FLT3 - fms related receptor tyrosine kinase 3 Gene

Also Known as FLK2; STK1; CD135; FLK-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2322

About FLT3

Cytogenetic location: 13q12.2 Genomic coordinates (GRCh38): 13:28,003,274-28,100,576 (from NCBI)

This gene has 3 transcripts (splice variants), 134 orthologues, 53 paralogues and is associated with 140 phenotypes. Broad expression in spleen (RPKM 4.2), lymph node (RPKM 3.7) and 16 other tissues.

Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in Apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

FLT3 Products (7)

mRNA	Protein	Name
XM_011535018.3	XP_011533320.1	receptor-type tyrosine-protein kinase FLT3 isoform X3
XM_017020486.2	XP_016875975.1	receptor-type tyrosine-protein kinase FLT3 isoform X2
NM_004119.3	NP_004110.2	receptor-type tyrosine-protein kinase FLT3 precursor
XM_017020488.2	XP_016875977.1	receptor-type tyrosine-protein kinase FLT3 isoform X4
XM_047430216.1	XP_047286172.1	receptor-type tyrosine-protein kinase FLT3 isoform X3
NR_130706.2
XM_011535015.3	XP_011533317.1	receptor-type tyrosine-protein kinase FLT3 isoform X1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16982329	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within hemopoiesis	IDA IDA: Inferred from direct assay	7507245	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLT3 Protein Structure

Pkinase_Tyr

0
200
400
600
800
993 a.a.

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein kinase FLT3	CD135 antigen FL cytokine receptor fetal liver kinase 2 fms related tyrosine kinase 3 fms-like tyrosine kinase 3 growth factor receptor tyrosine kinase type III stem cell tyrosine kinase 1

FLT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FLT3	P36888	RASA1	Homo sapiens	P20936	Protein Array	28086240
Intra	FLT3	P36888	ABL2	Homo sapiens	P42684	Protein Array	28086240
Intra	FLT3	P36888	ABL2	Homo sapiens	P42684	Anti Tag CoIP	28086240
Intra	FLT3	P36888	LCK	Homo sapiens	P06239	Protein Array	28086240
Cross	FLT3	P36888	Sla2	Mus musculus	Q8R4L0	Pull Down	27458164
Cross	FLT3	P36888	Sla2	Mus musculus	Q8R4L0	Anti Tag CoIP	27458164
Intra	FLT3	P36888	ABL1	Homo sapiens	P00519	Protein Array	28086240
Intra	FLT3	P36888	FYN	Homo sapiens	P06241	Protein Array	28086240
Intra	FLT3	P36888	SYK	Homo sapiens	P43405	Anti Bait CoIP	24525236
Intra	FLT3	P36888	SYK	Homo sapiens	P43405	Anti Tag CoIP	24525236
Intra	FLT3	P36888	SYK	Homo sapiens	P43405	Protein Array	28086240
Intra	FLT3	P36888	SYK	Homo sapiens	P43405	Confocal	24525236
Intra	FLT3	P36888	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	16982329
Intra	FLT3	P36888	GRB10	Homo sapiens	Q13322	Anti Bait CoIP	23246379
Intra	FLT3	P36888	IKBKG	Homo sapiens	Q9Y6K9	Protein Array	20098747
Intra	FLT3	P36888	CRK	Homo sapiens	P46108	Protein Array	28086240
Intra	FLT3	P36888	CRKL	Homo sapiens	P46109	Protein Array	28086240

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FLT3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70178	FLT3 Protein, Human (HEK293, hFc, solution)	AAI26351.1 (N27-N541)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75183	FLT3 Protein, Human (T227M, HEK293, His)	P36888-1 (N27-N541, T227M)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75184	FLT3 Protein, Human (HEK293, hFc)	P36888-1 (N27-S543)	≥ 95%, as determined by reducing SDS-PAGE.

FLT3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84286	FLT3 Antibody (YA3983)	IHC-P, ELISA	Human
HY-P84286A	FLT3 Antibody (YA3983)(PBS only)	IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Acute Myeloblastic Leukemia Without Maturation	Aml M1 Acute Myeloblastic Leukemia M1 Acute Myeloblastic Leukemia Type 1
Immunodeficiency 21	Monocytopenia And Mycobacterial Infection Syndrome Monomac Monocytopenia With Susceptibility To Infections Dcml Gata2 Deficiency IMD21 Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections Monocyte - B - Natural Killer - Dendritic Cell Deficiency Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Leukemia, Acute Monocytic	Acute Monocytic Leukemia Acute Monoblastic Leukemia And Acute Monocytic Leukemia Acute Monocytic Leukaemia Acute Monocytic Leukaemia Without Mention Of Remission Acute Monocytic Leukemia Without Mention Of Remission Acute Monocytic Leukemia, Fab M5 Acute Monocytic Leukemia, Morphology Leukemia, Monocytic, Acute M5b Acute Differentiated Monocytic Leukemia
Leukocyte Disease	Leukocyte Disorders
Neutrophilia, Hereditary	Hereditary Neutrophilia NEUTROPHILIA Leukocytosis Disorders With Increased Neutrophil Counts
Childhood Acute Myeloid Leukemia	Childhood Acute Myeloid Leukaemia Paediatric Acute Myeloid Leukaemia Pediatric Acute Myeloid Leukemia
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Core Binding Factor Acute Myeloid Leukemia	Cbf Acute Myeloid Leukemia Cbf-Aml Core-Binding Factor Aml
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Childhood Acute Lymphocytic Leukemia	Childhood Acute Lymphoblastic Leukemia Childhood All Pediatric Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Childhood
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Patau Syndrome	Trisomy 13 Complete Trisomy 13 Syndrome Trisomy 13 Syndrome D1 Trisomy Patau'S Syndrome Chromosome 13, Trisomy 13 Complete D Trisomy Syndrome Bartholin-Patau Syndrome Chromosome 13 Duplication D1 Trisomy Syndrome D>1< Trisomy Syndrome Patau Chromosome 13 Trisomy Abnormal Autosomes 13
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Subacute Myeloid Leukemia
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Acute Myeloblastic Leukemia With Maturation	Aml M2 Acute Myeloblastic Leukemia M2 Acute Myeloblastic Leukemia Type 2 Lam M2 Acute Myeloid Leukemia
Pancytopenia
Autosomal Dominant Intellectual Developmental Disorder 8	Autosomal Dominant Non-Syndromic Intellectual Disability 8 Mental Retardation, Autosomal Dominant 8 Autosomal Dominant Mental Retardation 8 Mrd8
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Neutropenia	Leukopenia
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Mast-Cell Leukemia	Mast Cell Leukemia Leukemia, Mast-Cell Leukemia Mast Cell Mast Cell Leukaemia Nos Mast Cell Leukaemia Without Mention Of Remission
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Acute Myeloid Leukemia With Minimal Differentiation	Minimally Differentiated Acute Myeloblastic Leukemia Acute Myeloid Leukemia, Minimal Differentiation Aml-M0 Aml M0 Acute Myeloblastic Leukemia, Minimally Differentiated
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukaemia Atypical Chronic Myeloid Leukemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Mixed Phenotype Acute Leukemia With T	Mpal With T Kmt2a Rearranged Mpal With T Mll Rearranged
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Mixed Phenotype Acute Leukemia With T(9;22)(Q34.1;Q11.2)	Mpal With T(9 22)(Q34.1 Q11.2) Bcr-Abl1
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Acute Myeloid Leukemia With T(8;21)(Q22;Q22) Translocation	Aml With T(8 21)(Q22 Q22) Translocation
Acute Biphenotypic Leukemia	Mixed Phenotype Acute Leukemia Acute Leukemia Of Ambiguous Lineage Acute Undifferentiated Leukemia Acute Leukemia Of Indeterminate Lineage Hybrid Acute Leukemia Mixed Lineage Acute Leukemia All With Myeloid Markers Aml With Lymphoid Markers Acute Leukemia Of Undetermined Lineage Bal Biphenotypic Acute Leukemia Undifferentiated Acute Leukemia Mpal Acute Myeloid Leukemia, Minimal Differentiation, Fab M0 Leukemia, Biphenotypic, Acute
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic/Myeloproliferative Disease Myelodysplastic-Myeloproliferative Diseases Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Mast Cell Neoplasm	Mastocytoma Mast Cell Proliferative Disease Mast Cell Tumor Benign Mastocytoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Myeloid Sarcoma	Granulocytic Sarcoma Chloroma Extramedullary Myeloid Tumor Sarcoma, Granulocytic Sarcoma Granulocytic Sarcoma, Myeloid Myelosarcoma Myeloid Sarcoma Disease Myeloid Sarcoma Nos Myeloid Sarcoma Without Mention Of Remission
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Acute Myeloid Leukemia With Bcr-Abl1	Acute Myeleoid Leukemia With Bcr-Abl1
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Mixed Phenotype Acute Leukemia, T/Myeloid	Doid:0081039
Acute Myelomonocytic Leukemia	Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16 16)(P13 Q22) Aml M4 Ammol Acute Myeloblastic Leukemia Type 4 Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16 16)(P13 Q22) Aml-M4 Aml With Inv(16)(P13.1q22) Or T(16 16)(P13.1 Q22) Cbfb-Myh11 Leukemia Myelomonocytic Acute Acute Myelomonocytic Leukaemia Without Mention Of Remission Myelomonocytic Leukaemia Nos
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Childhood Leukemia
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10201	Sorafenib	Inhibitor	99.85%	Yes
HY-13016	Cabozantinib	Inhibitor	99.97%	Yes
HY-12432	Gilteritinib	Inhibitor	99.84%	Yes
HY-13001	Quizartinib	Inhibitor	99.08%	Yes
HY-13038A	Fostamatinib	Inhibitor	99.70%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-10201A	Sorafenib tosylate	Inhibitor	99.98%	Yes
HY-112306	Ripretinib	Inhibitor	98.90%	Yes
HY-10201S	Sorafenib-d3	Inhibitor	99.57%	Unkown
HY-50867	Lestaurtinib	Inhibitor	99.66%	Unkown
HY-12432A	Gilteritinib hemifumarate	Inhibitor	99.75%	Yes
HY-14217	Quizartinib dihydrochloride	Inhibitor	99.81%	Unkown
HY-10201R	Sorafenib (Standard)	Inhibitor	99.71%	Unkown
HY-13038	Fostamatinib Disodium	Inhibitor	98.94%	Yes
HY-13038B	Fostamatinib disodium hexahydrate	Inhibitor	99.46%	Yes
HY-12432R	Gilteritinib (Standard)	Inhibitor	99.60%	Unkown
HY-16379B	Pacritinib citrate	Inhibitor	99.68%	Unkown
HY-13016A	Cabozantinib hydrochloride	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-13001R	Quizartinib (Standard)	Inhibitor	/	Unkown
HY-10201AR	Sorafenib tosylate (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (52)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13223	Crenolanib	Inhibitor	99.68%	Phase 3
HY-50751	Linifanib	Inhibitor	99.39%	Phase 3
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-50514	AT9283	Inhibitor	99.67%	Phase 3
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Phase 3
HY-172581	Clifutinib	Inhibitor	99.59%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-13024	Rebastinib	Inhibitor	99.84%	Phase 2
HY-135317	Emavusertib	Inhibitor	99.97%	Phase 2
HY-148669	Bleximenib	Inhibitor	99.36%	Phase 2
HY-101549	MRX-2843	Inhibitor	99.92%	Phase 2
HY-148669A	Bleximenib oxalate	Inhibitor	98.97%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.86%	Phase 2
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-145015	Tuspetinib	Inhibitor	99.69%	Phase 2
HY-130247	Flonoltinib	Inhibitor	99.48%	Phase 2
HY-145964	INE963	Inhibitor	99.58%	Phase 2
HY-10987A	ENMD-2076	Inhibitor	99.99%	Phase 2
HY-10206	Amuvatinib	Inhibitor	99.40%	Phase 2
HY-10202	Tandutinib	Inhibitor	99.48%	Phase 2
HY-15163	Zotiraciclib	Inhibitor	99.88%	Phase 2
HY-145723	MAX-40279	Inhibitor	97.04%	Phase 2
HY-109179	Itacnosertib	Inhibitor	99.06%	Phase 2
HY-10202A	Tandutinib hydrochloride	Inhibitor	99.29%	Phase 2
HY-10987	ENMD-2076 Tartrate	Inhibitor	99.66%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2
HY-130247A	Flonoltinib TFA	Inhibitor	98.94%	Phase 2
HY-118304B	AKN-028 acetate	Inhibitor	98.38%	Phase 2
HY-145723C	MAX-40279 hemiadipate	Inhibitor	99.26%	Phase 2
HY-118304	AKN-028	Inhibitor	99.72%	Phase 2
HY-135317B	Emavusertib hydrochloride	Inhibitor	/	Phase 2
HY-100867	Mivavotinib	Inhibitor	/	Phase 2
HY-145723A	MAX-40279 hydrochloride	Inhibitor	/	Phase 2
HY-10206A	Amuvatinib hydrochloride	Inhibitor	/	Phase 2
HY-10058	AT9283 lactic acid	Inhibitor	/	Phase 2
HY-145723B	MAX-40279 hemifumarate	Inhibitor	99.52%	Phase 2
HY-145015A	Tuspetinib hydrate	Inhibitor	/	Phase 2
HY-118304A	AKN-028 TFA	Inhibitor	/	Phase 2
HY-15163A	Zotiraciclib hydrochloride	Inhibitor	/	Phase 2
HY-10339	KW-2449	Inhibitor	99.91%	Phase 1
HY-10032	PF 477736	Inhibitor	99.04%	Phase 1
HY-B0791	Altiratinib	Inhibitor	99.29%	Phase 1
HY-111361	FN-1501	Inhibitor	98.72%	Phase 1
HY-13072	Cenisertib	Inhibitor	99.86%	Phase 1
HY-139535	Luxeptinib	Inhibitor	98.95%	Phase 1
HY-153857	Lasmotinib	Inhibitor	98.16%	Phase 1
HY-19897	4SC-203	Inhibitor	98.98%	Phase 1
HY-13223A	Crenolanib benzenesulfonate	Inhibitor	99.45%	Phase 1
HY-118084	LS-104	Inhibitor	/	Phase 1
HY-16449	SB1578	Inhibitor	/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99916	Emirodatamab	Inhibitor	99.05%	Phase 1
HY-P991641	IMC-EB10		98%	Phase 1

Pre-clinical Phase

Bioactive Molecules (224)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12067	R406	Inhibitor	97.91%	Unkown
HY-12344	UNC2025	Inhibitor	99.92%	Unkown
HY-12494	LDC1267	Inhibitor	99.64%	Unkown
HY-13263	CHIR-124	Inhibitor	99.05%	Unkown
HY-12461	WS6	Modulator	99.09%	Unkown
HY-132166	Velzatinib	Inhibitor	99.40%	Unkown
HY-132200	UNC5293	Inhibitor	99.93%	Unkown
HY-11108	R406 free base	Inhibitor	99.07%	Unkown
HY-156794	Enzomenib	Inhibitor	99.88%	Unkown
HY-153886	Wu-5	Inhibitor	99.34%	Unkown
HY-15166	(E/Z)-Zotiraciclib	Inhibitor	99.96%	Unkown
HY-15002	AST 487	Inhibitor	98.90%	Unkown
HY-13894	Tyrphostin AG1296	Inhibitor	99.69%	Unkown
HY-100867A	Mivavotinib monohydrochloride	Inhibitor	99.91%	Unkown
HY-N0071	Crotonoside	Inhibitor	99.78%	Unkown
HY-15003	ATH686	Inhibitor	99.54%	Unkown
HY-12333	Denfivontinib	Inhibitor	98.0%	Unkown
HY-12344A	UNC2025 hydrochloride	Inhibitor	99.96%	Unkown
HY-10410	TG101209	Inhibitor	98.81%	Unkown
HY-15889	AMG 925	Inhibitor	99.02%	Unkown
HY-15166A	(E/Z)-Zotiraciclib hydrochloride	Inhibitor	99.90%	Unkown
HY-169396	TAE648	Ligand	99.50%	Unkown
HY-162037	CDDD11-8	Inhibitor	99.62%	Unkown
HY-120758	SEL24-B489	Inhibitor	99.02%	Unkown
HY-114331	DLK-IN-1	Inhibitor	98.27%	Unkown
HY-112145	FLT3-IN-3	Inhibitor	99.95%	Unkown
HY-120590	Ruserontinib	Inhibitor	99.32%	Unkown
HY-148070	FLT3-IN-17	Inhibitor	99.11%	Unkown
HY-114323	PROTAC FLT-3 degrader 1	Inhibitor	99.19%	Unkown
HY-100865	BPR1K871	Inhibitor	99.12%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-12420	JNJ-47117096 hydrochloride	Inhibitor	99.67%	Unkown
HY-15166B	(E/Z)-Zotiraciclib citrate	Inhibitor	99.83%	Unkown
HY-12960	SKLB4771	Inhibitor	99.20%	Unkown
HY-18161	CCT241736	Inhibitor	99.88%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	98.31%	Unkown
HY-108263	3-Hydroxy Midostaurin	Inhibitor	98.18%	Unkown
HY-159953	IRAK1/4/pan-FLT3 Kinase-IN-1	Inhibitor	99.25%	Unkown
HY-110293	CHMFL-FLT3-122	Inhibitor	98.47%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-109179A	Itacnosertib hydrochloride	Inhibitor	99.43%	Unkown
HY-132150A	HPK1-IN-2 dihydrochloride	Inhibitor	98.03%	Unkown
HY-107417	Hypothemycin	Inhibitor	98.0%	Unkown
HY-128571	FLT3-IN-4	Inhibitor	99.73%	Unkown
HY-177467	P0064	Inhibitor	98.0%	Unkown
HY-10201S2	Sorafenib-13C,d3	Inhibitor	98.35%	Unkown
HY-18952A	(Z)-SU5614	Inhibitor	98.09%	Unkown
HY-18744	FLT3-IN-2	Inhibitor	98.80%	Unkown
HY-13907	TCS 359	Inhibitor	99.76%	Unkown
HY-18179	AZD2932	Inhibitor	98.16%	Unkown
HY-128572	FLT3-IN-6	Inhibitor	99.25%	Unkown
HY-13016S	Cabozantinib-d6	Inhibitor	98.14%	Unkown
HY-151904	AXL-IN-13		98.03%	Unkown
HY-12432S1	Gilteritinib-d8	Inhibitor	98.53%	Unkown
HY-155195	FLT3/CHK1-IN-1	Inhibitor	99.37%	Unkown
HY-108263A	(S)-3-Hydroxy Midostaurin	Inhibitor	96.07%	Unkown
HY-148105	DS12881479	Inhibitor	99.63%	Unkown
HY-13016S1	Cabozantinib-d4	Inhibitor	99.04%	Unkown
HY-148669B	(S)-Bleximenib oxalate	Control	98.37%	Unkown
HY-110026	GTP-14564	Inhibitor	99.91%	Unkown
HY-50751S	Linifanib-d4	Inhibitor	/	Unkown
HY-16379S	Pacritinib-d4	Inhibitor	98.42%	Unkown
HY-144869	OTS447	Inhibitor	99.83%	Unkown
HY-148036	FLT3-IN-16	Inhibitor	98.98%	Unkown
HY-156794A	Enzomenib enantiomer	Inhibitor	98.01%	Unkown
HY-143286A	PF15 TFA	Degrader	99.72%	Unkown
HY-161708	PROTAC FLT3/CDKs degrader-1	Degrader	/	Unkown
HY-159953A	IRAK1/4/pan-FLT3 Kinase-IN-1 hydrochloride	Inhibitor	98.46%	Unkown
HY-134481	FLT3-IN-10	Inhibitor	98.80%	Unkown
HY-13537	BPR1J-097	Inhibitor	/	Unkown
HY-15198	KG5	Inhibitor	99.79%	Unkown
HY-13075	c-Fms-IN-3	Inhibitor	98.83%	Unkown
HY-15889A	AMG 925 (HCl)	Inhibitor	/	Unkown
HY-153473	FLT3-IN-19	Inhibitor	99.19%	Unkown
HY-13537A	BPR1J-097 Hydrochloride	Inhibitor	99.20%	Unkown
HY-13072R	Cenisertib (Standard)	Inhibitor	99.87%	Unkown
HY-13493	AC710	Inhibitor	99.13%	Unkown
HY-13223R	Crenolanib (Standard)	Inhibitor	98.12%	Unkown
HY-130247C	Flonoltinib sulfate	Inhibitor	/	Unkown
HY-10201S1	Sorafenib-d4	Inhibitor	99.9%	Unkown
HY-146749	FLT3/TrKA-IN-1	Inhibitor	/	Unkown
HY-13001S	Quizartinib-d8	Inhibitor	/	Unkown
HY-111545	BSc5371	Inhibitor	/	Unkown
HY-13024A	Rebastinib tosylate	Inhibitor	/	Unkown
HY-170576	FLT3-IN-28	Inhibitor	/	Unkown
HY-161709	FLT3/CDKs ligand-1	Degrader	/	Unkown
HY-163068	FLT3-IN-24	Inhibitor	/	Unkown
HY-171146	HSN748	Inhibitor	/	Unkown
HY-108263S	3-Hydroxy Midostaurin-d5	Inhibitor	/	Unkown
HY-143286	PF15	Inhibitor	/	Unkown
HY-145903	PDGFRα/FLT3-ITD-IN-2	Inhibitor	/	Unkown
HY-162906	FLT3/HDAC-IN-2	Inhibitor	/	Unkown
HY-148522	FLT3-IN-18	Inhibitor	/	Unkown
HY-168741	FLT3-ITD-IN-2	Inhibitor	/	Unkown
HY-112387	FLT3-IN-26	Inhibitor	/	Unkown
HY-162936	SILA-123	Inhibitor	/	Unkown
HY-175273	MA191	Degrader	/	Unkown
HY-149474	HDAC-IN-63	Inhibitor	/	Unkown
HY-E70723	FLT3 D835Y Recombinant Human Active Protein Kinase		/	Unkown
HY-123859	SR-2890	Inhibitor	/	Unkown
HY-18949	JI6	Inhibitor	/	Unkown
HY-145904	PDGFRα/FLT3-ITD-IN-3	Inhibitor	/	Unkown
HY-170689	CG-3-246	Inhibitor	/	Unkown
HY-144777	FLT3-IN-14	Inhibitor	/	Unkown
HY-E70724	FLT3 ITD Recombinant Human Active Protein Kinase		/	Unkown
HY-161280	PROTAC FLT-3 degrader 3	Degrader	/	Unkown
HY-173363	CHEMBL4444839	Inhibitor	/	Unkown
HY-168493	FLT3/VEGFR2-IN-1	Inhibitor	/	Unkown
HY-139619	LT-850-166	Inhibitor	/	Unkown
HY-120089	UNC1666	Inhibitor	/	Unkown
HY-174437A	FLT3-IN-32 TFA	Inhibitor	/	Unkown
HY-170640	FLT3-IN-29	Inhibitor	/	Unkown
HY-146680	FLT3/ITD-IN-4	Inhibitor	/	Unkown
HY-145015B	Tuspetinib dihydrochloride	Inhibitor	/	Unkown
HY-160690	GW632046X	Inhibitor	/	Unkown
HY-173214	FLT3-ITD-IN-3	Inhibitor	/	Unkown
HY-175611	FLT3/JAK2/BRD4 ligand-1	Ligand	/	Unkown
HY-115443	MZH29	Inhibitor	/	Unkown
HY-145691	HP1142	Inhibitor	/	Unkown
HY-126920	AFG206	Inhibitor	/	Unkown
HY-138032	SU11657	Inhibitor	/	Unkown
HY-179382	HSB401	Inhibitor	/	Unkown
HY-175473	HI042	Inhibitor	/	Unkown
HY-175900	FLT3 ligand-4	Ligand	/	Unkown
HY-125008	JH-IX-179	Inhibitor	/	Unkown
HY-143894	FLT3-IN-11	Inhibitor	/	Unkown
HY-150582	c-Met-IN-14	Inhibitor	/	Unkown
HY-181945	FLT3-IN-39	Inhibitor	/	Unkown
HY-162367	FLT3/CHK1-IN-2	Inhibitor	/	Unkown
HY-176735	FLT3/IRAK4-IN-1	Inhibitor	/	Unkown
HY-174437B	FLT3-IN-32 hydrochloride	Inhibitor	/	Unkown
HY-144709	FLT3/ITD-IN-1	Inhibitor	/	Unkown
HY-178858	PROTAC FLT3/CHK1 Degrader-1	Degrader	/	Unkown
HY-156410	FLT3-IN-23	Inhibitor	/	Unkown
HY-W751180	3-Hydroxy Midostaurin-13C6		/	Unkown
HY-123237	KRC-108	Inhibitor	/	Unkown
HY-158265	FLT3D835Y/F691L-IN-1	Inhibitor	/	Unkown
HY-182354	VEGFR2-IN-84	Inhibitor	/	Unkown
HY-160848	FLT3/ITD-IN-5	Inhibitor	/	Unkown
HY-178020	FLT3-IN-34	Inhibitor	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-145690	HP1328	Inhibitor	/	Unkown
HY-178996	FLT3-IN-36	Inhibitor	/	Unkown
HY-174137	FLT3-IN-31	Inhibitor	/	Unkown
HY-132150C	HPK1-IN-2 TFA	Inhibitor	/	Unkown
HY-155341	HSK205	Inhibitor	98.01%	Unkown
HY-18692	Multi-kinase-IN-12	Inhibitor	/	Unkown
HY-158325	PROTAC FLT-3 degrader 4	Inhibitor	/	Unkown
HY-115906	K783-0308	Inhibitor	/	Unkown
HY-175610	PROTAC FLT3/JAK2/BRD4 Degrader-1	Degrader	/	Unkown
HY-155112	Antiproliferative agent-30	Inhibitor	/	Unkown
HY-143278	FLT3-IN-13	Inhibitor	/	Unkown
HY-149539	PLM-101	Inhibitor	/	Unkown
HY-115778	UNC3133	Inhibitor	/	Unkown
HY-175274	MolPort-002-705-878	Inhibitor	/	Unkown
HY-184161	FYJ-195	Inhibitor	/	Unkown
HY-170769	FLT3 Ligand-Linker Conjugate 1	Inhibitor	/	Unkown
HY-174437	FLT3-IN-32	Inhibitor	/	Unkown
HY-15519	LBW242	Inhibitor	/	Unkown
HY-155594	LT-540-717	Inhibitor	/	Unkown
HY-121831	BDT001	Antagonist	/	Unkown
HY-169076	FLT3/HDAC-IN-1	Inhibitor	/	Unkown
HY-144711	FLT3/ITD-IN-3	Inhibitor	/	Unkown
HY-123586	L-783277	Inhibitor	/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib	Inhibitor	/	Unkown
HY-162032	FLT3-IN-25	Inhibitor	/	Unkown
HY-178908	FLT3-IN-35	Inhibitor	/	Unkown
HY-168982	Lomonitinib	Inhibitor	/	Unkown
HY-125051	SG3-179	Inhibitor	/	Unkown
HY-112378	D-65476	Inhibitor	/	Unkown
HY-115541	BRD4-IN-41		/	Unkown
HY-157213	LWY713	Degrader	/	Unkown
HY-155226	FLT3-IN-21	Inhibitor	/	Unkown
HY-151961	RSH-7	Inhibitor	98.74%	Unkown
HY-182293	BTK-IN-48	Inhibitor	/	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-144710	FLT3/ITD-IN-2	Inhibitor	/	Unkown
HY-179497	FLT3-IN-37	Inhibitor	/	Unkown
HY-161967	JAK2/FLT3-IN-3	Inhibitor	/	Unkown
HY-182004	FLT3-IN-40	Inhibitor	/	Unkown
HY-146886	FLT3-IN-15	Inhibitor	/	Unkown
HY-107144	LY2457546	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-178869	FLT3/CHK1 ligand-1	Ligand	/	Unkown
HY-161323	FLT3-ITD/D835Y-IN-1	Inhibitor	/	Unkown
HY-170846	FGFRs-IN-1	Inhibitor	/	Unkown
HY-143434	FLT3/D835Y-IN-1	Inhibitor	/	Unkown
HY-103464	5'-Fluoroindirubinoxime	Inhibitor	98.0%	Unkown
HY-155770	FLT3-IN-20	Inhibitor	/	Unkown
HY-50905S	Dovitinib-d8	Inhibitor	/	Unkown
HY-181086	FLT3/HDAC-IN-3	Inhibitor	/	Unkown
HY-111249	TTT 3002	Inhibitor	/	Unkown
HY-151945	TRK II-IN-1	Inhibitor	/	Unkown
HY-115904	FLT3/CDK4-IN-1	Inhibitor	/	Unkown
HY-175040	PROTAC FLT-3 degrader 5	Degrader	/	Unkown
HY-143895	FLT3-IN-12	Inhibitor	/	Unkown
HY-148521	PROTAC FLT3/CDK9 degrader-1	Degrader	/	Unkown
HY-155302	FLT3-IN-22	Inhibitor	/	Unkown
HY-10201S4	Sorafenib-d3 tosylate	Inhibitor	/	Unkown
HY-145902	PDGFRα/FLT3-ITD-IN-1	Inhibitor	/	Unkown
HY-182281	FLT3-IN-41	Inhibitor	/	Unkown
HY-112417	Ki11502	Inhibitor	99.30%	Unkown
HY-170558	FW-1	Inhibitor	/	Unkown
HY-178444	Flt-3-IN-1	Inhibitor	/	Unkown
HY-174911	FLT3-IN-33	Inhibitor	/	Unkown
HY-182937	FLC-8	Inhibitor	/	Unkown
HY-112475	Flt-3 Inhibitor III	Inhibitor	/	Unkown
HY-135317E	Emavusertib maleate	Inhibitor	/	Unkown
HY-130247B	Flonoltinib monomaleate	Inhibitor	/	Unkown
HY-112350	AGL 2043	Inhibitor	/	Unkown
HY-123201	KRN383 analog	Inhibitor	/	Unkown
HY-135317C	Emavusertib tosylate	Inhibitor	/	Unkown
HY-135317F	Emavusertib phosphate	Inhibitor	/	Unkown
HY-112366	FLT3-IN-38	Inhibitor	/	Unkown
HY-116129	BPR1J-340	Inhibitor	/	Unkown
HY-122240	AAE871	Inhibitor	/	Unkown
HY-13072B	Cenisertib benzoate	Inhibitor	/	Unkown
HY-101549A	MRX-2843 hydrochloride	Inhibitor	/	Unkown
HY-160787	NCGC1481	Inhibitor	/	Unkown
HY-10202B	Tandutinib sulfate	Inhibitor	/	Unkown
HY-148036S	FLT3-IN-16-d1	Inhibitor	/	Unkown
HY-168213	FLT3-IN-27	Inhibitor	/	Unkown
HY-135317D	Emavusertib mesylate	Inhibitor	/	Unkown
HY-12420A	JNJ-47117096	Inhibitor	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991114	Adezkibart	Ligand	96%	Unkown
HY-P990786	Anti-FLT3 Antibody (AGS62P)	Inhibitor	96.00%	Unkown
HY-P991208	Flt-3L-Ig (hum/hum)	Ligand	98%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FLT3	MGD	MGI:95559
Rattus norvegicus	FLT3	RGD	RGD:61308
Bos taurus	FLT3	VGNC	VGNC:29042
Felis catus	FLT3	VGNC	VGNC:62299
Canis familiaris	FLT3	VGNC	VGNC:40908
Macaca mulatta	FLT3	VGNC	VGNC:72679
Others	FLT3	NCBI