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Applications And Challenges Of cfDNA Fragmentomics

DNA Metabolism And Repair Cancer Immunotherapy Cell Death & Disease Multiprotein Complexes and Disease

Cell-free DNA fragmentomics extracts biological information from the physical patterns of circulating DNA rather than relying only on nucleotide variants. Plasma cfDNA is a mixture released by hematopoietic and other tissues through apoptosis, necrosis, and active processes. Nucleosome positioning, chromatin accessibility, DNA methylation, nuclease activity, and molecular topology shape fragment length, preferred genomic ends, end motifs, single-stranded jagged ends, and coverage footprints. Because these features retain information about tissue of origin and gene regulation, they can supplement mutation-based liquid biopsy. Established and proposed applications include noninvasive prenatal testing, transplant monitoring, cancer detection, tissue-of-origin mapping, and assessment of organ injury[1][2][3].

Fragmentomics can be useful when tumor-derived molecules are too sparse for reliable mutation detection. Tumor, fetal, and transplanted-organ cfDNA often show size distributions that differ from the predominantly hematopoietic background. Genome-wide or targeted models can integrate fragment size, end coordinates, motifs, nucleosomal footprints, methylation, and other modalities to distinguish disease signals and predict an anatomical source. Multi-cancer early-detection tests are a prominent application because a fixed low false-positive rate is necessary when screening asymptomatic populations for many cancers. However, sensitivity varies with cancer type and stage, and detecting a signal is not equivalent to proving clinical benefit. Localization errors, incidental findings, and downstream diagnostic procedures must be incorporated into evaluation. Health-economic evaluation is also necessary, because even a technically accurate screen can create substantial costs and harms when follow-up pathways are poorly defined[3][4][5].

Technical variation is a major challenge. Blood-collection tube, processing delay, centrifugation, storage, extraction chemistry, library preparation, sequencing depth, and bioinformatic filtering can all change observed fragmentation. Leukocyte lysis dilutes true plasma patterns with genomic DNA. Different nucleases and disease processes can produce overlapping features, while age, pregnancy, exercise, infection, inflammation, and clonal hematopoiesis can confound models. Machine-learning methods integrate high-dimensional signals but can exploit batch effects or population differences unless training, validation, and test cohorts are rigorously separated. Transparent feature definitions, calibration, external multi-site validation, ancestry and comorbidity assessment, and reproducible pipelines are necessary before a classifier is transported to clinical practice. An assay must reproducibly measure its intended fragment features, accurately classify disease in the target-use population, and improve outcomes when embedded in a care pathway. Fragmentomics is powerful because fragmentation reflects tissue biology; the same sensitivity makes it vulnerable to preanalytical and physiological confounding[1][2][3][4][5].

Clinical translation should distinguish analytical validity, clinical validity, and clinical utility. Prospective studies should predefine thresholds, report false positives and interval cancers, compare against standard screening, and assess harms, time to diagnosis, stage shift, and mortality rather than accuracy alone. Multimodal targeted sequencing may balance breadth, cost, and depth, but algorithm updates require version control and revalidation. Its best use will come from standardized workflows and clinically anchored models, not from adding ever more features without independent validation. Reference materials and shared benchmark datasets are needed to compare extraction, sequencing, and computational methods. Reporting absolute molecule counts and uncertainty, rather than only model scores, would improve interpretability. These requirements should be addressed prospectively before clinical deployment. Predefined reporting standards would strengthen comparability[3][4][5].

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Cat. No. Product Name Information Application Publication
HY-15484 Pifithrin-α hydrobromide
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
MDM-2/p53   Aryl Hydrocarbon Receptor   Ferroptosis   Apoptosis  
Lung Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation  
105
HY-K1073 Annexin V-FITC/PI Apoptosis Detection Kit

MCE Annexin V-FITC/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-), early apoptosis cells show green fluorescence(Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).

Cell Biology Cell Analysis Cell Apoptosis and Necrosis

87
HY-E0077 Adhesive Aluminium Foil Plate Seal
MCE adhesive aluminium foil plate seals are of strong adhesive that can reduce chance of well-to-well contamination and sample evaporation when applied to microplates. This aluminium foil seal is suitable for long-term storage of samples at -80°C. The high integrity sealing materials give the best protection against evaporation and contamination. The aluminium foil seal features excellent chemical resistance to DMSO and DNase- & RNase- free. MCE adhesive foil seal is pierceable, peelable and easy-to-use.
83
HY-L152 F-Fragments Library
19F-NMR has proved to be a detection mode in fragment-based drug discovery (FBDD) for studies of protein structure and interactions. 19F shows high sensitivity for NMR detection, and the exquisite sensitivity of 19F chemical shifts and linewidths to ligand binding all make it a valuable approach in FBDD.F (Fluorine) -Fragments can be used for 19F-NMR detection after binding to target proteins, and can be used as an effective 19F-NMR tool for FBDD. MCE designs a unique collection of 5,077 F-fragments, all of which obey a heuristic rule called the “Rule of Three (RO3)”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This F-fragments library is an important source of lead-like drugs.

According to Fragment Structures

83
HY-L173 Anti-Ovarian Cancer Compound Library
Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer. MCE designs a unique collection of 2,967 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

Disease Focused Libraries

83
HY-L184 Anti-Gastric Cancer Compound Library
Gastric Cancer (GC) is one of the most common malignant tumors in the world, ranking fourth in mortality rate globally. Because the early symptoms of stomach neoplasm are usually not obvious, are diagnosed with gastric cancer at terminal stage, and the relative survival rate within 5 years is very low. With the further understanding of the molecular characteristics of stomach neoplasm, many therapeutic targets for gastric cancer have been identified, and molecular targeted therapies such as CTLA-4, HER2 and immune checkpoint inhibitors have made rapid progress. Although survival rates for patients with gastric neoplasm have improved over the past few decades, the prognosis is still worrying. Therefore, there is an urgent need for new drugs to treat gastric cancer. MCE designs a unique collection of 1,203 small molecules with definite or potential anti-gastric cancer activity, which is an important tool for studying the pathological mechanism of stomach neoplasm and developing drugs for stomach neoplasm.

Disease Focused Libraries

83
HY-L229 Nephrotoxicity Compound Library
Kidneys are one of the vital organs in the human body. Due to their exposure to higher concentrations of circulating drugs or metabolites, they are highly susceptible to drug-induced renal injury (DIRI). According to statistics, drug-induced kidney injury accounts for approximately 20% of nephrotoxicity reports and can lead to acute kidney injury (AKI), chronic kidney disease (CKD), or even end-stage renal disease (ESRD). Early detection of drug nephrotoxicity is crucial for preventing irreversible kidney damage. Research into its mechanisms can help optimize clinical medication by adjusting dosages or avoiding combinations of nephrotoxic drugs. Additionally, predicting drug-induced nephrotoxicity in early drug development can reduce the risk of late-stage R&D failure. MCE offers 160 nephrotoxicity compounds that have been clearly reported by the FDA to be associated with kidney injury. This library can be used for studying molecular mechanisms of nephrotoxicity or developing novel biomarkers.
83
HY-L922 Good ADMET Diversity Library
A diverse compound library with favorable ADMET properties (Absorption, Distribution, Metabolism, Excretion, and Toxicity) is crucial in drug discovery. Early evaluation of ADMET properties allows for the exclusion of molecules with unfavorable profiles at the initial stages, thereby reducing the risk of late-stage development failures, lowering R&D costs, and accelerating optimization of lead compounds. Based on predictions from ADMET-related AI algorithms, the compounds in this library are predicted to exhibit favorable oral bioavailability (F > 30%), reasonable plasma protein binding (PPB < 98%), minimized CYP3A4 inhibition potential (inhibition probability < 50%, CYP3A4 is the most critical drug-metabolizing enzyme in the cytochrome P450 family) , low toxicity profiles, with 140 potentially toxic substructures pre-identified and excluded via substructure searching to eliminate compounds containing hazardous fragments. The diversity library enables broad applicability in high-throughput screening (HTS) and high-content screening (HCS).

Distinctive Diversity Libraries

83
HY-L927 10K Golden Scaffold Library
Designed to maximize efficiency in hit discovery and optimization, this compound library is built on a foundation of diverse Bemis-Murcko scaffolds, with each scaffold is represented by two specifically derived molecules. This strategy ensures broad chemical space through scaffold diversity while enabling preliminary functional group exploration. This approach provides early structure-activity relationship (SAR) insights for every scaffold, making it a valuable tool for accelerating drug discovery.

Distinctive Diversity Libraries

83
HY-L942 Allosteric Modulator Fragment Library
Unlike highly conserved orthosteric sites, allosteric sites exhibit low conservation, high hydrophobicity, weak polarity, confined geometry, and dynamic cryptic properties. Rather than rigid keyhole-like cavities, they typically appear as flexible grooves, subunit interface clefts, or shallow depressions formed by protein conformational changes. Based on the dynamic, hydrophobic, and elongated nature of allosteric pockets, MCE has carried out targeted fragment modification and screening under strict physicochemical criteria: MW 120–280 Da, HBD ≤ 2, HBA ≤ 3, PSA 30–80 Ų, rotatable bonds ≤ 2, cLogP 1–3.5. High 3D diversity was further ensured by PMI analysis, yielding fragments with excellent shape complementarity to allosteric pockets. This library contains 1,800 structurally diverse, drug-like fragments, this library supports allosteric drug development and pocket optimization. It significantly improves screening hit rates and enables efficient, precise early-stage R&D of allosteric drugs.

Functional Fragment Libraries

83
HY-L943 MCE‑18 Novelty drug‑like Library
MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets. This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.

Distinctive Diversity Libraries

83
HY-L944 MCE‑18 Novelty Focused Drug‑Like Library
MCE 18 stands for Medicinal Chemistry Evolution 2018. This metric was established based on structural data of 28,161 patented lead molecules, 1,370 marketed innovative drugs, and nearly 30,000 investigational candidates from preclinical to Phase III stages across 23 major global pharmaceutical companies from 1950 to 2018. After scaffold clustering analysis, a scoring model was constructed by integrating five three dimensional scaffold characteristics, including aromatic rings (AR), non aromatic heterocycles (NAR), chiral centers (CHIRAL), spirocycles (SPIRO), and the sp³ carbon ratio in cyclic and acyclic moieties, enabling quantitative assessment of molecular scaffold novelty and three dimensional complexity. According to the score distribution of patented molecules, the top 25% of the original patent dataset was defined as the high novelty region. MCE 18 high scoring compounds selected based on this criterion can effectively avoid scaffold patent conflicts and intellectual property risks from the source. Molecules in this range typically feature a high sp³ carbon ratio, abundant chiral centers, spirocycles, and fused heterocycles with prominent three dimensional conformations. Their spatial properties allow precise matching to complex non traditional undruggable target pockets such as PPI interfaces and allosteric sites, making them ideal structural types for early stage screening of First in class drugs. MCE‑18 Novelty Focused drug‑Like library strictly selects molecules from the aforementioned high scoring range, containing more than 10,000 premium drug like molecules with highly diverse scaffolds and rich 3D diversity. It can be used for high throughput screening of well established targets such as kinases, GPCRs, and proteases, and is especially suitable for hit identification in allosteric modulation, protein–protein interactions, and various undruggable orphan targets, fully supporting early stage drug discovery for cutting edge innovat

Distinctive Diversity Libraries

83
HY-L945 Sulfonyl Fluoride Fragment Library
Sulfonyl fluoride (-SO₂F) overcomes the poor target selectivity of traditional covalent warheads that rely heavily on cysteine. With high stability and tunable electrophilicity under physiological conditions, it targets multiple nucleophilic residues including Lys, Tyr, Ser and His, offering expanded druggable space, lower off-target risks and prolonged efficacy. It is widely used in covalent inhibitors, molecular glues, PROTACs and chemical probes. MCE has built a highly diverse sulfonyl fluoride fragment library with 1,162 structurally diverse, drug-like fragments. Designed for balanced reactivity, stability and compatibility, these molecules feature tunable electrophilicity, simple scaffolds and high derivatization potential. Combined with SuFEx click chemistry, the library enables efficient modular modification and rapid structure optimization. Ideal for targeting non-cysteine residues, this library improves covalent screening and probe development efficiency, serving as a precise tool for early-stage covalent drug discovery and chemical biology research.

According to Fragment Structures

83
HY-10029 Nutlin-3a
Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas.
MDM-2/p53   E1/E2/E3 Enzyme   Autophagy   Apoptosis  
Colorectal Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Digestive System Inflammation  
77
HY-17412 Minocycline hydrochloride
Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
Bacterial   Antibiotic   HIF/HIF Prolyl-Hydroxylase   Apoptosis   MDM-2/p53   Potassium Channel   Calcium Channel  
Metabolic or Endocrine Disease   Breast Cancer   Colorectal Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Bacterial Infection   Depression   Digestive System Inflammation   Cardiovascular Disease   SARS-CoV-2 Infection   Lung Fibrosis  
76
HY-13323 CX-5461
CX-5461 is a selective, orally active RNA polymerase I inhibitor. CX-5461 disrupts the formation of the SL1-rDNA complex, thereby blocking the transcription initiation of ribosomal RNA without altering the activity of RNA polymerase II, DNA replication, or protein translation processes. CX-5461 upregulates the expression of p21, MDM2, Sestrin1/2, and phosphorylated AMPKα, and reduces the level of phosphorylated Akt. CX-5461 induces G2/G2/M cell cycle arrest, Autophagy, Apoptosis, and cellular senescence, and activates CHK1, CHK2, and RPA. CX-5461 can be used in research related to osteosarcoma, cervical cancer, hematologic malignancies, high-grade serous ovarian cancer, and solid tumors.
DNA/RNA Synthesis   MDM-2/p53   AMPK   Akt   Autophagy   Apoptosis   Checkpoint Kinase (Chk)  
Musculoskeletal and Skin Disease   Cervical Cancer   Ovarian Cancer   Osteosarcoma  
72
HY-A0003 Lenalidomide
Lenalidomide (CC-5013) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide promotes IL-2 release and effector functions of CD8+ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide can be used in research related to hematological malignancies, acute liver failure and acute kidney injury.
Molecular Glues   Ligands for E3 Ligase   IKZF Family   Casein Kinase   Apoptosis   Pyroptosis   MDM-2/p53   TNF Receptor  
Inflammation or Immune System Disease   Renal Disease   Chronic Lymphocytic Leukemia   Diffuse Large B-cell Lymphoma   Multiple Myeloma   Myelodysplastic Syndrome   Liver Failure  
63
HY-15676 Idasanutlin
Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC50 of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors.
MDM-2/p53   E1/E2/E3 Enzyme   Apoptosis   Pyroptosis   Reactive Oxygen Species (ROS)   Caspase  
Musculoskeletal and Skin Disease   Colorectal Cancer   Melanoma   Neuroblastoma   Osteosarcoma   Non-Small Cell Lung Cancer   Acute Myeloid Leukemia   Non-Hodgkin Lymphoma  
52
HY-108882A Recombinant DNase I (RNase-free)
Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis.
Endonuclease  
46
HY-50696 Nutlin-3
Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
MDM-2/p53   E1/E2/E3 Enzyme  
Colorectal Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer  
43
HY-101563 Pemrametostat
GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma.
Histone Methyltransferase   SARS-CoV   MDM-2/p53   CDK   Apoptosis  
Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   HER-2 Positive Breast Cancer   SARS-CoV-2 Infection  
33
HY-N0171A Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
Bacterial   Apoptosis   Reactive Oxygen Species (ROS)   MDM-2/p53   Caspase   PARP   MMP   Bcl-2 Family   HIF/HIF Prolyl-Hydroxylase   TNF Receptor   Interleukin Related   NF-κB   mTOR   Lactate Dehydrogenase   CDK   Glutathione Peroxidase   SOD  
Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
24
HY-K0302 Cell-ATP Viability Detection Kit

MCE Cell-ATP Viability Detection Kit is used for detecting the number and viability of living cells in culture based on high-sensitivity bioluminescence detection technology of the ATP present.Product specifications: Large sizes are based on 100 mL increments.

Cell Biology Cell Analysis Cell Proliferation and Cytotoxicity

13
HY-N1485 Cycloastragenol
Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties.
Telomerase  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Cardiovascular Disease  
10
HY-108477 TMPyP4 tosylate
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2.
G-quadruplex   Telomerase   Cholinesterase (ChE)   SARS-CoV  
Cancer   Viral Infection  
10
HY-17423 Abacavir
Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity.
HIV   Reverse Transcriptase   Telomerase   Apoptosis  
Prostate Cancer   Viral Infection  
9
HY-N0453 Hypericin
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis.
Apoptosis   Influenza Virus   Antibiotic   Monoamine Oxidase   PKC   Cytochrome P450   Dopamine β-hydroxylase   Reverse Transcriptase   Telomerase  
Cancer   Digestive System Disease   Viral Infection   Depression   Digestive System Inflammation   Parkinson's Disease  
8
HY-17353 BIBR 1532
BIBR 1532 is a potent, selective and non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay.
Telomerase   Apoptosis  
Digestive System Disease   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Digestive System Inflammation  
8
HY-116770 PFM01
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
Endonuclease  
Cancer  
6
HY-P99340 Sotrovimab
Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease.

Species: Virus

SARS-CoV  
Cancer   SARS-CoV-2 Infection  
6
HY-101089 RHPS4
RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer.
Telomerase   Apoptosis  
Cancer   Digestive System Disease   Digestive System Inflammation  
6
HY-117695 AQC
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels.
Fluorescent Dye  
6
HY-129046 RNase A, Bovine pancreas
RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability.
Endonuclease   DNA/RNA Synthesis  
6
HY-15435A CHAPS hydrate
CHAPS hydrate is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS hydrate exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS hydrate stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm‑Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS hydrate is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS hydrate cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS hydrate is commonly used in research on the separation and purification of membrane proteins.
Biochemical Assay Reagents   Exosomes  
4
HY-145758 FEN1-IN-SC13
FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-SC13 interferes with DNA replication and repair in vitro and in cells.
Endonuclease  
Cancer  
4
HY-N1423 Glycocholic acid
Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).
P-glycoprotein   Endogenous Metabolite   FXR   LPL Receptor   G protein-coupled Bile Acid Receptor 1   Apoptosis   MDM-2/p53   Bcl-2 Family   Bacterial   Caspase  
Metabolic or Endocrine Disease   Lung Cancer   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
4
HY-120145 MST-312
MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM).
Telomerase  
Leukemia/Lymphoma/Myeloma  
3
HY-P2863 Deoxyribonuclease II
Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research.
Endonuclease  
2
HY-120951 PFM39
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity.
Endonuclease  
Cancer  
2
HY-E70131 Endo H, Streptomyces picatus
Endo H, Streptomyces picatus (Endo-β-N-acetylglucosaminidase H), isolated from Streptomyces plicatus, hydrolyzes the central glycosidic bond of the β1, 4-di-N-acetylchitobiose core in asparagine-linked oligosaccharides.

Species: Streptomyces picatus

Endonuclease  
Metabolic or Endocrine Disease  
2
HY-113679 Ceramides Mixture
Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of telomerase activity.
Telomerase  
Metabolic or Endocrine Disease   Lung Adenocarcinoma  
2
HY-141567 Pseudouridine 5'-triphosphate
Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection.
DNA/RNA Synthesis  
Viral Infection  
1
HY-155539 Cisd2 agonist 2
Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters.
IKZF Family   Zinc Finger Protein  
Digestive System Disease   Digestive System Inflammation  
1
HY-15933 TOPS
TOPS is a chromogenic substrate. TOPS undergoes an oxidative coupling reaction with 4-aminoantipyrine in the presence of H2O2 and nanocrystalline cobalt selenide. TOPS is used in studies related to uric acid detection.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
1
HY-W129633 2,6-Dichlorophenolindophenol sodium hydrate
2,6-Dichlorophenolindophenol (DCIP; DPIP) sodium hydrate is a redox chromogenic indicator with a redox potential of +217 mV relative to SHE, and it acts as a substrate for reduction reactions. During the metabolic process of nutrient consumption by Saccharomyces cerevisiae, 2,6-Dichlorophenolindophenol sodium hydrate is reduced from dark blue to colorless, resulting in a decrease in absorbance. 2,6-Dichlorophenolindophenol sodium hydrate is widely used in spectrophotometric biochemical oxygen demand determination and preclinical colorimetric toxicity analysis for heavy metal ion detection based on Saccharomyces cerevisiae.
Biochemical Assay Reagents  
1
HY-P9929 Bezlotoxumab
Bezlotoxumab (BLA761046; MBL-CDB1; MDX-1388) is a fully humanized IgG1/kappa monoclonal antibody directed against Clostridium difficile toxin B. Bezlotoxumab mediates the early reconstitution of gut microbiota to reduce the risk of recurrent Clostridium difficile infection (CDI). Bezlotoxumab can be used for the study of recurrent Clostridium difficile infection prevention.

Species: Human

Bacterial  
Clostridium Difficile Infection  
1
HY-P2963 Nuclease P1
Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries. Nuclease P1 can be obtained by fermentation of Penicillium citrinum: through extraction process, ultrafiltration concentration, drying and purification, etc.
Endonuclease  
1
HY-P1149A Epitalon TFA
Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa.
Telomerase  
Cancer   Neurological, Eye or Ear Disease  
1
HY-141567A Pseudouridine 5'-triphosphate trisodium solution (100 mM)
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection.
DNA/RNA Synthesis  
Viral Infection  
1
HY-153368 Zomiradomide
Zomiradomide (KT-413) is an orally active IRAK4 PROTAC degrader with a DC50 of 6 nM. Zomiradomide inhibits the NF-κB signaling pathway, while its molecular glue function mediates the degradation of Ikaros and Aiolos (with a DC50 of 1 nM for both), activates the IFN-I signaling pathway, and selectively degrades IMiD substrates. Zomiradomide inhibits cancer cell proliferation and tumor growth. Zomiradomide can be used in research related to B-cell non-Hodgkin's lymphoma and diffuse large B-cell lymphoma.
PROTACs   IRAK   NF-κB   IFNAR   Zinc Finger Protein   Molecular Glues  
Non-Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
1
HY-P1149 Epitalon
Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa.
Telomerase  
Cancer   Neurological, Eye or Ear Disease  
1
HY-P70310 EGR1/ZNF225 Protein, Human (His)
The EGR1/ZNF225 protein is a multifunctional transcriptional regulator that binds to the EGR site in the promoter of target genes and is independent of cytosine methylation. It controls the transcription of multiple target genes, affecting responses to growth factors, DNA damage, and ischemia. EGR1/ZNF225 Protein, Human (His) is the recombinant human-derived EGR1/ZNF225 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

1
HY-P79315 HMGN1 Protein, Human
The HMGN1 protein is a key player in the immune response, binding to the Fc region of immunoglobulin alpha and specifically promoting the production of cytokines. HMGN1 is intricately related to the Fc epsilon RI gamma 2 receptor, can induce tyrosine phosphorylation of gamma 2, and actively participates in the complex coordination of immune signaling pathways. HMGN1 Protein, Human is the recombinant human-derived HMGN1 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

1
HY-K1080 Annexin V-iFluor 488/PI Apoptosis Detection Kit

MCE Annexin V-iFluor 488/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-),, early apoptosis cells show green fluorescence (Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).

Cell Biology Cell Analysis Cell Apoptosis and Necrosis

1
HY-K1096 Annexin V-FITC/7-AAD Apoptosis Detection Kit

MCE Annexin V-FITC/7-AAD Apoptosis Detection Kit can be utilized to detect the occurrence of early apoptosis.

Cell Biology Cell Analysis Cell Apoptosis and Necrosis

1
HY-K2111 HOLO Mouse Interferon-γ (IFN-γ) Detection Kit

MCE HOLO Mouse Interferon-γ (IFN-γ) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of mouse IFN-γ concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

1
HY-P992393 JMT203
JMT203 is a monoclonal antibody against GFRAL and a body weight gain inducer. JMT203 induces early-onset, sustained and progressive body weight gain in cancer cachexia. JMT203 can be used for research related to cancer cachexia.

Species: Human

TGF-β Receptor  
Cancer  
/
HY-P11577 TGGGPLGVARGKGGC
TGGGPLGVARGKGGC is a polypeptide that can be specifically cleaved by MMP-9. TGGGPLGVARGKGGC modifies manganese dioxide supraparticles. TGGGPLGVARGKGGC can be used in the research of early cancer diagnosis.
MMP   Biochemical Assay Reagents  
/
HY-P11936 GPC3 targeting peptide 2
GPC3 targeting peptide 2 is a glypican-3 (GPC3) targeting peptide that binds specifically to GPC3 with a Kd of 39.5 nM. GPC3 targeting peptide 2 can be conjugated to IRDye800 via a GGGSC linker for near-infrared fluorescence and photoacoustic imaging, with a tumor-to-adjacent liver fluorescence intensity ratio of approximately 2-fold. GPC3 targeting peptide 2 shows high specificity for immunofluorescence staining of HCC specimens. GPC3 targeting peptide 2 can be used in studies related to GPC3-targeted molecular imaging and early detection of hepatocellular carcinoma.
Glycoprotein VI   Biochemical Assay Reagents  
Liver Cancer  
/
HY-126047AS (R,S)-Anatabine-d4
(R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-113767 Momordin II
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity.
DNA/RNA Synthesis  
Metabolic or Endocrine Disease  
/
HY-P10065 RKLLW-NH2
RKLLW-NH2 is a Cathepsin L inhibitor.
Cathepsin  
Inflammation or Immune System Disease  
/
HY-15926S ONPG-13C
ONPG-13C is the 13C labeled ONPG. ONPG is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activit.
Isotope-Labeled Compounds  
/
HY-175875 HRZ-01-082-5
HRZ-01-082-5 is an analog of Glutarimide (HY-I0466). HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8  nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research.
Molecular Glues   Zinc Finger Protein   Drug Derivative  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-DY1070 AQC (solution)
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) (solution) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels.
Solvent and concentration: DMSO: 10 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
Fluorescent Dye  
/
HY-183629 ZNF281-IN-1
ZNF281-IN-1 is a ZNF281 inhibitor. ZNF281-IN-1 disrupts the binding of transcriptionally active DNA-bound ZNF281 to the promoters of target genes including TRIM35 and ZEB1. ZNF281-IN-1 inhibits tumor cell proliferation, stabilizes P53 and upregulates PUMA to induce apoptosis, while triggering cellular senescence. ZNF281-IN-1 completely prevents Doxorubicin (HY-15142A)-induced cardiotoxicity (AIC), and enhances rather than impairs the antitumor efficacy of Doxorubicin. ZNF281-IN-1 completely blocks the distant metastasis of melanoma to the lungs. ZNF281-IN-1 can be used in the research of cardiotoxicity, lung cancer and metastatic melanoma.
Zinc Finger Protein   Apoptosis  
Lung Cancer   Heart Disease   Mutant Melanoma  
/
HY-157354 Urease Agar Base
Urease Agar Base can be used for the detection of urease activity.
Biochemical Assay Reagents  
/
HY-D1959 ATTO 565 NHS ester
ATTO 565 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 565 NHS ester is an NHS ester derivative of ATTO 565 that can be used to label proteins or antibodies.
Fluorescent Dye  
/
HY-180281 PLAGL2-IN-1
PLAGL2-IN-1 is a inhibitor of pleiomorphic adenoma-like protein 2 (PLAGL2) with a Kd of 2.23 µM. PLAGL2-IN-1 suppresses PLAGL2 transcriptional activity, induces G0/G1 cell cycle arrest, and apoptosis, thereby inhibiting hepatocellular carcinoma (HCC) cell proliferation. PLAGL2-IN-1 disrupts extracellular matrix organization and suppresses the PI3K-AKT pathway by reducing AKT phosphorylation. PLAGL2-IN-1 inhibits tumor growth in an HCCLM3 xenograft mouse model. PLAGL2-IN-1 can be used for the research of HCC.
Zinc Finger Protein   Apoptosis   PI3K   Akt  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-157926 Nitroso-PSAP
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe2+), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe2+) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >).
Biochemical Assay Reagents  
/
HY-P5229 IHRIC
IHRIC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Others  
/
HY-P11262 GUB021794
GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC50 value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC50 value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes.
GLP Receptor  
Metabolic or Endocrine Disease  
/
HY-P3430 JM3A
JM3A is a highly specific peptoid reagent that targets newly appears cell surface vimentin (CSV) on tumor-transformed early lung cancer cells. JM3A can detect and stain CSV by coupling with fluorophores.
Biochemical Assay Reagents  
/
HY-159570 XD2-149
XD2-149 is a ZFP91 PROTAC degrader with DC50 values of 0.08 μM and 0.06 μM, respectively. ZFP91 is a bifunctional nuclear protein with both transcription factor and E3 ubiquitin ligase activities, and is classified as an oncogenic non-canonical NF-κB pathway regulator in tumor and immune regulation. XD2-149 induces proteasome-dependent degradation of the E3 ubiquitin-protein ligase ZFP91. XD2-149 inhibits the STAT3 signaling pathway in pancreatic cancer cells and induces NQO1-dependent cell death independent of ZFP91 degradation. XD2-149 can be used for the research of pancreatic cancer.
PROTACs   Zinc Finger Protein   STAT   NF-κB   Quinone Reductase  
Pancreatic Cancer  
/
HY-152014S Stearoylcarnitine-d3-1 hydrochloride
Stearoylcarnitine-d3-1 (hydrochloride) is deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is a human endogenous metabolite. Stearoylcarnitine acts as a metabolomics biomarker for early-onset-preeclampsia and late-onset-preeclampsia.
Isotope-Labeled Compounds   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-P10324 TAT-p16
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex.
Others  
Cancer  
/
HY-P5228 KSDSC
KSDSC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Biochemical Assay Reagents  
/
HY-P991572 MM-151
MM-151 is a humanized IgG1 monoclonal antibody targeting EGFR. MM-151 binds multiple regions of the EGFR extracellular domain (ECD) and reduces its mutations in circulating cell-free tumor DNA with EGFR resistance. MM-151 significantly inhibits EGFR signaling and cell growth. MM-151 can be used for drug-resistant cancers research, such as colorectal, non-small cell lung and triple negative breast cancer.

Species: Human

EGFR  
Cancer  
/
HY-173256 Hyp-dBET1
Hyp-dBET1 is a hypoxia-activated BRD4 PROTAC degrader. The IC50 of Hyp-dBET1 for reducing cell viability under hypoxic conditions is approximately 153 nM to 192 nM, while it shows low activity under normoxic conditions (IC50 of approximately 2.8 μM to 3.8 μM). Hyp-dBET1 induces BRD4 degradation under hypoxic conditions, converts to dBET1 in hypoxic environments, and downregulates the expression level of ZFP-91. Hyp-dBET1 can be used in studies related to breast cancer, cervical cancer and solid tumors.
PROTACs   Epigenetic Reader Domain   Zinc Finger Protein  
Breast Cancer   Cervical Cancer  
/
HY-B0870S Bensulfuron-methyl-d6
Bensulfuron-methyl-d6 is a deuterated Bensulfuron-methyl (HY-B0870). Bensulfuron-methyl is a kind of sulfonylurea herbicide widely used to control broad-leaf weeds in rice paddies.
Isotope-Labeled Compounds   Herbicide  
/
HY-P99648A Gosuranemab (powder)
Gosuranemab (BMS-986168; IPN007; BIIB092) (powder) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab (powder) neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab (powder) can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease.
Tau Protein  
Alzheimer's Disease  
/
HY-P10317 Suc-YVAD-AMC
Suc-YVAD-AMC is used to measure the cysteine proteins of the proteasome.Suc-YVAD-AMC releases fluorescent AMC when cleaved by cysteine proteases to assess the enzymatic activity of the proteasome.
Fluorescent Dye  
/
HY-W616313S Cyprosulfamide-d4
Cyprosulfamide-d4 is deuterium labeled Cyprosulfamide. Cyprosulfamide serves as a herbicide that safeguards plants against salinity stress while promoting vigorous growth, including the development of new tillers and early flowering.
Isotope-Labeled Compounds   Herbicide   HBV  
/
HY-W091784R 3'-O-Methylguanosine (Standard)
3'-O-Methylguanosine (Standard) is an analytical standard of 3'-O-Methylguanosine (HY-W091784). This product is intended for research and analytical applications. 3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.
Reference Standards   Endogenous Metabolite   Orthopoxvirus   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
Infection  
/
HY-N15402 Porritoxin
Porritoxin (compound 1 ) is a metabolite of Alternaria porri. Porritoxin shows the inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA (HY-18739).

Source: Alternaria porri

EBV  
Infection  
/
HY-B1374S ent-Florfenicol-d3
ent-Florfenicol-d3 is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for the treatment of bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
Bacterial   Antibiotic  
Infection  
/
HY-113281 5-Hydroxyhexanoic acid
5-Hydroxyhexanoic acid is a normal monohydroxy carboxylic acid degradation product of
fatty acids with medium chain lengths (particularly hexanoic acid). 5-Hydroxyhexanoic acid functions as a predictor of early renal functional decline in type 2 diabetes with microalbuminuria.
Endogenous Metabolite  
Type 2 Diabetes  
/
HY-13578S Brivudine-13C, 15N2
Brivudine-13C, 15N2 (Bromovinyldeoxyuridine-13C, 15N2) is 13C and 15N labeled Brivudine. Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
Isotope-Labeled Compounds   CMV  
Cancer   Infection  
/
HY-P99664 Inolimomab
Inolimomab is an anti-interleukin-2 receptor (IL-2R) α chain monoclonal antibody. Inolimomab improves the survival rate in the early research of treating acute graft-versus-host disease (aGVHD).

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P5229A IHRIC TFA
IHRIC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Others  
/
HY-P4426 Lys-Pro-AMC
Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes.
Fluorescent Dye  
/
HY-P5228A KSDSC TFA
KSDSC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Biochemical Assay Reagents  
/
HY-B0497S1 Niclosamide-13C6
Niclosamide-13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
Isotope-Labeled Compounds   STAT   Parasite   Antibiotic  
Cancer   Infection  
/
HY-W585887 Fructose-L-tryptophan
Fructose-L-tryptophan (Trp-Fru), an early Maillard reaction product formed from tryptophan and glucose.
Biochemical Assay Reagents  
/
HY-123065 Chromotropic acid disodium dihydrate
Chromotropic acid (disodium dihydrate) can be used for the detection of formaldehyde.
Biochemical Assay Reagents  
/
HY-148043 Schnurri-3 inhibitor-1
Schnurri-3 inhibitor-1 is a potent schnurri-3 inhibitor which is an essential regulator of adult bone formation. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in osteoblast cell line Shn3FFL with an AC50 value of 2.09 μM. Schnurri-3 inhibitor-1 can be used to research osteoporosis.
Zinc Finger Protein  
/
HY-P99859A Donanemab (powder)
Donanemab (LY3002813) (powder) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab (powder) has the potential for early Alzheimer's disease research.
Amyloid-β  
Alzheimer's Disease  
/
HY-W076042 Cesibor dihydrate
Cesibor dihydrate is an additive salt used in ion-selective electrodes (ISEs) and micro ion-selective field effect transistors (μ-ISFETs) to enhance or modulate their selective responses to specific ions.
Biochemical Assay Reagents  
/
HY-123533S Resorufin-d6
Resorufin-d6 is the deuterium labeled Resorufin. Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte.
Reactive Oxygen Species (ROS)  
/
HY-D2001A ATTO 488 NHS ester TEA
TTO 488 NHS ester TEA is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. TTO 488 NHS ester TEA is an NHS ester derivative of ATTO 488 that can be used to label proteins or antibodies.
Fluorescent Dye  
/
HY-D0844F Biotin-glutathione oxidized TFA
Biotin-glutathione oxidized TFA ((N,N-Biotinyl glutathione disulfide TFA; Biotin-GSSG TFA) is an inducer of protein S-glutathionylation and a detection probe for S-glutathionylated proteins. Biotin-glutathione oxidized TFA forms protein-glutathione disulfide adducts, mimics components of oxidative stress, and drives protein S-glutathionylation. Biotin-glutathione oxidized TFA enables the labeling, detection, localization and purification of proteins susceptible to S-glutathionylation.
Others  
/
HY-128699R D-Desthiobiotin (Standard)
D-Desthiobiotin (Standard) is the analytical standard of D-Desthiobiotin. This product is intended for research and analytical applications. D-Desthiobiotin is a biotin derivative. D-Desthiobiotin increases testosterone. D-Desthiobiotin is used in affinity chromatography and protein chromatography, also can be used for protein and cell labeling, detection and isolation.
Endogenous Metabolite   Reference Standards  
Metabolic or Endocrine Disease  
/
HY-107260 Lucidenic acid D
Lucidenic acid D is a highly oxidized triterpenoid with anti-inflammatory and antiviral activities. Lucidenic acid D attenuates lipopolysaccharide-induced release of proinflammatory cytokines and nitric oxide, reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and inhibits skin inflammation. Lucidenic acid D suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of Epstein-Barr virus (EBV) early antigen and maintains the viability of Raji cells. Lucidenic acid D can be used in studies of cancer chemoprevention.
NO Synthase   COX  
Cancer   Inflammation or Immune System Disease   Viral Infection  
/
HY-P99834 Crefmirlimab
Crefmirlimab (IAB22M2C; ImaginAb) is a humanized CD8-specific single-domain antibody. Conjugation of Crefmirlimab with radioisotopes (e.g., 89Zr) enables tumor immune infiltration assessment, autoimmune disease detection, and immunotherapy response monitoring. Crefmirlimab is applicable for cancer research.

Species: Human

Transmembrane Glycoprotein  
Lung Cancer  
/
HY-161303 ZNF207-IN-1
ZNF207-IN-1 is an orally active and brain-penetrant ZNF207 inhibitor with a target KD of 67 nM. ZNF207-IN-1 binds directly to ZNF207, downregulates stem-related genes and weakens glioma cell stemness. ZNF207-IN-1 hinders tumorigenesis and migration and promotes apoptosis. ZNF207-IN-1 can be used for the research of glioma[1].
Zinc Finger Protein   Apoptosis  
Glioma  
/
HY-W661499 Orellanine
Orellanine, a nephrotoxic alkaloid found in Cortinarius orellanus, is an orally active and selective non-competitive inhibitor of alkaline phosphatase. Orellanine chelates iron, generates reactive oxygen species (ROS), induces DNA scission, forms ortho-semiquinone radicals, downregulates antioxidant defenses, and inhibits mitochondrial function. Orellanine induces caspase 8/9-mediated apoptosis. Orellanine inhibits synthesis of proteins, RNA, DNA, and mitochondrial protein synthesis, with metabolic activation required for cell-free protein synthesis inhibition. Orellanine can be used for the research of metastatic clear cell renal cell carcinoma, acute renal failure, chronic renal insufficiency, and kidney damage.

Source: Cortinarius orellanus

Phosphatase   Apoptosis   Reactive Oxygen Species (ROS)   Caspase  
Cancer  
/
HY-150058 Bocconoline
Bocconoline is a potent early endosome antigen 1 (EEA1) inhibitor. Bocconoline can be isolated from Macleaya cordata. Bocconoline can be used for the research of Parkinson’s disease (PD).
Others  
Neurological, Eye or Ear Disease  
/
HY-P991319 TAB-004
TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.

Species: Human

Others  
Pancreatic Cancer   Triple-Negative Breast Cancer  
/
HY-W004263 1-Eicosanol
1-Eicosanol (Arachidyl alcohol) is a long-chain fatty alcohol and volatile organic compound that can be isolated from the leaves of Leea indica and produced by Bacillus velezensis ZJ1. 1-Eicosanol inhibits mycelial growth of Alternaria solani and Botrytis cinerea. 1-Eicosanol is applicable to research related to tomato early blight and tomato gray mold.
Fungal  
Fungal Infection   Plant Infection  
/
HY-D1262 BODIPY-TS
BODIPY-TS (Thiol-green 2) is a fast response and thiol-specific turn-on probe. BODIPY-TS utilizes the thiosulfonate scaffold as a thiol recognition unit. BODIPY-TS has low toxicity, and features high selectivity, low detection limit, and quantitative reaction to thiols. Ex: 490 nM; Em: 515 nM.
Fluorescent Dye  
/
HY-N7691 3,29-O-Dibenzoyloxykarounidiol
3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a multiflorane-type triterpene benzoate that inhibits Phorbol 12-myristate 13-acetate (TPA) (HY-18739)-induced Epstein-Barr virus early antigen activation and exhibits tumor-promotion inhibitory activity. 3,29-O-Dibenzoyloxykarounidiol is used in cancer-related research.
EBV  
Cancer  
/
HY-D2001 ATTO 488 NHS ester
ATTO 488 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 NHS ester is an NHS ester derivative of ATTO 488 that can be used to label proteins or antibodies.
Fluorescent Dye  
/
HY-B1374S1 Florfenicol-d3
Florfenicol-d3 ((-)-Florfenicol-d3)?is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
Isotope-Labeled Compounds   Bacterial   Antibiotic  
Infection  
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HY-W091784 3'-O-Methylguanosine
3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.
Endogenous Metabolite   Orthopoxvirus   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
Lung Cancer   Leukemia/Lymphoma/Myeloma   Orthopoxvirus Infection  
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HY-W015996 4-Nitrophenyl-N-acetyl-α-D-galactosaminide
4-Nitrophenyl-N-acetyl-α-D-galactosaminide (pNP-GalNAc) can be used as a chromogenic substrate for N-acetyl-D-galactosaminase. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide is cleaved by N-acetyl-D-galactosaminase to generate a yellow solution. The enzyme activity is quantitatively determined by absorbance detection.
Fluorescent Dye  
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HY-P99648 Gosuranemab
Gosuranemab (BMS-986168; IPN007; BIIB092) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease.

Species: Human

Tau Protein  
Neurological, Eye or Ear Disease  
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HY-403538 iZMYND8-34
iZMYND8-34 is a ZMYND8 inhibitor with an IC50 of 0.66 μM. iZMYND8-34 inhibits the binding of H3K4me1–H3K14ac peptide to the ZMYND8 protein. iZMYND8-34 inhibits ZMYND8’s histone recognition. iZMYND8-34 blocks neuroendocrine prostate cancer development.
Zinc Finger Protein  
Prostate Cancer  
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HY-P2754 Micrococcal nuclease
Micrococcal nuclease is a secreted nuclease from Staphylococcus aureus. It digests single-stranded and double-stranded DNA (ssDNA and dsDNA) as well as RNA, cleaves oligonucleotide linkers with T-T sites, and cuts neutrophil extracellular traps and biofilm extracellular DNA into mononucleotides and dinucleotides. Micrococcal nuclease stimulates the formation of Staphylococcus aureus biofilms and mediates immune evasion. It triggers on-demand release of antibiotics from hydrogel coatings, prolongs the formation of neutrophil extracellular traps, and promotes the dissemination and survival of MRSA during infection. Micrococcal nuclease is applicable to research and characterization related to Staphylococcus aureus infection.

Species: Staphylococcus aureus

Endonuclease   Bacterial  
Staphylococcus Aureus Infection  
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HY-77962 2-Thiobarbituric acid
2-Thiobarbituric acid is a commonly used colorimetric reagent for the detection of malondialdehyde (MDA), a marker of lipid peroxidation. 2-Thiobarbituric acid forms a complex with MDA that can be quantified by colorimetric detection at 532 nm as a measure of lipid peroxidation.
Biochemical Assay Reagents  
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HY-W007337 3-Bromopropan-1-ol
3-Bromopropan-1-ol is an endogenous metabolite. 3-Bromopropan-1-ol is significantly up-regulated during the estrous period of buffaloes. 3-Bromopropan-1-ol acts as an alkylating agent. 3-Bromopropan-1-ol participates in the enantioselective synthesis of nornicotine enantiomers. 3-Bromopropan-1-ol can be used in studies related to estrus detection in buffaloes.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
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HY-D1249 Calcein (mixture of isomers)
Calcein (mixture of isomers), Calcein (HY-D0040) Derivative, is a fluorescent dye (Ex/Em = 495/515 nm). Calcein (mixture of isomers) can be used for the researches for live cell staining, calcium ion detection, bone fluorescence labeling and membrane permeability leakage detection.
Fluorescent Dye  
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HY-159529 DBCO-PEG4-Eosin 5-isothiocyanate
DBCO-PEG4-Eosin 5-isothiocyanate (DBCO-PEG4-Eosin Y) is a fluorescent probe. DBCO-PEG4-Eosin 5-isothiocyanate contains a clickable functional group, DBCO, and four PEG units. DBCO-PEG4-Eosin 5-isothiocyanate can be used for various imaging detections.
Fluorescent Dye  
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HY-129046C RNase B, Bovine Pancreas
RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability. RNase B, Bovine Pancreas (Ribonuclease B, Bovine Pancreas) is the N-glycosylated form of RNase A. RNase B, Bovine Pancreas can promote the folding of polypeptide chains and play a role similar to molecular chaperones.
Endonuclease   DNA/RNA Synthesis  
Thyroid Cancer   Bladder Cancer   Pancreatic Cancer   Ovarian Cancer  
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HY-P99859 Donanemab
Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research.

Species: Human

Amyloid-β  
Alzheimer's Disease  
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HY-128699 D-Desthiobiotin
D-Desthiobiotin is a biotin derivative. D-Desthiobiotin increases testosterone. D-Desthiobiotin is used in affinity chromatography and protein chromatography, also can be used for protein and cell labeling, detection and isolation.

Source: Synechococcus elongatus

Endogenous Metabolite  
Metabolic or Endocrine Disease  
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HY-P72713 CD69 Protein, Human (HEK293, His)
CD69 protein, a key player in lymphocyte proliferation, acts as a signaling receptor in lymphocytes, natural killer (NK) cells, and platelets. It forms homodimers connected by disulfide bonds, highlighting its central role in cellular signaling for immune responses and platelet function. CD69 Protein, Human (HEK293, His) is the recombinant human-derived CD69 protein, expressed by HEK293 , with N-8*His labeled tag.

Species: Human; Source: HEK293

CD Antigens Receptor Proteins B Cell CD Proteins NK Cell CD Proteins Stem Cell CD Proteins Platelet CD Proteins Epithelial cell CD Proteins Pattern Recognition Receptors C-type Lectin Receptors CD69

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HY-P702796 EsxA Protein, Mycobacterium tuberculosis (His, Myc)
EsxA Protein, Mycobacterium tuberculosis (His, Myc) is the recombinant EsxA, expressed by E. coli , with N-10*His, C-Myc labeled tag.

Species: Others; Source: E. coli

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HY-P70833 INSL4 Protein, Human (HEK293, His)
The INSL4 protein plays a potentially critical role in the regulation of trophoblast development and bone formation. The specific mechanism of trophoblast development deserves further study. INSL4 Protein, Human (HEK293, His) is the recombinant human-derived INSL4 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Peptide Hormone & Neuropeptides

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HY-P74274 CD69 Protein, Mouse (HEK293, His)
CD69 Protein, a signal transmitting receptor, mediates lymphocyte proliferation in NK cells, platelets, and lymphocytes. It facilitates homodimer formation through disulfide-linkage. CD69 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD69 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens Receptor Proteins B Cell CD Proteins NK Cell CD Proteins Stem Cell CD Proteins Platelet CD Proteins Epithelial cell CD Proteins Pattern Recognition Receptors C-type Lectin Receptors CD69

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HY-P77502 ULBP-6/RAET1L Protein, Human (HEK293, Fc)
ULBP-6/RAET1L Protein, a key immune response modulator, activates the KLRK1/NKG2D receptor, triggering natural killer (NK) cell cytotoxicity. This engagement is pivotal for the immune system's defense against threats, showcasing ULBP-6/RAET1L's orchestration of NK cell responses. Its specificity is highlighted by the absence of a binding association with beta2-microglobulin in molecular interactions. ULBP-6/RAET1L Protein, Human (HEK293, Fc) is the recombinant human-derived ULBP-6/RAET1L protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

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HY-P74275 CD69 Protein, Mouse (HEK293, Fc)
CD69 Protein, a signal transmitting receptor, mediates lymphocyte proliferation in NK cells, platelets, and lymphocytes. It facilitates homodimer formation through disulfide-linkage. CD69 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD69 protein, expressed by HEK293 , with N-hFc labeled tag.

Species: Mouse; Source: HEK293

CD Antigens Receptor Proteins B Cell CD Proteins NK Cell CD Proteins Stem Cell CD Proteins Platelet CD Proteins Epithelial cell CD Proteins Pattern Recognition Receptors C-type Lectin Receptors CD69

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HY-P75810 HMGN3 Protein, Human (His)
HMGN3 binds to nucleosomes, regulates chromatin structure, and affects chromatin-dependent processes such as transcription and DNA repair. It affects insulin and glucagon levels and regulates pancreatic gene expression related to insulin secretion. HMGN3 Protein, Human (His) is the recombinant human-derived HMGN3 protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

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HY-P77503 ULBP-6/RAET1L Protein, Human (HEK293, His)
ULBP-6/RAET1L Protein, a key immune response modulator, activates the KLRK1/NKG2D receptor, triggering natural killer (NK) cell cytotoxicity. This engagement is pivotal for the immune system's defense against threats, showcasing ULBP-6/RAET1L's orchestration of NK cell responses. Its specificity is highlighted by the absence of a binding association with beta2-microglobulin in molecular interactions. ULBP-6/RAET1L Protein, Human (HEK293, His) is the recombinant human-derived ULBP-6/RAET1L protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P700685 CD69 Protein, Cynomolgus (HEK293, His)
CD69 protein, a key player in lymphocyte proliferation, acts as a signaling receptor in lymphocytes, natural killer (NK) cells, and platelets. It forms homodimers connected by disulfide bonds, highlighting its central role in cellular signaling for immune responses and platelet function. CD69 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD69 protein, expressed by HEK293 , with N-His labeled tag.

Species: Cynomolgus; Source: HEK293

CD Antigens Receptor Proteins B Cell CD Proteins NK Cell CD Proteins Stem Cell CD Proteins Platelet CD Proteins Epithelial cell CD Proteins Pattern Recognition Receptors C-type Lectin Receptors CD69

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HY-P703120 EGR2 Protein, Human (His, Strep)
EGR2 Protein, Human (His, Strep) is the recombinant human-derived EGR2, expressed by E. coli , with Strep, His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P701611 BPTF Protein, Human
BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human is the recombinant human-derived BPTF protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

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HY-P701612 BPTF Protein, Human (His)
BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human (His) is the recombinant human-derived BPTF protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P82445 Cpn10 Antibody (YA2190)
Cpn10 Antibody (YA2190) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cpn10.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810257 INSL4 Antibody (YA9601)
INSL4 Antibody (YA9601) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to INSL4.

Host: Mouse; Reactivity: human

Monoclonal Antibodies Primary Antibodies

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HY-P810353 NOXA Antibody (YA9675)
NOXA Antibody (YA9675) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to NOXA.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811059 ICER Antibody
ICER Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ICER.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811705 ICER Antibody (YA10176)
ICER Antibody (YA10176) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to ICER.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85004 CD69 Antibody (YA4696)
CD69 Antibody (YA4696) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD69.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Nanobodies Primary Antibodies

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HY-P810689 INSL4 Antibody
INSL4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to INSL4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P87439A EDR1/PHC1 Antibody (YA7127)(PBS only)
EDR1/PHC1 Antibody (YA7127) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EDR1/PHC1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P811141 SRSF5 Antibody
SRSF5 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SRSF5.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811299 IEX1 Antibody
IEX1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to IEX1.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

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HY-K1064 Exosome Protein Detection Kit (CD63 & TSG101)

MCE Exosome Protein Detection Kit (CD63&TSG101) can specifically detect exosome proteins CD63 and TSG101. This product is suitable for the detection of human, rat and mouse exosomes.


Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-K2110 HOLO Human Interferon-γ (IFN-γ) Detection Kit

MCE HOLO Human Interferon-γ (IFN-γ) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IFN-γ concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

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HY-K2112 HOLO Human Tumor Necrosis Factor-α (TNF-α) Detection Kit

MCE HOLO Human Tumor Necrosis Factor-α (TNF-α) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human TNF-α concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

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HY-K2113 HOLO Human Tumor Necrosis Factor-β (TNF-β) Detection Kit

MCE HOLO Human Tumor Necrosis Factor-β (TNF-β) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human TNF-β concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

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HY-K6017 3D Cell-ATP Viability Detection Kit

MCE 3D Cell-ATP Viability Detection kit is based on high-sensitivity bioluminescence detection technology (luciferase system) that quantitatively measures ATP to detect the number and viability of 3D cells in culture.

Cell Biology Cell Analysis 3D Cell Culture Cell Proliferation and Cytotoxicity Organoid Research

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Keywords

cell-free DNA | fragmentomics | liquid biopsy | multi-cancer early detection | nucleosome footprints | machine learning