Cdk2 - cyclin dependent kinase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362817

About Cdk2

Primary_assembly 7: 1,129,811-1,137,403 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 203 orthologues, 24 paralogues and is associated with 15 phenotypes. Biased expression in Thymus (RPKM 127.6), Spleen (RPKM 69.2) and 9 other tissues.

Summary

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to Insulin stimulus; response to cAMP; and response to estradiol. Located in cytosol and nucleus. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in prostate Cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdk2 Products (1)

mRNA Protein Name
NM_199501.2 NP_955795.1 cyclin-dependent kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
15809057 RGD
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11823715 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10952244 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
19151707 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16534847 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
15994754 RGD
involved in lens development in camera-type eye IEP
IEP: Inferred from expression pattern
10620399 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
15994754 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
16730872 RGD
involved in response to electrical stimulus IDA
IDA: Inferred from direct assay
15607308 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16019103 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16689928 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17343987 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17706465 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk2 Protein Structure

STKc_CDK2_3

STKc_CDK2_3: cd07860 (2 - 333)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 2

  • cell division protein kinase 2

  • cyclin dependent kinase 2-alpha

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-10492 Dinaciclib Inhibitor 99.80% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-B0402 Amantadine Inhibitor 99.90% Unkown
HY-B0402A Amantadine hydrochloride Inhibitor 98.0% Yes
HY-B0263 Thiabendazole 99.94% Unkown
HY-B1165 Cyproheptadine (hydrochloride sesquihydrate) 99.74% Unkown
HY-B0402B Amantadine sulfate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-112272 Lerociclib Inhibitor 96.42% Phase 3
HY-10005 Flavopiridol Inhibitor 99.72% Phase 2
HY-30237 (R)-Roscovitine Inhibitor 99.53% Phase 2
HY-137894A Tagtociclib hydrate Inhibitor 99.73% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-101212 Fadraciclib Inhibitor 99.77% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Phase 2
HY-10424 Milciclib Inhibitor 99.89% Phase 2
HY-103712 Samuraciclib Inhibitor 99.55% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Phase 2
HY-15163 Zotiraciclib Inhibitor 99.88% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-50940A AT7519 TFA Inhibitor 99.75% Phase 2
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-138293 SY-5609 Inhibitor 99.93% Phase 1
HY-141680 CPS2 Inhibitor 99.33% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-111361 FN-1501 Inhibitor 98.72% Phase 1
HY-137443 Ipivivint Inhibitor 99.95% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.09% Phase 1

Pre-clinical Phase

Bioactive Molecules (242)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12529 Ro-3306 Inhibitor 99.83% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.82% Unkown
HY-12302 Kenpaullone Inhibitor 98.20% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-101257 YKL-5-124 Inhibitor 99.53% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-114177 Ebvaciclib Inhibitor 99.98% Unkown
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.94% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.52% Unkown
HY-122609 XO44 99.38% Unkown
HY-18930 NU6300 Inhibitor 98.44% Unkown
HY-15004 AUZ 454 Inhibitor 99.15% Unkown
HY-18299A Purvalanol A Inhibitor 98.61% Unkown
HY-15275 BMS-265246 Inhibitor 99.59% Unkown
HY-130665 TL12-186 Inhibitor 99.23% Unkown
HY-130709 PROTAC CDK2/9 Degrader-1 Degrader 99.85% Unkown
HY-127104 FMF-04-159-2 Inhibitor 99.64% Unkown
HY-13914 Roniciclib Inhibitor 98.00% Unkown
HY-163814 CDK2 degrader 1 Degrader 99.74% Unkown
HY-108359 Alsterpaullone Inhibitor 99.85% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-18629 SU9516 Inhibitor 99.85% Unkown
HY-144117 GFB-12811 Inhibitor 98.04% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-117535 CDK2-IN-4 Inhibitor 99.85% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-W019806 Lacto-N-fucopentaose I Activator 99.92% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% Unkown
HY-13461 PHA-767491 Inhibitor 99.97% Unkown
HY-176444 CDK2 degrader 6 Degrader 99.81% Unkown
HY-N0260 Epmedin C Inhibitor 99.47% Unkown
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.62% Unkown
HY-18299 Purvalanol B Inhibitor 97.0% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-175842 CDK2 degrader 7 Degrader 99.51% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-112358 GW8510 Inhibitor 99.04% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-108136A Bisindolylmaleimide X hydrochloride Antagonist 98.90% Unkown
HY-145694 CDK5-IN-3 Inhibitor 99.49% Unkown
HY-103647 K00546 Inhibitor 99.48% Unkown
HY-164664 CDK2-IN-30 Inhibitor 98.40% Unkown
HY-120497 PKCζ-IN-1 Inhibitor 99.1% Unkown
HY-162919 YK-2168 Inhibitor 98.05% Unkown
HY-164827 CDK2 degrader 3 Degrader 99.91% Unkown
HY-101257B YKL-5-124 TFA Inhibitor 99.74% Unkown
HY-170442 ECI830 Inhibitor 98.01% Unkown
HY-50914 AZD5597 Inhibitor 98.09% Unkown
HY-N5072 Desmethylglycitein Inhibitor 99.99% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-W011428 Olomoucine Inhibitor 99.88% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.90% Unkown
HY-112403 (S)-Roscovitine Inhibitor 99.15% Unkown
HY-169912 CDK2 degrader 5 Degrader 99.17% Unkown
HY-155218 TMX-2172 Degrader 99.38% Unkown
HY-N0699 Daphnoretin Inhibitor 99.83% Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor 98.20% Unkown
HY-139329 CDK12-IN-6 Inhibitor 99.15% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% Unkown
HY-13816 NU6027 Inhibitor 98.01% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-N7045 Isosilybin B Inhibitor 99.32% Unkown
HY-N1465 Aristolochic acid D Inhibitor 99.74% Unkown
HY-159805 CDK2-IN-31 Inhibitor 98.22% Unkown
HY-107419 NU6140 Inhibitor 99.53% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-154851 GSK-3 inhibitor 3 Inhibitor 99.10% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 99.83% Unkown
HY-14372 BS-194 Inhibitor 99.13% Unkown
HY-169910 CDK2 degrader 4 Inhibitor 99.71% Unkown
HY-112462 Cdk1/2 Inhibitor III Inhibitor 99.69% Unkown
HY-112460 CDK2-IN-3 Inhibitor 95.12% Unkown
HY-100600 BGG463 Inhibitor 98.0% Unkown
HY-123045 PNU-292137 Inhibitor 99.95% Unkown
HY-41076 Ca2+ channel agonist 1 Inhibitor 98.87% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-157516 CDK2-IN-22 Inhibitor 98.64% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-19316 NU2058 Inhibitor 99.66% Unkown
HY-45661 Inixaciclib Inhibitor 99.93% Unkown
HY-119715 AG-012986 Inhibitor 99.78% Unkown
HY-176444A (R)-CDK2 degrader 6 Degrader 99.55% Unkown
HY-139328 CDK12-IN-5 Inhibitor 98.03% Unkown
HY-103646 CK7 Inhibitor 99.72% Unkown
HY-117393 Bisindolylmaleimide III Inhibitor 98.95% Unkown
HY-179688 PROTAC CDK2/4 Degrader-1 Degrader / Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-168440 Aurora-A ligand 1 Ligand 98.75% Unkown
HY-170897 CDK2-IN-40 Inhibitor 99.80% Unkown
HY-119979 Cardanol monoene 98.02% Unkown
HY-114903 (E/Z)-BIO-acetoxime Inhibitor 99.9% Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader 97.22% Unkown
HY-170820 XYD049 Inhibitor 99.46% Unkown
HY-154852 GSK-3 inhibitor 4 Inhibitor 99.02% Unkown
HY-201330 GDC-4198 Inhibitor / Unkown
HY-139011 IV-361 Inhibitor 99.60% Unkown
HY-12843 Bohemine Inhibitor 98.93% Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-100035 PT-262 Inhibitor 99.21% Unkown
HY-148868A Akt1&PKA-IN-2 Inhibitor / Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-164906 TMX-2138 Degrader / Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader / Unkown
HY-148868 Akt1&PKA-IN-1 Inhibitor / Unkown
HY-158170 CDK7-IN-28 Inhibitor / Unkown
HY-149636 Multi-target kinase inhibitor 2 Inhibitor 99.82% Unkown
HY-112450 Olomoucine II Inhibitor 98.0% Unkown
HY-111207 CA224 Inhibitor 99.94% Unkown
HY-151409 CDK1-IN-5 Inhibitor / Unkown
HY-151407 CDK1-IN-3 Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-130981 FN-1501-propionic acid / Unkown
HY-130001 CDK9-IN-9 Inhibitor / Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-173348 BLINK15 Inhibitor / Unkown
HY-173310 CDK2-IN-44 Inhibitor / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-161595 CDK5-IN-4 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-139651 CDK2-IN-7 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-112471 TrkA Inhibitor Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-160556 RLY-2139 Inhibitor / Unkown
HY-128491 UNC10112785 Inhibitor / Unkown
HY-150573 CDK2-IN-12 Inhibitor / Unkown
HY-15570 NU6301 Inhibitor / Unkown
HY-171826 PROTAC CDK2/4/6 Degrader-1 Inhibitor / Unkown
HY-144811 CDK2-IN-9 Inhibitor / Unkown
HY-180242 EGFR/CDK2-IN-5 Inhibitor / Unkown
HY-180355 SY-5102 Inhibitor / Unkown
HY-180546 CDK2-IN-53 Inhibitor / Unkown
HY-173347 BLINK11 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown
HY-162416 CDK7-IN-27 Inhibitor / Unkown
HY-178157 Multi-target kinase-IN-7 Inhibitor / Unkown
HY-145867 EGFR-IN-45 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-155602 CDK2-IN-18 Inhibitor / Unkown
HY-177957 CDK2-IN-52 Inhibitor / Unkown
HY-183273 BRD4/AKT-IN-1 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-10793 CDK2-IN-56 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-149407 Multi-kinase-IN-4 Inhibitor / Unkown
HY-168067 CDK-IN-14 Inhibitor / Unkown
HY-170441 CDK2-IN-36 Inhibitor / Unkown
HY-162528 CDK12-IN-7 Inhibitor / Unkown
HY-147771 ZLWT-37 Inhibitor / Unkown
HY-186126 CDK2 modulator 1 Modulator / Unkown
HY-180157 CDK2-IN-51 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-160941 CDK2-IN-29 Inhibitor / Unkown
HY-183789 CDK2-IN-59 Inhibitor / Unkown
HY-W1047040 CDK2/4 ligand 1 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-161776 P-gp/CDK2-IN-1 Inhibitor / Unkown
HY-182789 VEGFR2-IN-86 Inhibitor / Unkown
HY-181838 CIRc-014 Inhibitor / Unkown
HY-180630 CDK2-IN-54 Inhibitor / Unkown
HY-119831 Rohitukine Inhibitor / Unkown
HY-147698 ZLHQ-5f Inhibitor / Unkown
HY-182734 BMS-357075 Inhibitor / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-178084 CDK2 ligand-3 / Unkown
HY-181620 CDK2 degrader 9 Degrader / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-178142 Multi-kinase-IN-7 Inhibitor / Unkown
HY-186132 PROTAC CDK2-pRb degrader-1 Degrader / Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-182752 CDK1-IN-9 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-173224 CDK2/PIM1-IN-1 Inhibitor / Unkown
HY-181116 Anticancer agent 298 / Unkown
HY-172153 CDK2-IN-41 Inhibitor / Unkown
HY-181501 CDK2/4/6-IN-3 Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-111356 IIIM-290 Inhibitor / Unkown
HY-148651 CDK2-IN-15 Inhibitor / Unkown
HY-176718 VEGFR-2-IN-69 Inhibitor / Unkown
HY-176124 CDK2 ligand-2 Ligand / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-183710 CDK9-IN-50 Inhibitor / Unkown
HY-179022 CAIX/CDK-2-IN-1 Inhibitor / Unkown
HY-112363 Aloisine A Inhibitor / Unkown
HY-183854 AG-12286 Inhibitor / Unkown
HY-170965 Anticancer agent 264 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-145693 CDK5-IN-2 Inhibitor / Unkown
HY-168845 CDK2/9-IN-1 Inhibitor / Unkown
HY-179231 CDK2-IN-50 Inhibitor / Unkown
HY-151580S CDK2-IN-14-d3 Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-183146 CDK2-IN-57 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-172872 CDK2-IN-45 Inhibitor / Unkown
HY-151408 CDK1-IN-4 Inhibitor / Unkown
HY-178756 CDK2-IN-48 Inhibitor / Unkown
HY-144810 CDK2-IN-8 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-176282 CDK8-IN-19 Inhibitor / Unkown
HY-181906 ZnPc-PEG2-VH032 Inhibitor / Unkown
HY-168513 ALK-IN-29 Inhibitor / Unkown
HY-182605 NU6310 Inhibitor / Unkown
HY-115943 Anticancer agent 30 Inhibitor / Unkown
HY-173203 CDK2-IN-43 Inhibitor / Unkown
HY-176281 PI3Kα-IN-26 Inhibitor / Unkown
HY-156470 Multi-kinase-IN-6 Inhibitor / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-155441 CDK2-IN-20 Inhibitor / Unkown
HY-159155 CDK2/4-IN-1 Inhibitor / Unkown
HY-150570 Carbonic anhydrase inhibitor 14 Inhibitor / Unkown
HY-180817 CDK2-IN-55 Inhibitor 98.91% Unkown
HY-179633 ZLMT-72 Inhibitor / Unkown
HY-151984 CDK9-IN-22 Inhibitor / Unkown
HY-161690 EF-4-177 Inhibitor / Unkown
HY-19926A GDC-0425 hydrochloride Inhibitor / Unkown
HY-183529 Antitrypanosomal agent 31 Inhibitor / Unkown
HY-183534 CDK2-IN-58 Inhibitor / Unkown
HY-160643 CDK2-IN-27 Inhibitor / Unkown
HY-123826 CCT68127 Inhibitor / Unkown
HY-160185 CDK2-IN-21 Inhibitor / Unkown
HY-11001A PHA-793887 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk2 NCBI NCBI:1017