Topics

NECSO: A Novel Necrotic Cell Death Characterized by Sodium Overload

Cell Programmed Death Cellular Stress Calcium Homeostasis Mitochondrial Dysfunction

Ion overload serves as an execution mechanism. In 2025, following the identification of a small-molecule compound named "Necrocide 1" (NC1), this process—characterized as necrosis induced by sodium overload—was termed "Natroptosis," with the formally published designation being NECSO. This research established that sodium influx is not merely associated with damaged tissue but can directly cause cell death. NECSO is characterized by excessive intracellular sodium accumulation, membrane depolarization, osmotic imbalance, cell swelling, and lysis. Its pharmacological profile and reliance on specific ion channels distinguish it from apoptosis, necroptosis, ferroptosis, and other established cell death mechanisms[1][2].

NC1 binds to and persistently activates TRPM4, a calcium-activated, non-selective monovalent cation channel. Cells lacking TRPM4 are resistant to NC1-induced NECSO, establishing the channel as the primary target. This response is species-specific; NC1 activates human TRPM4 but not mouse TRPM4. Structural analysis and domain-swapping experiments indicate that this difference arises from determinants within the channel's transmembrane region. Regarding downstream pathways, TRPM4-mediated sodium influx elevates mitochondrial sodium concentrations and promotes sodium/calcium exchange via NCLX, thereby reducing mitochondrial calcium levels. This inhibition of oxidative phosphorylation and tricarboxylic acid (TCA) cycle activity leads to severe ATP depletion and loss of Na+/K+-ATPase function; the resulting disruption of ion gradients transforms the sodium load into osmotic swelling and plasma membrane rupture[1][3][4].

NECSO offers potential therapeutic applications. Its activation could kill tumors expressing susceptible human TRPM4 variants and bypass resistance to other cell death pathways.

A key study reported differential sensitivities among human cancer cells, and subsequent transcriptomic research explored NECSO-related signatures in lung and kidney cancers. However, co-expression-based signatures extend beyond experimentally validated execution mechanisms and should not be taken as evidence of pathway activity. Conversely, inhibiting TRPM4 activation or the downstream mitochondrial sodium cycle could protect tissues from damage caused by sodium influx, ischemia, hyperosmotic stress, or energy depletion. These applications remain experimental: prognostic gene signatures do not prove that tumors inevitably undergo NECSO, and the human-specific channel pharmacology of NC1 limits the applicability of traditional murine models for assessing efficacy and safety[1][2][4].

Several issues must be addressed before clinical development can proceed. The entire process—from channel opening to irreversible cell death—requires the establishment of quantitative thresholds for sodium loading, ATP loss, and duration of exposure. Researchers need to identify the endogenous triggers for sustained TRPM4 opening, determine whether NECSO can occur in human disease independently of NC1, and develop markers that distinguish it from secondary sodium accumulation seen in other forms of necrosis. Furthermore, interpreting the role of NCLX requires caution; altering mitochondrial Na+/Ca2+ exchange affects not only energy production, calcium signaling, and stress responses but may also entail broader biological effects beyond the scope of NECSO. Drug development must distinguish between controlled, tumor-selective activation and the cardiac and neurological risks associated with TRPM4 function. Species-relevant organoids, humanized channel models, and patient-derived tumors will play a crucial role in evaluating efficacy and toxicity. Structural information regarding the NC1 binding site could facilitate the design of more selective agonists or antagonists, while real-time monitoring of sodium concentration, mitochondrial calcium levels, ATP content, cell volume, and membrane integrity could provide a multi-step pharmacodynamic profile of pathway activation. Direct comparisons with necroptosis and osmotic lysis help establish which markers are specific, rather than merely general consequences of membrane damage[1][3][4].

Articles

All
  • All
  • Scientific Reviews
  • EDM
  • Blog
Most Recent
  • Most Recent
  • Oldest

Products

All
  • All
  • Inhibitors & Agonists
  • Isotope-Labeled Compounds
  • Fluorescent Dye
  • Peptides
  • Recombinant Proteins
  • Antibodies
  • Screening Libraries
  • Kits
  • Inhibitory Antibodies
  • Reference Standards
  • Induced Disease Models Products
  • Enzyme
  • Biochemical Assay Reagents
  • Natural Products
Cat. No. Product Name Information Application Publication
HY-B1756 Rotenone
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Environmental Pollutants   Autophagy   Mitochondrial Metabolism   Apoptosis  
Parkinson's Disease  
206
HY-17386 Rosiglitazone
Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM), with blood-brain barrier permeability. Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer.
PPAR   TRP Channel   Autophagy   Ferroptosis   Apoptosis  
Digestive System Disease   Prostate Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Non-Small Cell Lung Cancer   SARS-CoV-2 Infection   Type 2 Diabetes   Obesity  
197
HY-K0601 JC-1 Mitochondrial Membrane Potential Assay Kit

MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.

Cell Biology Cell Analysis Cell Apoptosis and Necrosis

169
HY-P1410 GsMTx4
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
TRP Channel   Piezo Channel  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
135
HY-101840 EIPA
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
TRP Channel   Prostaglandin Receptor   Autophagy   COX   Na+/H+ Exchanger (NHE)  
Colorectal Cancer   Prostate Cancer   Gastric Cancer   Pancreatic Cancer   Depression   Pain   Rheumatoid Arthritis  
112
HY-L089 Mitochondria-Targeted Compound Library
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 1,182 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Signaling Pathway Targeting Libraries

89
HY-10448 Capsaicin
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects.
Environmental Pollutants   Endogenous Metabolite   Autophagy   TRP Channel   Apoptosis  
Digestive System Disease   Breast Cancer   Prostate Cancer   Viral Infection   Pain   Digestive System Inflammation   SARS-CoV-2 Infection  
87
HY-L034 Anti-Aging Compound Library
Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. MCE Anti-Aging Compound Library contains 7,771 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

Disease Focused Libraries

84
HY-L076 Drug-Induced Liver Injury (DILI) Compound Library
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver. MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 641 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

Compound Characteristic Classified Libraries

84
HY-L180 Mitophagy Compound Library
Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms. MCE can provide a library of 655 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Signaling Pathway Targeting Libraries

84
HY-L034M Anti-Aging Compound Library Mini
Research has shown that drugs targeting aging pathways demonstrate promising potential in models of age-related diseases such as Alzheimer's disease, cardiovascular diseases, metabolic syndrome, osteoarthritis, and various malignancies. This suggests that intervening in the biological processes of aging may enable synergistic prevention and treatment of multiple chronic diseases. Against the backdrop of the gradual elucidation of core aging mechanisms-including cellular senescence, telomere attrition, epigenetic dysregulation, and chronic inflammation anti-aging research has shifted from traditional phenotypic interventions toward targeting key pathways that regulate biological age. The MCE Anti-Aging Compound Library Mini is precisely built upon this cutting-edge concept. It focuses on aging-related targets validated through genetic or functional studies, comprising 381 compounds designed to provide systematic research tools for aging biology and intervention strategy development. The library covers core mechanisms such as mTOR, SIRT, energy metabolism, clearance of senescent cells, optimization of mitochondrial function, and telomere maintenance. For each target, 1-5 compounds with clear activity and strong representativeness have been carefully selected, spanning the entire translational spectrum from preclinical tool molecules to clinically investigational drugs.

Disease Focused Libraries

83
HY-L085 Anti-Parkinson's Disease Compound Library
Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD. MCE offers a unique collection of 2,199 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

Disease Focused Libraries

83
HY-L144 Mitochondrial Protection Compound Library
Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases. The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 1,112 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.

Signaling Pathway Targeting Libraries

83
HY-L155 Mitochondrial Toxicity Compound Library
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 545 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Compound Characteristic Classified Libraries Signaling Pathway Targeting Libraries

83
HY-L161 Cytokine Inhibitors Library
Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases. MCE designs a unique collection of 1,416 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

Signaling Pathway Targeting Libraries

83
HY-L227 Amino Acid Metabolite Compound Library
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 195 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Metabolism Focused Libraries

83
HY-L263 Energy Metabolites Library
Energy metabolism is the most fundamental biochemical process in living organisms, encompassing glycolysis, the TCA cycle, oxidative phosphorylation, the pentose phosphate pathway, and fatty acid oxidation. These core pathways directly regulate cell survival, proliferation, differentiation, and apoptosis. Dysregulation of energy metabolism is closely linked to major diseases including cancer, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders, and ischemia‑reperfusion injury. Targeting these metabolic pathways has become a frontier in drug discovery and mechanistic research. The MCE Energy Metabolite Compound Library features 89 structurally defined small‑molecule compounds. It covers energy substrates, pathway intermediates, coenzymes and redox carriers, nucleotide derivatives, and microenvironmental modulators. This library is applicable to research areas including tumor metabolism, insulin resistance, mitochondrial dysfunction, oxidative stress, neuroprotection, and cardiometabolic diseases, providing a high‑quality tool for mechanistic studies, biomarker discovery, and high‑throughput drug screening.

Signaling Pathway Targeting Libraries

83
HY-W009724 2-Aminoethyl diphenylborinate
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue.
Calcium Channel   TRP Channel   CRAC Channel  
Inflammation or Immune System Disease   Pain   Hypertension   Lung Fibrosis  
82
HY-B0285 Amiloride
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel.
Sodium Channel   TRP Channel   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Pain   Digestive System Inflammation   Cardiovascular Disease  
72
HY-100965 Diphenyleneiodonium chloride
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
TRP Channel   NADPH Oxidase   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Pain   Lung Fibrosis  
66
HY-15640 Capsazepine
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.
TRP Channel   Apoptosis  
Cancer   Digestive System Disease   Pain   Digestive System Inflammation  
65
HY-B0545 Probenecid
Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.
TRP Channel   Bacterial   HIV  
Cancer   Metabolic or Endocrine Disease   Viral Infection   Bacterial Infection   Pain  
50
HY-135056 MitoTracker Green FM
Mito-Tracker Green is a green fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Green FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 490/523 nm.
Fluorescent Dye  
27
HY-N2333 Resiniferatoxin
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period.
TRP Channel  
Cancer   Blood or Cardio-cerebrovascular Disease  
14
HY-P99731 Milatuzumab
Milatuzumab (hLL1; MEDI-115) is a humanized anti-CD74 monoclonal antibody. CD74, a integral membrane protein, is associated with the promotion of B-cell growth and survival. Milatuzumab causes free radical oxygen generation, and loss of mitochondrial membrane potential. Milatuzumaba also decreases CD20/CD74 aggregates and cell adhesion, to lead to cell death.

Species: Human

CD74  
Cancer  
7
HY-100807 Quinolinic acid
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
MOFs   iGluR   Endogenous Metabolite   Reactive Oxygen Species (ROS)   NO Synthase   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
7
HY-135897 Urolithin C
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation.
Calcium Channel   Reactive Oxygen Species (ROS)   Apoptosis   Endogenous Metabolite  
Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation  
5
HY-139109 IR-783
IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and Apoptosis in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research.
Fluorescent Dye   Apoptosis   Mitochondrial Metabolism   ATP Synthase   Cytochrome P450   Dynamin  
Breast Cancer  
4
HY-100807S Quinolinic acid-d3
Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
Isotope-Labeled Compounds   iGluR   Endogenous Metabolite   Reactive Oxygen Species (ROS)   NO Synthase   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
4
HY-P1077 CALP1
CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.
mGluR   Phosphodiesterase (PDE)   Apoptosis   Calmodulin  
Digestive System Disease   Depression   Digestive System Inflammation   Parkinson's Disease  
3
HY-N2344 Procyanidin A1
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.
PKC  
Cancer   Digestive System Disease   Digestive System Inflammation  
3
HY-N5112A β,β-Dimethylacrylalkannin
β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC50=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis.
FGFR   Necroptosis   Apoptosis   CDK   JNK  
Inflammation or Immune System Disease  
3
HY-N0724 Mesaconitine
Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na+ and Ca2+ influx into endothelial cells, increases intracellular Na+ and Ca2+ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research.
NO Synthase  
Pain  
2
HY-N7395 Cyclic ADP-​ribose
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.
Calcium Channel   TRP Channel   Endogenous Metabolite  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
2
HY-B1756R Rotenone (Standard)
Rotenone (Standard) is the analytical standard of Rotenone. This product is intended for research and analytical applications. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Reference Standards   Mitochondrial Metabolism   Autophagy   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
2
HY-30267 4-Hydroxyphenyl acetate
4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor.
Quinone Reductase   Endogenous Metabolite  
Parkinson's Disease  
2
HY-134427 Palmitoyl coenzyme A lithium
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
2
HY-125857 Cytochrome C
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis.
Biochemical Assay Reagents   Apoptosis   Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
2
HY-N4246R Bacopaside I (Standard)
Bacopaside I (Standard) is the analytical standard of Bacopaside I. This product is intended for research and analytical applications. Bacopaside I is an orally active aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases.
Reference Standards   PKC   Akt   PI3K   Apoptosis   Pregnane X Receptor (PXR)   Monoamine Oxidase   Aquaporin  
Neurological, Eye or Ear Disease  
1
HY-136406S Bongkrekic acid-13C28
Bongkrekic acid-13C28 is the 13C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.
Isotope-Labeled Compounds   ATP Synthase  
Cancer  
1
HY-W127775 Demethyl Rhod-2 AM
Demethyl Rhod-2 AM is a fluorescent mitochondrial probe (λex=552 nm, λem=581 nm).
Biochemical Assay Reagents  
1
HY-D1359 Mito Red
Mito Red is a vital dye and mitochondrial stain that can be used to detect and evaluate mitochondrial function and status. Mito Red accumulates in mitochondria, and its fluorescence intensity is positively correlated with mitochondrial membrane potential. When the mitochondrial membrane potential increases, the fluorescence signal of Mito Red increases.
Fluorescent Dye  
1
HY-N2877 Annonacin
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways.
Potassium Channel   Sodium Channel   Na+/K+ ATPase   Calcium Channel   Apoptosis  
Neurological, Eye or Ear Disease  
1
HY-W040307 Saccharopine
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-119976 Boscalid
Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis.
Environmental Pollutants   Mitochondrial Metabolism   Fungal   Apoptosis   Succinate Dehydrogenase  
Fungal Infection  
1
HY-W040307B Saccharopine hydrochloride
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-133168 Englerin A
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload.
TRP Channel  
Cancer  
1
HY-P703329 TRPM4 Protein, Human (HEK293, Flag)
TRPM4 Protein, Human (HEK293, Flag) is the recombinant human-derived TRPM4, expressed by HEK293 , with Flag labeled tag. ,

Species: Human; Source: HEK293

1
HY-P86575 TOMM20 Antibody (YA6267)
TOMM20 Antibody (YA6267) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TOMM20.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

1
HY-P11380 Capa-2
Capa-2 is a neuropeptide. Capa-2 activates calcium ion influx, stimulates the production of NO, activates soluble guanylate cyclase (sGC), increases intracellular cGMP, and drives ion and fluid secretion. Capa-2 can be used in studies of diuresis.
Neurotensin Receptor   Calcium Channel   NO Synthase   Guanylate Cyclase  
/
HY-B0817S Pyridaben-d13
Pyridaben-d13 is the deuterium labeled Pyridaben. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function.
Parasite  
Infection  
/
HY-P1287 Conantokin-T
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa.
iGluR  
Neurological, Eye or Ear Disease  
/
HY-P10622 SHLP-3
SHLP-3 is a mitochondrial derived peptide encoded by the 16S ribosomal RNA (MT-RNR2) gene. SHLP-3 increases cell viability and reduces apoptosis in insulinoma NIT-1β cells and human prostate cancer 22Rv1 cells. SHLP-3 increases mitochondrial function and exerts cytoprotective effects by increasing mitochondrial oxygen consumption rate (OCR), cellular ATP and reducing the ability to produce ROS. SHLP-3 can be used in the study of diabetes and cancer.
Apoptosis   Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
/
HY-A0057AS2 Gabapentin-d4 hydrochloride
Gabapentin-d4 hydrochloride is the deuterium labeled Gabapentin hydrochloride (HY-A0057A). Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain.
Isotope-Labeled Compounds   Calcium Channel  
Cancer   Neurological, Eye or Ear Disease  
/
HY-D3527 MitoLumina 545
MitoLumina 545 is a mitochondria-targeting fluorescent probe used to label mitochondria in live cells. MitoLumina 545 contains a chloromethyl group that allows for covalent binding to mitochondrial thiol-containing proteins. MitoLumina 545 is primarily used for mitochondrial imaging, live-cell mitochondrial tracking, and multicolor fluorescence microscopy (Ex/Em = 540/565 nm).
Fluorescent Dye  
/
HY-P10618 BTM-P1
BTM-P1 is a polycationic peptide that exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. BTM-P1 can form ion-permeable channels in the inner mitochondrial membrane to interfere with mitochondrial energy processes.
Bacterial  
/
HY-P5796 FS-2
FS-2 is a potent and specific L-type CaV channel inhibitor. FS-2 inhibits high K+ or glucose induced L-type Ca2+ influx in RIN beta cells.
Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-D3513 MitoLumina 750
MitoLumina 750 is a mitochondria-targeting fluorescent probe used to label mitochondria in live cells. MitoLumina 750 contains a chloromethyl group that allows for covalent binding to mitochondrial thiol-containing proteins. MitoLumina 750 is primarily used for mitochondrial imaging, live-cell mitochondrial tracking, and multicolor fluorescence microscopy (Ex/Em = 745/775 nm).
Fluorescent Dye  
/
HY-P992072 Anti-Human/Mouse CD95 Antibody (HFE7A)
Anti-Human/Mouse CD95 Antibody (HFE7A) is an antibody targeting human/mouse Fas (CD95), with a Kd of 1.6 nM in mice. Anti-Human/Mouse CD95 Antibody (HFE7A) modulates the Fas-mediated apoptotic signaling pathway without blocking the binding of Jo2 to Fas. Anti-Human/Mouse CD95 Antibody (HFE7A) inhibits Jo2-induced caspase activation, mitochondrial depolarization, hepatocyte death and apoptosis. Anti-Human/Mouse CD95 Antibody (HFE7A) protects BALB/c mice against Jo2-induced acute liver injury and reduces Jo2-associated elevation of serum transaminase levels. Anti-Human/Mouse CD95 Antibody (HFE7A) can be used in studies related to liver injury. For isotype control, refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).

Species: Human/Mouse

Apoptosis   Caspase  
Liver Injury  
/
HY-B1756S Rotenone-d3
Rotenone-d3 is the deuterium labeled Rotenone (HY-B1756). Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Isotope-Labeled Compounds   Autophagy   Mitochondrial Metabolism   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P11638 Mitochondrial-targeted peptide BP29
Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia.
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-N3729 (-)-Denudatin B
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels. And (-)-Denudatin B has nonspecific antiplatelet action
Calcium Channel  
Neurological, Eye or Ear Disease   Hypertension  
/
HY-103293 Lys-Bradykinin
Lys-Bradykinin, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation.
Bradykinin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-B0517S Mepivacaine-d3
Mepivacaine-d3 is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-W721517 Gabapentin-d10
Gabapentin-d10 is the deuterium labeled Gabapentin (HY-A0057). Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain.
Isotope-Labeled Compounds   Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-P11637 Mitochondrial-targeted peptide BP19
Mitochondrial-targeted peptide BP19 is a fluorescent probe for the selective measurement of labile iron in the mitochondriairon. Mitochondrial-targeted peptide BP19 exhibits iron-selective sensing activity with mitochondrial accumulation, reduced fluorescence in iron-loaded cells, and fluorescence reinstatement upon iron chelation. Mitochondrial-targeted peptide BP19 evaluates mitochondrial labile iron levels in cultured fibroblasts with Friedreich's ataxia.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-P5288 BMAP-28
BMAP-28 is an antibiotic peptide and an inducer of the mitochondrial permeability transition pore. BMAP-28 induces cell death through opening of the mitochondrial permeability transition pore. BMAP-28 can be used in study of microbial infections and cancer.
Antibiotic  
Cancer   Infection  
/
HY-D3529 MitoLumina 640
MitoLumina 640 is a mitochondria-targeting fluorescent probe used to label mitochondria in live cells. MitoLumina 640 contains a chloromethyl group that allows for covalent binding to mitochondrial thiol-containing proteins. MitoLumina 640 is primarily used for mitochondrial imaging, live-cell mitochondrial tracking, and multicolor fluorescence microscopy (Ex/Em = 640/665 nm).
Fluorescent Dye  
/
HY-125714 Isoapoptolidin
Isoapoptolidin is a mitochondrial F0F1-ATPase inhibitor (Ki>100 μM, selective for mitochondrial complex V). Isoapoptolidin is promising for research of mitochondrial energy metabolism-related diseases (e.g., cancer, neurodegeneration).

Source: Nocardiopsis sp.

Mitochondrial Metabolism   ATP Synthase  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P991590 1D09C3
1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, JNK activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL).

Species: Human

MHC   Apoptosis   JNK   Reactive Oxygen Species (ROS)  
Cancer  
/
HY-138905 S-15176 difumarate
S-15176 difumarate is a compound with the activity of regulating mitochondrial membrane potential. S-15176 difumarate can act on the inner mitochondrial membrane to change the mitochondrial membrane potential.
Biochemical Assay Reagents  
/
HY-N20662 (+)-Neoalbaconol
(+)-Neoalbaconol is a selective Akt/PDK1 inhibitor (with an IC50 of 10 μM against hPDK1). (+)-Neoalbaconol selectively inhibits cancer cell proliferation, and induces energy depletion, apoptosis, autophagy and necroptosis in cancer cells. In addition, (+)-Neoalbaconol downregulates cIAP1/2 and TRAFs to activate non-canonical NF-κB and promote TNFα transcription, blocks EGFR-mediated VEGF production and receptor activation, and mediates cell necrosis via the RIPK3-ROS-dependent pathway. (+)-Neoalbaconol can be used in research related to nasopharyngeal carcinoma, melanoma, breast cancer and gastric cancer.

Source: Dictyopteris divaricata Okam

Akt   PDK-1  
Breast Cancer   Melanoma  
/
HY-107855S1 DL-Mevalonolactone-d3
DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-B0317AS1 Amlodipine-d9 maleate
Amlodipine-d9 maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
Calcium Channel   Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-139312S L-Mannitol-1-13C
L-Mannitol-1-13C is the 13C-labeled L-Mannitol (HY-139312). L-Mannitol is a synthetic L-configured acyclic sugar alcohol. L-Mannitol scavenges free radicals, reduces injection-related inflammation and swelling, and inhibits hyaluronic acid degradation. L-Mannitol can be oxidized as a substrate to L-fructose. L-Mannitol serves as a pharmaceutical excipient and can be used in relevant research in the food and pharmaceutical fields.
Isotope-Labeled Compounds   Biochemical Assay Reagents   Drug Intermediate  
Inflammation or Immune System Disease  
/
HY-P11743 Mitochondrial penetrating peptide
Mitochondrial penetrating peptide is a peptide sequence (FrFKFrFK-CONH2) that selectively transports cargo into mitochondria. Mitochondrial penetrating peptide possesses special physicochemical properties, enabling it to selectively translocate dinuclear Ru (II) polypyridine complexes into mitochondria of living mammalian cells without the aid of solvents or membrane permeabilization treatments, thus achieving precise mitochondrial localization and enrichment of the complexes while excluding their distribution in the nucleus. Mitochondrial penetrating peptide enables dynamic monitoring of mitochondrial oxygen concentration and ROS production in living mammalian cells via changes in the luminescence lifetime of the coupled Ru (II) complex.
Biochemical Assay Reagents   Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
/
HY-P992365 HFB101110
HFB101110 is a human-derived inhibitor and Treg depleter that specifically targets CCR8. It does not bind to the homologous CCR4 receptor and is mainly used in research on solid tumors, renal cell carcinoma and colorectal cancer. HFB101110 blocks hCCL1 binding by interacting with the N-terminal extracellular domain of hCCR8, thereby inhibiting hCCL1-induced calcium influx, chemotaxis and downstream signaling pathways. Meanwhile, HFB101110 can mediate ADCC effects to specifically deplete CCR8-positive cells, including intratumoral Tregs. HFB101110 exhibits favorable anti-tumor activity and pharmacokinetic properties.

Species: Human

CCR  
Colorectal Cancer  
/
HY-14656S1 Diltiazem-(acetoxy-d3) hydrochloride
Diltiazem-(acetoxy-d3) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].
Isotope-Labeled Compounds   Calcium Channel  
Blood or Cardio-cerebrovascular Disease  
/
HY-D3514 MitoLumina 680
MitoLumina 680 is a mitochondria-targeting fluorescent probe used to label mitochondria in live cells. MitoLumina 680 contains a chloromethyl group that allows for covalent binding to mitochondrial thiol-containing proteins. MitoLumina 680 is primarily used for mitochondrial imaging, live-cell mitochondrial tracking, and multicolor fluorescence microscopy (Ex/Em = 678/700 nm).
Fluorescent Dye  
/
HY-D3512 MitoLumina 780
MitoLumina 780 is a mitochondria-targeting fluorescent probe used to label mitochondria in live cells. MitoLumina 780 contains a chloromethyl group that allows for covalent binding to mitochondrial thiol-containing proteins. MitoLumina 780 is primarily used for mitochondrial imaging, live-cell mitochondrial tracking, and multicolor fluorescence microscopy (Ex/Em = 778/805 nm).
Fluorescent Dye  
/
HY-D3528 MitoLumina 590
MitoLumina 590 is a mitochondria-targeting fluorescent probe used to label mitochondria in live cells. MitoLumina 590 contains a chloromethyl group that allows for covalent binding to mitochondrial thiol-containing proteins. MitoLumina 590s primarily used for mitochondrial imaging, live-cell mitochondrial tracking, and multicolor fluorescence microscopy (Ex/Em = 589/606 nm).
Fluorescent Dye  
/
HY-P0245 Speract
Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
Mitochondrial Metabolism  
Metabolic or Endocrine Disease  
/
HY-N6663R 3-Carene (Standard)
3-Carene (Standard) is the analytical standard of 3-Carene (HY-N6663). This product is intended for research and analytical applications. 3-Carene is an orally active TCA cycle enzyme inhibitor. 3-Carene inhibits succinate dehydrogenase and malate dehydrogenase as well as pyruvate kinase, disrupting energy metabolism. 3-Carene disrupts cell wall and cell membrane integrity, leading to potassium ion leakage, protein leakage, membrane depolarization, ATP depletion, morphological disruption, and cell lysis. 3-Carene interferes with amino acid metabolism, pantothenate and CoA biosynthesis, purine and pyrimidine metabolism, and aminoacyl-tRNA biosynthesis. 3-Carene enhances GABA receptor-mediated synaptic responses. 3-Carene can be used in research on bacterial infections, inflammation, anxiety, and sleep disorders.
Reference Standards   Mitochondrial Metabolism   Bacterial   GABA Receptor   Succinate Dehydrogenase   Malate Dehydrogenase (MDH)   Pyruvate Kinase  
Bacterial Infection   Anxiety or Fear-Related Disease   Sleep-Wake Disorder   Rheumatoid Arthritis  
/
HY-100168R BAPTA (Standard)
BAPTA (Standard) is the analytical standard of BAPTA. This product is intended for research and analytical applications. BBAPTA is a selective and cell-impermeant chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
Reference Standards   Phospholipase  
/
HY-W751874 Acetyl methylene blue
Acetyl methylene blue can be used to synthesize mitochondrial development stimulators, which can be used for eye diseases related to insufficient mitochondrial function in nerve cells.
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease  
/
HY-N0391G L-Citrulline (GMP)
L-Citrulline GMP is an orally active, blood-brain barrier permeable neutral α-amino acid. L-Citrulline GMP inhibits the mitochondrial translocation of Drp1 and maintains mitochondrial homeostasis via a NO-dependent pathway, thereby reducing excessive ROS production. Consequently, L-Citrulline GMP protects sperm DNA integrity, stabilizes the blood-testis barrier and improves semen quality. L-Citrulline GMP can be used in research related to male infertility, mycobacterial infection (tuberculosis) and radiation combined injury.
Dynamin   Reactive Oxygen Species (ROS)  
Genitourinary Inflammation   Mycobacterium Tuberculosis Infection  
/
HY-B1474S1 Alexidine-d10
Alexidine-d10 is the deuterium labeled Alexidine (HY-B1474). Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.
Isotope-Labeled Compounds   Fungal  
Cancer   Infection  
/
HY-14771S Imeglimin-d3
Imeglimin-d3 (EMD 387008-d3) is deuterium labeled Imeglimin. Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.
Isotope-Labeled Compounds   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism  
Metabolic or Endocrine Disease  
/
HY-103293B Lys-Bradykinin tetraacetate
Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation.
Bradykinin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-100807S1 Quinolinic acid-13C7
Quinolinic acid-13C7 is the 13C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   Reactive Oxygen Species (ROS)   NO Synthase   Apoptosis  
Huntington's Disease  
/
HY-14656S2 Diltiazem-d6 hydrochloride
Diltiazem-d6 (hydrochloride) (CRD-401-d6 (hydrochloride)) is deuterium labeled Diltiazem (hydrochloride). Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
Isotope-Labeled Compounds   Calcium Channel  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-100168BR BAPTA tetrapotassium (Standard)
BAPTA tetrapotassium (Standard) is the analytical standard of BAPTA tetrapotassium (HY-100168B). This product is intended for research and analytical applications. BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA tetrapotassium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
Reference Standards   Phospholipase  
/
HY-30267R 4-Hydroxyphenyl acetate (Standard)
4-Hydroxyphenyl acetate (Standard) is the analytical standard of 4-Hydroxyphenyl acetate. This product is intended for research and analytical applications. 4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor.
Endogenous Metabolite   Reference Standards  
/
HY-N12560 Fusaramin
Fusaramin is a mitochondrial inhibitor, has antiplant pathogenic fungal activity.

Source: Saccharomyces cerevisiae

Mitochondrial Metabolism  
Infection  
/
HY-P3384 Pezadeftide
Pezadeftide is a potent antifungal peptide. Pezadeftide can enter fungal cells and cause a rapid mitochondrial response that results in hyperpolarization of the mitochondrial membrane.
Fungal  
Inflammation or Immune System Disease  
/
HY-N7875 Celangulin
Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca2+ after influx from the external. Celangulin activates the calcium channel in the ER.
Others  
/
HY-B0263S1 Thiabendazole-13C6
Thiabendazole-13C6 is the 13C6 labeled Thiabendazole. Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.
Isotope-Labeled Compounds   Mitochondrial Metabolism   Parasite  
Infection  
/
HY-P11638A Mitochondrial-targeted peptide BP29 acetate
Mitochondrial-targeted peptide BP29 acetate is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 acetate protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 acetate prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 acetate can be used for the research of Friedreich's ataxia.
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-N1214A (E/Z)-Squalene
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner.

Source: Human Blood, Feces, Sweat

Apoptosis  
Cancer  
/
HY-119976R Boscalid (Standard)
Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis.
Reference Standards   Apoptosis   Fungal   Mitochondrial Metabolism   Succinate Dehydrogenase  
Infection  
/
HY-B0317AS Amlodipine-d4 maleate
Amlodipine-d4 (maleate) is the deuterium labeled Amlodipine maleate. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
Isotope-Labeled Compounds   Calcium Channel  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-14656S Diltiazem-d3 hydrochloride
Diltiazem-d3 (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].
Calcium Channel  
Blood or Cardio-cerebrovascular Disease  
/
HY-100573S Necrosulfonamide-d4
Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide (HY-100573). Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.
Isotope-Labeled Compounds   Mixed Lineage Kinase   Necroptosis   Pyroptosis   Caspase   NOD-like Receptor (NLR)   Keap1-Nrf2   TNF Receptor   Integrin   NO Synthase   Heme Oxygenase (HO)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P991736 Anti-IL11 Antibody (X203, Mouse IgG)
Anti-IL11 Antibody (X203, Mouse IgG) is an antibody targeting IL-11. Anti-IL11 Antibody (X203, Mouse IgG) inhibits IL-11-mediated activation of the ERK-mTORC1 axis, inactivation of LKB1-AMPK, and pro-senescence pathways. Anti-IL11 Antibody (X203, Mouse IgG) alleviates age-related metabolic decline, improves muscle function, reduces tissue fibrosis, decreases the expression of senescence markers, and maintains telomere length and mtDNA copy number. Anti-IL11 Antibody (X203, Mouse IgG) restores browning of white adipose tissue, upregulates thermogenic and mitochondrial biogenesis gene programs, reduces lipid droplet size, and decreases immune cell infiltration in visceral white adipose tissue. Anti-IL11 Antibody (X203, Mouse IgG) extends the median lifespan of mice and reduces the incidence of age-related tumors. Anti-IL11 Antibody (X203, Mouse IgG) can be used in the research of age-related metabolic decline, sarcopenia and age-related cancers.

Species: Human

Interleukin Related   ERK   mTOR   AMPK  
Cancer   Inflammation or Immune System Disease  
/
HY-107855S DL-Mevalonolactone-d7
DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-113006 3-Methylglutarylcarnitine
3-Methylglutarylcarnitine is a biomarker of disease associated with compromised mitochondrial energy metabolism.
Endogenous Metabolite  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-N6663 3-Carene
3-Carene is an orally active TCA cycle enzyme inhibitor. 3-Carene inhibits succinate dehydrogenase and malate dehydrogenase as well as pyruvate kinase, disrupting energy metabolism. 3-Carene disrupts cell wall and cell membrane integrity, leading to potassium ion leakage, protein leakage, membrane depolarization, ATP depletion, morphological disruption, and cell lysis. 3-Carene interferes with amino acid metabolism, pantothenate and CoA biosynthesis, purine and pyrimidine metabolism, and aminoacyl-tRNA biosynthesis. 3-Carene enhances GABA receptor-mediated synaptic responses. 3-Carene can be used in research on bacterial infections, inflammation, anxiety, and sleep disorders.
Mitochondrial Metabolism   Bacterial   GABA Receptor   Succinate Dehydrogenase   Malate Dehydrogenase (MDH)   Pyruvate Kinase  
Bacterial Infection   Anxiety or Fear-Related Disease   Sleep-Wake Disorder   Rheumatoid Arthritis  
/
HY-P3037A Imperatoxin A TFA
Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca2+-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca2+ from the sarcoplasmatic reticulum into the cell.
Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-P3003S Cereulide-13C6
Cereulide-13C6 is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.
Isotope-Labeled Compounds   Mitochondrial Metabolism   Potassium Channel   Reactive Oxygen Species (ROS)   Apoptosis   Autophagy  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P990189 Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243)
Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to monkey/human MHC class II. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can inhibits tumor cells proliferation and induce apoptosis. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) increases cellular reactive oxygen species (ROS) and loss of mitochondrial membrane potential in human endothelial cells. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can be used for the researches of cancer and infection, such as lymphoma.

Species: Human/Monkey

MHC   Apoptosis   Reactive Oxygen Species (ROS)  
Cancer   Infection  
/
HY-P10933 PRO20
PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. PRO20 inhibits Prorenin-induced calcium influx with an IC50 value of 81 nmol/L. PRO20 exerts antihypertensive activity by blocking the binding of prorenin to the PRR, inhibiting the activation of the renin-angiotensin system (RAS), and reducing the production of angiotensin II (Ang II). PRO20 is promising for research of antihypertensive agents.
Renin  
Blood or Cardio-cerebrovascular Disease  
/
HY-N4246 Bacopaside I
Bacopaside I is an orally active aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases.
Aquaporin   PKC   Akt   PI3K   Apoptosis   Monoamine Oxidase   Pregnane X Receptor (PXR)  
Breast Cancer   Cancer Immunology   Immunotherapy for Colorectal Cancer   Ischemic Stroke   Vascular Dementia  
/
HY-P3003 Cereulide
Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.

Source: Bacillus cereus

Potassium Channel   Apoptosis   Autophagy   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Fungal Infection  
/
HY-P10629 PSMα2
PSMα2 is a potent PSM (phenol-soluble modulin) peptide toward mouse neutrophils, led to strong influx of leukocytes.
Others  
Inflammation or Immune System Disease  
/
HY-103293A Lys-Bradykinin TFA
Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin (HY-103293). Lys-Bradykinin TFA is a ligand for kallidin and bradykinin receptor, which can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin TFA serves as a vasodilator, which widens blood vessels and increases blood flow. Lys-Bradykinin TFA stimulates net Na+ influx, and contributes to DNA synthesis. Lys-Bradykinin TFA involves in vascular regulation, inflammation and pain sensation.
Bradykinin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-N2060 Evocarpine
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity.
Apoptosis   Bacterial  
Cancer   Digestive System Disease   Bacterial Infection   Digestive System Inflammation  
/
HY-34740S Ethylmalonic acid-d3
Ethylmalonic acid-d3 is the deuterium labeled Ethylmalonic acid (HY-34740). Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation.
Mitochondrial Metabolism   Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-108398B 11(Z),14(Z),17(Z)-Eicosatrienoic acid
11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is an unsaturated fatty acid that affects mitochondrial genome maintenance. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid fully incorporates into cell membrane phospholipids and supports the initial induction of cellular respiration, but fails to sustain the continuous replication and retention of mitochondrial genomes. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is applicable to research related to fatty acid acyl chain structure-dependent mitochondrial genome maintenance and mitochondrial biogenesis.

Source: Saccharomyces cerevisiae

Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W012550 D-Carnitine
D-Carnitine is an orally available isomer of the essential nutrient L-carnitine that promotes long-chain fatty acid transport into the mitochondrial matrix for beta-oxidation. D-Carnitine has antiparasitic activity.
Parasite  
Parasitic Infection  
/
HY-P10409 SHLP2
SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinson’s disease.
Apoptosis   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-DY1032 MitoTracker Green FM (solution)
Mito-Tracker Green (solution) is a green fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Green FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 490/523 nm.
Solvent and concentration: DMSO: 1 mM
Fluorescent Dye  
/
HY-100807R Quinolinic acid (Standard)
Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

Source: Human Blood, Cerebrospinal Fluid (CSF), Urine

Reference Standards   iGluR   Endogenous Metabolite   Reactive Oxygen Species (ROS)   NO Synthase   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-Y0262B Sodium oxalate,ACS,99.5%
Sodium oxalate is an orally active dispersant and coordination agent. Sodium oxalate causes mitochondrial dysfunction. Sodium oxalate has catalytic enhancing activity. Sodium oxalate induces stable chronic kidney disease. Sodium oxalate induces highly malignant and undifferentiated breast tumors.
Environmental Pollutants   Mitochondrial Metabolism   Biochemical Assay Reagents  
Cancer   Metabolic or Endocrine Disease  
/
HY-P99761 Obexelimab
Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus.

Species: Human

CD19   Apoptosis  
Inflammation or Immune System Disease  
/
HY-401424 Cremophor EL-36
Cremophor EL-36 is a non-ionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel (HY-B0015). For example, Cremophor EL-36 can enhance the intracellular influx of Etoposide (HY-13629) without affecting drug efflux, and can dose-dependently increase the accumulation of VP-16 in lung adenocarcinoma cells (such as PC-14 and A549), significantly enhancing its cytotoxic effect.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-P701737 PDK4 Protein, Human (Active, GST)
PDK4 Protein phosphorylates PDHA1 and PDHA2, inhibiting pyruvate dehydrogenase activity. This reduces glucose utilization, enhances fat metabolism, and helps maintain blood glucose levels during fasting. PDK4 also regulates fatty acid oxidation and biosynthesis, generates reactive oxygen species, protects epithelial cells, and regulates cell proliferation through metabolic regulation. PDK4 Protein, Human (GST) is the recombinant human-derived PDK4 protein, expressed by E. coli , with N-GST labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins Atypical Kinases PDHK PDK4/PDHK4

/
HY-P76556 PTPMT1 Protein, Human (His)
The PTPMT1 protein is a lipid phosphatase that critically regulates cellular lipid metabolism by dephosphorylating phosphatidylglycerolphosphate (PGP) to form phosphatidylglycerol (PG). This step is critical for the biosynthesis of cardiolipin, a key mitochondrial phospholipid that regulates membrane integrity and mitochondrial activity. PTPMT1 Protein, Human (His) is the recombinant human-derived PTPMT1 protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

/
HY-P70821 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P7307 TRAIL R2/TNFRSF10B Protein, Human (HEK293)
TRAIL R2/TNFRSF10B Protein, Human (HEK293) is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

Species: Human; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P702727 FYN Protein, Human (Active, Biotinylated, sf9, His, Flag, Avi)
FYN Protein, Human (Biotinylated, sf9, His, Flag, Avi) is the recombinant human-derived FYN, expressed by Sf9 insect cells , with Avi, His, Flag labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Biotinylated Proteins Transferases (EC 2) Protein Tyrosine Kinases TK Src FYN

/
HY-P74497 TRAIL R2/TNFRSF10B Protein, Human (HEK293, hFc)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (HEK293, hFc) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P72098 ATP5D Protein, Human (His)
ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-10*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Translocases (EC 7)

/
HY-P74639 PDK4 Protein, Mouse (sf9, His-GST)
PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2.This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration.PDK4 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived PDK4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Mouse; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins Atypical Kinases PDHK PDK4/PDHK4

/
HY-P78220 TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His-Avi)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Receptor Proteins Biotinylated Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily

/
HY-P78530 TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P72977 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P78363 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily

/
HY-P74498 TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Receptor Proteins Biotinylated Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P71378 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His)
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P72097 ATP5D Protein, Human (His-SUMO)
ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His-SUMO) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Translocases (EC 7)

/
HY-P72779 TRAIL R2/TNFRSF10B Protein, Human
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

Cytokines and Growth Factors Receptor Proteins TNF Superfamily Cytokine Receptors TNF Receptor Superfamily Death Receptor 5

/
HY-P76264 CKMT1A Protein, Human (sf9, His)
CKMT1A is a creatine kinase isoenzyme that plays a key role in the reversible transfer of phosphate between ATP and creatine phosphate. The function of this enzyme is critical for tissues with dynamic energy needs, such as skeletal muscle, heart, brain, and sperm. CKMT1A Protein, Human (sf9, His) is the recombinant human-derived CKMT1A protein, expressed by Sf9 insect cells , with N-His labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Transferases (EC 2)

/
HY-P76706 ABHD10 Protein, Human (sf9, His)
The ABHD10 protein is an acylprotein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. It regulates mitochondrial S-depalmitoylation of peroxiredoxin-5/PRDX5 and modulates mitochondrial antioxidant capacity. ABHD10 Protein, Human (sf9, His) is the recombinant human-derived ABHD10 protein, expressed by Sf9 insect cells , with N-His labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Hydrolases (EC 3)

/
HY-P76827 CKMT2 Protein, Rat (His)
CKMT2 Protein is a member of the ATP:guanido phosphotransferase family. CKMT2 Protein, Rat (His) is the recombinant rat-derived CKMT2 protein, expressed by E. coli , with N-His labeled tag.

Species: Rat; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

/
HY-P702782 MTFP1 Protein, Human (GST)
MTFP1 Protein, Human (GST) is the recombinant human-derived MTFP1, expressed by E. coli , with N-GST labeled tag. ,

Species: Human; Source: E. coli

/
HY-P76827A CKMT2 Protein, Rat (His, Solution)
The CKMT2 protein is predicted to have ubiquitin protein transferase activity and participate in the regulation of the epidermal growth factor receptor signaling pathway. It is involved in autoubiquitination and ubiquitin-dependent protein catabolic processes through the multivesicular body sorting pathway. CKMT2 Protein, Rat (His, Solution) is the recombinant rat-derived CKMT2 protein, expressed by E. coli , with N-His labeled tag.

Species: Rat; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

/
HY-P81635 TOMM20 Antibody (YA1380)
TOMM20 Antibody (YA1380) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TOMM20.

Host: Rabbit; Reactivity: Human, Hamster

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P83608 Mitochondrial Ferritin Antibody (YA3353)
Mitochondrial Ferritin Antibody (YA3353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mitochondrial Ferritin.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P80672 FH Antibody (YA763)
FH Antibody (YA763) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FH.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P88210 TRPM4 Antibody (YA7894)
TRPM4 Antibody (YA7894) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRPM4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

/
HY-P88210A TRPM4 Antibody (YA7894)(PBS only)
TRPM4 Antibody (YA7894) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRPM4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

/
HY-P85468 CKMT2 Antibody (YA5160)
CKMT2 Antibody (YA5160) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CKMT2.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P85545 Fyn Antibody (YA5237)
Fyn Antibody (YA5237) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fyn.

Host: Mouse; Reactivity: Human, Monkey, Rat, Mouse

Monoclonal Antibodies Primary Antibodies

/
HY-P811593 SLC8B1 Antibody
SLC8B1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SLC8B1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

/
HY-P81635A TOMM20 Antibody (YA1380)(PBS only)
TOMM20 Antibody (YA1380) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TOMM20.

Host: Rabbit; Reactivity: Human, Hamster

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P85560 CKMT2 Antibody (YA5252)
CKMT2 Antibody (YA5252) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CKMT2.

Host: Mouse; Reactivity: Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P85577 DR5 Antibody (YA5269)
DR5 Antibody (YA5269) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DR5.

Host: Mouse; Reactivity: Human, Mouse

Monoclonal Antibodies Primary Antibodies

/
HY-P87096 Sulfite oxidase Antibody (YA6789)
Sulfite oxidase Antibody (YA6789) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sulfite oxidase.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P811018 CKMT2 Antibody
CKMT2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CKMT2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

/
HY-P811308 MIMP Antibody
MIMP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MIMP.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

/

Keywords

NECSO | necrosis by sodium overload | TRPM4 | necrocide 1 | sodium influx | mitochondrial sodium | NCLX | energy depletion | osmotic swelling | regulated necrosis