352 Results for "

Cyclo(

" in MedChemExpress (MCE) Product Catalog:
Products (352)

352 Results for "Cyclo(" in MCE Product Catalog:

32
Cyclo(-RGDfK)
Cyclo(-RGDfK)
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32 Publications Verification
Referencia número: HY-P0023
No. CAS: 161552-03-0
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
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32
Cyclo(-RGDfK) TFA
Cyclo(-RGDfK) TFA
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32 Publications Verification
Referencia número: HY-P0023A
No. CAS: 500577-51-5
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
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17
Alisporivir
Alisporivir
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17 Cited Publications
Referencia número: HY-12559
No. CAS: 254435-95-5
Pureza:  98.08%
Synonyms: Debio-025; DEB-025
Target:  

Cyclophilin HCV

Áreas de investigación:  

Infection

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
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16
Salicylic acid
Salicylic acid
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16 Cited Publications
Referencia número: HY-B0167
No. CAS: 69-72-7
Synonyms: 2-Hydroxybenzoic acid
Category:  

Anti-aging Plants Endogenous metabolite Agricultural Research other families Monophenols Ketones, Aldehydes, Acids Phenols Phytohormone Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Endogenous Metabolite COX Autophagy Apoptosis Mitophagy

Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Salicylic acid has blood-brain barrier permeability .
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16
Sodium Salicylate
Sodium Salicylate
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16 Cited Publications
Referencia número: HY-B0167A
No. CAS: 54-21-7
Synonyms: Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt
Category:  

Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Ribosomal S6 Kinase (RSK) Endogenous Metabolite Apoptosis COX Autophagy NF-κB

Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .
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8
Cyclo(Phe-Pro)
Cyclo(Phe-Pro)
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8 Cited Publications
Referencia número: HY-P1934
No. CAS: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Target:  

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Áreas de investigación:  

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
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5
Fraxin
Fraxin
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5 Cited Publications
Referencia número: HY-N0579
No. CAS: 524-30-1
Synonyms: Fraxoside
Category:  

Oleaceae Fraxinus rhynchophylla Hance Coumarins Plants other families Monophenols Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology

Target:  

Phosphodiesterase (PDE)

Fraxin isolated from Cortex Fraxini, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action , anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme .
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4
Cyclo(RGDyK)
Cyclo(RGDyK)
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4 Cited Publications
Referencia número: HY-100563A
No. CAS: 217099-14-4
Pureza:  99.83%
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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4
Cyclo(RGDyK) trifluoroacetate
Cyclo(RGDyK) trifluoroacetate
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4 Cited Publications
Referencia número: HY-100563
No. CAS: 250612-42-1
Pureza:  99.92%
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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4
BQ-123
BQ-123
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4 Cited Publications
Referencia número: HY-12378
No. CAS: 136553-81-6
Pureza:  99.82%
Target:  

Endothelin Receptor

Áreas de investigación:  

Cardiovascular Disease

BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .
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4
Murepavadin TFA
Murepavadin TFA
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4 Cited Publications
Referencia número: HY-P1674A
No. CAS: 3053070-05-3
Synonyms: POL7080 TFA
Target:  

Bacterial Antibiotic

Áreas de investigación:  

Infection

Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
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3
Astressin
Astressin
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3 Cited Publications
Referencia número: HY-P0257
No. CAS: 170809-51-5
Target:  

CRFR

Áreas de investigación:  

Neurological Disease

Astressin is a potent corticotropin releasing factor (CRF) antagonist.
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2
Cyclo(Arg-Gly-Asp-D-Phe-Cys)
Cyclo(Arg-Gly-Asp-D-Phe-Cys)
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2 Cited Publications
Referencia número: HY-P2300
No. CAS: 862772-11-0
Synonyms: Cyclo(RGDfC)
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
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2
cyclo(RLsKDK)
cyclo(RLsKDK)
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2 Cited Publications
Referencia número: HY-P1676
No. CAS: 1975145-82-4
Synonyms: BK-1361
Target:  

MMP

Áreas de investigación:  

Cancer

cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer .
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2
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
0 Images
2 Cited Publications
Referencia número: HY-P2300A
Synonyms: Cyclo(RGDfC) TFA
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors .
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2
cyclo(RLsKDK) TFA
cyclo(RLsKDK) TFA
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2 Cited Publications
Referencia número: HY-P1676A
Synonyms: BK-1361 TFA
Target:  

MMP

Áreas de investigación:  

Cancer

cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer .
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2
Brevianamide F
Brevianamide F
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2 Cited Publications
Referencia número: HY-100385
No. CAS: 38136-70-8
Pureza:  99.03%
Synonyms: Cyclo(L-Pro-L-Trp)
Category:  

Infection Alkaloids Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Disease Research Fields Indole Alkaloids

Target:  

PI3K Bacterial

Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC50 of 4.8 μM .
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2
TAT-cyclo-CLLFVY
TAT-cyclo-CLLFVY
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2 Cited Publications
Referencia número: HY-P1420
No. CAS: 1446322-66-2
Target:  

HIF/HIF Prolyl-Hydroxylase

Áreas de investigación:  

Cancer

TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts HIF-1α/HIF-1β protein-protein interaction with an IC50 of 1.3 μM .
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2
Segetalin B
Segetalin B
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2 Cited Publications
Referencia número: HY-107245
No. CAS: 164991-89-3
Pureza:  99.51%
Category:  

Vaccaria segetalis (Neck.) Garcke Cyclopeptides Metabolic Disease Plants Disease Research Fields Caryophyllaceae

Target:  

Estrogen Receptor/ERR Sirtuin RUNX

Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .
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2
Gramicidin S
Gramicidin S
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2 Cited Publications
Referencia número: HY-P5712
No. CAS: 113-73-5
Synonyms: Gramicidin soviet
Target:  

Antibiotic Bacterial Na+/K+ ATPase

Áreas de investigación:  

Infection

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
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