Nlrp3 - NLR family, pyrin domain containing 3 Gene

Also Known as Cias1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287362

About Nlrp3

Primary_assembly 10: 44,328,566-44,352,811 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 87 orthologues, 21 paralogues and is associated with 32 phenotypes. Biased expression in Spleen (RPKM 82.9), Lung (RPKM 27.1) and 8 other tissues.

Summary

Predicted to enable DNA-binding transcription factor binding activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in leukocyte migration involved in inflammatory response; response to ethanol; and response to organic cyclic compound. Predicted to be located in Golgi membrane and nucleus. Predicted to be part of NLRP3 inflammasome complex. Biomarker of alcoholic hepatitis. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp3 Products (1)

mRNA Protein Name
NM_001191642.1 NP_001178571.1 NACHT, LRR and PYD domains-containing protein 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in leukocyte migration involved in inflammatory response IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nlrp3 Protein Structure

Pyrin_NALPs

Pyrin_NALPs: cd08320 (9 - 89)

FISNA

FISNA: pfam14484 (137 - 207)

NACHT

NACHT: pfam05729 (217 - 386)

NOD2_WH

NOD2_WH: pfam17779 (461 - 517)

LRR_RI

LRR_RI: cd00116 (574 - 951)

LRR_RI

LRR_RI: sd00033 (741 - 769)

LRR_RI

LRR_RI: sd00033 (770 - 797)

LRR_RI

LRR_RI: sd00033 (798 - 826)

LRR_RI

LRR_RI: sd00033 (827 - 854)

LRR_RI

LRR_RI: sd00033 (855 - 883)

LRR_RI

LRR_RI: sd00033 (884 - 911)

LRR_RI

LRR_RI: sd00033 (912 - 936)

LRR_RI

LRR_RI: sd00033 (941 - 968)

LRR_RI

LRR_RI: smart00368 (966 - 993)

LRR_RI

LRR_RI: sd00033 (969 - 993)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1035 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 3

  • PYRIN-containing APAF1-like protein 1

  • cold autoinflammatory syndrome 1 homolog

  • cold autoinflammatory syndrome 1 protein homolog

  • cryopyrin

  • mast cell maturation-associated-inducible protein 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2176 ATP Activator 99.88% Unkown
HY-132591A Inclisiran sodium Inhibitor 99.08% Unkown
HY-132591 Inclisiran Inhibitor 99.48% Unkown
HY-B0116 Stavudine Inhibitor 99.89% Yes
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.97% Unkown
HY-16059 Arglabin Inhibitor 99.87% Unkown
HY-B1239 Drofenine hydrochloride 98.10% Unkown
HY-17355B Dexpramipexole Inhibitor 99.56% Yes
HY-B0516 Articaine hydrochloride Inhibitor 99.38% Unkown
HY-B0516A Articaine Inhibitor / Unkown
HY-B0516R Articaine hydrochloride (Standard) Inhibitor / Unkown
HY-B1239A Drofenine / Unkown
HY-B0116A Stavudine sodium Inhibitor 99.40% Yes

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-17629 Dapansutrile Inhibitor 99.92% Phase 3
HY-156034 JT001 Inhibitor / Phase 3
HY-168264 MC1 Inhibitor / Phase 3
HY-13535 ATN-161 Inhibitor 99.36% Phase 2
HY-139396 BMS-986299 Agonist 99.96% Phase 1
HY-19309 ABT-546 hydrochloride Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99555 Tomaralimab Inhibitor 99.42% Phase 2

Pre-clinical Phase

Bioactive Molecules (178)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12815 MCC950 Inhibitor 99.78% Unkown
HY-127019 Nigericin Activator 99.64% Unkown
HY-100381 Nigericin sodium salt Activator 99.60% Unkown
HY-12815A MCC950 sodium Inhibitor 99.75% Unkown
HY-100573 Necrosulfonamide Inhibitor 98.61% Unkown
HY-12497 ANA-12 Inhibitor 99.90% Unkown
HY-116084 Trimethylamine N-oxide Activator 98.0% Unkown
HY-144226 NLRP3/AIM2-IN-3 Inhibitor 98.23% Unkown
HY-103666 CY-09 Inhibitor 99.01% Unkown
HY-101092 QS-21-Api Activator 99.73% Unkown
HY-156798 ADS032 Inhibitor 99.89% Unkown
HY-113298 Citraconic acid Inhibitor 99.08% Unkown
HY-N0373 Licochalcone B Inhibitor 99.91% Unkown
HY-N3005 Britannin Inhibitor 99.93% Unkown
HY-108915 Trimethylamine N-oxide dihydrate Activator 99.86% Unkown
HY-N0633 Muscone Inhibitor 98.0% Unkown
HY-N0806 Sweroside Inhibitor 99.76% Unkown
HY-155876 NVP-DFV890 Antagonist 99.97% Unkown
HY-100581 CORM-3 Inhibitor 97.5% Unkown
HY-N0496 Ruscogenin Inhibitor 99.85% Unkown
HY-132831 Selnoflast Inhibitor 99.46% Unkown
HY-W019670 N4-Acetylcytidine Activator 99.65% Unkown
HY-N2414 Periplogenin Inhibitor ≥99.70% Unkown
HY-161834 RG100204 Inhibitor 99.50% Unkown
HY-N5042 Forsythoside I Inhibitor 99.94% Unkown
HY-159520 Ofirnoflastum Inhibitor 99.93% Unkown
HY-N5063 Plantainoside D Inhibitor 99.15% Unkown
HY-169996 NP3-253 Inhibitor 99.78% Unkown
HY-173154B NK7-902 diTFA Inhibitor 99.88% Unkown
HY-162333 BAL-0028 Inhibitor 99.86% Unkown
HY-130494 (±)11(12)-EET Inhibitor 98.30% Unkown
HY-N0257 Epimedin A Inhibitor 99.43% Unkown
HY-P10227 Xelafaslatide Inhibitor 99.88% Unkown
HY-152670 JC2-11 Inhibitor 98.03% Unkown
HY-119684 Maresin 2 Inhibitor 97.20% Unkown
HY-78263 MNS 99.55% Unkown
HY-W082785A L6H21 Inhibitor 99.19% Unkown
HY-N0381 Maackiain Activator 99.83% Unkown
HY-N1939 Icariside I Agonist 98.76% Unkown
HY-B2176I ATP disodium salt, 100 mM Solution, PCR Grade Activator / Unkown
HY-N1431 Tabersonine Inhibitor 98.13% Unkown
HY-137888A Oxidized ATP trisodium salt Inhibitor 98.0% Unkown
HY-117878 ML345 Inhibitor 99.37% Unkown
HY-164304 INF 195 Inhibitor 99.58% Unkown
HY-144223 NLRP3-IN-94 Inhibitor 99.93% Unkown
HY-150206 NLRP3-IN-13 Inhibitor 98.03% Unkown
HY-P2310 Defensin HNP-1 human Activator 98.12% Unkown
HY-N6893 Ergolide Inhibitor 99.48% Unkown
HY-N3242 Moronic acid Inhibitor 98.6% Unkown
HY-101868 INF39 Inhibitor 99.84% Unkown
HY-153261 NLRP3-IN-17 Inhibitor 99.02% Unkown
HY-N0699 Daphnoretin Inhibitor 99.83% Unkown
HY-120007 JC124 Inhibitor 99.72% Unkown
HY-W158030 2-Guanidinobezimidazole Agonist 95.74% Unkown
HY-163358 SLC3037 Inhibitor 99.85% Unkown
HY-176860 NEK7 degrader-1 Activator 99.94% Unkown
HY-N2485 4'-Methoxyresveratrol Activator 99.48% Unkown
HY-122920 Soyasaponin II Inhibitor 99.81% Unkown
HY-163159 NP3-562 Inhibitor 98.16% Unkown
HY-130252 YQ128 Inhibitor 99.74% Unkown
HY-N2128 Nigakinone Inhibitor 99.95% Unkown
HY-137245 Emlenoflast Inhibitor 99.30% Unkown
HY-N2157 Pteryxin Inhibitor 99.55% Unkown
HY-155751 HMGB1-IN-1 Inhibitor 98.40% Unkown
HY-N7695 Physalin B Inhibitor 97.20% Unkown
HY-156034A JT001 sodium Inhibitor 98.39% Unkown
HY-N8599 Cichoriin Inhibitor 99.9% Unkown
HY-160757 NLRP3 modulator 7 Modulator / Unkown
HY-146765 AMS-17 Inhibitor 98.09% Unkown
HY-179494 M464 Inhibitor 99.58% Unkown
HY-161727 P2Y14R antagonist 1 Inhibitor 98.76% Unkown
HY-126941 Hecogenin acetate Inhibitor 98.57% Unkown
HY-172941 VEN-02XX Inhibitor 99.66% Unkown
HY-161627 Anemoside A3-methyl 6-aminohexanoate Inhibitor 98.62% Unkown
HY-175278 BAL-1516 Inhibitor / Unkown
HY-174270 NLRP3-IN-79 Inhibitor 99.10% Unkown
HY-W011082 NLRP3-IN-2 Inhibitor 98.00% Unkown
HY-164853 Kanglexin Inhibitor 99.65% Unkown
HY-137245A Emlenoflast sodium Inhibitor 98.31% Unkown
HY-117432 JC-171 Inhibitor 98.06% Unkown
HY-131040 NLRP3-IN-NBC6 Inhibitor 99.40% Unkown
HY-161297 NT-0249 Inhibitor / Unkown
HY-145087A NP3-146 sodium Inhibitor 99.26% Unkown
HY-P6084 RP-220 Inhibitor / Unkown
HY-W017087 1,2,4-Trimethoxybenzene Inhibitor / Unkown
HY-179421 PROTAC HDAC6 degrader 7 Inhibitor / Unkown
HY-121988 INF4E Inhibitor 99.38% Unkown
HY-186072 NT-0527 Inhibitor 99.80% Unkown
HY-148187 NLRP3-IN-11 Inhibitor 98.79% Unkown
HY-153554 NLRP3-IN-18 Inhibitor 98.06% Unkown
HY-162588 MC-ND-18 Degrader / Unkown
HY-N10173 (+)-Epiloliolide Inhibitor 95.0% Unkown
HY-W010253 Benzylurea Modulator 99.94% Unkown
HY-N10359 Isoandrographolide Inhibitor 98.34% Unkown
HY-150965 NDT-30805 Inhibitor / Unkown
HY-149087 MR2938 Inhibitor / Unkown
HY-178898 7-Oxogedunin Inhibitor / Unkown
HY-159482 SBN-284 Inhibitor / Unkown
HY-179682 HDAC3 degrader-1 Inhibitor / Unkown
HY-175814 NLRP3-IN-83 Inhibitor / Unkown
HY-145087 NP3-146 Inhibitor / Unkown
HY-169227 NLRP3-IN-55 Inhibitor / Unkown
HY-179132 TN-101 Inhibitor / Unkown
HY-175645 NLRP3/URAT1-IN-1 Inhibitor / Unkown
HY-145910 NLRP3-IN-6 Inhibitor / Unkown
HY-163744 NLRP3-IN-42 Inhibitor / Unkown
HY-135283 ABT-546 Inhibitor / Unkown
HY-183296 NLRP3-IN-91 Inhibitor / Unkown
HY-185311 NEK7 degrader-3 Inhibitor / Unkown
HY-172102 NLRP3-IN-68 Inhibitor / Unkown
HY-169188 NLRP3-IN-50 Inhibitor / Unkown
HY-178953 NLRP3-IN-84 Inhibitor / Unkown
HY-103715 NLRP3 modulator 1 Modulator / Unkown
HY-N10312 Yadanzigan Inhibitor / Unkown
HY-149122 NLRP3-IN-15 Inhibitor / Unkown
HY-163695 NLRP3-IN-41 Inhibitor / Unkown
HY-N20708 Chiisanogenin Inhibitor / Unkown
HY-180168 NQO2 activator-1 Inhibitor / Unkown
HY-175464 NLRP3-IN-82 Inhibitor / Unkown
HY-181809 BLT1-IN-1 Inhibitor / Unkown
HY-N17383 Ligusticum cycloprolactam Inhibitor / Unkown
HY-173294 NLRP3-IN-74 Inhibitor / Unkown
HY-159007 BD-AcAc2 Inhibitor / Unkown
HY-182102 NLRP3-IN-88 Inhibitor / Unkown
HY-149123 NLRP3-IN-16 Inhibitor / Unkown
HY-172134 NLRP3-IN-70 Inhibitor / Unkown
HY-132892 NLRP3-IN-4 Inhibitor / Unkown
HY-179131 TN-783 Inhibitor / Unkown
HY-180916 CAII-IN-11 Inhibitor / Unkown
HY-183283 CAII-IN-15 Inhibitor / Unkown
HY-182779 JNUTS013 Inhibitor / Unkown
HY-168594 α-Glucosidase/NLRP3-IN-1 Inhibitor / Unkown
HY-184357 NLRP3-IN-92 Inhibitor / Unkown
HY-183995 SH-26 Inhibitor / Unkown
HY-145911 NLRP3-IN-7 Inhibitor / Unkown
HY-161329 NLRP3-IN-32 Inhibitor / Unkown
HY-113298R Citraconic acid (Standard) Inhibitor / Unkown
HY-179387 CXCR2-IN-3 Inhibitor / Unkown
HY-159898 AChE/BChE-IN-23 Inhibitor / Unkown
HY-132831C Selnoflast monopotassium Inhibitor / Unkown
HY-N19847 LYRM03 Inhibitor / Unkown
HY-146802 NLRP3-IN-9 Inhibitor / Unkown
HY-168737 NEK7-IN-2 Inhibitor / Unkown
HY-177559 NEK7 degrader-2 Inhibitor / Unkown
HY-184711 Z1456467176 Inhibitor / Unkown
HY-401677 Abdenoflast Modulator / Unkown
HY-168009 NLRP3-IN-45 Inhibitor / Unkown
HY-182778 Anti-inflammatory agent 114 Inhibitor / Unkown
HY-171589 NLRP3-IN-77 Inhibitor / Unkown
HY-183796 GFAP/NF-κB/APOE/NLRP3-IN-1 Inhibitor / Unkown
HY-179429 NLRP3-IN-85 Inhibitor / Unkown
HY-177128 Sebrinoflast Inhibitor / Unkown
HY-146594 NLRP3-IN-8 Inhibitor / Unkown
HY-149121 NLRP3-IN-14 Inhibitor / Unkown
HY-N10650 Caulerpin Inhibitor / Unkown
HY-180830 NLRP3-IN-86 Inhibitor / Unkown
HY-163494 NLRP3-IN-36 Inhibitor / Unkown
HY-181488 NLRP3-IN-87 Inhibitor / Unkown
HY-N6189 MBL-1 Inhibitor / Unkown
HY-182803 NLRP3-IN-90 Inhibitor / Unkown
HY-163497 NLRP3-IN-38 Inhibitor / Unkown
HY-184651 NLRP3-IN-93 Inhibitor / Unkown
HY-174312 NLRP3-IN-81 Inhibitor / Unkown
HY-180890 PPARγ agonist-21 Inhibitor / Unkown
HY-178950 Hck-IN-3 Inhibitor / Unkown
HY-P11581 MNP2 Inhibitor / Unkown
HY-182287 PRDX1-IN-4 Inhibitor / Unkown
HY-182794 NLRP3-IN-89 Inhibitor / Unkown
HY-182380 ODZ10117 Inhibitor / Unkown
HY-172778 HNW005 Inhibitor / Unkown
HY-179024 NP3-742 Inhibitor / Unkown
HY-165316 Myristoyllysophosphatidylcholine Inhibitor / Unkown
HY-184844 NLRP3 modulator 8-1 Inhibitor / Unkown
HY-183889 p-Ethoxychrysoidin Inhibitor / Unkown
HY-W929472 13(S)-HOTrE Inhibitor 99.9% Unkown
HY-119684S Maresin 2 Inhibitor / Unkown
HY-N1431A Tabersonine hydrochloride Inhibitor 98.55% Unkown
HY-184882 NLRP3-IN-95 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlrp3 NCBI NCBI:114548