PEG3 - paternally expressed 3 Gene

Also Known as PW1; ZNF904; ZSCAN24; ZKSCAN22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5178

About PEG3

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:56,810,082-56,840,726 (from NCBI)

This gene has 18 transcripts (splice variants), 333 orthologues and 29 paralogues. Biased expression in ovary (RPKM 126.4), placenta (RPKM 67.7) and 4 other tissues.

Summary

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in Other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely Other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type Zinc Finger Protein family. PEG3 may play a role in cell proliferation and p53-mediated Apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]

PEG3 Products (27)

mRNA Protein Name
NM_001146184.2 NP_001139656.1 paternally-expressed gene 3 protein isoform 1
NM_001146185.2 NP_001139657.1 paternally-expressed gene 3 protein isoform 2
NM_001146187.2 NP_001139659.1 paternally-expressed gene 3 protein isoform 3
NM_001369717.1 NP_001356646.1 paternally-expressed gene 3 protein isoform 4
NM_001369718.1 NP_001356647.1 paternally-expressed gene 3 protein isoform 4
NM_001369719.1 NP_001356648.1 paternally-expressed gene 3 protein isoform 5
NM_001369720.1 NP_001356649.1 paternally-expressed gene 3 protein isoform 3
NM_001369721.1 NP_001356650.1 paternally-expressed gene 3 protein isoform 3
NM_001369722.1 NP_001356651.1 paternally-expressed gene 3 protein isoform 3
NM_001369723.1 NP_001356652.1 paternally-expressed gene 3 protein isoform 3
NM_001369724.1 NP_001356653.1 paternally-expressed gene 3 protein isoform 3
NM_001369725.1 NP_001356654.1 paternally-expressed gene 3 protein isoform 3
NM_001369726.1 NP_001356655.1 paternally-expressed gene 3 protein isoform 3
NM_001369727.1 NP_001356656.1 paternally-expressed gene 3 protein isoform 3
NM_001369728.1 NP_001356657.1 paternally-expressed gene 3 protein isoform 3
NM_001369729.1 NP_001356658.1 paternally-expressed gene 3 protein isoform 3
NM_001369730.1 NP_001356659.1 paternally-expressed gene 3 protein isoform 3
NM_001369731.1 NP_001356660.1 paternally-expressed gene 3 protein isoform 3
NM_001369732.1 NP_001356661.1 paternally-expressed gene 3 protein isoform 3
NM_001369733.1 NP_001356662.1 paternally-expressed gene 3 protein isoform 3
NM_001369734.1 NP_001356663.1 paternally-expressed gene 3 protein isoform 6
NM_001369735.1 NP_001356664.1 paternally-expressed gene 3 protein isoform 6
NM_001369736.1 NP_001356665.1 paternally-expressed gene 3 protein isoform 6
NM_001369737.1 NP_001356666.1 paternally-expressed gene 3 protein isoform 6
NM_001369738.1 NP_001356667.1 paternally-expressed gene 3 protein isoform 6
NM_001369739.1 NP_001356668.1 paternally-expressed gene 3 protein isoform 3
NM_006210.3 NP_006201.1 paternally-expressed gene 3 protein isoform 1

PEG3 Protein Structure

SCAN

SCAN: SCAN domain (41 - 132)

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (452 - 474)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (505 - 527)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (563 - 585)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (627 - 649)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (969 - 991)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1107 - 1129)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1163 - 1185)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1226 - 1247)

zf-C2HC_2

zf-C2HC_2: zinc-finger of a C2HC-type (1281 - 1302)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1332 - 1354)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1505 - 1527)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1564 - 1586)

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  • 1588 a.a.
Protein Preferred Names Protein Names

paternally-expressed gene 3 protein

  • Kruppel-type zinc finger protein

Related Diseases

Diseases Alias
Glioma
Non-Syndromic X-Linked Intellectual Disability 2
  • Mrx2

Transient Neonatal Diabetes Mellitus
  • Diabetes Mellitus, Transient Neonatal

  • Tndm

  • Chromosome 6-Associated Transient Diabetes Mellitus

  • Dmtn

  • Diabetes Mellitus, 6q24-Related Transient Neonatal

  • Tndm1

  • Neonatal Diabetes Mellitus, Transient

  • Tndm -[Transient Neonatal Diabetes Mellitus]

Ureter Transitional Cell Carcinoma
  • Transitional Cell Carcinoma Of Ureter

  • Ureteral Urothelial Cell Carcinoma

Silver-Russell Syndrome 1
  • Silver-Russell Syndrome

  • Russell-Silver Syndrome

  • Silver-Russell Dwarfism

  • Rss

  • SRS1

  • Srs

  • Silver Russell Dwarfism

  • Russell Silver Syndrome

  • Silver Russell Syndrome

Gestational Trophoblastic Neoplasm
  • Hydatidiform Mole

  • Molar Pregnancy

  • Gestational Trophoblastic Neoplasia

  • Gestational Trophoblastic Tumor

  • Gtn

  • Gestational Trophoblastic Disease

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole Benign

  • Trophoblastic Disease

  • Trophoblastic Disease Nos

  • Trophoblastic Disorder

  • Vesicular Mole Nos

  • Vesicular Mole

  • Hydatidiform Mole Nos

Beckwith-Wiedemann Syndrome
  • Wiedemann-Beckwith Syndrome

  • BWS

  • Exomphalos-Macroglossia-Gigantism Syndrome

  • Emg Syndrome

  • Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

  • Emg Abnormality

  • Wbs

  • Exomphalos Macroglossia Gigantism Syndrome

  • Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

  • Macroglossia Exomphalos Gigantism

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PEG3 VGNC VGNC:44413
Rattus norvegicus PEG3 RGD RGD:2323590
Bos taurus PEG3 VGNC VGNC:109388
Mus musculus PEG3 MGD MGI:104748
Others PEG3 NCBI