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2639

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

146

Peptides

MCE Kits

Inhibitory Antibodies

323

Natural
Products

165

Recombinant Proteins

145

Isotope-Labeled Compounds

215

Antibodies

Click Chemistry

200

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0603

20(S)-Ginsenoside Rg3 5+ Cited Publications 20(S)-Propanaxadiol; S-ginsenoside Rg3	Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na ⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-N1376

(20R)-Ginsenoside Rg3 5 Publications Verification (20R)-Propanaxadiol; R-ginsenoside Rg3	Others	Cancer
(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

HY-N6979

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-N0605

Ginsenoside Rh2 4 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2	Caspase Apoptosis Endogenous Metabolite	Cancer
Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.

HY-N0835

(20S)-Protopanaxatriol 1 Publications Verification 20(S)-APPT; g-PPT	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis	Cardiovascular Disease Endocrinology Cancer
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N0797

(20S)-Protopanaxadiol 3 Publications Verification 20-Epiprotopanaxadiol; 20(S)-APPD	P-glycoprotein Reactive Oxygen Species (ROS) Apoptosis	Cancer
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-W034597

20-(tert-Butoxy)-20-oxoicosanoic acid	ADC Linker PROTAC Linkers	Cancer
20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

HY-160186

20-SOLA 1 Publications Verification	Cytochrome P450	Cardiovascular Disease Metabolic Disease Endocrinology
20-SOLA is an orally active *20-HETE* antagonist. 20-SOLA greatly ameliorates changes in blood pressure and renal injury associated with a Streptozotocin (STZ) (HY-13753)-diabetic mouse model. 20-SOLA facilitates the restoration of coronary collateral growth (CCG) after ischemic injury. 20-SOLA can be studied for research in cardiovascular diseases and diabetes .

HY-12316

20(S)-Hydroxycholesterol 3 Publications Verification 20α-Hydroxycholesterol	Smo Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

HY-N0866

20-Deoxyingenol 5 Publications Verification	Autophagy	Inflammation/Immunology
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

HY-101527

20-HEDE 2 Publications Verification WIT 002	Cytochrome P450	Cancer
20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE).

HY-148226

20-5,14-HEDGE	Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease
20-5,14-HEDGE is a 20-HETE analog. 20-5,14-HEDGE induces cell death in organotypic hippocampal slice cultures (OHSCs). 20-5,14-HEDGE enhances ROS production and reduces hypoxia-reoxygenation (HR)-induced apoptosis in ex vivo rat lung slices. 20-5,14-HEDGE protects against lung ischemic reperfusion injury in rats. 20-5,14-HEDGE can be used for the study of pulmonary vascular signaling and lung injury-related research .

HY-156876

20-HETE inhibitor-2	Cytochrome P450	Metabolic Disease
20-HETE inhibitor-2 is an orally active *20-HETE* inhibitor. 20-HETE inhibitor-2 can inhibit the activities of CYP4F2 and CYP4A11, thereby suppressing the production of *20-HETE. 20-HETE inhibitor-2 has the effect of improving blood glucose and can be used for the research of various diseases related to 20-HETE* such as obesity .

HY-N2040

(20R)-Protopanaxadiol 1 Publications Verification	Bacterial Interleukin Related	Infection Inflammation/Immunology Cancer
(20R)-Protopanaxadiol is a metabolite of ginsenosides. (20R)-Protopanaxadiol has anti-inflammatory and antibacterial activities, but shows no significant cytotoxicity against tumor cell lines. In addition, (20R)-Protopanaxadiol can inhibit the uptake of 2-deoxy-D-glucose (2-DG) .

HY-145001

20-HC-Me-Pyrrolidine	LDLR CETP	Metabolic Disease
20-HC-Me-Pyrrolidine (compound AI-3d) is a potent Aster protein inhibitor with IC₅₀s of 0.11 μM, 0.06 μM, and 0.71 μM for Aster-A, Aster-B, and Aster-C, respectively. 20-HC-Me-Pyrrolidine blocks the ability of Asters to bind and transfer cholesterol. 20-HC-Me-Pyrrolidine also inhibits the movement of low-density lipoprotein (LDL) cholesterol to the endoplasmic reticulum (ER) .

HY-N1401

20(R)-Ginsenoside Rh2 2 Publications Verification	MMP Apoptosis HSV DNA/RNA Synthesis NO Synthase Prostaglandin Receptor Reactive Oxygen Species (ROS) Akt	Infection Inflammation/Immunology Cancer
20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect .

HY-15598S

20-HETE-d6 20-Hydroxyarachidonic acid-d₆; 20-Hydroxyeicosatetraenoic acid-d₆	Isotope-Labeled Compounds	Others
20-HETE-d₆ is the deuterium labeled 20-HETE.

HY-N0798

20(R)-Protopanaxatriol 1 Publications Verification 20(R)-APPT	Others	Others
20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

HY-N1400

(20R)-Ginsenoside Rh1	PKC	Cardiovascular Disease
(20R)-Ginsenoside Rh1 is the R-isomer of Ginsenoside Rh1 (HY-N0604), and it is found in red ginseng, ginseng, and other sources. (20R)-Ginsenoside Rh1 inhibits thrombin-induced conversion of fibrinogen to fibrin, exerting anticoagulant and antithrombotic effects .

HY-113062

20α-Dihydroprogesterone 20-OH-P	Endogenous Metabolite Cytochrome P450	Endocrinology Cancer
20α-Dihydroprogesterone is the metabolite of Progesterone (HY-N0437). 20α-Dihydroprogesterone inhibits cell proliferation and migration in breast tissue. 20α-Dihydroprogesterone inhibits aromatase in cell MCF-7aro with IC₅₀ about 5 μM .

HY-160099

20-5,14-HEDE WIT003	Apoptosis Caspase DNA/RNA Synthesis PI3K Akt Reactive Oxygen Species (ROS)	Cardiovascular Disease
20-5,14-HEDE (WIT003) is an analog of 20-HETE. 20-5,14-HEDE activates PI3K/Akt signaling pathway, thereby exhibiting anti-apoptotic and cell survival promoting effects. 20-5,14-HEDE is the agonist for *20-HETE* that increases intracellular Ca ²⁺ concentrations, thereby enhancing vasoconstriction .

HY-N2039

20(R)-Ginsenoside Rg2	Others	Cancer
20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities .

HY-146917S

20:0-20:1-20:0 TG-d5	Isotope-Labeled Compounds	Others
20:0-20:1-20:0 TG-d₅ is deuterium labeled 20:0-20:1-20:0 TG.

HY-N0797R

(20S)-Protopanaxadiol (Standard) 20-Epiprotopanaxadiol (Standard); 20(S)-APPD (Standard)	Reference Standards P-glycoprotein Reactive Oxygen Species (ROS) Apoptosis	Cancer
(20S)-Protopanaxadiol (Standard) is the analytical standard of (20S)-Protopanaxadiol. This product is intended for research and analytical applications. 20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-154825

20-Hydroxyvitamin D3 20(OH)D3; 20S-Hydroxyvitamin D3	VD/VDR Aryl Hydrocarbon Receptor NF-κB Cytochrome P450	Inflammation/Immunology Cancer
20-Hydroxyvitamin D3 (20(OH)D3), a product of vitamin D3 hydroxylation, is a noncalcemic immunomodulator. 20-Hydroxyvitamin D3 binds to vitamin D receptor (VDR), activates VDR and aryl hydrocarbon receptor (AhR) signaling, stimulates CYP24A1 expression, and drives VDR nuclear translocation. 20-Hydroxyvitamin D3 inhibits NF-κB activity via IκBα upregulation. 20-Hydroxyvitamin D3 acts as a substrate for CYP27B1 and rat CYP24A1, undergoing hydroxylation to form dihydroxy-derivatives. 20-Hydroxyvitamin D3 inhibits cell proliferation, colony formation, migration, and tumor growth, and induces cell differentiation in cancer cells. 20-Hydroxyvitamin D3 can be used for the research of inflammatory and autoimmune diseases, melanoma, breast carcinomas, and hepatocarcinoma .

HY-113483

20-Carboxy-Leukotriene B4 20-COOH LTB4	Drug Metabolite Leukotriene Receptor	Metabolic Disease
20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis) .

HY-150187

20:4 Lyso PI	GPR55 ERK ROCK Calcium Channel	Neurological Disease
20:4 Lyso PI acts as an activator of GPR55 and RhoA. 20:4 Lyso PI activates the GPR55-RhoA-ROCK pathway, thereby inducing morphological changes, cytoskeleton assembly, cell rounding and stress fiber formation. 20:4 Lyso PI can be used in research related to diseases such as those of the nervous system .

HY-139114

20-Carboxyarachidonic acid	PPAR	Metabolic Disease
20-Carboxyarachidonic acid, a relatively stable metabolite of 20-HETE, is an endogenous dual activator of PPARalpha and PPARgamma .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 3 Publications Verification 20α-Hydroxycholesterol (Standard)	Reference Standards Smo Endogenous Metabolite	Cancer
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-122944

20-Deoxocarnosol	Others	Cancer
20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells .

HY-124311

20-Hydroxyeicosanoic acid	Drug Derivative	Metabolic Disease
20-Hydroxyeicosanoic acid is an ester product.

HY-146931S

20:1 SM (d18:1/20:1)-d9	Isotope-Labeled Compounds	Others
20:1 SM (d18:1/20:1)-d₉ is deuterium labeled 20:1 SM (d18:1/20:1).

HY-113479

20-Hydroxy-leukotriene B4 20-Hydroxy-LTB4; 20-OH-LTB4	Endogenous Metabolite	Inflammation/Immunology
20-Hydroxy-leukotriene B4 is an endogenous metabolite present in Urine that can be used for the research of Sjogren Larsson Syndrome .

HY-N6262

20(S),24(R)-Ocotillol	Others	Others
20(S),24(R)-Ocotillol is isolated from Panax ginseng .

HY-W744549

20β-Dihydrocortisol 20β-DHF	Glucocorticoid Receptor Drug Metabolite	Metabolic Disease
20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity .

HY-W684071

20α-Dihydrocortisol 20α-DHF	Drug Metabolite	Metabolic Disease
20α-Dihydrocortisol (20α-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583) .

HY-W614895

20-Bromoicosanoic acid	PROTAC Linkers	Cancer
20-Bromoicosanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-N0603R

20(S)-Ginsenoside Rg3 (Standard) 20(S)-Propanaxadiol(Standard); S-ginsenoside Rg3 (Standard)	Reference Standards Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
20(S)-Ginsenoside Rg3 (Standard) is the analytical standard of 20(S)-Ginsenoside Rg3. This product is intended for research and analytical applications. 20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-N8901

20-Gluco-ginsenoside-Rf	Biochemical Assay Reagents	Others
20-Gluco-ginsenoside-Rf (compound 4) is a bisdesmosidic saponin that can be obtained from the roots of Panax ginseng .

HY-N2049

20(R)-Notoginsenoside R2	Others	Neurological Disease
20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng .

HY-N10382

20,26-Dihydroxyecdysone	Drug Metabolite	Others
20,26-Dihydroxyecdysone is a predominant ecdysteroid metabolite .

HY-N3502

20(21)-Dehydrolucidenic acid A	HIV Protease	Infection
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .

HY-139105

20-O-Demethyl-AP3	Microtubule/Tubulin	Infection Cancer
20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. Ansamitocin P-3, a microtubule inhibitor, is a macrocyclic antitumor antibiotic .

HY-CE00798

20-Methylpentacosanoyl-CoA 20-Methylpentacosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
20-Methylpentacosanoyl-CoA (20-Methylpentacosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00803

20-Methyltricosanoyl-CoA 20-Methyltricosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
20-Methyltricosanoyl-CoA (20-Methyltricosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00801

20-Methyltetracosanoyl-CoA 20-Methyltetracosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
20-Methyltetracosanoyl-CoA (20-Methyltetracosanoyl-coenzyme A) is a coenzyme A derivative.

HY-N0798R

20(R)-Protopanaxatriol (Standard) 20(R)-APPT (Standard)	Reference Standards Others	Others
20(R)-Protopanaxatriol (Standard) is the analytical standard of 20(R)-Protopanaxatriol. This product is intended for research and analytical applications. 20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

HY-N3792

20-Hydroxyecdysone 2,3:20,22-diacetonide	Others	Metabolic Disease
20-Hydroxyecdysone 2,3:20,22-diacetonide is a natural ecdysteroid .

HY-N0835R

(20S)-Protopanaxatriol (Standard) 20(S)-APPT (Standard); g-PPT (Standard)	Reference Standards Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis	Cardiovascular Disease Endocrinology Cancer
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-113516

20-HETE Ethanolamide	Endogenous Metabolite	Neurological Disease
20-HETE Ethanolamide is a metabolite of endocannabinoid Anandamide. 20-HETE Ethanolamide binds to the rat brain cannabinoid CB1 receptor with a K_i of 985 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0603

20(S)-Ginsenoside Rg3 5+ Cited Publications 20(S)-Propanaxadiol; S-ginsenoside Rg3	Panax ginseng C. A. Meyer Triterpenes Neurological Disease Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na ⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-N1376

(20R)-Ginsenoside Rg3 5 Publications Verification (20R)-Propanaxadiol; R-ginsenoside Rg3	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Cancer Source Classification	Others
(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

HY-N6979

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Cardiovascular Disease other families Animals Classification of Application Fields Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Disease Research Fields Steroids Source Classification	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-N0605

Ginsenoside Rh2 4 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2	Panax ginseng C. A. Meyer Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.

HY-N0835

(20S)-Protopanaxatriol 1 Publications Verification 20(S)-APPT; g-PPT	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N0797

(20S)-Protopanaxadiol 3 Publications Verification 20-Epiprotopanaxadiol; 20(S)-APPD	Panax ginseng C. A. Meyer Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	P-glycoprotein Reactive Oxygen Species (ROS) Apoptosis
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-12316

20(S)-Hydroxycholesterol 3 Publications Verification 20α-Hydroxycholesterol	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

HY-N0596

Panaxadiol 4 Publications Verification 20(R)-Panaxadiol	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .

HY-N0866

20-Deoxyingenol 5 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

HY-112016

C20 Ceramide (d18:1/20:0) C20 Ceramide; N-Arachidoyl-D-sphingosine	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
C20 Ceramide (d18:1/20:0) (N-Arachidoyl-D-sphingosine) is a natural 20:0 ceramide and a N-acylsphingosine in which the ceramide N-acyl group is specified as eicosanoyl. C20 Ceramide (d18:1/20:0) acts as a key signal molecule mediating biological processes .

HY-N0598

Ginsenoside F1 1 Publications Verification 20(S)-Ginsenoside F1	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	Cytochrome P450 Endogenous Metabolite
Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.

HY-N2040

(20R)-Protopanaxadiol 1 Publications Verification	Panax ginseng C. A. Meyer Infection Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Bacterial Interleukin Related
(20R)-Protopanaxadiol is a metabolite of ginsenosides. (20R)-Protopanaxadiol has anti-inflammatory and antibacterial activities, but shows no significant cytotoxicity against tumor cell lines. In addition, (20R)-Protopanaxadiol can inhibit the uptake of 2-deoxy-D-glucose (2-DG) .

HY-N1401

20(R)-Ginsenoside Rh2 2 Publications Verification	Panax ginseng C. A. Meyer Infection Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	MMP Apoptosis HSV DNA/RNA Synthesis NO Synthase Prostaglandin Receptor Reactive Oxygen Species (ROS) Akt
20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect .

HY-N0798

20(R)-Protopanaxatriol 1 Publications Verification 20(R)-APPT	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Others
20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

HY-N1400

(20R)-Ginsenoside Rh1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	PKC
(20R)-Ginsenoside Rh1 is the R-isomer of Ginsenoside Rh1 (HY-N0604), and it is found in red ginseng, ginseng, and other sources. (20R)-Ginsenoside Rh1 inhibits thrombin-induced conversion of fibrinogen to fibrin, exerting anticoagulant and antithrombotic effects .

HY-N0909

Notoginsenoside R2 1 Publications Verification 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Neurological Disease Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Apoptosis MEK ERK Reactive Oxygen Species (ROS) Caspase COX β-catenin Src MDM-2/p53 JAK STAT
Notoginsenoside R2 (20(S)-Notoginsenoside R2; Ginsenoside Ng-R2) is an orally active notoginsenoside . Notoginsenoside R2 activates P90RSK and Nrf2 via the MEK1/2-ERK1/2 pathway to inhibit 6-OHDA-induced apoptotic damage in nerve cells. Notoginsenoside R2 upregulates SOX8/β-catenin by reducing miR-27a, thereby suppressing Aβ_25-35-induced neuronal apoptosis and inflammatory responses . Notoginsenoside R2 alleviates lipid accumulation and mitochondrial dysfunction in diabetic nephropathy by inhibiting c-Src. Notoginsenoside R2 alleviates hepatic fibrosis by inducing hepatic stellate cell senescence and inhibiting the inflammatory microenvironment via JAK/STAT3 suppression . Notoginsenoside R2 can be used in research related to Parkinson's disease, Alzheimer's disease, diabetic nephropathy and hepatic fibrosis .

HY-113062

20α-Dihydroprogesterone 20-OH-P	Animals Steroids Source Classification	Endogenous Metabolite Cytochrome P450
20α-Dihydroprogesterone is the metabolite of Progesterone (HY-N0437). 20α-Dihydroprogesterone inhibits cell proliferation and migration in breast tissue. 20α-Dihydroprogesterone inhibits aromatase in cell MCF-7aro with IC₅₀ about 5 μM .

HY-N15905

C20 Glucosyl(β) ceramide (d18:1/20:0)	Structural Classification Lipid	Biochemical Assay Reagents
C20 Glucosyl(β) ceramide (d18:1/20:0) is a β-glucosyl ceramide.

HY-N2039

20(R)-Ginsenoside Rg2	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	Others
20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities .

HY-137295

Ingenol 3,20-dibenzoate	Classification of Application Fields Terpenoids Diterpenoids Euphorbia esula L. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC Apoptosis
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-N0797R

(20S)-Protopanaxadiol (Standard) 20-Epiprotopanaxadiol (Standard); 20(S)-APPD (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Plants Endogenous metabolite Araliaceae Source Classification	Reference Standards P-glycoprotein Reactive Oxygen Species (ROS) Apoptosis
(20S)-Protopanaxadiol (Standard) is the analytical standard of (20S)-Protopanaxadiol. This product is intended for research and analytical applications. 20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-N15809

C20 Galactosyl(ß) ceramide (d18:1/20:0)	Lipid	Biochemical Assay Reagents
C20 Galactosyl(?) ceramide (d18:1/20:0) is a β-Glucosyl ceramide.

HY-N8349

19,20-Epoxycytochalasin D	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-N0870

Ingenol-5,20-acetonide-3-O-angelate Ingenol 5,20-acetonide 3-angelate; Ingenol 3-angelate 5,20-acetonide	Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	Others
Ingenol-5,20-acetonide-3-O-angelate is a natural compound.

HY-N15352

C20 Sphingomyelin (d18:1/20:1)	Structural Classification Endogenous metabolite Lipid Source Classification	Liposome
C20 Sphingomyelin (d18:1/20:1) is a sphingomyelin substance. The level of C20 Sphingomyelin (d18:1/20:1) is associated with amyotrophic lateral sclerosis and primary lateral sclerosis .

HY-134104

C20-Sphingosine D-erythro-Sphingosine-C20	Natural Products Endogenous metabolite Source Classification	Others
C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development .

HY-N16008

C20:4 Anandamide (AEA)	Lipid	Biochemical Assay Reagents
C20:4 Anandamide (AEA) is a class of anandamides.

HY-116663

(±)20-HDHA (±)20-HDoHE	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
(±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate .

HY-139114

20-Carboxyarachidonic acid	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	PPAR
20-Carboxyarachidonic acid, a relatively stable metabolite of 20-HETE, is an endogenous dual activator of PPARalpha and PPARgamma .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 3 Publications Verification 20α-Hydroxycholesterol (Standard)	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Reference Standards Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-122944

20-Deoxocarnosol	Genista cinerea (Vill.) DC. Terpenoids Labiatae Diterpenoids Plants	Others
20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells .

HY-113479

20-Hydroxy-leukotriene B4 20-Hydroxy-LTB4; 20-OH-LTB4	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
20-Hydroxy-leukotriene B4 is an endogenous metabolite present in Urine that can be used for the research of Sjogren Larsson Syndrome .

HY-N6262

20(S),24(R)-Ocotillol	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Others
20(S),24(R)-Ocotillol is isolated from Panax ginseng .

HY-W744549

20β-Dihydrocortisol 20β-DHF	Structural Classification Endogenous metabolite Steroids Source Classification	Glucocorticoid Receptor Drug Metabolite
20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity .

HY-W684071

20α-Dihydrocortisol 20α-DHF	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Metabolite
20α-Dihydrocortisol (20α-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583) .

HY-N17267

2-Deoxy-20-hydroxyecdysone	Structural Classification Marine natural products Other marine organisms Steroids Source Classification	Others
2-Deoxy-20-hydroxyecdysone is an ecdysteroid. 2-Deoxy-20-hydroxyecdyson can be isolated from zoanthid Zoanthus sp.. 2-Deoxy-20-hydroxyecdysone exhibits lower moulting hormone activity than 20-hydroxyecdysone in Musca bioassays .

HY-N0603R

20(S)-Ginsenoside Rg3 (Standard) 20(S)-Propanaxadiol(Standard); S-ginsenoside Rg3 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Neurological Disease Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Reference Standards Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite
20(S)-Ginsenoside Rg3 (Standard) is the analytical standard of 20(S)-Ginsenoside Rg3. This product is intended for research and analytical applications. 20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-N8901

20-Gluco-ginsenoside-Rf	Panax ginseng C. A. Meyer Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Plants Araliaceae Source Classification	Biochemical Assay Reagents
20-Gluco-ginsenoside-Rf (compound 4) is a bisdesmosidic saponin that can be obtained from the roots of Panax ginseng .

HY-N2049

20(R)-Notoginsenoside R2	Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Plants Araliaceae Source Classification	Others
20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng .

HY-N6639

3-O-Acetyl-20-Hydroxyecdysone	Commelinaceae Classification of Application Fields Other Diseases Cyanotis arachnoidea C. B. Clarke Plants Disease Research Fields Steroids Source Classification	Others
3-O-Acetyl-20-Hydroxyecdysone is an steroid isolated from the roots of Cyanotis arachnoidea C.B.Clark.

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Source Classification	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .

HY-N0869

Ingenol-5,20-acetonide	Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	Others
Ingenol-5,20-acetonide is a natural compound.

HY-N0871

Ingenol-3,4,5,20-diacetonide Ingenol 3,4:5,20-bisacetonide	Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	Others
Ingenol-3,4,5,20-diacetonide is a natural compound.

HY-Z8245

20b-Dihydroprogesterone Progesterone EP impurity C	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Drug Derivative
20b-Dihydroprogesterone (Compond III) is a C-21 steroid found in water beetles Cybister limbatus, C. tripunctatus and C. confuses .

HY-N0798R

20(R)-Protopanaxatriol (Standard) 20(R)-APPT (Standard)	Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Araliaceae Source Classification	Reference Standards Others
20(R)-Protopanaxatriol (Standard) is the analytical standard of 20(R)-Protopanaxatriol. This product is intended for research and analytical applications. 20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

HY-N3792

20-Hydroxyecdysone 2,3:20,22-diacetonide	Triterpenes Terpenoids Rhaponticum carthamoides (Willd.) Iljin Plants Compositae Source Classification	Others
20-Hydroxyecdysone 2,3:20,22-diacetonide is a natural ecdysteroid .

HY-N4174

Raddeanoside 20	Triterpenes Classification of Application Fields Terpenoids Ranunculaceae Anemone raddeana Regel Metabolic Disease Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Raddeanoside 20 is a triterpenoid isolated from the rhizome of Anemone raddeana. Raddeanoside 20 can suppresse superoxide generation .

HY-113125

Dolichol-20	Microorganisms Source Classification	Biochemical Assay Reagents
Dolichol-20 is an ester product.

HY-N16024

FP-20 sodium	Lipid	Toll-like Receptor (TLR)
FP-20 sodium, a selective TLR4 agonist, is a vaccine adjuvant. FP-20 sodium induces MAPK- and NLRP3-dependent inflammasome activation. FP20 shows no toxicity in mouse vaccination experiments with OVA antigen and induces IgG production .

HY-N0835R

(20S)-Protopanaxatriol (Standard) 20(S)-APPT (Standard); g-PPT (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

Cat. No.	Product Name	Chemical Structure

HY-Y0479AS

L-Lactic acid-13C3 sodium (20% w/w in water) 1 Publications Verification
L-Lactic acid- ¹³C₃ ((S)-2-hydroxypropanoic- ¹³C₃) sodium (20% in water) is the ¹³C labeled L-Lactic acid. L-Lactic acid- ¹³C₃ sodium (20% in water) can be used for lactate metabolism research .

HY-N0437S

Progesterone-d9
Progesterone-d₉ is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-10201S

Sorafenib-d3 1 Publications Verification
Sorafenib-d₃ (Donafenib), a deuterated compound of Sorafenib, is the first deuterium-generation tumor suppressor small molecule. Sorafenib is a multikinase inhibitor IC₅₀s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively .

HY-70013S

Abiraterone-d4
Abiraterone-d₄ is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.

HY-B2227BS3

L-Lactic acid-13C-1 sodium (20% w/w in water)
L-Lactic acid- ¹³C₁ (L-E-270- ¹³C₁) sodium (20% in water) is the ¹³C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activityy .

HY-15598S

20-HETE-d6
20-HETE-d₆ is the deuterium labeled 20-HETE.

HY-W654342

Spermine-d20
Spermine-d₂₀ (NSC 268508-d₂₀) is deuterium labeled Spermine. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects .

HY-17512S

Losartan-d4
Losartan-d₄ is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

HY-10201S2

Sorafenib-13C,d3

1 Publications Verification

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC₅₀s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC₅₀s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator .

HY-40354S

Tofacitinib-13C3
Tofacitinib- ¹³C₃ is the ¹³C-labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.

HY-Y0479AS2

L-Lactate-13C sodium (20% in water) 1 Publications Verification
L-Lactate- ¹³C ((S)-2-Hydroxypropanoic acid- ¹³C) sodium is the ¹³C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .

HY-B0101S

Fluconazole-d4
Fluconazole-d₄ is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .

HY-146917S

20:0-20:1-20:0 TG-d5
20:0-20:1-20:0 TG-d₅ is deuterium labeled 20:0-20:1-20:0 TG.

HY-W006492S

5a-Pregnane-3,20-dione-d6
5a-Pregnane-3,20-dione-d₆ is the deuterium labeled 5a-Pregnane-3,20-dione. 5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-129336S

Abemaciclib metabolite M20-d8
Abemaciclib metabolite M20-d₈ is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor .

HY-B0151S2

Pregnenolone-d4-1

Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-A0143S

Dihomo-γ-linolenic acid-d6
Dihomo-γ-linolenic acid-d₆ (DGLA-d₆) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system .

HY-N0717AS

D-Valine-d8
D-Valine-d₈ is the deuterium labeled D-Valine. D-Valine is the enantiomer of L-Valine (HY-N0717). L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.

HY-10201S1

Sorafenib-d4
Sorafenib-d₄ (Bay 43-9006-d₄) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

HY-N0437S2

Progesterone-13C3 1 Publications Verification
Progesterone- ¹³C₃ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-146931S

20:1 SM (d18:1/20:1)-d9
20:1 SM (d18:1/20:1)-d₉ is deuterium labeled 20:1 SM (d18:1/20:1).

HY-B0312S

Dipyridamole-d20
Dipyridamole-d₂₀ is the deuterium labeled Dipyridamole. Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells .

HY-W009240S

1,10-Dibromodecane-d20
1,10-Dibromodecane-d₂₀ is the deuterium labeled 1,10-Dibromodecan .

HY-110189S1

Pregnenolone monosulfate-d4 sodium

Pregnenolone monosulfate-d₄ sodium is the deuterium labeled Pregnenolone monosulfate sodium (HY-110189) . Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-13458S1

Droxidopa-13C2,15N hydrochloride
Droxidopa- ¹³C₂, ¹⁵N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier .

HY-17512S3

Losartan-d2
Losartan-d₂ is the deuterium labeled Losartan . Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-B0183S

Ellagic acid-13C12
Ellagic acid- ¹³C₁₂ is ¹³ C-labeled Ellagic acid (HY-B0183). Ellagic acid is a natural antioxidant and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM .

HY-40354AS

Tofacitinib-d3 citrate
Tofacitinib-d₃ (citrate) is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.

HY-133671S

Monooctyl phthalate-d4
Monooctyl phthalate-d₄ (Mono-n-octyl phthalate-d₄) is a deuterium labeled Monooctyl phthalate (HY-133671). Monooctyl phthalate (Mono-n-octyl phthalate) exhibits antimycobacterial activity with a MIC of 20 μg/mL .

HY-40354S1

Tofacitinib-13C3,15N
Tofacitinib- ¹³C₃, ¹⁵N (Tasocitinib- ¹³C₃, ¹⁵N) is ¹³C and ¹⁵N labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC₅₀s of 1, 20, and 112 nM, respectively.

HY-B0124S

Zonisamide-d4
Zonisamide-d₄ is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with K_is of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease .

HY-B0151S

Pregnenolone-d4

Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B0660S1

Eicosapentaenoic acid 1,2,3,4,5-13C5

Eicosapentaenoic acid 1,2,3,4,5- ¹³C₅ (EPA 1,2,3,4,5- ¹³C, FA 20:5- ¹³C₅) is ¹³C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-B0580S

Ketorolac-d5
Ketorolac-d₅ is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2 .

HY-159578S

VU6036864
VU6036864 (compound 45) is an orally active, selective mAChR M5 antagonist with IC₅₀=20 nM for human M5. VU6036864 is >500-fold selective for human M1-4, with BBB characteristic and high oral bioavailability (%F>100%) .

HY-N0437S3

Progesterone-13C2
Progesterone- ¹³C₂ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-150678S

Adenosine:H20-13c
Adenosine:H20- ¹³C is the ¹³C labeled Adenosine:H20 .

HY-113062S

20α-Dihydroprogesterone-13C5
20a-Dihydroprogesterone- ¹³C₅ is the ¹³C labeled 20a-Dihydroprogesterone .

HY-W724370

Tetraethylammonium bromide-d20

Tetraethylammonium bromide-d₂₀ (TEA bromide-d₂₀) is the deuterium labeled Tetraethylammonium bromide (HY-W014408). Tetraethylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetraethylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, an electrolyte in electrochemical experiments, and a source of tetraethylammonium ions in biochemical and pharmacological research.

HY-W742214

20α-Dihydro pregnenolone-d5
20α-Dihydro pregnenolone-d₅ is the deuterium labeled 20a-Dihydro Pregnenolone (HY-W742213).

HY-W738909

Dicyclopentamethylenethiuram Disulfide-d20
Dicyclopentamethylenethiuram Disulfide-d₂₀ is the deuterium labeled Piperidine-1-carbothioic dithioperoxyanhydride (HY-W327830).

HY-143963S

Irbesartan impurity 20-d4

Irbesartan impurity 20-d₄ is the deuterium labeled Irbesartan impurity 20 . Irbesartan impurity 20-d₄ is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-146781S

20:3 Cholesteryl ester-d7
20:3 Cholesteryl ester-d₇ is deuterium labeled 20:3 Cholesteryl ester.

HY-146935S

C20:1 Ceramide-d7
C20:1 Ceramide-d₇ is deuterium labeled C20:1 Ceramide.

HY-W707358

12-Hydroxydodecanoic acid-d20
12-Hydroxydodecanoic acid-d₂₀ is the deuterium labeled 12-Hydroxydodecanoic acid (HY-128743). 12-Hydroxydodecanoic acid is an endogenous metabolite.

HY-W707099

Ro 20-0657/000-d3
Ro 20-0657/000-d₃ is the deuterium labeled Ro 20-0657/000 (HY-100622). Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine .

HY-146850S

17:0-20:3 PC-d5
17:0-20:3 PC-d₅ is deuterium labeled 17:0-20:3 PC.

HY-146858S

17:0-20:3 PG-d5
17:0-20:3 PG-d₅ is deuterium labeled 17:0-20:3 PG.

HY-146846S

17:0-20:3 PE-d5
17:0-20:3 PE-d₅ is deuterium labeled 17:0-20:3 PE.

HY-W742200

5b-Pregnane-3a,20a-diol-d5
5b-Pregnane-3a,20a-diol-d₅ is the deuterium labeled 5b-Pregnane-3a,20a-diol.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10407G

SU 5402	VEGFR EGFR PDGFR	Cancer
SU 5402 (GMP) is SU 5402 (HY-10407) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC₅₀ of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively .

HY-13067G

Celastrol Tripterine; Tripterin	Endogenous Metabolite Proteasome Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Inflammation/Immunology Cancer
Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-N0322GL

Cholesterol (GMP Like)	Liposome Estrogen Receptor/ERR Endogenous Metabolite	Metabolic Disease Cancer
Cholesterol (GMP Like) is Cholesterol (HY-N0322) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-10227G

Bortezomib PS-341; LDP-341; NSC 681239	Proteasome NF-κB Apoptosis Autophagy TREM receptor	Cancer
Bortezomib (GMP) (PS-341 (GMP)) is Bortezomib (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

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