2. Gene
  3. HDAC6 - histone deacetylase 6 Gene

HDAC6 - histone deacetylase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 480907 | Gene type: protein coding

About HDAC6

Primary_assembly X: 42,140,480-42,160,909 forward strand.ROS_Cfam_1.0:CM025138.1

This gene has 2 transcripts (splice variants), 182 orthologues and 10 paralogues.

HDAC6 Products(6)

mRNA Protein Name
XM_038449953.1 XP_038305881.1 histone deacetylase 6 isoform X4
XM_038449952.1 XP_038305880.1 histone deacetylase 6 isoform X3
XM_038449950.1 XP_038305878.1 histone deacetylase 6 isoform X1
XM_038449951.1 XP_038305879.1 histone deacetylase 6 isoform X2
XM_038449956.1 XP_038305884.1 histone deacetylase 6 isoform X4
XM_038449955.1 XP_038305883.1 histone deacetylase 6 isoform X4

HDAC6 Protein Structure

Arginase_HDAC

Arginase_HDAC: cl17011 (167 - 508)

HDAC6-dom2

HDAC6-dom2: cd10003 (557 - 907)

zf-UBP

zf-UBP: pfam02148 (1134 - 1196)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1217 a.a.
Protein Preferred Names Protein Names

histone deacetylase 6

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-10225 Belinostat Inhibitor 99.97% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-B0494 Bufexamac Inhibitor 98.0% Unkown
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes
Clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-14718A Resminostat hydrochloride Inhibitor 99.67% Phase 4
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-101780 Tinostamustine Inhibitor 99.64% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-138799 KA2507 Inhibitor 99.24% Phase 2
HY-13432A Nanatinostat TFA Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1
Pre-clinical Phase
Bioactive Molecules (271)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13271A Tubastatin A Inhibitor 99.07% Unkown
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-N0931 Santacruzamate A Inhibitor 99.54% Unkown
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13428 Tubacin Inhibitor 97.11% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 99.31% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.28% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-153392 TYA-018 Inhibitor 99.84% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-19328 ACY-775 Inhibitor 99.71% Unkown
HY-N0071 Crotonoside Inhibitor 99.78% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.87% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-111791 ACY-1083 Inhibitor 99.80% Unkown
HY-161307 T-518 Inhibitor 98.40% Unkown
HY-13267 Droxinostat Inhibitor 99.08% Unkown
HY-18976 UF010 99.83% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-161305 SE-7552 Inhibitor 99.48% Unkown
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 99.01% Unkown
HY-164099 LSD1/HDAC6-IN-2 Inhibitor 99.66% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-123976 MPT0G211 Inhibitor 99.79% Unkown
HY-126147 J22352 Inhibitor 99.04% Unkown
HY-18712 BG45 Inhibitor 99.95% Unkown
HY-150109 Purinostat mesylate Inhibitor 99.45% Unkown
HY-173266A TO-1187 TFA Degrader 98.41% Unkown
HY-171139 PROTAC HDAC6 degrader 2 Inhibitor 99.80% Unkown
HY-130493 HPB Inhibitor 99.11% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-135890 CG347B Inhibitor 98.07% Unkown
HY-124295 Imofinostat Inhibitor 99.40% Unkown
HY-158075 DNMT/HDAC-IN-1 Inhibitor 99.87% Unkown
HY-116818 Crebinostat Inhibitor 98.83% Unkown
HY-152134 HDAC6 degrader-3 Degrader 98.12% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-124053 BRD2492 Inhibitor 99.22% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-114483 AES-135 Inhibitor 98.68% Unkown
HY-170495 HDAC6 degrader-5 Inhibitor 99.55% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.59% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-156850 ITF 3756 Inhibitor 98.55% Unkown
HY-161304 HDAC6-IN-33 Inhibitor 98.96% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-178948 HDAC10-IN-3 Inhibitor / Unkown
HY-149721 HDAC4-IN-1 Inhibitor / Unkown
HY-159109 HDAC6-IN-46 Inhibitor 98.51% Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-124782 HDAC8-IN-8 Inhibitor 99.01% Unkown
HY-138831 AES-350 Inhibitor 99.30% Unkown
HY-174444 PROTAC HDAC degrader-2 Degrader / Unkown
HY-120448 QTX125 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-173266 TO-1187 Degrader / Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-120448A QTX125 TFA Inhibitor 99.93% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-172177 ROCK/HDAC-IN-2 Inhibitor / Unkown
HY-131970 LSD1/HDAC6-IN-1 Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-123976A MPT0G211 mesylate Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-172129 HDAC6-IN-52 Inhibitor / Unkown
HY-161854 LASSBio-1911 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-180829 HDAC6-IN-71 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-180811 ALK/HDAC-IN-2 Inhibitor / Unkown
HY-183320 HDAC6-IN-81 Inhibitor / Unkown
HY-182649 NN-429 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-169940 Fibrostat Inhibitor / Unkown
HY-143241 HDAC-IN-34 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-139181 NR160 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-174449 HDAC6-IN-62 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-181086 FLT3/HDAC-IN-3 Inhibitor / Unkown
HY-141541 MPT0G413 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-158371 HDAC/CK2-IN-1 Inhibitor / Unkown
HY-172159 FF2039 Inhibitor / Unkown
HY-178021 HDAC1-IN-11 Inhibitor / Unkown
HY-178336 AC-340 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-144449 mTOR/HDAC6-IN-1 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-157385 HDAC-IN-67 Inhibitor / Unkown
HY-158308 HDAC6-IN-41 Inhibitor / Unkown
HY-123971 HDAC6 degrader-4 Degrader / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-175467 HDAC6/HSP90-IN-3 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-181678 DNA-PK/HDAC6-IN-1 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-176561 IOR-160 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-178104 HDAC-IN-93 Inhibitor / Unkown
HY-161306 ITF5924 Inhibitor / Unkown
HY-174877 PROTAC HDAC6 degrader 6 Degrader / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-181793 VEGFR2/HDAC-IN-1 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-172200 PD-L1/HDAC6-IN-1 Inhibitor / Unkown
HY-162330 HDAC6-IN-36 Inhibitor / Unkown
HY-157314 HDAC6-IN-27 Inhibitor / Unkown
HY-176064 HDAC6-IN-58 Inhibitor / Unkown
HY-169157 HDAC6-IN-50 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / Unkown
HY-183057 GRK2 modulator 1 Inhibitor / Unkown
HY-172873 HDSI-18 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-174396 PI3Kδ/HDAC6-IN-1 Inhibitor / Unkown
HY-163894 HDAC6-IN-48 Inhibitor / Unkown
HY-126566 Trichostatin C Inhibitor / Unkown
HY-172200A PD-L1/HDAC6-IN-1 TFA Inhibitor / Unkown
HY-174265 HDAC6-IN-60 Inhibitor / Unkown
HY-161516 HDAC6-IN-42 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-182777 HDAC6-IN-80 Inhibitor / Unkown
HY-172359 PROTAC HDAC6 degrader 4 Degrader / Unkown
HY-178110 HDAC6-IN-65 Inhibitor / Unkown
HY-179421 PROTAC HDAC6 degrader 7 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-150597 HDAC-IN-46 Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-161155 HDAC6-IN-31 Inhibitor / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-179422 HDAC6-IN-68 Inhibitor / Unkown
HY-178333 HDAC6-IN-66 Inhibitor / Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-173184 HDAC6-IN-53 Inhibitor / Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-181805 HDAC6-IN-76 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-163369 HDAC6-IN-35 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-162378 LT-630 Inhibitor / Unkown
HY-161984 HDAC-IN-76 Inhibitor / Unkown
HY-162781 HDAC1/6-IN-2 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-153514 HDAC-IN-54 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-172394 ZSNI-21 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-181577 HDAC6-IN-73 Inhibitor / Unkown
HY-182904 GV-001 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-168508 PB200 Inhibitor / Unkown
HY-177759 PROTAC HDAC6 degrader 9 Degrader / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-152133 PROTAC HDAC6 degrader 1 Degrader / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-175988 DNMT/HDAC-IN-2 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-180994 HDAC6-IN-72 Inhibitor / Unkown
HY-163368 HDAC6-IN-34 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-177758 PROTAC HDAC6 degrader 8 Degrader / Unkown
HY-180224 HDAC6-IN-70 Inhibitor / Unkown
HY-178022 HDAC6-IN-63 Inhibitor / Unkown
HY-168477 HDAC1-IN-8 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-181843 HDAC-IN-99 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-178023 HDAC6-IN-64 Inhibitor / Unkown
HY-119316 CM-414 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-163503 HDAC6-IN-38 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-161667 GSK-3β/HDAC-IN-1 Inhibitor / Unkown
HY-147892 HDAC-IN-42 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-181639 HDAC6-IN-75 MDM2 Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-181942 HDAC6-IN-77 Inhibitor / Unkown
HY-152235 HDAC6-IN-15 Inhibitor / Unkown
HY-181541 HIT211504993 Inhibitor / Unkown
HY-179654 ST13 Inhibitor / Unkown
HY-174149 HDAC6-IN-59 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-169156 HDAC6-IN-49 Inhibitor / Unkown
HY-123699 NCT-10b Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-175176 HDAC1/6-IN-3 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-161688 HDAC-IN-73 Inhibitor / Unkown
HY-173555 HDAC6-IN-54 Inhibitor / Unkown
HY-182720 FT108 Inhibitor / Unkown
HY-151153 HDAC1-IN-5 Inhibitor / Unkown
HY-150694 HDAC6-IN-11 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-162678 HDAC-IN-75 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-180934 AMC-3-030 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-163359 CYP17A1/HDAC6-IN-1 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-144725 HDAC1/6-IN-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-150586 PTG-0861 Inhibitor / Unkown
HY-119316A CM-545 Inhibitor / Unkown
HY-181926 COX-2/HDAC6-IN-1 Inhibitor / Unkown
HY-139795 ZYJ-25e Inhibitor / Unkown
HY-139815 ZYJ-34c Inhibitor / Unkown
HY-W555601 Nicoxamat Inhibitor / Unkown
HY-160846 HDAC6-IN-40 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-185359 HDAC6-IN-78 Inhibitor / Unkown
HY-160845 HDAC6-IN-39 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HDAC6 NCBI NCBI:10013