Nlrp3 - NLR family, pyrin domain containing 3 Gene

Mus musculus

Also known as FCU; MWS; FCAS; Cias1; Mmig1; NALP3; Pypaf1; AII/AVP; AGTAVPRL

Gene ID: 216799 | Gene type: protein coding

About Nlrp3

Chromosome 11: 59,432,394-59,457,782 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 87 orthologues, 22 paralogues and is associated with 95 phenotypes. Broad expression in spleen adult (RPKM 1.1), lung adult (RPKM .8) and 25 other tissues.

Summary

Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of T-helper cell differentiation; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly; activation of cysteine-type endopeptidase activity involved in apoptotic process; and defense response to virus. Located in cytoplasm and nucleus. Part of NLRP3 inflammasome complex. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp3 Products(2)

mRNA	Protein	Name
NM_001359638.1	NP_001346567.1	NACHT, LRR and PYD domains-containing protein 3
NM_145827.4	NP_665826.1	NACHT, LRR and PYD domains-containing protein 3

Nlrp3 Protein Structure

Pyrin_NALPs

FISNA

NACHT

NOD2_WH

LRR_RI

0
200
400
600
800
1033 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 3

NACHT/LRR/pyrin domain-containing protein 3	PYRIN-containing APAF1-like protein 1
cold autoinflammatory syndrome 1 protein homolog	cryopyrin
mast cell maturation-associated-inducible protein 1

Recombinant Nlrp3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71598	NLRP3 Protein, Mouse (His-SUMO)	Q8R4B8 (M1-R153)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0116	Stavudine	Inhibitor	99.87%	Yes
HY-16059	Arglabin	Inhibitor	99.87%	Unkown
HY-B0116A	Stavudine sodium	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17629	Dapansutrile	Inhibitor	≥98.0%	Phase 3
HY-156034A	JT001 sodium	Inhibitor	/	Phase 3
HY-139396	BMS-986299	Agonist	99.76%	Phase 1

Pre-clinical Phase

Bioactive Molecules (49)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12815A	MCC950 sodium	Inhibitor	99.61%	Unkown
HY-100381	Nigericin sodium salt	Activator	99.36%	Unkown
HY-12815	MCC950	Inhibitor	99.62%	Unkown
HY-103666	CY-09	Inhibitor	98.01%	Unkown
HY-116084	Trimethylamine N-oxide	Activator	≥98.0%	Unkown
HY-N0633	Muscone	Inhibitor	≥98.0%	Unkown
HY-132831	Selnoflast	Inhibitor	98.58%	Unkown
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.00%	Unkown
HY-N0496	Ruscogenin	Inhibitor	99.59%	Unkown
HY-N0373	Licochalcone B	Inhibitor	99.93%	Unkown
HY-108915	Trimethylamine N-oxide dihydrate	Activator	≥98.0%	Unkown
HY-152670	JC2-11	Inhibitor	98.02%	Unkown
HY-137245A	Emlenoflast sodium	Inhibitor	98.76%	Unkown
HY-N2485	4'-Methoxyresveratrol	Activator	99.48%	Unkown
HY-130252	YQ128	Inhibitor	99.83%	Unkown
HY-150206	NLRP3-IN-13	Inhibitor	99.01%	Unkown
HY-122920	Soyasaponin II	Inhibitor	99.58%	Unkown
HY-137245	Emlenoflast	Inhibitor	98.19%	Unkown
HY-151343	NLRP3-IN-10	Inhibitor	98.97%	Unkown
HY-W082785A	L6H21	Inhibitor	99.46%	Unkown
HY-153554	NLRP3-IN-18	Inhibitor	98.06%	Unkown
HY-117432	JC-171	Inhibitor	98.41%	Unkown
HY-137888A	Oxidized ATP trisodium salt	Inhibitor	≥98.0%	Unkown
HY-121988	INF4E	Inhibitor	99.38%	Unkown
HY-130494	(±)11(12)-EET	Inhibitor	≥98.0%	Unkown
HY-148187	NLRP3-IN-11	Inhibitor	98.79%	Unkown
HY-163159	NP3-562	Inhibitor	/	Unkown
HY-131040	NLRP3-IN-NBC6	Inhibitor	99.40%	Unkown
HY-153261	NLRP3-IN-17	Inhibitor	99.23%	Unkown
HY-155751	HMGB1-IN-1	Inhibitor	≥95.0%	Unkown
HY-155876	NLRP3 antagonist 2	Antagonist	/	Unkown
HY-127019	Nigericin	Activator	/	Unkown
HY-150965	NDT-30805	Inhibitor	/	Unkown
HY-132892	NLRP3-IN-4	Inhibitor	/	Unkown
HY-146802	NLRP3-IN-9	Inhibitor	/	Unkown
HY-156034	NLRP3-IN-19	Inhibitor	/	Unkown
HY-149122	NLRP3-IN-15	Inhibitor	/	Unkown
HY-149123	NLRP3-IN-16	Inhibitor	/	Unkown
HY-161297	NT-0249	Inhibitor	/	Unkown
HY-149087	MR2938	Inhibitor	/	Unkown
HY-146765	AMS-17	Inhibitor	/	Unkown
HY-145910	NLRP3-IN-6	Inhibitor	/	Unkown
HY-145087	NP3-146	Inhibitor	/	Unkown
HY-161329	NLRP3-IN-32	Inhibitor	/	Unkown
HY-146594	NLRP3-IN-8	Inhibitor	/	Unkown
HY-145911	NLRP3-IN-7	Inhibitor	/	Unkown
HY-149121	NLRP3-IN-14	Inhibitor	/	Unkown
HY-162333	BAL-0028	Inhibitor	/	Unkown
HY-163358	SLC3037	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlrp3	NCBI	NCBI:114548

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