2. Gene
  3. Mmp9 - matrix metallopeptidase 9 Gene

Mmp9 - matrix metallopeptidase 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Clg4b; Gel B; MMP-9; B/MMP9; pro-MMP-9

Gene ID: 17395 | Gene type: protein coding

About Mmp9

Chromosome 2: 164,782,700-164,797,770 forward strand.GRCm39:CM000995.3

This gene has 4 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 97 phenotypes. Broad expression in liver E18 (RPKM 9.8), thymus adult (RPKM 8.9) and 21 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]

Mmp9 Products(1)

mRNA Protein Name
NM_013599.5 NP_038627.1 matrix metalloproteinase-9 preproprotein

Mmp9 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (114 - 443)

FN2

FN2: smart00059 (222 - 270)

FN2

FN2: smart00059 (280 - 328)

fn2

fn2: pfam00040 (346 - 387)

PT

PT: pfam04886 (473 - 524)

HX

HX: cd00094 (531 - 728)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-9

92 kDa gelatinase

92 kDa type IV collagenase

92kD gelatinase

92kD type IV collagenase

collagenase type IVB

gelatinase B

Recombinant Mmp9 Proteins

Cat. No. Product Name Accession Purity
HY-P70351 MMP-9 Protein, Mouse (HEK293, His) P41245 (A20-P730) ≥95%
HY-P73807 MMP-9 Protein, Mouse (HEK293) P41245 (P21-P730) ≥95%
HY-P70351A MMP-9 Protein, Mouse (HEK293, C-His) P41245 (A20-P730) ≥95%

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0099 Edaravone 99.83% Yes
HY-B0493 Niflumic acid Inhibitor 99.88% Unkown
HY-B1451 Imidapril hydrochloride Inhibitor 99.80% Yes
HY-B1451A Imidapril Inhibitor ≥99.0% Yes
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
HY-12170 Prinomastat ≥98.0% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-106992 S 3304 Inhibitor 99.11% Phase 2
HY-19485 XL-784 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
HY-N0318 Salvianolic acid A 99.72% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99351 Andecaliximab Inhibitor 95.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (89)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15768 Ilomastat Inhibitor 98.33% Yes
HY-N0431 Astragaloside IV Inhibitor ≥98.0% Unkown
HY-N2117 Isoginkgetin 99.95% Unkown
HY-19956 GI254023X Inhibitor 99.67% Unkown
HY-113952 Actinonin 98.61% Unkown
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-12354 SB-3CT Inhibitor 99.59% Unkown
HY-135232 MMP-9-IN-1 Inhibitor 99.71% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-N1463 Luteolin 7-O-glucuronide 99.80% Unkown
HY-N0069 Solamargine 99.97% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-103482 JNJ0966 Inhibitor 99.39% Unkown
HY-P2036A FSL-1 TFA 99.76% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-W016412 Coenzyme Q0 99.88% Unkown
HY-N0084 Betulinaldehyde Inhibitor 98.72% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-N2497 Isoliquiritin apioside Inhibitor 99.87% Unkown
HY-P3513 β-Neo-Endorphin Activator 98.22% Unkown
HY-P4373A Hepcidin-1 (mouse) (TFA) Inducer 98.94% Unkown
HY-N1454 Apigenin-7-glucuronide 99.04% Unkown
HY-116626 SM-7368 Inhibitor 99.90% Unkown
HY-120213 YH-306 98.01% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-N3063 Pimaric acid 99.83% Unkown
HY-P0273A Histatin 5 TFA Inhibitor 99.89% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.60% Unkown
HY-N2205 Esculentoside H 98.02% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor ≥99.0% Unkown
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.25% Unkown
HY-117970 MMPI-1154 Inhibitor 99.87% Unkown
HY-12168 Tanomastat Inhibitor ≥99.0% Unkown
HY-124373 ND-336 Inhibitor ≥95.0% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.90% Unkown
HY-131417 cis-ACCP Inhibitor / Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-161285 MMP-9/10-IN-2 Inhibitor / Unkown
HY-B0099S Edaravone-d5 98.73% Unkown
HY-E70005C Collagenase, Type III / Unkown
HY-N6862 Lucideric acid A Inhibitor ≥98.0% Unkown
HY-P4373 Hepcidin-1 (mouse) Inducer / Unkown
HY-N2199 Sotetsuflavone 96.75% Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-111172 Inotilone Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-114785 BPHA Inhibitor / Unkown
HY-114911 Feprazone Inhibitor 99.88% Unkown
HY-119423 MMP Inhibitor II Inhibitor / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-136699 Excisanin A / Unkown
HY-143407 FAK-IN-3 Inhibitor / Unkown
HY-146216 MMP-9-IN-3 / Unkown
HY-146217 MMP-9-IN-4 / Unkown
HY-146218 MMP-9-IN-5 / Unkown
HY-147867 MMP-2/9-IN-1 Inhibitor / Unkown
HY-149848 MMP-9-IN-6 Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-155960 SH491 / Unkown
HY-156247 IVMT-Rx-3 Inhibitor / Unkown
HY-157138 MMP-9-IN-8 / Unkown
HY-161284 MMP-9/10-IN-1 Inhibitor / Unkown
HY-162038 RXP03 Inhibitor / Unkown
HY-162079 Anticancer agent 183 Inhibitor / Unkown
HY-162344 Ir-CA Inducer / Unkown
HY-N10176 D-Isofloridoside Inhibitor / Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.84% Unkown
HY-N6860 Lucidenic acid C Inhibitor / Unkown
HY-N7385 Nudol / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2004 FFAGLDD / Unkown
HY-P2004A FFAGLDD TFA / Unkown
HY-P2179 MMP-1/MMP-9 Substrate, Fluorogenic / Unkown
HY-P3484 Dnp-PLGLWA-DArg-NH2 TFA / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-RS08557 MMP9 Human Pre-designed siRNA Set A / Unkown
HY-RS08558 Mmp9 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08559 Mmp9 Rat Pre-designed siRNA Set A / Unkown
HY-W011085 CP-471474 Inhibitor / Unkown
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / Unkown
HY-116302 MMP-9-IN-9 Inhibitor / Unkown
HY-13564A Batimastat sodium salt Inhibitor / Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-P0273 Histatin 5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp9 NCBI NCBI:4318