Mmp9 - matrix metallopeptidase 9 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81687

About Mmp9

Primary_assembly 3: 153,683,858-153,692,120 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 259 phenotypes. Biased expression in Thymus (RPKM 39.9), Kidney (RPKM 35.9) and 6 other tissues.

Summary

Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mmp9 Products (1)

mRNA Protein Name
NM_031055.2 NP_112317.2 matrix metalloproteinase-9 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibronectin binding IPI
IPI: Inferred from physical interaction
18039280 RGD
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
11826121 RGD
enables peptidase activity IDA
IDA: Inferred from direct assay
8531210 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17148685 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9732233 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cell-matrix adhesion IEP
IEP: Inferred from expression pattern
20218972 RGD
involved in cellular response to cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
12963432 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
19909738 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
16046515 RGD
involved in cellular response to iron(III) ion IEP
IEP: Inferred from expression pattern
21683124 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
21683124 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
19554388 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
22410640 RGD
involved in collagen catabolic process IDA
IDA: Inferred from direct assay
22410640 RGD
involved in heart development IDA
IDA: Inferred from direct assay
12061388 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
9733107 RGD
involved in macrophage chemotaxis IDA
IDA: Inferred from direct assay
20110414 RGD
involved in modification of synaptic structure, modulating synaptic transmission EXP
EXP: Inferred from Experiment
19047646 RGD
involved in modification of synaptic structure, modulating synaptic transmission IDA
IDA: Inferred from direct assay
19047646 RGD
involved in negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
22490164 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
15883642 RGD
involved in parturition IEP
IEP: Inferred from expression pattern
7492685 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
19948826 RGD
involved in positive regulation of leukocyte migration IDA
IDA: Inferred from direct assay
16698855 RGD
involved in positive regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17493927 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
11788364 RGD
involved in proteolysis IDA
IDA: Inferred from direct assay
20110414 RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping IDA
IDA: Inferred from direct assay
19420267 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19889233 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17603938 RGD
involved in response to high light intensity IEP
IEP: Inferred from expression pattern
17854381 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
19099751 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17289933 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17452115 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17158349 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
19879865 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17650800 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17114644 RGD
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
15642321 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
19099751 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
17704356 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
17164434 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16846501 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17603938 RGD
involved in tissue remodeling IDA
IDA: Inferred from direct assay
16740171 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
19047646 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
19047646 RGD
is active in extracellular matrix of synaptic cleft IDA
IDA: Inferred from direct assay
18332222 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17603938 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18332222 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
18332222 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16935996 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp9 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (115 - 444)

FN2

FN2: smart00059 (223 - 271)

FN2

FN2: smart00059 (281 - 329)

FN2

FN2: smart00059 (340 - 388)

PT

PT: cl04822 (457 - 488)

PT

PT: pfam04886 (474 - 509)

HX

HX: cd00094 (516 - 706)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-9

  • 92 kDa gelatinase

  • 92-kDa type IV collagenase

  • GELB

  • MMP-9

  • gelatinase B

  • matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)

Recombinant Mmp9 Proteins

Cat. No. Product Name Accession Purity
HY-P73301 MMP-9 Protein, Rat (HEK293, His) EDL96479.1 (A20-P708) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0099 Edaravone 99.94% Yes
HY-B0633A Hyaluronic acid Activator / Yes
HY-B0633 Hyaluronic acid sodium Activator 98.0% Unkown
HY-12723 Apomorphine 99.48% Unkown
HY-B0493 Niflumic acid Inhibitor 99.61% Unkown
HY-B0012 Pamidronic acid Inhibitor 99.05% Yes
HY-B0012A Pamidronate disodium Inhibitor 98.0% Yes
HY-14744A Levamlodipine besylate Inhibitor 99.84% Unkown
HY-90003 Tianeptine 99.84% Unkown
HY-B0730 Pamidronate disodium pentahydrate 98.0% Unkown
HY-14744 Levamlodipine Inhibitor 98.06% Unkown
HY-90003A Tianeptine sodium salt 99.90% Unkown
HY-B1451A Imidapril Inhibitor 99.0% Yes
HY-B0493R Niflumic acid (Standard) Inhibitor 99.93% Unkown
HY-B1451 Imidapril hydrochloride Inhibitor 99.91% Yes
HY-12723R Apomorphine (Standard) / Unkown
HY-90003AR Tianeptine sodium salt (Standard) / Unkown

Clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor 99.90% Phase 3
HY-12170 Prinomastat 98.41% Phase 3
HY-12168 Tanomastat Inhibitor 99.74% Phase 3
HY-121872 DP-b99 Inhibitor 95.0% Phase 3
HY-175275 10-Butyl Ether Minocycline Inhibitor / Phase 3
HY-15768 Ilomastat Inhibitor 99.14% Phase 2
HY-107581 MK-1903 99.68% Phase 2
HY-W014841 Sodium hippurate, 98% 99.91% Phase 2
HY-106992 S 3304 Inhibitor 99.75% Phase 2
HY-101276 AZD-1236 Inhibitor 99.62% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
HY-N0318 Salvianolic acid A 99.72% Phase 1
HY-114214 CKD-712 / Phase 1
HY-148527 LAS190792 / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99351 Andecaliximab Inhibitor 98.57% Phase 3
HY-P991419 MSB-0254 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (200)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0431 Astragaloside IV Inhibitor 99.93% Unkown
HY-19956 GI254023X Inhibitor 99.67% Unkown
HY-N2117 Isoginkgetin 99.91% Unkown
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-12354 SB-3CT Inhibitor 99.84% Unkown
HY-W016562 Hippuric acid 99.98% Unkown
HY-135232 MMP-9-IN-1 Inhibitor 99.82% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-E70005C Collagenase, Type III / Unkown
HY-113952 Actinonin 98.37% Unkown
HY-N0069 Solamargine 99.87% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-103482 JNJ0966 Inhibitor 99.80% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.74% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-108527 CD1530 98.01% Unkown
HY-P2036A FSL-1 TFA 99.81% Unkown
HY-P4373A Hepcidin-1 (mouse) TFA Inducer 98.86% Unkown
HY-159059 Ganoderma lucidum polysaccharide 41.20% Unkown
HY-W016412 Coenzyme Q0 99.79% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-124373 ND-336 Inhibitor 97.16% Unkown
HY-N3945 Glaucine 99.57% Unkown
HY-N1508 Ecliptasaponin A 99.81% Unkown
HY-P2179 MMP-1/MMP-9 Substrate, Fluorogenic 98.83% Unkown
HY-N2374 Eupatorin Inhibitor 99.53% Unkown
HY-N6983 Licoricesaponin G2 99.87% Unkown
HY-B0633D Hyaluronic acid sodium (MW 200-1560) 99.41% Unkown
HY-W004486 Gallic aldehyde Inhibitor 99.92% Unkown
HY-12964 SGI-7079 Inhibitor 99.32% Unkown
HY-119423 MMP Inhibitor II Inhibitor 99.7% Unkown
HY-124813 PDZ1i Inhibitor 99.29% Unkown
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-B0633I Hyaluronic acid sodium (MW 800kDa) / Unkown
HY-N0084 Betulinaldehyde Inhibitor 98.72% Unkown
HY-N2132 Flavokawain B 99.99% Unkown
HY-116626 SM-7368 Inhibitor 99.77% Unkown
HY-P3513 β-Neo-Endorphin Activator 98.97% Unkown
HY-N2497 Isoliquiritin apioside Inhibitor 99.87% Unkown
HY-116302 MMP-9-IN-9 Inhibitor 99.26% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-116474 Viridicatol 99.93% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.68% Unkown
HY-161285 MMP-9/10-IN-2 Inhibitor 99.87% Unkown
HY-N0757 8-​O-​Acetylharpagide 99.75% Unkown
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.48% Unkown
HY-117970 MMPI-1154 Inhibitor 99.76% Unkown
HY-12170A Prinomastat hydrochloride 98.53% Unkown
HY-N1401 20(R)-Ginsenoside Rh2 99.84% Unkown
HY-W001925 7-Methoxy-1-tetralone 99.93% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-120213 YH-306 98.34% Unkown
HY-125847 Salvianolic acid F 99.50% Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-125864B Murine Fibrinogen / Unkown
HY-N6812 Karacoline 99.58% Unkown
HY-P3484 Dnp-PLGLWA-DArg-NH2 TFA 99.78% Unkown
HY-114785 BPHA Inhibitor 99.88% Unkown
HY-176184 PROTAC DDR1 degrader-1 98.69% Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.83% Unkown
HY-N6896 Isoviolanthin Inhibitor 99.87% Unkown
HY-P10143 MMP-2/MMP-9 Substrate Substrate 98.48% Unkown
HY-111186 Flocoumafen Inhibitor 99.35% Unkown
HY-114911 Feprazone Inhibitor 99.88% Unkown
HY-119979 Cardanol monoene Inducer 99.51% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-181654 Snail IN-1 Inhibitor 98.27% Unkown
HY-B0633E Hyaluronic acid, low endotoxin / Unkown
HY-N6862 Lucideric acid A Inhibitor 98.44% Unkown
HY-N7385 Nudol 99.60% Unkown
HY-P0273A Histatin 5 TFA Inhibitor 99.98% Unkown
HY-P4905 Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 Inhibitor 98.02% Unkown
HY-13564A Batimastat sodium salt Inhibitor 99.04% Unkown
HY-RS08557 MMP9 Human Pre-designed siRNA Set A / Unkown
HY-RS08558 Mmp9 Mouse Pre-designed siRNA Set A / Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.4% Unkown
HY-131417 cis-ACCP Inhibitor 97.0% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-149848 MMP-9-IN-6 Inhibitor 99.80% Unkown
HY-177701 MMP-9-IN-13 Inhibitor 98.07% Unkown
HY-B0099S Edaravone-d5 99.76% Unkown
HY-N2199 Sotetsuflavone 96.75% Unkown
HY-N2205 Esculentoside H Inhibitor 98.73% Unkown
HY-N6860 Lucidenic acid C Inhibitor 99.76% Unkown
HY-P10359A TAT-QFNP12 acetate Inhibitor 95.90% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.52% Unkown
HY-P4373 Hepcidin-1 (mouse) Inducer / Unkown
HY-109747 RO-28-2653 Inhibitor / Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-111172 Inotilone Inhibitor 95.26% Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-116474R Viridicatol (Standard) / Unkown
HY-119185 AZD-6605 / Unkown
HY-120339 STK899704 / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-123255 BSc2118 / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-136699 Excisanin A Inhibitor / Unkown
HY-137839 Anti-inflammatory agent 121 Inhibitor / Unkown
HY-138195 NEO212 / Unkown
HY-14237 SC-77964 Inhibitor / Unkown
HY-143407 FAK-IN-3 Inhibitor / Unkown
HY-144224S Tianeptine-d6 hydrochloride / Unkown
HY-146216 MMP-9-IN-3 / Unkown
HY-146217 MMP-9-IN-4 / Unkown
HY-146218 MMP-9-IN-5 / Unkown
HY-14744B Levamlodipine hydrochloride Inhibitor / Unkown
HY-14744C Levamlodipine hydrobromide Inhibitor / Unkown
HY-147867 MMP-2/9-IN-1 Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-155960 SH491 Inhibitor / Unkown
HY-156247 IVMT-Rx-3 Inhibitor / Unkown
HY-157138 MMP-9-IN-8 / Unkown
HY-161284 MMP-9/10-IN-1 Inhibitor / Unkown
HY-161707 MMP2-IN-4 Inhibitor / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-162079 Anticancer agent 183 Inhibitor / Unkown
HY-162344 Ir-CA Inducer / Unkown
HY-163760 ZM-32 Inhibitor / Unkown
HY-168560 MMP Inhibitor 4 Inhibitor / Unkown
HY-168605 DH-18 / Unkown
HY-169062 RJF02215 Inhibitor / Unkown
HY-171776 OPB-3206 Inhibitor / Unkown
HY-172088 Tubulin/MMP-IN-3 / Unkown
HY-172551 anti-TNBC agent-9 / Unkown
HY-173500 MG-3C / Unkown
HY-175558 MMP-9-IN-12 / Unkown
HY-175815 Apoptosis inducer 44 / Unkown
HY-176412 MMP-9-IN-11 Inhibitor / Unkown
HY-178460 BRK/PTK6-IN-1 Inhibitor / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-179439 Multi-kinase-IN-8 / Unkown
HY-179724 PZ-1657 Inhibitor / Unkown
HY-179724A PZ-1657 hydrochloride Inhibitor / Unkown
HY-180117 MMP-2/9-IN-2 / Unkown
HY-180324 Candidone / Unkown
HY-180765 Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene Activator / Unkown
HY-181272 MMP-9-IN-14 / Unkown
HY-182069 CDK9-IN-47 / Unkown
HY-182614 BJ-2302 Inhibitor / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-182818 SH494 / Unkown
HY-183316 Anticancer agent 319 / Unkown
HY-183784 P2X7R antagonist-1 / Unkown
HY-184162 HSP110-IN-1 / Unkown
HY-184501 UE01 / Unkown
HY-184926 PEG9MA10-PAB10-GalMA10 / Unkown
HY-18694 CGS 27023A Inhibitor / Unkown
HY-18694A CGS 27023A free base Inhibitor / Unkown
HY-B0012B Pamidronic acid sodium Inhibitor / Unkown
HY-E70617 Neutrophil Gelatinase Associated Lipocalin (NGAL), Human / Unkown
HY-N0757R 8-O-Acetylharpagide (Standard) / Unkown
HY-N10176 D-Isofloridoside Inhibitor 98.59% Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-N16746 Nordentatin Inhibitor / Unkown
HY-N17617 S-Petasin / Unkown
HY-N19029 Vernodalin / Unkown
HY-N2497R Isoliquiritin apioside (Standard) Inhibitor / Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-P11577 TGGGPLGVARGKGGC Substrate / Unkown
HY-P11780 KAFDITYVRLKF / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2004 FFAGLDD / Unkown
HY-P2004A FFAGLDD TFA / Unkown
HY-P3513A β-Neo-Endorphin acetate Activator / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-RS08559 Mmp9 Rat Pre-designed siRNA Set A / Unkown
HY-W095774 (E)-N-(3-Methoxyphenyl)cinnamamide Inhibitor / Unkown
HY-W185542 E09241 / Unkown
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / Unkown
HY-W783478 Calebin A Inhibitor 98.0% Unkown
HY-W801479S Edaravone sulfate-d5 / Unkown
HY-105854A Pipoxolan / Unkown
HY-107581R MK-1903 (Standard) / Unkown
HY-112726A PXS-4728A free base Inhibitor / Unkown
HY-119110 LY52 Inhibitor / Unkown
HY-122585 proMMP-9 inhibitor-3c Inhibitor / Unkown
HY-124068 LQB-118 / Unkown
HY-133845 CIL-102 / Unkown
HY-14744D Levamlodipine besylate Hemipentahydrate Inhibitor / Unkown
HY-14744S Levamlodipine-d4 Inhibitor 99.74% Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-183377 DMBT / Unkown
HY-183400 BIM-46174 / Unkown
HY-183408 MMI-166 / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor 98.0% Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-90003S Tianeptine-d12 / Unkown
HY-B1451S Imidapril-d3 hydrochloride Inhibitor / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown
HY-W1058004 (E)-N-(2-Fluorophenyl)cinnamamide Inhibitor / Unkown
HY-W747703 Hippuric acid-13C6 / Unkown
HY-P0273 Histatin 5 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992200 Anti-CD146 Antibody (AA98) / Unkown
HY-P990468 Anti-MMP9 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp9 NCBI NCBI:4318