Bche - butyrylcholinesterase Gene
Also Known as C730038G20Rik
Species: Mus musculus
Gene Type: protein coding
Gene ID: 12038
About Bche
Chromosome 3: 73,543,141-73,615,748 reverse strand.GRCm39:CM000996.3
This gene has 4 transcripts (splice variants), 130 orthologues, 25 paralogues and is associated with 2 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 7.4), liver E18 (RPKM 6.) and 21 other tissues.
Summary
Enables acetylcholinesterase activity. Predicted to be involved in several processes, including acetylcholine catabolic process; neuroblast differentiation; and response to folic acid. Located in endoplasmic reticulum and nuclear envelope lumen. Is expressed in several structures, including adrenal gland; alimentary system; ear; liver; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BChE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]
Bche Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_009738.3 | NP_033868.3 | cholinesterase precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables acetylcholinesterase activity |
IDA
IDA: Inferred from direct assay
|
17212694 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in endoplasmic reticulum |
IDA
IDA: Inferred from direct assay
|
8651510 | MGI |
| located in nuclear envelope lumen |
IDA
IDA: Inferred from direct assay
|
8651510 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
Bche Protein Structure
COesterase
COesterase: pfam00135 (30 - 550)
AChE_tetra
AChE_tetra: pfam08674 (565 - 599)
- 0
- 100
- 200
- 300
- 400
- 500
- 603 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cholinesterase |
|
|
Recombinant Bche Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72859 | Butyrylcholinesterase/BCHE Protein, Mouse (HEK293, His) | Q03311 (H28-L603) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Bioactive Molecules
(9)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-17368 | Rivastigmine | Inhibitor | 99.95% | Yes |
| HY-B1488 | Tacrine hydrochloride | Inhibitor | 99.90% | Unkown |
| HY-107922 | Ethopropazine hydrochloride | Inhibitor | 99.32% | Unkown |
| HY-B1239 | Drofenine hydrochloride | Inhibitor | 98.10% | Unkown |
| HY-100919 | Ambenonium chloride | Inhibitor | 96.18% | Yes |
| HY-B2244 | Tacrine hydrochloride hydrate | Inhibitor | 99.98% | Unkown |
| HY-B1542A | Benactyzine hydrochloride | Inhibitor | 99.02% | Unkown |
| HY-16183 | Echothiopate iodide | Inhibitor | / | Unkown |
| HY-B1239A | Drofenine | Inhibitor | / | Unkown |
Clinical Phase
Bioactive Molecules
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-114422 | p38α-IN-13 | Inhibitor | / | Phase 3 |
| HY-105157A | Icopezil maleate | Inhibitor | / | Phase 2 |
| HY-108048 | Desoxypeganine | Inhibitor | / | Phase 1 |
Pre-clinical Phase
Bioactive Molecules
(211)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-N0285 | Imperatorin | Inhibitor | 98.59% | Unkown |
| HY-107569 | Garcinol | Inhibitor | 98.85% | Unkown |
| HY-N0226A | Epiberberine chloride | Inhibitor | 98.68% | Unkown |
| HY-N0631 | Cornuside | Inhibitor | 99.99% | Unkown |
| HY-N4225 | Aaptamine | Inhibitor | 99.71% | Unkown |
| HY-W130025 | p-Xylene bispyridinium bromide | Inhibitor | 99.60% | Unkown |
| HY-122140 | ACG548B | Inhibitor | 99.72% | Unkown |
| HY-34408 | 6-Methoxy-1-tetralone | 99.89% | Unkown | |
| HY-N2157 | Pteryxin | Inhibitor | 99.55% | Unkown |
| HY-121382 | Gypsogenin | Inhibitor | 99.51% | Unkown |
| HY-N2129 | N-Nornuciferine | Inhibitor | 99.94% | Unkown |
| HY-W130236 | Methylene Violet 3RAX | Inhibitor | 95.54% | Unkown |
| HY-N2284 | Sophoflavescenol | Inhibitor | 98.78% | Unkown |
| HY-155140 | BChE-IN-17 | Inhibitor | 99.07% | Unkown |
| HY-107275 | Ebeiedinone | Inhibitor | 99.90% | Unkown |
| HY-119577 | Ubretid | 99.0% | Yes | |
| HY-121072 | ASS234 | Inhibitor | 99.6% | Unkown |
| HY-N7263 | Galanthamine N-Oxide | Inhibitor | 99.90% | Unkown |
| HY-149212 | SD-6 | Inhibitor | ≥98.0% | Unkown |
| HY-N12581 | Kuwanon U | Inhibitor | 97.30% | Unkown |
| HY-151368 | AChE/BChE-IN-10 | Inhibitor | 99.67% | Unkown |
| HY-103373 | PE154 | Inhibitor | 99.01% | Unkown |
| HY-P11392 | Ac-IEAR-pNA | Substrate | 99.82% | Unkown |
| HY-N0226 | Epiberberine | Inhibitor | 98.46% | Unkown |
| HY-N2960 | Broussonin A | Inhibitor | 97% | Unkown |
| HY-N10488 | BChE-IN-11 | Inhibitor | 98.78% | Unkown |
| HY-N7346 | Lucidadiol | Inhibitor | 98.0% | Unkown |
| HY-W185336 | Dibutyl phenyl phosphate | Inhibitor | 98.06% | Unkown |
| HY-162340 | Z32439948 | Inhibitor | / | Unkown |
| HY-151436 | ZLMT-12 | Inhibitor | / | Unkown |
| HY-173152 | AChE/BChE-IN-26 | Inhibitor | / | Unkown |
| HY-161508 | AChE/BChE-IN-19 | Inhibitor | / | Unkown |
| HY-172782 | BuChE-IN-20 | Inhibitor | / | Unkown |
| HY-180783 | AChE/BChE/MAO-A-IN-1 | Inhibitor | / | Unkown |
| HY-168052 | hAChE-IN-9 | Inhibitor | / | Unkown |
| HY-151405 | Z164597606 | Inhibitor | / | Unkown |
| HY-149087 | MR2938 | Inhibitor | / | Unkown |
| HY-146251 | BuChE-IN-6 | Inhibitor | / | Unkown |
| HY-184664 | BChE-IN-51 | Inhibitor | / | Unkown |
| HY-157382 | AChE-IN-51 | Inhibitor | / | Unkown |
| HY-163883 | BChE-IN-34 | Inhibitor | / | Unkown |
| HY-157437 | AChE/BChE-IN-16 | Inhibitor | / | Unkown |
| HY-149300 | SB-1436 | Inhibitor | / | Unkown |
| HY-161507 | CAI/II-IN-8 | Inhibitor | / | Unkown |
| HY-150545 | AChE-IN-21 | Inhibitor | / | Unkown |
| HY-162693 | AChE-IN-68 | Inhibitor | / | Unkown |
| HY-170417 | hAChE/hBuChE/GSK-3β-IN-1 | Inhibitor | / | Unkown |
| HY-161643 | S21-1011 | Inhibitor | / | Unkown |
| HY-175973 | AChE/BChE-IN-30 | Inhibitor | / | Unkown |
| HY-146315 | AChE/BChE-IN-6 | Inhibitor | / | Unkown |
| HY-183750 | BChE reactivator-1 | / | Unkown | |
| HY-179363 | BChE-IN-46 | Inhibitor | / | Unkown |
| HY-108048A | Desoxypeganine hydrochloride | Inhibitor | / | Unkown |
| HY-N10489 | BChE-IN-12 | Inhibitor | / | Unkown |
| HY-163909 | AChE-IN-72 | Inhibitor | / | Unkown |
| HY-149993 | hBChE-IN-2 | Inhibitor | 99.76% | Unkown |
| HY-153432 | TRV-7019 | 98.00% | Unkown | |
| HY-158696 | BChE/MAO-B-IN-1 | Inhibitor | / | Unkown |
| HY-144762 | K027 | Inhibitor | / | Unkown |
| HY-155085 | hAChE-IN-3 | Inhibitor | / | Unkown |
| HY-N21822 | (+)-(R)-Ribalinine | Inhibitor | / | Unkown |
| HY-162338 | BChE-IN-29 | Inhibitor | / | Unkown |
| HY-162812 | H3R antagonist 4 | Inhibitor | / | Unkown |
| HY-186298 | Brassicasteryl linoleate | Inhibitor | / | Unkown |
| HY-179126 | BChE/MAO-A-IN-1 | Inhibitor | / | Unkown |
| HY-180243 | AChE-IN-102 | Inhibitor | / | Unkown |
| HY-N2129A | N-Nornuciferine hydrochloride | Inhibitor | / | Unkown |
| HY-149243 | BChE-IN-16 | Inhibitor | / | Unkown |
| HY-162671 | BuChE-IN-12 | Inhibitor | / | Unkown |
| HY-175658 | AChE/BChE-IN-29 | Inhibitor | / | Unkown |
| HY-162681 | eeAChE-IN-3 | Inhibitor | / | Unkown |
| HY-181445 | NSC 620023 TFA | Inhibitor | / | Unkown |
| HY-180146 | BChE-IN-48 | Inhibitor | / | Unkown |
| HY-181865 | BuChE-IN-22 | Inhibitor | / | Unkown |
| HY-170976 | BuChE-IN-16 | / | Unkown | |
| HY-146687 | BuChE-IN-4 | Inhibitor | / | Unkown |
| HY-183352 | BuChE-IN-23 | Inhibitor | / | Unkown |
| HY-181597 | LINS05414 | Inhibitor | / | Unkown |
| HY-150585 | BuChE-IN-5 | Inhibitor | / | Unkown |
| HY-161453 | BChE-IN-32 | Inhibitor | / | Unkown |
| HY-174399 | AChE/BChE-IN-27 | Inhibitor | / | Unkown |
| HY-163514 | hAChE-IN-8 | Inhibitor | / | Unkown |
| HY-157982 | BChE-IN-28 | Inhibitor | / | Unkown |
| HY-169234 | BChE-IN-35 | Inhibitor | / | Unkown |
| HY-N9846 | Luteolin 5,3'-dimethyl ether | / | Unkown | |
| HY-172460 | AChE/BChE/MAO-B-IN-5 | Inhibitor | / | Unkown |
| HY-149090 | AChE/BuChE/MAO-B-IN-2 | / | Unkown | |
| HY-159482 | SBN-284 | Inhibitor | / | Unkown |
| HY-147870 | COX-2-IN-22 | Inhibitor | / | Unkown |
| HY-168731 | AChE/BChE-IN-25 | Inhibitor | / | Unkown |
| HY-182786 | MAO-B-IN-56 | Inhibitor | / | Unkown |
| HY-147939 | AChE/BuChE-IN-3 | Inhibitor | / | Unkown |
| HY-152632 | BuChE-IN-7 | Inhibitor | / | Unkown |
| HY-N10486 | BChE-IN-10 | Inhibitor | / | Unkown |
| HY-179726 | BChE-IN-47 | Inhibitor | / | Unkown |
| HY-W800535 | Cryptolepine | Inhibitor | / | Unkown |
| HY-159081 | AChE/BChE-IN-20 | Inhibitor | / | Unkown |
| HY-183760 | AChE/BChE-IN-37 | Inhibitor | / | Unkown |
| HY-N19871 | Monogynol A | Inhibitor | / | Unkown |
| HY-149273 | hBChE-IN-1 | Inhibitor | / | Unkown |
| HY-184791 | AChE-IN-120 | Inhibitor | / | Unkown |
| HY-175211 | BChE-IN-42 | Inhibitor | / | Unkown |
| HY-184583 | S27-1047 | Inhibitor | / | Unkown |
| HY-184159 | AChE/BChE/MAO-A-IN-2 | Inhibitor | / | Unkown |
| HY-174328 | BChE/AChE-IN-1 | Inhibitor | / | Unkown |
| HY-DY1110 | PE154 (solution) | Inhibitor | / | Unkown |
| HY-170561 | AChE/BuChE-IN-6 | Inhibitor | / | Unkown |
| HY-N10781 | Isograndifoliol | Inhibitor | / | Unkown |
| HY-180797 | S1R agonist/BChE-IN-1 | Inhibitor | / | Unkown |
| HY-179496 | ChE/GSK-3β-IN-1 | Inhibitor | / | Unkown |
| HY-170389 | BChE-IN-39 | Inhibitor | / | Unkown |
| HY-180892 | Multi-kinase-IN-10 | Inhibitor | / | Unkown |
| HY-183303 | AChE-IN-116 | Inhibitor | / | Unkown |
| HY-105157 | Icopezil | Inhibitor | / | Unkown |
| HY-149287 | hAChE/hBACE-1-IN-1 | Inhibitor | / | Unkown |
| HY-179122 | BChE-IN-45 | Inhibitor | / | Unkown |
| HY-127087 | Isogarcinol | Inhibitor | / | Unkown |
| HY-181248 | BChE-IN-49 | Inhibitor | / | Unkown |
| HY-N21823 | Methyl isoplatydesmine | Inhibitor | / | Unkown |
| HY-161842 | AChE-IN-67 | Inhibitor | / | Unkown |
| HY-182615 | Cymserine | Inhibitor | / | Unkown |
| HY-152112 | AChE/BChE/MAO-B-IN-2 | Inhibitor | / | Unkown |
| HY-161512 | hAChE/hBACE-1-IN-4 | Inhibitor | / | Unkown |
| HY-178017 | BChE/hCA II-IN-1 | Inhibitor | / | Unkown |
| HY-161331 | S16–1029 | Inhibitor | / | Unkown |
| HY-175655 | BChE/p38-α MAPK-IN-1 | Inhibitor | / | Unkown |
| HY-146663A | AChE/BChE-IN-3 hydrochloride | Inhibitor | / | Unkown |
| HY-158978 | Multitarget AD inhibitor-2 | Inhibitor | / | Unkown |
| HY-181503 | AChE/BuChE-IN-8 | Inhibitor | / | Unkown |
| HY-158092 | ChEs/MAOs-IN-2 | Inhibitor | / | Unkown |
| HY-158261 | AChE-IN-63 | Inhibitor | / | Unkown |
| HY-175524 | BChE/MAO-B-IN-2 | Inhibitor | / | Unkown |
| HY-169962 | hCA I-IN-4 | Inhibitor | / | Unkown |
| HY-155366 | hAChE-IN-6 | Inhibitor | / | Unkown |
| HY-159898 | AChE/BChE-IN-23 | Inhibitor | / | Unkown |
| HY-107272 | Chuanbeinone | Inhibitor | / | Unkown |
| HY-W746884 | 2-Methyl-2-butenyl (E)-Caffeate | Inhibitor | / | Unkown |
| HY-170938 | AChE-IN-82 | Inhibitor | / | Unkown |
| HY-178356 | BChE-IN-44 | Inhibitor | / | Unkown |
| HY-185347 | AChE-IN-114 | Inhibitor | / | Unkown |
| HY-144689 | BChE-IN-3 | Inhibitor | / | Unkown |
| HY-149272 | tau/Aβ40 aggregation-IN-1 | Inhibitor | / | Unkown |
| HY-162036 | α-Amylase/α-Glucosidase-IN-7 | Inhibitor | / | Unkown |
| HY-157978 | AChE-IN-59 | Inhibitor | / | Unkown |
| HY-182290 | AChE/BChE-IN-36 | Inhibitor | / | Unkown |
| HY-152113 | AChE/BChE/MAO-B-IN-3 | Inhibitor | / | Unkown |
| HY-162639 | α-Glucosidase-IN-68 | Inhibitor | / | Unkown |
| HY-182254 | AChE/BChE-IN-35 | Inhibitor | / | Unkown |
| HY-121191 | Bisnorcymserine | Inhibitor | / | Unkown |
| HY-178433 | BChE/p38-α MAPK-IN-2 | Inhibitor | / | Unkown |
| HY-N18289 | 8-Hydroxydihydrochelerythrine | Inhibitor | / | Unkown |
| HY-N10490 | Blestrin D | Inhibitor | / | Unkown |
| HY-N21824 | (+)-(3S)-ψ-Ribalinine | Inhibitor | / | Unkown |
| HY-149288 | hAChE/hBACE-1-IN-2 | Inhibitor | / | Unkown |
| HY-161156 | BChE-IN-26 | Inhibitor | / | Unkown |
| HY-179711 | AChE/BChE-IN-32 | Inhibitor | / | Unkown |
| HY-149211 | AChE/BChE-IN-12 | Inhibitor | / | Unkown |
| HY-157981 | AChE-IN-60 | Inhibitor | / | Unkown |
| HY-143465 | BChE-IN-5 | Inhibitor | / | Unkown |
| HY-169162 | hBChE-IN-3 | Inhibitor | / | Unkown |
| HY-184704 | BChE-IN-52 | Inhibitor | / | Unkown |
| HY-182001 | Multi-kinase-IN-13 | Inhibitor | / | Unkown |
| HY-175523 | MAO-B-IN-48 | Inhibitor | / | Unkown |
| HY-180819 | AChE/BChE-IN-33 | Inhibitor | / | Unkown |
| HY-180891 | Multitarget AD-IN-4 | Inhibitor | / | Unkown |
| HY-N17425 | Lakoochin C | Inhibitor | / | Unkown |
| HY-174464 | AChE/BChE-IN-28 | Inhibitor | / | Unkown |
| HY-181041 | Multitarget AD-IN-5 | Inhibitor | / | Unkown |
| HY-131971 | AChE/BChE-IN-1 | Inhibitor | / | Unkown |
| HY-172461 | MAO-IN-6 | Inhibitor | / | Unkown |
| HY-152232 | BChE-IN-15 | Inhibitor | / | Unkown |
| HY-169961 | BChE-IN-38 | Inhibitor | / | Unkown |
| HY-159143 | BChE-IN-33 | Inhibitor | / | Unkown |
| HY-163537 | AChE/BuChE-IN-5 | Inhibitor | / | Unkown |
| HY-159880 | AChE/BChE-IN-24 | Inhibitor | / | Unkown |
| HY-180552 | AChE-IN-104 | Inhibitor | / | Unkown |
| HY-144446 | BuChE-IN-1 | Inhibitor | / | Unkown |
| HY-146669 | BChE-IN-6 | Inhibitor | / | Unkown |
| HY-158334 | NDs-IN-1 | Inhibitor | / | Unkown |
| HY-181851 | AChE-IN-109 | Inhibitor | / | Unkown |
| HY-D3171 | AD-BChE/HClO | / | Unkown | |
| HY-181167 | AChE/BChE-IN-34 | Inhibitor | / | Unkown |
| HY-N15710 | Magnotriol B | Inhibitor | / | Unkown |
| HY-172219 | CUR-IPA | Inhibitor | / | Unkown |
| HY-178943 | Neuroprotective agent 15 | Inhibitor | / | Unkown |
| HY-168301 | CL-13 | Inhibitor | / | Unkown |
| HY-163746 | BuChE-IN-11 | Inhibitor | / | Unkown |
| HY-156031 | BChE-IN-19 | Inhibitor | / | Unkown |
| HY-119292 | AP2238 | Inhibitor | / | Unkown |
| HY-155284 | K1833 | Inhibitor | / | Unkown |
| HY-161150 | AChE/BChE-IN-17 | Inhibitor | / | Unkown |
| HY-163441 | BChE-IN-31 | Inhibitor | / | Unkown |
| HY-184658 | BChE-IN-50 | Inhibitor | / | Unkown |
| HY-118729 | Difeterol | Inhibitor | / | Unkown |
| HY-184292 | COX-2-IN-67 | Inhibitor | / | Unkown |
| HY-151562 | AChE/BuChE/MAO-B-IN-1 | Inhibitor | / | Unkown |
| HY-157384 | BChE-IN-22 | Inhibitor | / | Unkown |
| HY-183798 | BChE/MAO-B-IN-6 | Inhibitor | / | Unkown |
| HY-N10701 | AChE/BChE-IN-11 | Inhibitor | / | Unkown |
| HY-169163 | BChE-IN-36 | Inhibitor | / | Unkown |
| HY-W332450 | Demeton-S | Inhibitor | / | Unkown |
| HY-113905 | ZINC12613047 | Inhibitor | / | Unkown |
| HY-113737 | Trichlorfon ethyl | Inhibitor | / | Unkown |
| HY-159977 | 1,2-Didehydrotanshinone IIA | Inhibitor | / | Unkown |
| HY-W1058380 | BChE-IN-53 | Inhibitor | / | Unkown |
| HY-B1542 | Benactyzine | Inhibitor | / | Unkown |
| HY-N1151 | Thunberginol C | Inhibitor | / | Unkown |
| HY-183403 | Ganstigmine | Inhibitor | / | Unkown |
| HY-N19401 | Vescalagin | Inhibitor | / | Unkown |
| HY-W049312 | 7-Methoxytacrine | Inhibitor | / | Unkown |
| HY-116041 | Anabasamine | Inhibitor | / | Unkown |
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