HDAC1 - histone deacetylase 1 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 487309

About HDAC1

Primary_assembly 2: 69,467,851-69,502,759 reverse strand.ROS_Cfam_1.0:CM025101.1

This gene has 1 transcript (splice variant), 277 orthologues and 10 paralogues.

HDAC1 Products (2)

mRNA Protein Name
XM_038659538.1 XP_038515466.1 histone deacetylase 1 isoform X2
XM_038659537.1 XP_038515465.1 histone deacetylase 1 isoform X1

HDAC1 Protein Structure

Arginase_HDAC

Arginase_HDAC: cl17011 (55 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 521 a.a.
Protein Preferred Names Protein Names

histone deacetylase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-10585 Valproic acid Inhibitor 99.89% Unkown
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-10585A Valproic acid sodium Inhibitor 99.65% Unkown
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes
HY-10585B Valproic acid sodium (2:1) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Phase
HY-14718A Resminostat hydrochloride Inhibitor 99.67% Phase 4
HY-12163 Entinostat Inhibitor 99.98% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-13606 Dacinostat Inhibitor 98.45% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-153358 TNG260 Inhibitor 99.33% Phase 2
HY-100748 Zabadinostat Inhibitor 99.83% Phase 2
HY-16012A Domatinostat Inhibitor 99.34% Phase 2
HY-101780 Tinostamustine Inhibitor 99.64% Phase 2
HY-14718 Resminostat Inhibitor 99.44% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-13432A Nanatinostat TFA Inhibitor / Phase 2
HY-13216 Pyroxamide Inhibitor 99.54% Phase 1
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-16425 RG2833 Inhibitor 99.31% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1
HY-164782 PT3 Inhibitor 99.94% Phase 1
HY-10226 JNJ-16241199 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (266)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13271A Tubastatin A Inhibitor 99.07% Unkown
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13428 Tubacin Inhibitor 97.11% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 99.31% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-19618 BRD3308 Inhibitor 98.34% Unkown
HY-144315 CYD19 Inhibitor 99.76% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-100719 BRD-6929 Inhibitor 99.01% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-N11692 9-Hydroxyoctadecanoic acid Inhibitor 98.0% Unkown
HY-19328 ACY-775 Inhibitor 99.71% Unkown
HY-104008 ACY-957 Inhibitor 99.63% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-102083 BRD4884 Inhibitor 99.14% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-18976 UF010 99.83% Unkown
HY-10585R Valproic acid (Standard) Inhibitor 99.97% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 98.10% Unkown
HY-145815A JPS014 TFA Degrader 98.12% Unkown
HY-18712 BG45 Inhibitor 99.95% Unkown
HY-150109 Purinostat mesylate Inhibitor 99.45% Unkown
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor 95.0% Unkown
HY-161464 Chlopynostat Inhibitor 98.36% Unkown
HY-162361 HDAC1-IN-7 Inhibitor 99.97% Unkown
HY-130493 HPB Inhibitor 99.11% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-158075 DNMT/HDAC-IN-1 Inhibitor 99.87% Unkown
HY-N2150 Psammaplin A Inhibitor 96.0% Unkown
HY-116818 Crebinostat Inhibitor 98.83% Unkown
HY-124295 Imofinostat Inhibitor 99.40% Unkown
HY-124053 BRD2492 Inhibitor 99.22% Unkown
HY-146346 HD-TAC7 Degrader 98.53% Unkown
HY-152134 PROTAC HDAC6 degrader 11 Degrader 98.12% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-N0857 Deoxyandrographolide 98.0% Unkown
HY-150109A Purinostat Inhibitor 98.04% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-145819 JPS036 99.31% Unkown
HY-170495 HDAC6 degrader-5 Inhibitor 99.55% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-142690A HDAC-IN-27 dihydrochloride Inhibitor 99.08% Unkown
HY-156422 KPZ560 Inhibitor 99.72% Unkown
HY-124337 BG48 Inhibitor 99.09% Unkown
HY-114303 CM-675 Inhibitor 99.53% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.59% Unkown
HY-178948 HDAC10-IN-3 Inhibitor / Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-178948A HDAC10-IN-3 formic Inhibitor / Unkown
HY-124782 HDAC8-IN-8 Inhibitor 99.01% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117374 HDAC3-IN-1 Inhibitor 99.28% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-141427 MOCPAC 99.64% Unkown
HY-117583 cis-BG47 Inhibitor 98.02% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-112147 IDO1 and HDAC1 Inhibitor Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-168088 DNMT1/HDAC-IN-1 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-145815 JPS014 / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-P11678 HDAC-IN-100 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-180934 AMC-3-030 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-162769 HDAC3-IN-5 Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-152133 PROTAC HDAC6 degrader 1 Degrader / Unkown
HY-176561 IOR-160 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-142690 HDAC-IN-27 Inhibitor 98.12% Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-172359 PROTAC HDAC6 degrader 4 Degrader / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-169433 Naph-Se-TMZ Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-184165 F2F-202 Inhibitor / Unkown
HY-183150 HDAC1-IN-13 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-181577 HDAC6-IN-73 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-N16881 Andrographidine E Inhibitor / Unkown
HY-186073 HDAC1 activator-1 Activator / Unkown
HY-161868 DLC-50 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-181640 HDAC1/3-IN-1 Inhibitor 99.81% Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-174149 HDAC6-IN-59 Inhibitor / Unkown
HY-173160 HDAC1-IN-10 Inhibitor / Unkown
HY-150597 HDAC-IN-46 Inhibitor / Unkown
HY-175988 DNMT/HDAC-IN-2 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-172200 PD-L1/HDAC6-IN-1 Inhibitor / Unkown
HY-178485 SJY26 Inhibitor / Unkown
HY-181843 HDAC-IN-99 Inhibitor / Unkown
HY-181877 IHCH-3185 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-151153 HDAC1-IN-5 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-161155 HDAC6-IN-31 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-162678 HDAC-IN-75 Inhibitor / Unkown
HY-178161 HDAC degrader-2 Degrader / Unkown
HY-174401 PROTAC HDAC6 degrader 5 Inhibitor / Unkown
HY-163894 HDAC6-IN-48 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-183366 HDAC1-IN-14 Inhibitor / Unkown
HY-W409652 CLK1/4-IN-2 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-172159 FF2039 Inhibitor / Unkown
HY-180829 HDAC6-IN-71 Inhibitor / Unkown
HY-175176 HDAC1/6-IN-3 Inhibitor / Unkown
HY-172889 PI3K/HDAC-IN-4 Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-181793 VEGFR2/HDAC-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-169156 HDAC6-IN-49 Inhibitor / Unkown
HY-178333 HDAC6-IN-66 Inhibitor / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-175021 HDAC-IN-91 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-161984 HDAC-IN-76 Inhibitor / Unkown
HY-145816 JPS016 / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-176904 JPS004 Degrader / Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-158371 HDAC/CK2-IN-1 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-162487 HDAC-IN-72 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-183320 HDAC6-IN-81 Inhibitor / Unkown
HY-180811 ALK/HDAC-IN-2 Inhibitor / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-157385 HDAC-IN-67 Inhibitor / Unkown
HY-179655 ST17 / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-145818 JPS035 / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-173520 EGFR/HDAC-IN-1 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-143462 c-Met/HDAC-IN-2 Inhibitor / Unkown
HY-175671 LSD1/HDAC-IN-3 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-172891 CDK9/HDAC1/HDAC3-IN-1 Inhibitor / Unkown
HY-162330 HDAC6-IN-36 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-172133 HDAC3-IN-6 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-181086 FLT3/HDAC-IN-3 Inhibitor / Unkown
HY-162781 HDAC1/6-IN-2 Inhibitor / Unkown
HY-163535 J208 Inhibitor / Unkown
HY-178021 HDAC1-IN-11 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-178023 HDAC6-IN-64 Inhibitor / Unkown
HY-119316 CM-414 Inhibitor / Unkown
HY-179374 Aurora kinase/HDAC-IN-1 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-119316A CM-545 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-147892 HDAC-IN-42 Inhibitor / Unkown
HY-150004 c-Met/HDAC-IN-3 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-168477 HDAC1-IN-8 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-177768 HDAC-IN-96 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-125645 M122 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / Unkown
HY-163503 HDAC6-IN-38 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-172878 HDAC/PSMD14-IN-1 Inhibitor / Unkown
HY-156444 HDAC1/CDK7-IN-1 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-174221 IMPDH II/HDAC1-IN-1 Inhibitor / Unkown
HY-163090 HR488B Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-161688 HDAC-IN-73 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-143241 HDAC-IN-34 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-124792 MRLB-223 Inhibitor / Unkown
HY-169439 Temozolomide-amino hydrochloride / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-170966 HDAC1-IN-9 Inhibitor / Unkown
HY-168502 HDAC-IN-81 Inhibitor / Unkown
HY-180224 HDAC6-IN-70 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-126566 Trichostatin C Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-144725 HDAC1/6-IN-1 Inhibitor / Unkown
HY-174449 HDAC6-IN-62 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-178022 HDAC6-IN-63 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-172394 ZSNI-21 Inhibitor / Unkown
HY-179654 ST13 Inhibitor / Unkown
HY-181768 HDAC3-IN-8 Inhibitor / Unkown
HY-163368 HDAC6-IN-34 Inhibitor / Unkown
HY-153514 HDAC-IN-54 Inhibitor / Unkown
HY-117583A BG47 Inhibitor / Unkown
HY-181010 HDAC1-IN-12 Inhibitor / Unkown
HY-P2044 Azumamide E Inhibitor / Unkown
HY-155222 TW9 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HDAC1 NCBI NCBI:3065