HDAC6 - histone deacetylase 6 Gene

Also Known as HD6; JM21; CPBHM; PPP1R90

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10013

About HDAC6

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,801,398-48,824,982 (from NCBI)

This gene has 84 transcripts (splice variants), 182 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 18.6), testis (RPKM 15.9) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each Other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

HDAC6 Products (17)

mRNA	Protein	Name
XM_047441706.1	XP_047297662.1	histone deacetylase 6 isoform X3
NM_001321225.2	NP_001308154.1	histone deacetylase 6 isoform a
NR_135591.1
NM_001321229.1	NP_001308158.1	histone deacetylase 6 isoform b
XM_047441704.1	XP_047297660.1	histone deacetylase 6 isoform X2
NM_001321226.2	NP_001308155.1	histone deacetylase 6 isoform b
NM_001321231.2	NP_001308160.1	histone deacetylase 6 isoform c
NR_135593.2
XM_047441705.1	XP_047297661.1	histone deacetylase 6 isoform X3
NM_006044.4	NP_006035.2	histone deacetylase 6 isoform b
XR_007068179.1
NM_001321227.2	NP_001308156.1	histone deacetylase 6 isoform b
NM_001321228.2	NP_001308157.1	histone deacetylase 6 isoform b
XM_047441703.1	XP_047297659.1	histone deacetylase 6 isoform X1
NM_001321230.2	NP_001308159.1	histone deacetylase 6 isoform c
XM_047441707.1	XP_047297663.1	histone deacetylase 6 isoform X4
NR_135592.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	15916966	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24413532	GOA
NOT enables acetylspermidine deacetylase activity	IDA IDA: Inferred from direct assay	28516954	GOA
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	19228685	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	18356165	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	14675537	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10220385	GOA
enables histone deacetylase activity	IMP IMP: Inferred from mutant phenotype	23322205	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12620231	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	19228685	GOA
enables misfolded protein binding	EXP EXP: Inferred from Experiment	17785525	GOA
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	14675537	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16919237	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	28516954	GOA
enables tau protein binding	IDA IDA: Inferred from direct assay	18636984	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	12535528	GOA
enables tubulin deacetylase activity	EXP EXP: Inferred from Experiment	12024216	GOA
enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	12620231	GOA
enables tubulin deacetylase activity	IMP IMP: Inferred from mutant phenotype	19457097	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21753002	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in aggresome assembly	IMP IMP: Inferred from mutant phenotype	14675537	GOA
involved in axonal transport of mitochondrion	IGI IGI: Inferred from genetic interaction	28105056	GOA
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	18606987	GOA
involved in cellular response to topologically incorrect protein	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in cilium disassembly	IDA IDA: Inferred from direct assay	26246421	GOA
involved in cilium disassembly	IMP IMP: Inferred from mutant phenotype	17604723	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in negative regulation of aggrephagy	IDA IDA: Inferred from direct assay	31857589	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24413532	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	23962722	GOA
involved in negative regulation of protein-containing complex disassembly	IMP IMP: Inferred from mutant phenotype	15916966	GOA
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	18356165	GOA
involved in peptidyl-lysine deacetylation	IMP IMP: Inferred from mutant phenotype	18356165	GOA
NOT involved in polyamine deacetylation	IDA IDA: Inferred from direct assay	28516954	GOA
involved in polyubiquitinated misfolded protein transport	IMP IMP: Inferred from mutant phenotype	14675537	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	12024216	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23962722	GOA
acts upstream of positive regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	15916966	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	28516954	GOA
involved in protein deacetylation	IMP IMP: Inferred from mutant phenotype	15916966	GOA
involved in protein quality control for misfolded or incompletely synthesized proteins	IMP IMP: Inferred from mutant phenotype	14675537	GOA
involved in regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	23580651	GOA
involved in response to growth factor	IMP IMP: Inferred from mutant phenotype	18356165	GOA
involved in response to misfolded protein	IMP IMP: Inferred from mutant phenotype	14675537	GOA
NOT involved in spermidine deacetylation	IDA IDA: Inferred from direct assay	28516954	GOA
involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	19228685	GOA
involved in type 2 mitophagy	IGI IGI: Inferred from genetic interaction	20457763	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in aggresome	IDA IDA: Inferred from direct assay	14675537	GOA
located in caveola	IDA IDA: Inferred from direct assay	18356165	GOA
located in cell leading edge	IDA IDA: Inferred from direct assay	12024216	GOA
located in centrosome	IDA IDA: Inferred from direct assay	26246421	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	17604723	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24687993	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	11948178	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	16192271	GOA
located in microtubule	IDA IDA: Inferred from direct assay	12620231	GOA
part of microtubule associated complex	IDA IDA: Inferred from direct assay	19228685	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12024216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC6 Protein Structure

Hist_deacetyl

zf-UBP

0
200
400
600
800
1000
1215 a.a.

Protein Preferred Names	Protein Names
histone deacetylase 6	protein phosphatase 1, regulatory subunit 90 tubulin-lysine deacetylase HDAC6

HDAC6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HDAC6	Q9UBN7	PRKCA	Homo sapiens	P17252	Anti Tag CoIP	21952047
Intra	HDAC6	Q9UBN7	CYLD	Homo sapiens	Q9NQC7	Anti Tag CoIP	19893491
Intra	HDAC6	Q9UBN7	CYLD	Homo sapiens	Q9NQC7	Anti Bait CoIP	19893491
Intra	HDAC6	Q9UBN7	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	HDAC6	Q9UBN7	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	HDAC6	Q9UBN7	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Protein Kinase Assay	20029029
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Anti Tag CoIP	24658140
Intra	HDAC6	Q9UBN7	PROM1	Homo sapiens	O43490	Anti Bait CoIP	23084749
Intra	HDAC6	Q9UBN7	PROM1	Homo sapiens	O43490	Anti Tag CoIP	23084749
Cross	HDAC6	Q9UBN7	Cttn	Mus musculus	Q60598	IF	21847094
Intra	HDAC6	Q9UBN7	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	29281743
Intra	HDAC6	Q9UBN7	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	18356165
Intra	HDAC6	Q9UBN7	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	23084749
Intra	HDAC6	Q9UBN7	ATP13A2	Homo sapiens	Q9NQ11	Ub Reconstruction	22645275
Intra	HDAC6	Q9UBN7	PRKN	Homo sapiens	O60260	Pull Down	19036992
Cross	HDAC6	Q9UBN7	GRK2	Bos taurus	P21146	Pull Down	22193721
Cross	HDAC6	Q9UBN7	GRK2	Bos taurus	P21146	Protein Kinase Assay	22193721
Cross	HDAC6	Q9UBN7	Cdc20	Rattus norvegicus	Q62623	Anti Tag CoIP	19167333
Cross	HDAC6	Q9UBN7	Cdc20	Rattus norvegicus	Q62623	Pull Down	19167333
Cross	HDAC6	Q9UBN7	Tax	Human T-cell leukemia virus 1	P03409	Confocal	21532619
Cross	HDAC6	Q9UBN7	Tax	Human T-cell leukemia virus 1	P03409	Anti Tag CoIP	21532619
Cross	HDAC6	Q9UBN7	tat	Human immunodeficiency virus	P04610	Anti Tag CoIP	21220424

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HDAC6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72224	HDAC6 Protein, Human (His)	Q9UBN7-1 (M489-E840)	≥ 90%, as determined by reducing SDS-PAGE.

HDAC6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80154	HDAC6 Antibody (YA390)	WB, ICC/IF, IHC-P, IP	Human
HY-P80701	HDAC6 Antibody (YA740)	WB	Human, Rat
HY-P80701A	HDAC6 Antibody (YA740)(PBS only)	WB	Human, Rat
HY-P86103	HDAC6 Antibody (YA5795)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Atrial Septal Defect 8	ASD8 Atrial Heart Septal Defect 8 Septal Defect, Atrial, Type 8
Alexander Disease	Alexander'S Disease ALXDRD Alexanders Leukodystrophy Axd Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia Alx Demyelinogenic Leukodystrophy Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration Of Astrocytes Leukodystrophy With Rosenthal Fibers Alexander Disease Type Ii Axd Type Ii Alexander Disease Type I Axd Type I Alexanders Disease Alexander'S Leukodystrophy
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Joubert Syndrome 8	JBTS8 Joubert Syndrome, Type 8
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Spinal And Bulbar Muscular Atrophy, X-Linked 1	Kennedy Disease Sbma Spinal And Bulbar Muscular Atrophy Kennedy'S Disease X-Linked Spinal And Bulbar Muscular Atrophy SMAX1 Kd Kennedy Spinal And Bulbar Muscular Atrophy Spinobulbar Muscular Atrophy Bulbospinal Muscular Atrophy, X-Linked Bulbospinal Neuronopathy, X-Linked Recessive Xbsn Spinal And Bulbar Muscular Atrophy Of Kennedy Bulbospinal Muscular Atrophy X-Linked Bulbospinal Amyotrophy Bulbo-Spinal Atrophy, X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bulbo-Spinal Atrophy X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bsma X-Linked Bulbospinal Muscular Atrophy Spinal And Bulbar Muscular Atrophy X-Linked 1 Bulbospinal Muscular Atrophy X-Linked Bulbospinal Neuronopathy X-Linked Recessive Kennedy Disease) Kennedy Syndrome Atrophy, Muscular, Spinal And Bulbar, Kennedy Type Atrophy, Muscular, Spinobulbar Bulbospinal Neuronopathy
Charcot-Marie-Tooth Disease And Deafness	Charcot-Marie-Tooth Disease Type 1e CMT1E Charcot-Marie-Tooth Disease Type 1 Charcot-Marie-Tooth Disease, Demyelinating, Type 1e Hereditary Motor And Sensory Neuropathy Type 1 Charcot-Marie-Tooth Disease, Type I Charcot-Marie-Tooth Neuropathy And Deafness, Autosomal Dominant Charcot-Marie-Tooth Disease, Type 1e Charcot-Marie-Tooth Disease Demyelinating Type 1e Autosomal Dominant Demyelinating Charcot-Marie-Tooth Disease Cmt1 Charcot-Marie-Tooth Neuropathy Type 1 Autosomal Dominant Charcot-Marie-Tooth Neuropathy And Deafness Charcot-Marie-Tooth Disease-Deafness Charcot-Marie-Tooth Type 1 Hmsn1 Hereditary Motor And Sensory Neuropathy 1 Cmt 1e Charcot Marie Tooth Disease Type 1e Charcot-Marie-Tooth Disease-Deafness Syndrome Charcot-Marie-Tooth Disease-Hearing Loss Syndrome Charcot-Marie-Tooth Disease 1e Charcot-Marie-Tooth Disease And Deafness Autosomal Dominant Charcot-Marie-Tooth Neuropathy Type 1e Charcot-Marie-Tooth Disease, Type Ie Hereditary Motor And Sensory Neuropathy Type I
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia	X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type X-Linked Dominant Chondrodysplasia-Hydrocephaly-Microphthalmia Syndrome CDP-PBHM Chondrodysplasia, With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Prolapse Of Urethra	Urethrocele
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Meckel Syndrome, Type 1	Meckel Syndrome Meckel-Gruber Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Brachydactyly
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Charcot-Marie-Tooth Disease, Axonal, Type 2f	Charcot-Marie-Tooth Disease Axonal Type 2f CMT2F Charcot-Marie-Tooth Disease, Neuronal, Type 2f Charcot-Marie-Tooth Neuropathy, Type 2f Autosomal Dominant Charcot-Marie-Tooth Disease Type 2f Charcot-Marie-Tooth Neuropathy Type 2f Charcot-Marie-Tooth Neuronal Type 2f Charcot-Marie-Tooth Disease Type 2f Cmt 2f Charcot Marie Tooth Disease Type 2f Charcot-Marie-Tooth Disease 2f Charcot-Marie-Tooth Disease Neuronal Type 2f Charcot-Marie-Tooth Disease, Type 2f

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-10225	Belinostat	Inhibitor	99.97%	Yes
HY-14842	Givinostat	Inhibitor	98.67%	Yes
HY-13322	Pracinostat	Inhibitor	99.80%	Yes
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	99.63%	Yes
HY-B0494	Bufexamac	Inhibitor	98.47%	Unkown
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Yes

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14718	Resminostat	Inhibitor	99.44%	Phase 4
HY-10990	Abexinostat	Inhibitor	99.00%	Phase 3
HY-101780	Tinostamustine	Inhibitor	99.64%	Phase 3
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Phase 3
HY-175513	ZWZH-21	Inhibitor	/	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	99.71%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-13432	Nanatinostat	Inhibitor	99.67%	Phase 2
HY-138799	KA2507	Inhibitor	99.17%	Phase 2
HY-124295	Imofinostat	Inhibitor	99.40%	Phase 2
HY-184424	HDAC6-IN-84	Inhibitor	/	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.55%	Phase 1

Pre-clinical Phase

Bioactive Molecules (303)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13271A	Tubastatin A	Inhibitor	99.07%	Unkown
HY-18361	TMP195	Inhibitor	99.82%	Unkown
HY-N0931	Santacruzamate A	Inhibitor	99.54%	Unkown
HY-15224	PCI-34051	Inhibitor	99.84%	Unkown
HY-13428	Tubacin	Inhibitor	98.71%	Unkown
HY-13271	Tubastatin A Hydrochloride	Inhibitor	99.31%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-18360	TMP269	Inhibitor	98.16%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.69%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-18613	CAY10603	Inhibitor	99.76%	Unkown
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Unkown
HY-153392	TYA-018	Inhibitor	99.84%	Unkown
HY-111400	SR-4370	Inhibitor	98.38%	Unkown
HY-103596	Thalidomide-4-OH	Degrader	99.62%	Unkown
HY-N0071	Crotonoside	Inhibitor	99.78%	Unkown
HY-111818	TH34	Inhibitor	99.52%	Unkown
HY-19328	ACY-775	Inhibitor	99.71%	Unkown
HY-144779	HDAC10-IN-1	Inhibitor	99.87%	Unkown
HY-111791	ACY-1083	Inhibitor	99.61%	Unkown
HY-13267	Droxinostat	Inhibitor	99.08%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.10%	Unkown
HY-161307	T-518	Inhibitor	98.40%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.91%	Unkown
HY-18976	UF010		99.83%	Unkown
HY-161305	SE-7552	Inhibitor	99.48%	Unkown
HY-164099	LSD1/HDAC6-IN-2	Inhibitor	99.66%	Unkown
HY-169259	HDAC9-IN-1	Inhibitor	95.13%	Unkown
HY-114414	HDACs/mTOR Inhibitor 1	Inhibitor	98.10%	Unkown
HY-126147	J22352	Inhibitor	99.04%	Unkown
HY-123976	MPT0G211	Inhibitor	99.79%	Unkown
HY-173266A	TO-1187 TFA	Degrader	98.41%	Unkown
HY-18712	BG45	Inhibitor	99.95%	Unkown
HY-14718A	Resminostat hydrochloride	Inhibitor	99.67%	Yes
HY-135714	Bavarostat	Inhibitor	99.51%	Unkown
HY-171139	PROTAC HDAC6 degrader 2	Inhibitor	99.80%	Unkown
HY-130493	HPB	Inhibitor	99.11%	Unkown
HY-171140	PROTAC HDAC6 degrader 3	Degrader	99.81%	Unkown
HY-116818	Crebinostat	Inhibitor	98.83%	Unkown
HY-158075	DNMT/HDAC-IN-1	Inhibitor	99.87%	Unkown
HY-100871	WT-161	Inhibitor	98.04%	Unkown
HY-135890	CG347B	Inhibitor	98.07%	Unkown
HY-152134	PROTAC HDAC6 degrader 11	Degrader	98.12%	Unkown
HY-124053	BRD2492	Inhibitor	99.22%	Unkown
HY-114483	AES-135	Inhibitor	98.68%	Unkown
HY-19747	HPOB	Inhibitor	99.54%	Unkown
HY-161304	HDAC6-IN-33	Inhibitor	98.96%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-170495	HDAC6 degrader-5	Inhibitor	99.55%	Unkown
HY-18700	BRD73954	Inhibitor	99.13%	Unkown
HY-156850	ITF 3756	Inhibitor	98.55%	Unkown
HY-171141	HDAC6 ligand-2	Ligand	98.70%	Unkown
HY-162616	SelSA	Inhibitor	99.83%	Unkown
HY-110280	MC1742	Inhibitor	98.95%	Unkown
HY-126141	JAK/HDAC-IN-1	Inhibitor	98.63%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-130538	1-Naphthohydroxamic acid	Inhibitor	99.59%	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	98.11%	Unkown
HY-178948A	HDAC10-IN-3 formic	Inhibitor	97.16%	Unkown
HY-178948	HDAC10-IN-3	Inhibitor	/	Unkown
HY-12954	PTACH	Inhibitor	99.65%	Unkown
HY-159109	HDAC6-IN-46	Inhibitor	98.51%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-148624	CHDI-00484077	Inhibitor	98.38%	Unkown
HY-124782	HDAC8-IN-8	Inhibitor	99.01%	Unkown
HY-138831	AES-350	Inhibitor	99.30%	Unkown
HY-157740	XSJ-10	Inhibitor	95.16%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-173266	TO-1187	Degrader	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.12%	Unkown
HY-120448A	QTX125 TFA	Inhibitor	99.93%	Unkown
HY-120448	QTX125	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	95.73%	Unkown
HY-174444	PROTAC HDAC degrader-2	Degrader	/	Unkown
HY-179421	PROTAC HDAC6 degrader 7	Inhibitor	/	Unkown
HY-169938	LSD1/HDAC-IN-2	Inhibitor	/	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-131970	LSD1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-123976A	MPT0G211 mesylate	Inhibitor	/	Unkown
HY-172177	ROCK/HDAC-IN-2	Inhibitor	/	Unkown
HY-128582	PI3K/HDAC-IN-1	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-155397	PRO-HD2	Degrader	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-180214	HDAC6-IN-69	Inhibitor	/	Unkown
HY-149946	HDAC-IN-57	Inhibitor	/	Unkown
HY-181541	HIT211504993	Inhibitor	/	Unkown
HY-170379	HDAC-IN-84	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-174396	PI3Kδ/HDAC6-IN-1	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-173064	DS-103	Inhibitor	/	Unkown
HY-169400	HDACs/EZH2-IN-1	Inhibitor	/	Unkown
HY-168175	PROTAC HDAC8 Degrader-2	Degrader	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-161984	HDAC-IN-76	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-178104	HDAC-IN-93	Inhibitor	/	Unkown
HY-118160	PPM-18	Inhibitor	99.17%	Unkown
HY-168962	HDAC-IN-88	Inhibitor	/	Unkown
HY-181926	COX-2/HDAC6-IN-1	Inhibitor	/	Unkown
HY-162678	HDAC-IN-75	Inhibitor	/	Unkown
HY-174877	PROTAC HDAC6 degrader 6	Degrader	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-177776	HDAC-IN-97	Degrader	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-144449	mTOR/HDAC6-IN-1	Inhibitor	/	Unkown
HY-181805	HDAC6-IN-76	Inhibitor	/	Unkown
HY-119316	CM-414	Inhibitor	/	Unkown
HY-150586	PTG-0861	Inhibitor	/	Unkown
HY-175988	DNMT/HDAC-IN-2	Inhibitor	/	Unkown
HY-179654	ST13	Inhibitor	/	Unkown
HY-181579	HDAC6-IN-74	Inhibitor	/	Unkown
HY-169940	Fibrostat	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-180829	HDAC6-IN-71	Inhibitor	/	Unkown
HY-181793	VEGFR2/HDAC-IN-1	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-159172	HDAC3-IN-4	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-182904	GV-001	Inhibitor	/	Unkown
HY-153514	HDAC-IN-54	Inhibitor	/	Unkown
HY-161306	ITF5924	Inhibitor	/	Unkown
HY-182777	HDAC6-IN-80	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-182747	HDAC6-IN-79	Inhibitor	/	Unkown
HY-126566	Trichostatin C	Inhibitor	/	Unkown
HY-174302	PIM-1/HDAC-IN-2	Inhibitor	/	Unkown
HY-144098	HDAC8-IN-2	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-177758	PROTAC HDAC6 degrader 8	Degrader	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-149578	Tubulin/HDAC-IN-3	Inhibitor	/	Unkown
HY-169157	HDAC6-IN-50	Inhibitor	/	Unkown
HY-179422	HDAC6-IN-68	Inhibitor	/	Unkown
HY-175628	HDAC6 ligand-Linker Conjugate 2		/	Unkown
HY-187387	PROTAC HDAC6/ERα degrader 1	Degrader	/	Unkown
HY-178110	HDAC6-IN-65	Inhibitor	/	Unkown
HY-162330	HDAC6-IN-36	Inhibitor	/	Unkown
HY-163369	HDAC6-IN-35	Inhibitor	/	Unkown
HY-187212	SH-17	Inhibitor	/	Unkown
HY-184430	HDAC6 ligand-8	Ligand	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-163894	HDAC6-IN-48	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-161516	HDAC6-IN-42	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-172360	HDAC6 ligand-3	Ligand	/	Unkown
HY-184389	PROTAC HDAC6 degrader 10	Degrader	/	Unkown
HY-181577	HDAC6-IN-73	Inhibitor	/	Unkown
HY-184706	SHN7	Inhibitor	/	Unkown
HY-178023	HDAC6-IN-64	Inhibitor	/	Unkown
HY-162910	HDAC-IN-79	Inhibitor	/	Unkown
HY-144332	PHD2/HDACs-IN-1	Inhibitor	/	Unkown
HY-187388	HDAC6/ERα ligand-1	Ligand	/	Unkown
HY-13432A	Nanatinostat TFA	Inhibitor	/	Unkown
HY-157481	HDAC1-IN-6	Inhibitor	/	Unkown
HY-175030	TNI-97	Inhibitor	/	Unkown
HY-150774	HDAC6/HSP90-IN-2	Inhibitor	/	Unkown
HY-162378	LT-630	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-184165	F2F-202	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-173184	HDAC6-IN-53	Inhibitor	/	Unkown
HY-172394	ZSNI-21	Inhibitor	/	Unkown
HY-147991	PDE5/HDAC-IN-1	Inhibitor	/	Unkown
HY-175176	HDAC1/6-IN-3	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-174149	HDAC6-IN-59	Inhibitor	/	Unkown
HY-183560	HDAC6-IN-82	Inhibitor	/	Unkown
HY-162781	HDAC1/6-IN-2	Inhibitor	/	Unkown
HY-146750	HDAC-IN-37	Inhibitor	/	Unkown
HY-141701	mTOR/HDAC-IN-1	Inhibitor	/	Unkown
HY-180994	HDAC6-IN-72	Inhibitor	/	Unkown
HY-115941	HDAC-IN-9	Inhibitor	/	Unkown
HY-151364	HDAC6/8/BRPF1-IN-1	Inhibitor	/	Unkown
HY-178336	AC-340	Inhibitor	/	Unkown
HY-181843	HDAC-IN-99	Inhibitor	/	Unkown
HY-172200A	PD-L1/HDAC6-IN-1 TFA	Inhibitor	99.55%	Unkown
HY-174398	GSK-3β/HDAC-IN-2	Inhibitor	/	Unkown
HY-151153	HDAC1-IN-5	Inhibitor	/	Unkown
HY-176868	Rodin-C	Inhibitor	/	Unkown
HY-177759	PROTAC HDAC6 degrader 9	Degrader	/	Unkown
HY-178022	HDAC6-IN-63	Inhibitor	/	Unkown
HY-161350	ALK/HDAC-IN-1	Inhibitor	/	Unkown
HY-180934	AMC-3-030	Inhibitor	/	Unkown
HY-182649	NN-429	Inhibitor	/	Unkown
HY-176561	IOR-160	Inhibitor	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-172159	FF2039	Inhibitor	/	Unkown
HY-180224	HDAC6-IN-70	Inhibitor	/	Unkown
HY-184525	HDAC6-IN-85	Inhibitor	97.58%	Unkown
HY-161783	HDAC6-IN-45	Inhibitor	/	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-168508	PB200	Inhibitor	/	Unkown
HY-174449	HDAC6-IN-62	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-146293	HDAC6/HSP90-IN-1	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-161155	HDAC6-IN-31	Inhibitor	/	Unkown
HY-172873	HDSI-18	Inhibitor	/	Unkown
HY-187210	HDAC6-IN-86	Inhibitor	/	Unkown
HY-183985	Hsp110/HDAC6-IN-1	Inhibitor	/	Unkown
HY-147731	HDAC6-IN-9	Inhibitor	/	Unkown
HY-144782	HDAC10-IN-2	Inhibitor	/	Unkown
HY-161524	HDAC6-IN-43	Inhibitor	/	Unkown
HY-178021	HDAC1-IN-11	Inhibitor	/	Unkown
HY-173330	HDAC-IN-89	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-168477	HDAC1-IN-8	Inhibitor	/	Unkown
HY-158308	HDAC6-IN-41	Inhibitor	/	Unkown
HY-184574	HDAC-IN-104	Inhibitor	/	Unkown
HY-161667	GSK-3β/HDAC-IN-1	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-181086	FLT3/HDAC-IN-3	Inhibitor	/	Unkown
HY-163368	HDAC6-IN-34	Inhibitor	/	Unkown
HY-143241	HDAC-IN-34	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-176733	HDAC6-IN-61	Inhibitor	/	Unkown
HY-184203	SM-06-09	Inhibitor	/	Unkown
HY-169156	HDAC6-IN-49	Inhibitor	/	Unkown
HY-152235	HDAC6-IN-15	Inhibitor	/	Unkown
HY-184304	HDAC6-IN-83	Inhibitor	/	Unkown
HY-182720	FT108	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-169405	AAK1/HDACs-IN-1	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-158371	HDAC/CK2-IN-1	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-152133	PROTAC HDAC6 degrader 1	Degrader	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-123699	NCT-10b	Inhibitor	/	Unkown
HY-150503	KH-259	Inhibitor	/	Unkown
HY-163359	CYP17A1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-180811	ALK/HDAC-IN-2	Inhibitor	/	Unkown
HY-173386	HDAC6 ligand-4	Inhibitor	/	Unkown
HY-181678	DNA-PK/HDAC6-IN-1	Inhibitor	/	Unkown
HY-181942	HDAC6-IN-77	Inhibitor	/	Unkown
HY-173555	HDAC6-IN-54	Inhibitor	/	Unkown
HY-119316A	CM-545	Inhibitor	/	Unkown
HY-144725	HDAC1/6-IN-1	Inhibitor	/	Unkown
HY-157385	HDAC-IN-67	Inhibitor	/	Unkown
HY-162319	Tubulin/HDAC-IN-4	Inhibitor	/	Unkown
HY-181639	HDAC6-IN-75	MDM2 Inhibitor	99.86%	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-161688	HDAC-IN-73	Inhibitor	/	Unkown
HY-174471	HDAC-IN-90	Ligand	/	Unkown
HY-161854	LASSBio-1911	Inhibitor	/	Unkown
HY-15433B	Quisinostat hydrochloride	Inhibitor	/	Unkown
HY-183320	HDAC6-IN-81	Inhibitor	/	Unkown
HY-184505	(±)-trans-BAS-2	Inhibitor	/	Unkown
HY-179019	HDAC-IN-94	Inhibitor	/	Unkown
HY-172359	PROTAC HDAC6 degrader 4	Degrader	/	Unkown
HY-178333	HDAC6-IN-66	Inhibitor	/	Unkown
HY-183057	GRK2 modulator 1	Inhibitor	/	Unkown
HY-179272	Wee1/HDAC-IN-1	Inhibitor	/	Unkown
HY-163503	HDAC6-IN-38	Inhibitor	/	Unkown
HY-176064	HDAC6-IN-58	Inhibitor	/	Unkown
HY-172200	PD-L1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-172129	HDAC6-IN-52	Inhibitor	/	Unkown
HY-181009	HDAC-IN-98	Inhibitor	98.36%	Unkown
HY-139181	NR160	Inhibitor	98.9%	Unkown
HY-150694	HDAC6-IN-11	Inhibitor	/	Unkown
HY-123971	PROTAC HDAC6 degrader 12	Degrader	/	Unkown
HY-152226	MC2590	Inhibitor	98.71%	Unkown
HY-162658	Leuxinostat	Inhibitor	/	Unkown
HY-150597	HDAC-IN-46	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-162955	LSD1/HDAC-IN-1	Inhibitor	/	Unkown
HY-150772	Tubulin/HDAC-IN-1	Inhibitor	/	Unkown
HY-184550	HDAC6 ligand-9	Ligand	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-175627	HDAC6 ligand-6		/	Unkown
HY-184415	Syk/HDAC6-IN-1	Inhibitor	/	Unkown
HY-179227	HDAC6 ligand-7	Inhibitor	/	Unkown
HY-146539	HDAC-IN-35	Inhibitor	/	Unkown
HY-184398	cGAS/HDAC-IN-1	Inhibitor	/	Unkown
HY-174265	HDAC6-IN-60	Inhibitor	/	Unkown
HY-141541	MPT0G413	Inhibitor	/	Unkown
HY-175467	HDAC6/HSP90-IN-3	Inhibitor	/	Unkown
HY-184979	HDAC6 ligand 10	Inhibitor	/	Unkown
HY-147892	HDAC-IN-42	Inhibitor	/	Unkown
HY-157314	HDAC6-IN-27	Inhibitor	/	Unkown
HY-139815	ZYJ-34c	Inhibitor	/	Unkown
HY-W555601	Nicoxamat	Inhibitor	99.05%	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown
HY-185359	HDAC6-IN-78	Inhibitor	/	Unkown
HY-139795	ZYJ-25e	Inhibitor	/	Unkown
HY-160846	HDAC6-IN-40	Inhibitor	/	Unkown
HY-160845	HDAC6-IN-39	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HDAC6	VGNC	VGNC:50613
Rattus norvegicus	HDAC6	RGD	RGD:619981
Macaca mulatta	HDAC6	VGNC	VGNC:73164
Mus musculus	HDAC6	MGD	MGI:1333752
Canis familiaris	HDAC6	VGNC	VGNC:50630
Felis catus	HDAC6	VGNC	VGNC:62769
Others	HDAC6	NCBI