Il2 - interleukin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116562

About Il2

Primary_assembly 2: 120,004,862-120,009,566 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 89 orthologues and is associated with 121 phenotypes. Biased expression in Testes (RPKM 9.7), Thymus (RPKM 1.9) and 1 other tissue.

Summary

Enables carbohydrate binding activity; glycosphingolipid binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of T cell activation; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of protein phosphorylation. Located in extracellular space. Used to study cystitis. Biomarker of allergic rhinitis; colorectal carcinoma; and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Apr 2022]

Il2 Products (1)

mRNA Protein Name
NM_053836.1 NP_446288.1 interleukin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbohydrate binding IDA
IDA: Inferred from direct assay
6609839 RGD
enables cytokine activity IDA
IDA: Inferred from direct assay
6979751 RGD
enables glycosphingolipid binding IDA
IDA: Inferred from direct assay
6609839 RGD
enables interleukin-2 receptor binding IMP
IMP: Inferred from mutant phenotype
3124825 RGD
enables kappa-type opioid receptor binding IMP
IMP: Inferred from mutant phenotype
11907831 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11907831 RGD
involved in negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
3124825 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
7859920 RGD
involved in positive regulation of T cell differentiation IDA
IDA: Inferred from direct assay
9352365 RGD
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
6609839 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
11907831 RGD
involved in positive regulation of dendritic spine development IDA
IDA: Inferred from direct assay
20225203 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
3124825 RGD
involved in positive regulation of regulatory T cell differentiation IDA
IDA: Inferred from direct assay
6233372 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
8045674 RGD
involved in response to tacrolimus IEP
IEP: Inferred from expression pattern
23867624 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8186377 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il2 Protein Structure

IL2

IL2: smart00189 (0 - 153)

  • 0
  • 100
  • 155 a.a.
Protein Preferred Names Protein Names

interleukin-2

  • IL-2

  • T-cell growth factor

  • TCGF

Recombinant Il2 Proteins

Cat. No. Product Name Accession Purity
HY-P70718 IL-2 Protein, Rat (HEK293, His) P17108 (A21-Q155) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700649 IL-2 Protein, Rat (145a.a, HEK293, C-His) P17108 (A11-Q155) ≥ 95%, as determined by reducing SDS-PAGE.

Orthologs Information

Species Symbol Source ID
Homo sapiens Il2 NCBI NCBI:3558