Bche - butyrylcholinesterase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65036

About Bche

Primary_assembly 2: 158,307,584-158,401,148 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 130 orthologues, 27 paralogues and is associated with 57 phenotypes. Biased expression in Heart (RPKM 176.5), Liver (RPKM 64.) and 8 other tissues.

Summary

Enables choline binding activity and cholinesterase activity. Involved in several processes, including neuroblast differentiation; response to folic acid; and response to glucocorticoid. Located in endoplasmic reticulum lumen; extracellular space; and membrane. Used to study amnestic disorder and hyperhomocysteinemia. Biomarker of leptospirosis and trypanosomiasis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BChE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]

Bche Products (1)

mRNA Protein Name
NM_022942.1 NP_075231.1 cholinesterase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables choline binding IDA
IDA: Inferred from direct assay
126256 RGD
enables cholinesterase activity IDA
IDA: Inferred from direct assay
126256 RGD
Biological Process GO Annotation Evidence References Source
involved in choline metabolic process IDA
IDA: Inferred from direct assay
126256 RGD
involved in learning IDA
IDA: Inferred from direct assay
16275899 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21771623 RGD
involved in negative regulation of synaptic transmission IDA
IDA: Inferred from direct assay
16275899 RGD
involved in neuroblast differentiation IMP
IMP: Inferred from mutant phenotype
21771623 RGD
involved in response to alkaloid IDA
IDA: Inferred from direct assay
17159811 RGD
involved in response to folic acid IDA
IDA: Inferred from direct assay
16442260 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
16179131 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
15002734 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16572919 RGD
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
1133098 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17194019 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bche Protein Structure

COesterase

COesterase: pfam00135 (24 - 544)

AChE_tetra

AChE_tetra: pfam08674 (559 - 593)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
Protein Preferred Names Protein Names

cholinesterase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17368 Rivastigmine Inhibitor 99.95% Yes
HY-B1488 Tacrine hydrochloride Inhibitor 99.90% Unkown
HY-107922 Ethopropazine hydrochloride Inhibitor 99.32% Unkown
HY-B1239 Drofenine hydrochloride Inhibitor 98.10% Unkown
HY-100919 Ambenonium chloride Inhibitor 96.18% Yes
HY-B2244 Tacrine hydrochloride hydrate Inhibitor 99.98% Unkown
HY-B1542A Benactyzine hydrochloride Inhibitor 99.02% Unkown
HY-16183 Echothiopate iodide Inhibitor / Unkown
HY-B1239A Drofenine Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-114422 p38α-IN-13 Inhibitor / Phase 3
HY-105157A Icopezil maleate Inhibitor / Phase 2
HY-108048 Desoxypeganine Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (211)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0285 Imperatorin Inhibitor 98.59% Unkown
HY-107569 Garcinol Inhibitor 98.85% Unkown
HY-N0226A Epiberberine chloride Inhibitor 98.68% Unkown
HY-N0631 Cornuside Inhibitor 99.99% Unkown
HY-N4225 Aaptamine Inhibitor 99.71% Unkown
HY-W130025 p-Xylene bispyridinium bromide Inhibitor 99.60% Unkown
HY-122140 ACG548B Inhibitor 99.72% Unkown
HY-34408 6-Methoxy-1-tetralone 99.89% Unkown
HY-N2157 Pteryxin Inhibitor 99.55% Unkown
HY-121382 Gypsogenin Inhibitor 99.51% Unkown
HY-N2129 N-Nornuciferine Inhibitor 99.94% Unkown
HY-W130236 Methylene Violet 3RAX Inhibitor 95.54% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.78% Unkown
HY-155140 BChE-IN-17 Inhibitor 99.07% Unkown
HY-107275 Ebeiedinone Inhibitor 99.90% Unkown
HY-119577 Ubretid 99.0% Yes
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% Unkown
HY-149212 SD-6 Inhibitor ≥98.0% Unkown
HY-N12581 Kuwanon U Inhibitor 97.30% Unkown
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% Unkown
HY-103373 PE154 Inhibitor 99.01% Unkown
HY-P11392 Ac-IEAR-pNA Substrate 99.82% Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-N2960 Broussonin A Inhibitor 97% Unkown
HY-N10488 BChE-IN-11 Inhibitor 98.78% Unkown
HY-N7346 Lucidadiol Inhibitor 98.0% Unkown
HY-W185336 Dibutyl phenyl phosphate Inhibitor 98.06% Unkown
HY-162340 Z32439948 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-161508 AChE/BChE-IN-19 Inhibitor / Unkown
HY-173152 AChE/BChE-IN-26 Inhibitor / Unkown
HY-172782 BuChE-IN-20 Inhibitor / Unkown
HY-180783 AChE/BChE/MAO-A-IN-1 Inhibitor / Unkown
HY-168052 hAChE-IN-9 Inhibitor / Unkown
HY-151405 Z164597606 Inhibitor / Unkown
HY-149087 MR2938 Inhibitor / Unkown
HY-146251 BuChE-IN-6 Inhibitor / Unkown
HY-184664 BChE-IN-51 Inhibitor / Unkown
HY-163883 BChE-IN-34 Inhibitor / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-149300 SB-1436 Inhibitor / Unkown
HY-161507 CAI/II-IN-8 Inhibitor / Unkown
HY-162693 AChE-IN-68 Inhibitor / Unkown
HY-150545 AChE-IN-21 Inhibitor / Unkown
HY-170417 hAChE/hBuChE/GSK-3β-IN-1 Inhibitor / Unkown
HY-161643 S21-1011 Inhibitor / Unkown
HY-175973 AChE/BChE-IN-30 Inhibitor / Unkown
HY-183750 BChE reactivator-1 / Unkown
HY-146315 AChE/BChE-IN-6 Inhibitor / Unkown
HY-179363 BChE-IN-46 Inhibitor / Unkown
HY-108048A Desoxypeganine hydrochloride Inhibitor / Unkown
HY-N10489 BChE-IN-12 Inhibitor / Unkown
HY-163909 AChE-IN-72 Inhibitor / Unkown
HY-149993 hBChE-IN-2 Inhibitor 99.76% Unkown
HY-158696 BChE/MAO-B-IN-1 Inhibitor / Unkown
HY-153432 TRV-7019 98.00% Unkown
HY-144762 K027 Inhibitor / Unkown
HY-155085 hAChE-IN-3 Inhibitor / Unkown
HY-N21822 (+)-(R)-Ribalinine Inhibitor / Unkown
HY-162338 BChE-IN-29 Inhibitor / Unkown
HY-162812 H3R antagonist 4 Inhibitor / Unkown
HY-186298 Brassicasteryl linoleate Inhibitor / Unkown
HY-179126 BChE/MAO-A-IN-1 Inhibitor / Unkown
HY-N2129A N-Nornuciferine hydrochloride Inhibitor / Unkown
HY-180243 AChE-IN-102 Inhibitor / Unkown
HY-149243 BChE-IN-16 Inhibitor / Unkown
HY-162671 BuChE-IN-12 Inhibitor / Unkown
HY-175658 AChE/BChE-IN-29 Inhibitor / Unkown
HY-181445 NSC 620023 TFA Inhibitor / Unkown
HY-162681 eeAChE-IN-3 Inhibitor / Unkown
HY-180146 BChE-IN-48 Inhibitor / Unkown
HY-181865 BuChE-IN-22 Inhibitor / Unkown
HY-146687 BuChE-IN-4 Inhibitor / Unkown
HY-170976 BuChE-IN-16 / Unkown
HY-183352 BuChE-IN-23 Inhibitor / Unkown
HY-150585 BuChE-IN-5 Inhibitor / Unkown
HY-181597 LINS05414 Inhibitor / Unkown
HY-161453 BChE-IN-32 Inhibitor / Unkown
HY-174399 AChE/BChE-IN-27 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-163514 hAChE-IN-8 Inhibitor / Unkown
HY-169234 BChE-IN-35 Inhibitor / Unkown
HY-N9846 Luteolin 5,3'-dimethyl ether / Unkown
HY-149090 AChE/BuChE/MAO-B-IN-2 / Unkown
HY-172460 AChE/BChE/MAO-B-IN-5 Inhibitor / Unkown
HY-159482 SBN-284 Inhibitor / Unkown
HY-147870 COX-2-IN-22 Inhibitor / Unkown
HY-168731 AChE/BChE-IN-25 Inhibitor / Unkown
HY-182786 MAO-B-IN-56 Inhibitor / Unkown
HY-147939 AChE/BuChE-IN-3 Inhibitor / Unkown
HY-152632 BuChE-IN-7 Inhibitor / Unkown
HY-N10486 BChE-IN-10 Inhibitor / Unkown
HY-179726 BChE-IN-47 Inhibitor / Unkown
HY-W800535 Cryptolepine Inhibitor / Unkown
HY-183760 AChE/BChE-IN-37 Inhibitor / Unkown
HY-159081 AChE/BChE-IN-20 Inhibitor / Unkown
HY-149273 hBChE-IN-1 Inhibitor / Unkown
HY-N19871 Monogynol A Inhibitor / Unkown
HY-184791 AChE-IN-120 Inhibitor / Unkown
HY-175211 BChE-IN-42 Inhibitor / Unkown
HY-184159 AChE/BChE/MAO-A-IN-2 Inhibitor / Unkown
HY-184583 S27-1047 Inhibitor / Unkown
HY-174328 BChE/AChE-IN-1 Inhibitor / Unkown
HY-DY1110 PE154 (solution) Inhibitor / Unkown
HY-N10781 Isograndifoliol Inhibitor / Unkown
HY-170561 AChE/BuChE-IN-6 Inhibitor / Unkown
HY-180797 S1R agonist/BChE-IN-1 Inhibitor / Unkown
HY-179496 ChE/GSK-3β-IN-1 Inhibitor / Unkown
HY-180892 Multi-kinase-IN-10 Inhibitor / Unkown
HY-170389 BChE-IN-39 Inhibitor / Unkown
HY-183303 AChE-IN-116 Inhibitor / Unkown
HY-105157 Icopezil Inhibitor / Unkown
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / Unkown
HY-179122 BChE-IN-45 Inhibitor / Unkown
HY-127087 Isogarcinol Inhibitor / Unkown
HY-N21823 Methyl isoplatydesmine Inhibitor / Unkown
HY-181248 BChE-IN-49 Inhibitor / Unkown
HY-161842 AChE-IN-67 Inhibitor / Unkown
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / Unkown
HY-178017 BChE/hCA II-IN-1 Inhibitor / Unkown
HY-161331 S16–1029 Inhibitor / Unkown
HY-175655 BChE/p38-α MAPK-IN-1 Inhibitor / Unkown
HY-182615 Cymserine Inhibitor / Unkown
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / Unkown
HY-158978 Multitarget AD inhibitor-2 Inhibitor / Unkown
HY-181503 AChE/BuChE-IN-8 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-158261 AChE-IN-63 Inhibitor / Unkown
HY-175524 BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-169962 hCA I-IN-4 Inhibitor / Unkown
HY-155366 hAChE-IN-6 Inhibitor / Unkown
HY-107272 Chuanbeinone Inhibitor / Unkown
HY-159898 AChE/BChE-IN-23 Inhibitor / Unkown
HY-170938 AChE-IN-82 Inhibitor / Unkown
HY-W746884 2-Methyl-2-butenyl (E)-Caffeate Inhibitor / Unkown
HY-178356 BChE-IN-44 Inhibitor / Unkown
HY-185347 AChE-IN-114 Inhibitor / Unkown
HY-144689 BChE-IN-3 Inhibitor / Unkown
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / Unkown
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / Unkown
HY-182290 AChE/BChE-IN-36 Inhibitor / Unkown
HY-157978 AChE-IN-59 Inhibitor / Unkown
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / Unkown
HY-182254 AChE/BChE-IN-35 Inhibitor / Unkown
HY-162639 α-Glucosidase-IN-68 Inhibitor / Unkown
HY-121191 Bisnorcymserine Inhibitor / Unkown
HY-178433 BChE/p38-α MAPK-IN-2 Inhibitor / Unkown
HY-N18289 8-Hydroxydihydrochelerythrine Inhibitor / Unkown
HY-N10490 Blestrin D Inhibitor / Unkown
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / Unkown
HY-N21824 (+)-(3S)-ψ-Ribalinine Inhibitor / Unkown
HY-179711 AChE/BChE-IN-32 Inhibitor / Unkown
HY-161156 BChE-IN-26 Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-169162 hBChE-IN-3 Inhibitor / Unkown
HY-143465 BChE-IN-5 Inhibitor / Unkown
HY-184704 BChE-IN-52 Inhibitor / Unkown
HY-175523 MAO-B-IN-48 Inhibitor / Unkown
HY-182001 Multi-kinase-IN-13 Inhibitor / Unkown
HY-180819 AChE/BChE-IN-33 Inhibitor / Unkown
HY-180891 Multitarget AD-IN-4 Inhibitor / Unkown
HY-174464 AChE/BChE-IN-28 Inhibitor / Unkown
HY-N17425 Lakoochin C Inhibitor / Unkown
HY-181041 Multitarget AD-IN-5 Inhibitor / Unkown
HY-131971 AChE/BChE-IN-1 Inhibitor / Unkown
HY-172461 MAO-IN-6 Inhibitor / Unkown
HY-169961 BChE-IN-38 Inhibitor / Unkown
HY-152232 BChE-IN-15 Inhibitor / Unkown
HY-159143 BChE-IN-33 Inhibitor / Unkown
HY-163537 AChE/BuChE-IN-5 Inhibitor / Unkown
HY-180552 AChE-IN-104 Inhibitor / Unkown
HY-159880 AChE/BChE-IN-24 Inhibitor / Unkown
HY-144446 BuChE-IN-1 Inhibitor / Unkown
HY-146669 BChE-IN-6 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-181851 AChE-IN-109 Inhibitor / Unkown
HY-181167 AChE/BChE-IN-34 Inhibitor / Unkown
HY-D3171 AD-BChE/HClO / Unkown
HY-N15710 Magnotriol B Inhibitor / Unkown
HY-172219 CUR-IPA Inhibitor / Unkown
HY-178943 Neuroprotective agent 15 Inhibitor / Unkown
HY-163746 BuChE-IN-11 Inhibitor / Unkown
HY-168301 CL-13 Inhibitor / Unkown
HY-156031 BChE-IN-19 Inhibitor / Unkown
HY-119292 AP2238 Inhibitor / Unkown
HY-155284 K1833 Inhibitor / Unkown
HY-161150 AChE/BChE-IN-17 Inhibitor / Unkown
HY-163441 BChE-IN-31 Inhibitor / Unkown
HY-184658 BChE-IN-50 Inhibitor / Unkown
HY-118729 Difeterol Inhibitor / Unkown
HY-184292 COX-2-IN-67 Inhibitor / Unkown
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / Unkown
HY-183798 BChE/MAO-B-IN-6 Inhibitor / Unkown
HY-N10701 AChE/BChE-IN-11 Inhibitor / Unkown
HY-169163 BChE-IN-36 Inhibitor / Unkown
HY-157384 BChE-IN-22 Inhibitor / Unkown
HY-W332450 Demeton-S Inhibitor / Unkown
HY-113905 ZINC12613047 Inhibitor / Unkown
HY-113737 Trichlorfon ethyl Inhibitor / Unkown
HY-159977 1,2-Didehydrotanshinone IIA Inhibitor / Unkown
HY-W1058380 BChE-IN-53 Inhibitor / Unkown
HY-B1542 Benactyzine Inhibitor / Unkown
HY-N1151 Thunberginol C Inhibitor / Unkown
HY-183403 Ganstigmine Inhibitor / Unkown
HY-N19401 Vescalagin Inhibitor / Unkown
HY-W049312 7-Methoxytacrine Inhibitor / Unkown
HY-116041 Anabasamine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bche NCBI NCBI:590