Mmp9 - matrix metallopeptidase 9 Gene

Also Known as Clg4b; Gel B; MMP-9; B/MMP9; pro-MMP-9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17395

About Mmp9

Chromosome 2: 164,782,700-164,797,770 forward strand.GRCm39:CM000995.3

This gene has 4 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 97 phenotypes. Broad expression in liver E18 (RPKM 9.8), thymus adult (RPKM 8.9) and 21 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]

Mmp9 Products (1)

mRNA Protein Name
NM_013599.5 NP_038627.1 matrix metalloproteinase-9 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
9291580 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
15800063 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
15800063 MGI
acts upstream of or within collagen catabolic process IDA
IDA: Inferred from direct assay
9291580 MGI
acts upstream of or within embryo implantation IDA
IDA: Inferred from direct assay
18556655 MGI
acts upstream of or within extracellular matrix organization IGI
IGI: Inferred from genetic interaction
15800063 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
15800063 MGI
involved in negative regulation of epithelial cell differentiation involved in kidney development IDA
IDA: Inferred from direct assay
24503540 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15800063 MGI
involved in response to amyloid-beta IDA
IDA: Inferred from direct assay
28912710 MGI
acts upstream of or within skeletal system development IGI
IGI: Inferred from genetic interaction
15800063 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
15800063 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp9 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (114 - 443)

FN2

FN2: smart00059 (222 - 270)

FN2

FN2: smart00059 (280 - 328)

fn2

fn2: pfam00040 (346 - 387)

PT

PT: pfam04886 (473 - 524)

HX

HX: cd00094 (531 - 728)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-9

  • 92 kDa gelatinase

  • 92 kDa type IV collagenase

  • 92kD gelatinase

  • 92kD type IV collagenase

  • collagenase type IVB

  • gelatinase B

Recombinant Mmp9 Proteins

Cat. No. Product Name Accession Purity
HY-P70351 MMP-9 Protein, Mouse (HEK293, His, solution) P41245 (A20-P730) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73807 MMP-9 Protein, Mouse (HEK293) P41245 (P21-P730, P514A, H639P, L711P) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P70351A MMP-9 Protein, Mouse (HEK293, C-His) P41245 (A20-P730) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0099 Edaravone 99.94% Yes
HY-B0633A Hyaluronic acid Activator / Yes
HY-B0633 Hyaluronic acid sodium Activator 98.0% Unkown
HY-12723 Apomorphine 99.48% Unkown
HY-B0493 Niflumic acid Inhibitor 99.61% Unkown
HY-B0012 Pamidronic acid Inhibitor 99.05% Yes
HY-B0012A Pamidronate disodium Inhibitor 98.0% Yes
HY-14744A Levamlodipine besylate Inhibitor 99.84% Unkown
HY-90003 Tianeptine 99.84% Unkown
HY-B0730 Pamidronate disodium pentahydrate 98.0% Unkown
HY-14744 Levamlodipine Inhibitor 98.06% Unkown
HY-90003A Tianeptine sodium salt 99.90% Unkown
HY-B1451A Imidapril Inhibitor 99.0% Yes
HY-B0493R Niflumic acid (Standard) Inhibitor 99.93% Unkown
HY-B1451 Imidapril hydrochloride Inhibitor 99.91% Yes
HY-12723R Apomorphine (Standard) / Unkown
HY-90003AR Tianeptine sodium salt (Standard) / Unkown

Clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor 99.90% Phase 3
HY-12170 Prinomastat 98.41% Phase 3
HY-12168 Tanomastat Inhibitor 99.74% Phase 3
HY-121872 DP-b99 Inhibitor 95.0% Phase 3
HY-175275 10-Butyl Ether Minocycline Inhibitor / Phase 3
HY-15768 Ilomastat Inhibitor 99.14% Phase 2
HY-107581 MK-1903 99.68% Phase 2
HY-W014841 Sodium hippurate, 98% 99.91% Phase 2
HY-106992 S 3304 Inhibitor 99.75% Phase 2
HY-101276 AZD-1236 Inhibitor 99.62% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
HY-N0318 Salvianolic acid A 99.72% Phase 1
HY-114214 CKD-712 / Phase 1
HY-148527 LAS190792 / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99351 Andecaliximab Inhibitor 98.57% Phase 3
HY-P991419 MSB-0254 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (199)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0431 Astragaloside IV Inhibitor 99.93% Unkown
HY-19956 GI254023X Inhibitor 99.67% Unkown
HY-N2117 Isoginkgetin 99.91% Unkown
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-12354 SB-3CT Inhibitor 99.84% Unkown
HY-W016562 Hippuric acid 99.98% Unkown
HY-135232 MMP-9-IN-1 Inhibitor 99.82% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-E70005C Collagenase, Type III / Unkown
HY-113952 Actinonin 98.37% Unkown
HY-N0069 Solamargine 99.87% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-103482 JNJ0966 Inhibitor 99.80% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.74% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-108527 CD1530 98.01% Unkown
HY-P2036A FSL-1 TFA 99.81% Unkown
HY-P4373A Hepcidin-1 (mouse) TFA Inducer 98.86% Unkown
HY-159059 Ganoderma lucidum polysaccharide 41.20% Unkown
HY-W016412 Coenzyme Q0 99.79% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-124373 ND-336 Inhibitor 97.16% Unkown
HY-N3945 Glaucine 99.57% Unkown
HY-N1508 Ecliptasaponin A 99.81% Unkown
HY-P2179 MMP-1/MMP-9 Substrate, Fluorogenic 98.83% Unkown
HY-N2374 Eupatorin Inhibitor 99.53% Unkown
HY-N6983 Licoricesaponin G2 99.87% Unkown
HY-B0633D Hyaluronic acid sodium (MW 200-1560) 99.41% Unkown
HY-W004486 Gallic aldehyde Inhibitor 99.92% Unkown
HY-12964 SGI-7079 Inhibitor 99.32% Unkown
HY-119423 MMP Inhibitor II Inhibitor 99.7% Unkown
HY-124813 PDZ1i Inhibitor 99.29% Unkown
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-B0633I Hyaluronic acid sodium (MW 800kDa) / Unkown
HY-N0084 Betulinaldehyde Inhibitor 98.72% Unkown
HY-N2132 Flavokawain B 99.99% Unkown
HY-116626 SM-7368 Inhibitor 99.77% Unkown
HY-P3513 β-Neo-Endorphin Activator 98.97% Unkown
HY-N2497 Isoliquiritin apioside Inhibitor 99.87% Unkown
HY-116302 MMP-9-IN-9 Inhibitor 99.26% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-116474 Viridicatol 99.93% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.68% Unkown
HY-161285 MMP-9/10-IN-2 Inhibitor 99.87% Unkown
HY-N0757 8-​O-​Acetylharpagide 99.75% Unkown
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.48% Unkown
HY-117970 MMPI-1154 Inhibitor 99.76% Unkown
HY-12170A Prinomastat hydrochloride 98.53% Unkown
HY-N1401 20(R)-Ginsenoside Rh2 99.84% Unkown
HY-W001925 7-Methoxy-1-tetralone 99.93% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-120213 YH-306 98.34% Unkown
HY-125847 Salvianolic acid F 99.50% Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-125864B Murine Fibrinogen / Unkown
HY-N6812 Karacoline 99.58% Unkown
HY-P3484 Dnp-PLGLWA-DArg-NH2 TFA 99.78% Unkown
HY-114785 BPHA Inhibitor 99.88% Unkown
HY-176184 PROTAC DDR1 degrader-1 98.69% Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.83% Unkown
HY-N6896 Isoviolanthin Inhibitor 99.87% Unkown
HY-P10143 MMP-2/MMP-9 Substrate Substrate 98.48% Unkown
HY-111186 Flocoumafen Inhibitor 99.35% Unkown
HY-114911 Feprazone Inhibitor 99.88% Unkown
HY-119979 Cardanol monoene Inducer 99.51% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-181654 Snail IN-1 Inhibitor 98.27% Unkown
HY-B0633E Hyaluronic acid, low endotoxin / Unkown
HY-N6862 Lucideric acid A Inhibitor 98.44% Unkown
HY-N7385 Nudol 99.60% Unkown
HY-P0273A Histatin 5 TFA Inhibitor 99.98% Unkown
HY-P4905 Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 Inhibitor 98.02% Unkown
HY-13564A Batimastat sodium salt Inhibitor 99.04% Unkown
HY-RS08557 MMP9 Human Pre-designed siRNA Set A / Unkown
HY-RS08558 Mmp9 Mouse Pre-designed siRNA Set A / Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.4% Unkown
HY-131417 cis-ACCP Inhibitor 97.0% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-149848 MMP-9-IN-6 Inhibitor 99.80% Unkown
HY-177701 MMP-9-IN-13 Inhibitor 98.07% Unkown
HY-B0099S Edaravone-d5 99.76% Unkown
HY-N2199 Sotetsuflavone 96.75% Unkown
HY-N2205 Esculentoside H Inhibitor 98.73% Unkown
HY-N6860 Lucidenic acid C Inhibitor 99.76% Unkown
HY-P10359A TAT-QFNP12 acetate Inhibitor 95.90% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.52% Unkown
HY-P4373 Hepcidin-1 (mouse) Inducer / Unkown
HY-109747 RO-28-2653 Inhibitor / Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-111172 Inotilone Inhibitor 95.26% Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-116474R Viridicatol (Standard) / Unkown
HY-119185 AZD-6605 / Unkown
HY-120339 STK899704 / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-123255 BSc2118 / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-136699 Excisanin A Inhibitor / Unkown
HY-138195 NEO212 / Unkown
HY-14237 SC-77964 Inhibitor / Unkown
HY-143407 FAK-IN-3 Inhibitor / Unkown
HY-144224S Tianeptine-d6 hydrochloride / Unkown
HY-146216 MMP-9-IN-3 / Unkown
HY-146217 MMP-9-IN-4 / Unkown
HY-146218 MMP-9-IN-5 / Unkown
HY-14744B Levamlodipine hydrochloride Inhibitor / Unkown
HY-14744C Levamlodipine hydrobromide Inhibitor / Unkown
HY-147867 MMP-2/9-IN-1 Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-155960 SH491 Inhibitor / Unkown
HY-156247 IVMT-Rx-3 Inhibitor / Unkown
HY-157138 MMP-9-IN-8 / Unkown
HY-161284 MMP-9/10-IN-1 Inhibitor / Unkown
HY-161707 MMP2-IN-4 Inhibitor / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-162079 Anticancer agent 183 Inhibitor / Unkown
HY-162344 Ir-CA Inducer / Unkown
HY-163760 ZM-32 Inhibitor / Unkown
HY-168560 MMP Inhibitor 4 Inhibitor / Unkown
HY-168605 DH-18 / Unkown
HY-169062 RJF02215 Inhibitor / Unkown
HY-171776 OPB-3206 Inhibitor / Unkown
HY-172088 Tubulin/MMP-IN-3 / Unkown
HY-172551 anti-TNBC agent-9 / Unkown
HY-173500 MG-3C / Unkown
HY-175558 MMP-9-IN-12 / Unkown
HY-175815 Apoptosis inducer 44 / Unkown
HY-176412 MMP-9-IN-11 Inhibitor / Unkown
HY-178460 BRK/PTK6-IN-1 Inhibitor / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-179439 Multi-kinase-IN-8 / Unkown
HY-179724 PZ-1657 Inhibitor / Unkown
HY-179724A PZ-1657 hydrochloride Inhibitor / Unkown
HY-180117 MMP-2/9-IN-2 / Unkown
HY-180324 Candidone / Unkown
HY-180765 Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene Activator / Unkown
HY-181272 MMP-9-IN-14 / Unkown
HY-182069 CDK9-IN-47 / Unkown
HY-182614 BJ-2302 Inhibitor / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-182818 SH494 / Unkown
HY-183316 Anticancer agent 319 / Unkown
HY-183784 P2X7R antagonist-1 / Unkown
HY-184162 HSP110-IN-1 / Unkown
HY-184501 UE01 / Unkown
HY-184926 PEG9MA10-PAB10-GalMA10 / Unkown
HY-18694 CGS 27023A Inhibitor / Unkown
HY-18694A CGS 27023A free base Inhibitor / Unkown
HY-B0012B Pamidronic acid sodium Inhibitor / Unkown
HY-E70617 Neutrophil Gelatinase Associated Lipocalin (NGAL), Human / Unkown
HY-N0757R 8-O-Acetylharpagide (Standard) / Unkown
HY-N10176 D-Isofloridoside Inhibitor 98.59% Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-N16746 Nordentatin Inhibitor / Unkown
HY-N17617 S-Petasin / Unkown
HY-N19029 Vernodalin / Unkown
HY-N2497R Isoliquiritin apioside (Standard) Inhibitor / Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-P11577 TGGGPLGVARGKGGC Substrate / Unkown
HY-P11780 KAFDITYVRLKF / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2004 FFAGLDD / Unkown
HY-P2004A FFAGLDD TFA / Unkown
HY-P3513A β-Neo-Endorphin acetate Activator / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-RS08559 Mmp9 Rat Pre-designed siRNA Set A / Unkown
HY-W095774 (E)-N-(3-Methoxyphenyl)cinnamamide Inhibitor / Unkown
HY-W185542 E09241 / Unkown
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / Unkown
HY-W783478 Calebin A Inhibitor 98.0% Unkown
HY-W801479S Edaravone sulfate-d5 / Unkown
HY-105854A Pipoxolan / Unkown
HY-107581R MK-1903 (Standard) / Unkown
HY-112726A PXS-4728A free base Inhibitor / Unkown
HY-119110 LY52 Inhibitor / Unkown
HY-122585 proMMP-9 inhibitor-3c Inhibitor / Unkown
HY-124068 LQB-118 / Unkown
HY-133845 CIL-102 / Unkown
HY-14744D Levamlodipine besylate Hemipentahydrate Inhibitor / Unkown
HY-14744S Levamlodipine-d4 Inhibitor 99.74% Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-183377 DMBT / Unkown
HY-183400 BIM-46174 / Unkown
HY-183408 MMI-166 / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor 98.0% Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-90003S Tianeptine-d12 / Unkown
HY-B1451S Imidapril-d3 hydrochloride Inhibitor / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown
HY-W1058004 (E)-N-(2-Fluorophenyl)cinnamamide Inhibitor / Unkown
HY-W747703 Hippuric acid-13C6 / Unkown
HY-P0273 Histatin 5 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992200 Anti-CD146 Antibody (AA98) / Unkown
HY-P990468 Anti-MMP9 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp9 NCBI NCBI:4318