99.92% Yes
HY-13016 Cabozantinib Inhibitor 99.96% Yes
HY-12432 Gilteritinib Inhibitor 99.88% Yes
HY-13001 Quizartinib Inhibitor 99.01% Yes
HY-10201A Sorafenib Tosylate Inhibitor 99.91% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-13038A Fostamatinib Inhibitor 99.50% Yes
HY-112306 Ripretinib Inhibitor 99.33% Yes
HY-10201S Sorafenib-d3 Inhibitor 99.57% Unkown
HY-13038 Fostamatinib Disodium Inhibitor 99.88% Yes
HY-12432A Gilteritinib hemifumarate Inhibitor 99.75% Yes
HY-13038B Fostamatinib disodium hexahydrate Inhibitor 99.73% Yes
HY-13016A Cabozantinib hydrochloride Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Phase
HY-50751 Linifanib Inhibitor 99.28% Phase 3
HY-50905 Dovitinib Inhibitor 99.94% Phase 3
HY-16961 Sitravatinib Inhibitor 99.59% Phase 3
HY-50867 Lestaurtinib Inhibitor 99.17% Phase 3
HY-10207 Dovitinib lactate Inhibitor 99.62% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
HY-B0062 Dovitinib lactate hydrate Inhibitor / Phase 3
HY-13024 Rebastinib Inhibitor 99.91% Phase 2
HY-135317 Emavusertib Inhibitor 99.96% Phase 2
HY-50514 AT9283 Inhibitor 99.70% Phase 2
HY-13034 Gandotinib Inhibitor 99.82% Phase 2
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-10206 Amuvatinib Inhibitor 99.47% Phase 2
HY-10987A ENMD-2076 Inhibitor 99.12% Phase 2
HY-10202 Tandutinib Inhibitor 99.48% Phase 2
HY-145015 Tuspetinib Inhibitor 99.77% Phase 2
HY-100867A TAK-659 hydrochloride Inhibitor 99.91% Phase 2
HY-10987 ENMD-2076 Tartrate Inhibitor 99.42% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-10202A Tandutinib hydrochloride Inhibitor 99.78% Phase 2
HY-118304B AKN-028 acetate Inhibitor 99.95% Phase 2
HY-100867 TAK-659 Inhibitor / Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2
HY-118304 AKN-028 Inhibitor / Phase 2
HY-10339 KW-2449 Inhibitor 99.69% Phase 1
HY-101549 MRX-2843 Inhibitor 99.70% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-B0791 Altiratinib Inhibitor 98.05% Phase 1
HY-139535 Luxeptinib Inhibitor 99.30% Phase 1
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-13072 Cenisertib Inhibitor 99.64% Phase 1
Pre-clinical Phase
Bioactive Molecules (118)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12067 R406 Inhibitor 98.72% Unkown
HY-13223 Crenolanib Inhibitor 99.68% Yes
HY-12344 UNC2025 Inhibitor 99.83% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-13263 CHIR-124 Inhibitor 98.57% Unkown
HY-11108 R406 free base Inhibitor 99.80% Unkown
HY-10410 TG101209 Inhibitor 99.22% Unkown
HY-15002 AST 487 Inhibitor 99.42% Unkown
HY-12344A UNC2025 hydrochloride Inhibitor 99.87% Unkown
HY-13894 Tyrphostin AG1296 Inhibitor 99.69% Unkown
HY-153886 Wu-5 Inhibitor 99.34% Unkown
HY-N0071 Crotonoside Inhibitor 99.64% Unkown
HY-12333 Denfivontinib Inhibitor ≥98.0% Unkown
HY-12420 JNJ-47117096 hydrochloride Inhibitor 99.68% Unkown
HY-15889 AMG 925 Inhibitor 98.20% Unkown
HY-145723 MAX-40279 Inhibitor 97.10% Unkown
HY-114323 PROTAC FLT-3 degrader 1 Inhibitor 99.74% Unkown
HY-132200 UNC5293 Inhibitor 95.07% Unkown
HY-120758 SEL24-B489 Inhibitor 98.58% Unkown
HY-130247 JAK2/FLT3-IN-1 Inhibitor 99.79% Unkown
HY-18161 CCT241736 Inhibitor 98.09% Unkown
HY-131906 JAK2-IN-7 Inhibitor 99.15% Unkown
HY-130247A JAK2/FLT3-IN-1 TFA Inhibitor 99.77% Unkown
HY-18952A (Z)-SU5614 Inhibitor 98.43% Unkown
HY-153857 PHI-101 Inhibitor 98.97% Unkown
HY-13907 TCS 359 Inhibitor 99.89% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 98.06% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.45% Unkown
HY-15003 ATH686 Inhibitor 99.38% Unkown
HY-13493 AC710 Inhibitor 98.56% Unkown
HY-112145 FLT3-IN-3 Inhibitor 99.73% Unkown
HY-18744 FLT3-IN-2 Inhibitor 98.38% Unkown
HY-13537A BPR1J-097 Hydrochloride Inhibitor 99.20% Unkown
HY-107417 Hypothemycin Inhibitor ≥98.0% Unkown
HY-144869 OTS447 Inhibitor 99.83% Unkown
HY-13016S Cabozantinib-d6 Inhibitor 98.14% Unkown
HY-162037 CDDD11-8 Inhibitor 98.74% Unkown
HY-132150A HPK1-IN-2 dihydrochloride Inhibitor 98.69% Unkown
HY-120590 Ruserontinib Inhibitor 99.82% Unkown
HY-151904 AXL-IN-13 / Unkown
HY-15889A AMG 925 HCl Inhibitor / Unkown
HY-12960 SKLB4771 Inhibitor 98.08% Unkown
HY-18179 AZD2932 Inhibitor 99.04% Unkown
HY-100865 BPR1K871 Inhibitor 98.45% Unkown
HY-128572 FLT3-IN-6 Inhibitor 99.14% Unkown
HY-128571 FLT3-IN-4 Inhibitor 98.19% Unkown
HY-15198 KG5 Inhibitor 99.79% Unkown
HY-108263 3-Hydroxy Midostaurin Inhibitor 97.02% Unkown
HY-134481 FLT3-IN-10 Inhibitor 98.80% Unkown
HY-143286A PF15 TFA Degrader 99.72% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-153473 FLT3-IN-19 Inhibitor 99.19% Unkown
HY-148070 FLT3-IN-17 Inhibitor 99.56% Unkown
HY-13537 BPR1J-097 Inhibitor / Unkown
HY-12432S1 Gilteritinib-d8 Inhibitor ≥98.0% Unkown
HY-135317B Emavusertib hydrochloride Inhibitor / Unkown
HY-146749 FLT3/TrKA-IN-1 Inhibitor / Unkown
HY-111545 BSc5371 Inhibitor / Unkown
HY-15496 E6201 Inhibitor / Unkown
HY-145723B MAX-40279 hemifumarate Inhibitor 99.56% Unkown
HY-145015A Tuspetinib hydrate Inhibitor / Unkown
HY-145723A MAX-40279 hydrochloride Inhibitor / Unkown
HY-145723C MAX-40279 hemiadipate Inhibitor 99.26% Unkown
HY-155341 HSK205 Inhibitor / Unkown
HY-145904 PDGFRα/FLT3-ITD-IN-3 Inhibitor / Unkown
HY-144711 FLT3/ITD-IN-3 Inhibitor / Unkown
HY-144709 FLT3/ITD-IN-1 Inhibitor / Unkown
HY-143286 PF15 Inhibitor / Unkown
HY-155112 Antiproliferative agent-30 Inhibitor / Unkown
HY-161323 FLT3-ITD/D835Y-IN-1 Inhibitor / Unkown
HY-148521 PROTAC FLT3/CDK9 degrader-1 Degrader / Unkown
HY-155302 FLT3-IN-22 Inhibitor / Unkown
HY-161280 PROTAC FLT-3 degrader 3 Degrader / Unkown
HY-112475 Flt-3 Inhibitor III Inhibitor / Unkown
HY-149539 PLM-101 Inhibitor / Unkown
HY-103464 5'-Fluoroindirubinoxime Inhibitor ≥98.0% Unkown
HY-139619 LT-850-166 Inhibitor / Unkown
HY-148036 FLT3-IN-16 Inhibitor 98.98% Unkown
HY-144710 FLT3/ITD-IN-2 Inhibitor / Unkown
HY-15519 LBW242 Inhibitor / Unkown
HY-145690 HP1328 Inhibitor / Unkown
HY-143894 FLT3-IN-11 Inhibitor / Unkown
HY-155594 LT-540-717 Inhibitor / Unkown
HY-150582 c-Met-IN-14 Inhibitor / Unkown
HY-50905S Dovitinib-d8 Inhibitor / Unkown
HY-157213 LWY713 Degrader / Unkown
HY-149474 HDAC-IN-63 Inhibitor / Unkown
HY-155226 FLT3-IN-21 Inhibitor / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown
HY-162367 FLT3/CHK1-IN-2 Inhibitor / Unkown
HY-151961 RSH-7 Inhibitor 99.07% Unkown
HY-115906 K783-0308 Inhibitor / Unkown
HY-143895 FLT3-IN-12 Inhibitor / Unkown
HY-146886 FLT3-IN-15 Inhibitor / Unkown
HY-108263S 3-Hydroxy Midostaurin-d5 Inhibitor / Unkown
HY-156410 FLT3-IN-23 Inhibitor / Unkown
HY-151945 TRK II-IN-1 Inhibitor / Unkown
HY-143434 FLT3/D835Y-IN-1 Inhibitor / Unkown
HY-10201S2 Sorafenib-13C,d3 Inhibitor / Unkown
HY-108263A (S)-3-Hydroxy Midostaurin Inhibitor / Unkown
HY-10201S1 Sorafenib-d4 Inhibitor / Unkown
HY-144777 FLT3-IN-14 Inhibitor / Unkown
HY-162032 FLT3-IN-25 Inhibitor / Unkown
HY-110026 GTP-14564 Inhibitor 99.91% Unkown
HY-145902 PDGFRα/FLT3-ITD-IN-1 Inhibitor / Unkown
HY-148522 FLT3-IN-18 Inhibitor / Unkown
HY-108263B (R)-3-Hydroxy Midostaurin Inhibitor / Unkown
HY-163068 FLT3-IN-24 Inhibitor / Unkown
HY-13016S1 Cabozantinib-d4 Inhibitor / Unkown
HY-155770 FLT3-IN-20 Inhibitor / Unkown
HY-111249 TTT 3002 Inhibitor / Unkown
HY-145691 HP1142 Inhibitor / Unkown
HY-115904 FLT3/CDK4-IN-1 Inhibitor / Unkown
HY-145903 PDGFRα/FLT3-ITD-IN-2 Inhibitor / Unkown
HY-143278 FLT3-IN-13 Inhibitor / Unkown
HY-10058 AT9283 lactic acid Inhibitor / Unkown
HY-16379B Pacritinib citrate Inhibitor / Unkown
HY-15163 Zotiraciclib Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flt3 NCBI NCBI:2322
Macaca fascicularis Flt3 NCBI NCBI:102144988
Susscrofa domestica Flt3 NCBI
Rattus norvegicus Flt3 NCBI NCBI:140635
Macaca mulatta Flt3 NCBI NCBI:721712